MST2

Species: Mouse
Alias: Stk3, MST2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MST

Sequence

Name Sequence Type Origin Length Description Download
MST2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
MST2.AA Protein Sugen 497 None Fasta, JSON
MST2.NA RNA Sugen 2928 None Fasta, JSON

Protein domain

Protein domains of MST2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MST2.AA MST 27-278 75 3.6e-233 748.63 In-house 1-254 (254) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-254/254
Sequence Identity: 75% (191 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIA
||..||||.||||||.|||||..|..||||.|||..|||||||||||||||.|.|.||||||||  ||...||||||||.|||.||......||.|..||
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIA

TILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADI
.||..||.||.|||...||||||||||||||.||..|||||||.|||||||||||||||||.||||||||||.|.|.||||||||| ||||||.|||.||
CILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDI

HPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
|||||.||||..|||||..|| ||..|.|||.|||.|.||||.||.||||||||
HPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI

Kinase MST2.AA STE20 27-278 54 8.20000000001e-176 590.36 In-house 1-288 (288) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-288/288
Sequence Identity: 54% (157 aa)

FDVLEKLGEGSYGSVFKAIHKESGQV----VAIKQVPVESD------LQEIIKEISIMQQCDSPYVVKYYGSYFKN----TDLWIVMEYCGAGSVSDIIR
.. |||.|.||||.|.||.||..|..    ||||....|..      ...|.||||||.||..|..|||||||.|.    ..|||||||||.||..||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---LRNK-----TLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTD----TMA-KRNTVIGTPFWMAPEVIQE----
    ..|     ...|..||.|.. .|.||.||| ...|||||||.||||...| .|||||||..|||.    ||. ||||..|||.||||||||.    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-IGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIP--TNPPPTFRK--PELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
  ||.. .|||||||| ||||||.|||.|.|||||.||||  .|||||...  |. ||..| |||.|||.| ||.|.||.|||.||||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI

Kinase MST2.AA YSK 27-278 54 9.3e-147 445.12 In-house 1-257 (257) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-257/257
Sequence Identity: 54% (140 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI---IKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR--NKTLTED
|  .|. | ||.| |.|.| .  ..||||| .  |..  ||    .|| .  ||||||. |||||| | | |||.||||| ||..| .. .  .. . | 
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQ-FDEK

EIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE--IGYNCVADIWSLGITSIEMAEGKP
 ||.||.  ||||.|||  ||||||||| |.||. .|  ||.|||||||.|||. |||| .|||.|||||||..   .|.  ||||||||| .||| | |
YIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEP

PYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
||.| ||||. | || |.||.  . . .|. | .||  ||.| |||| .| .|| | ||
PYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI

Kinase MST2.AA STE 27-278 40 6.5e-146 491.05 In-house 1-359 (359) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-359/359
Sequence Identity: 40% (146 aa)

FDVLEKLGEGSYGSVFKAIHK------ESGQV---------VAIKQVPVESD-------------------LQEIIKEISIMQQCD--SPYVVKYYGSYF
.. .||.|.|..|.|.||...      ..|.|         .||||...|..                   .|.|.|||.||..|.  .|..|||||.||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KN-------TDLWIVMEYCGAGSVSDIIR---LRNKTLT----------EDEIATILKSTLKG-LEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAG
|.       ..|||.|||...||..|||.    ..|.|.          |..||.|....||| |.||| ...||||||..||||     .||.||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLTDTMA----------------KRNTVIGTPFWMAPEVIQE------IGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN-----------
||||.||                ||||..||| ||||||||        ||.. .||||||.| ||||.||||..| |||||.||||.|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPTFRK-----------------PELWSDDFTDFVKKCLVKSPEQRATATQLLQ--HPFI
    |||..                   |. ||..| ||..|||.| |..|.||.|||.  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase MST2.AA PAKL 27-278 52 5.2e-131 441.53 In-house 1-256 (256) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-256/256
Sequence Identity: 52% (135 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV-ES-DLQEIIKEISIMQQCDSPYVVKYYGSYFKN-TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEI
|   ||||.||||||.|||||... . |||  .. || . ..| |||.|   | .|..| |.||     . .|| |.|| .||. |.. .  |||.| .|
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

ATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA-KRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYA
. ||. ||||| |||    ||||||| |||||  .  |.|||||  || |.     |  ||||.|||||.|    ||  .|||||||| ||||.| ||  
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHY

DIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
|. ||||  |||  ||||| .|  ||  | ||. .|.|| ||.|. . .|| ||||
DMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI

Kinase MST2.AA PAKA 27-278 43 1.4e-109 370.3 In-house 1-260 (260) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-260/260
Sequence Identity: 43% (112 aa)

FDVLEKLGEGSYGSVFKAIHKESGQV--VAIKQVPVESDLQE--IIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNK----TL
....||.|.|. |.|..|. .. .|   |||||  .. . .   || ||..| .|  . .|.|. ||  . .||.|||| ..|.  |.|   ..    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

TEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK
.|. || ... .|.|||..|    ||||||  ||||...|  |..||| . |||.   ||||. ||| |||||||.   |.   |||||||  |||.|| 
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
||| .  | ||.. | ||  | .. |. ||..| ||..||| . ...||.|..||.|||.
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL

Kinase MST2.AA S_TKc 27-278 34 2.5e-105 357.12 SMART 1-231 (231) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-231/231
Sequence Identity: 34% (92 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGA--GSVSDIIRLRNK-----TLT
...|.|.|.|..|.|.|..||..|..||||...     . |..||.|... . |..||.|...   ..|..|||||.   |.. |.|. |..      ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC-VADIWSLGITSIEMAEGK
| ... ... ....|||.| .. ||||.|  ||||..  | |..|||.| ||       .|..|||..|||||.   ||..  .|.||.|.. .||. |.
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQ-------HPFI
||.     | ..| .              |... ||..|||.| ||.| || ..||       ||..
PPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase MST2.AA Ste20-DD1 27-278 47 3.2e-105 355.88 In-house 1-268 (268) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-268/268
Sequence Identity: 47% (128 aa)

FDVLEKLGEGSYGSVFKA-------IHKESGQVVAIKQVPVES-DLQE---IIKEISIMQQC-DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR
| ..|  | ||.| |          .     .|.|.| | ..  |  |     ||| |.    | ||.||| | | |   | ||||||  ||. ||. . 
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC

NKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE----IGYNCVADIWSLGIT
 |.|.|..|| |.    ||| |||  | .||||||||.|.| || .|||||||   .  .  | ||||| |.||.||.|       ||   |||||||||
SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT

SIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
 ||||| |||  .. | | || ||  .||| . |  ||  | ||.| || . |. |  | ||| ||||
AIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI

Kinase MST2.AA KHS 27-278 47 6.8e-102 343.52 In-house 1-258 (258) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-258/258
Sequence Identity: 47% (124 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES--DLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIA
...| ..| | || |.|| ...|....|.| . .|   |.. | .|| .|..|  | .| |.|||...  |||.|||||.||. || ..  . |.|  ||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGP-LSELQIA

TILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCVADIWSLGITSIEMAEGKPPY
 . . ||.||.||| | |.|||||  ||||. .|. |||||||..|.| |.|||   ||||.||||||    .. |||   |||..||| ||.|| .|| 
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

ADIHPMRAIFMIPTNP--PPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
 |.|||||.|..      ||. .  . ||. | .||| .|.|.| .| ||..||||||.
FDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV

Kinase MST2.AA NinaC 27-278 46 8.3e-102 344.53 In-house 1-267 (267) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-267/267
Sequence Identity: 46% (125 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIK-QVPVESDLQEIIKEISIMQQ-CDSPYVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDIIR---LRNK
. . |  | | || |||.  |..||..|.| | ...    ||  |  |... || | ||..|| |.|        ||.|||||  ||| |...    . .
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCGR

TLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITS
 . |. || ||. .. ||  ||  . ||||.|  |||| |||  || ||||  ||. |  .||| .|||.|||||||      .  |   .|.|||||| 
RMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITA

IEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
||.. |.|| ||.|||||.| || ||||| ..||.|...| ||. .|| |  |.| . ...|.||||
IELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI

Kinase MST2.AA SLK 27-278 43 1.9e-93 315.66 In-house 1-259 (259) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-259/259
Sequence Identity: 43% (112 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES--DLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIA
....  ||.| .| | || ||| ... | | . ...  .|.. . || |. .|. |..|| |..|. . .||...|.|. | |  |.   ...|||| |.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

TILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKP
 . | .. .|..||  . ||||.||||||.  .|. .||||||. ... || || | ||||.||||||.     ..  | . ||||||||| ||||.. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
|. .. ||| .. |    |||  .|  || .| ||.|||||| |..| |. ||.||...
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV

Kinase MST2.AA Pkinase 27-278 31 1.5e-91 315.27 Pfam 1-293 (293) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIK------EISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAG----SVSDIIR-LRN
. ...|.|.||.|.|.|..|| .|..||.|.......  .  .      ||.||. ...|..|..|...  ......|||||. |    . .|.|.  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KTL--TEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA----KLADFGVAGQL-TDTMAKRNTVIGTPFWMAPEVIQ-EIGYNCVADIWSL
...  .|.|.  ... .|.||||.| |. ||||.|  |||.. .||     |..|||.| |. .      .|. |||..||||||.   .|   .|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GITSIEMAEGKPPYADI----HPMRAIFMIPTNPPPTFRKPELWS---------------------DDFTDFVKKCLVKSPEQRATATQLLQHPFI
|.. .||. |.||. .     . .. ..||  . .| .. .. |.                     ... ||.|.|| | |..| ||.|.||||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase MST2.AA Pkinase_Tyr 27-278 27 3.1e-36 123.36 Pfam 1-270 (270) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-270/270
Sequence Identity: 27% (76 aa)

FDVLEKLGEGSYGSVFKAIHK----ESGQVVAIKQV--PVESD---LQEIIKEISIMQQC-DSPYVVKYYGSYF-KNTD--LWIVMEYCGAGSVSDIIRL
   ..|||||..|.|.|.. |    . .. ||.| .     ..   ... ..|..|| |  . | .|..||    .     ..|||||.  |.  |  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---NKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL--TDTM-AKRNTVIGTPFWMAPEVIQEIGYNCVADIWSL
.   .. ||  ..  .     ||.|||. .. ||||. | |.|.. ....| .||| |  .  .|.   ||       .|||||.|..  ..   |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GITSIEMAE-GKPP-YADIHPMRAIFMI-PTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
|..  |.   |. | |... . . . .|   .      .||. .|.  |  |.|  . ||.| | ...  | ..
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL

Kinase MST2.AA TyrKc 27-278 25 1.8e-26 95.17 SMART 1-280 (280) Show / Hide
Range on Protein: 27-278
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC--DSPYVVKYYGSYFKN-------TDLWIVMEYCGAGSVSDIIRLRNKT
   ..||||| .| |.|.. |   . ||.| .  .. ......|..|| .   . | .|. ||   .          |.|||||.  |.  | .| . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT----MAKRNTVI----GTP-----FWMAPEVIQEIGYNCVADI
|. ..   .     .| |||| .. ||||. | |.|.. ....| .||| .  ..|      .|   .     |.       |||||.|..  ..   |.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSLGITSIEMAE-GKPPYAD-----IHPMRAIFMIPTN----PPPTFRKPEL----WSDDFTDFVKKCLVKSPEQRATATQLLQHPFI
|| |..  |.   |..|| .     . . ..|  . .     .||    | .     .|.  .  |.|    ||.| | ...  | ..
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Mst1_SARAH MST2.AA Mst1_SARAH 442-490 77 9.6e-36 117.86 Pfam 1-49 (49) Show / Hide
Range on Protein: 442-490
Range on HMM: 1-49/49
Sequence Identity: 77% (38 aa)

DFDFLKNLSLEELQMRLKALDPMMEREIEELHQRYSAKRQPILDAMDAK
||.|||..|.||||.||..||||||.|||||.|||.||||||||||.||
DFEFLKSWSYEELQQRLASLDPMMEQEIEELRQRYQAKRQPILDAMEAK