MUSK

Species: Mouse
Alias: MUSK, Musk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Musk

Sequence

Name Sequence Type Origin Length Description Download
MUSK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 281 Kinase domain by global Sugen HMM Fasta, JSON
MUSK.AA Protein Sugen 878 None Fasta, JSON
MUSK.NA RNA Sugen 3384 None Fasta, JSON

Protein domain

Protein domains of MUSK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set MUSK.AA I-set 28-117 30 1.3e-16 58.84 Pfam 1-92 (92) Show / Hide
Range on Protein: 28-117
Range on HMM: 1-92/92
Sequence Identity: 30% (28 aa)

PVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENG---QLLTILSVEDSDDGIYCCIANNGVGGAVESCGALQV
|..|...  | . . | |.| | |. .|.|..||...   ..  . |......|   . |||. |. .| |.| |.| |  .| .|.   |.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS-FGEAECTAELTV

IGc2 MUSK.AA IGc2 40-106 25 5.9e-11 43.65 SMART 1-56 (56) Show / Hide
Range on Protein: 40-106
Range on HMM: 1-56/56
Sequence Identity: 25% (17 aa)

LVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCIANNGVG
.  . .|. | .. .| |.|.|..    .           ... ||| .|. .|.|.| |.| | .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG

IG MUSK.AA IG 34-118 22 1.1e-08 36.11 SMART 1-58 (58) Show / Hide
Range on Protein: 34-118
Range on HMM: 1-58/58
Sequence Identity: 22% (20 aa)

LETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDD---GIYCCIANNGVGGAVES--CGALQVK
 . | . . | .|. | |.     .|.|.                     ||| .|. .|    |.| | |.   .| ..|     |.|.
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ

V-set MUSK.AA V-set 27-99 19 8.887749 1.06 Pfam 1-110 (128) Show / Hide
Range on Protein: 27-99
Range on HMM: 1-110/128
Sequence Identity: 19% (21 aa)

APVITT-PLE----TVDALVEEVATFMCAVE-SY----PQPEISWTR-NKI-----LIK-----------------LFDTRYSIRENGQ----LLTILSV
. ..|. | .     | . . . .|. | .  .|    .   |.| |  .      .|                   |  |...  |..     ||| ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

EDSDDGIYCC
. || |.| |
QPSDSGTYYC

I-set MUSK.AA I-set 121-208 39 3.5e-32 111.71 Pfam 1-92 (92) Show / Hide
Range on Protein: 121-208
Range on HMM: 1-92/92
Sequence Identity: 39% (37 aa)

PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNALRE-NSRIAVLESG----SLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEV
||.|..| .|.. ||  | . |.  |.|.|.||| |..  ||. ..|. . ..|    .|.| |||..|.|.|.|||.||.|.| .. ..|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECT-AELTV

IGc2 MUSK.AA IGc2 133-197 35 9.1e-17 62.94 SMART 1-56 (56) Show / Hide
Range on Protein: 133-197
Range on HMM: 1-56/56
Sequence Identity: 35% (23 aa)

IEGLKAVLPCTTMGNPKPSVSWIKGDNALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLG
.||  ..|.|   ||| |...|.| .  |          ...|.| ||..||.| |.|.| |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG

IG MUSK.AA IG 127-209 25 2e-14 55.17 SMART 1-58 (58) Show / Hide
Range on Protein: 127-209
Range on HMM: 1-58/58
Sequence Identity: 25% (22 aa)

PINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNALRENSRIAVLESGSLRIHNVQKEDA---GQYRCVAKNSLGTAYS-KLVKLEVE
|  |   ||  ..|.|        ...|                    |.| |||.||.   | |.|.|.   |...| . ..|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

V-set MUSK.AA V-set 134-208 18 8e-06 21.89 Pfam 20-128 (128) Show / Hide
Range on Protein: 134-208
Range on HMM: 20-128/128
Sequence Identity: 18% (20 aa)

EGLKAVLPCTTMGNP----KP-SVSWIK-GDN-----------------------ALRENSRIAVLESGS-----LRIHNVQKEDAGQYRCVAKNSLGTA
|| .. |||. . ..     . ...|.. ..                          | . |. .  ..|     |.|.|.| .| | | |...|.    
EGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDY

YSKLVKLEV
. . ..| |
FGHGTRLTV

IGv MUSK.AA IGv 137-192 16 0.000629 10.29 SMART 1-76 (76) Show / Hide
Range on Protein: 137-192
Range on HMM: 1-76/76
Sequence Identity: 16% (13 aa)

KAVLPCTTMGNPKPSVSWIKG-------DNALR-----ENSRIAVLESG---------SLRIHNVQKEDAGQYRCVA
 . |.|.. |.    ..|..        ...|        .|. .  .          .|...|.. || | | |  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR

IGc2 MUSK.AA IGc2 234-299 30 2e-06 28.42 SMART 1-56 (56) Show / Hide
Range on Protein: 234-299
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

TFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHG
  |  |||.| | | |.|.|.|.  |  ..             ...|..   .|   |.|||.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG

I-set MUSK.AA I-set 222-266 21 3e-05 20.34 Pfam 1-46 (92) Show / Hide
Range on Protein: 222-266
Range on HMM: 1-46/92
Sequence Identity: 21% (10 aa)

ARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSS-GS
 .... | .  |. |. ... |...| | |..||  .|  ... ..
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSD

IG MUSK.AA IG 228-310 20 0.000159 22.28 SMART 1-58 (58) Show / Hide
Range on Protein: 228-310
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

PESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP--------GLYTCIATNKHGEKFS--TAKAAAT
|. . |  |. |||.| .      .|.|                          | | .         | |.| ||  ||...|  ...   .
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

I-set MUSK.AA I-set 288-306 57 0.005633 12.61 Pfam 71-89 (92) Show / Hide
Range on Protein: 288-306
Range on HMM: 71-89/92
Sequence Identity: 57% (11 aa)

GLYTCIATNKHGEKFSTAK
| |||.|||. ||  .||.
GKYTCVATNSFGEAECTAE

Fz MUSK.AA Fz 327-458 28 5.3e-56 172.72 Pfam 1-143 (143) Show / Hide
Range on Protein: 327-458
Range on HMM: 1-143/143
Sequence Identity: 28% (41 aa)

CAQYR--GEVCDAVLAKDALVFFNTS-----YRDPEDAQELLIHTAWNELKAV----SPLCRPAAEALLCNHLFQECSPGVVPTP-MPICREYCLAVKEL
|...|  ...|  .. . ...... .     . . |...|.. ...|..|...    ||.|.|... .||...|..| .|....| .| ||..|.||||.
CQPIRNDIPMCHGMPYNMTWMPNLLHHETGTQKEAELQWEMM-IHQWWPLVHTSTHLSPKCHPHIQFFLCSMYFPMCTDGFHHPPPIPPCRSMCEAVKEQ

FCAKEWQAMEGKAHRGLYRSGMHLLPVPECSKLPSMHRDPTACT
.|....|.||.|.||..|. |.| . ...|.|.|..|.|...|.
GCEPVMQMMEDKKHRRMYPFGFHWPEMLNCNKFPHHHDDRHMCM

Kinase MUSK.AA Musk 584-865 75 4.5e-241 804.81 In-house 1-282 (282) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-282/282
Sequence Identity: 75% (214 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|.|||||||||||||||||||||.|||..|||||||||..||..||.||||||..|||||.||||||||||.||.||||||||||||||||||.|.|||.
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESI
.||..|.|...||.|||||||.|.|..|||.|.|.|.|||||||..||||||||||||..|.|.||||||||||.||..||||...||.|||||||||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

FYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRIL
.||..|.|||||||||.|||||||.|||||||.|||||||.|.||||.||||||...|.|||.||.|.|||||.||.||...
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI

Kinase MUSK.AA Pkinase_Tyr 584-865 45 5.9e-150 508.49 Pfam 1-270 (270) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-270/270
Sequence Identity: 45% (131 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADM--QADFQREAALMAEF-DNPNIVKLLGVCA-VGKP--MCLLFEYMAYGDLNEFLR
|.  . .||||||.|..... | .| .. . |||||||| |. .   ..|| |||..| .. ..||||.|.|||   |.|  ... .|||..||| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYY-KADGNDAIPIR
. .                    ....||.  . |....|.|.||.||......|||||.|||||.|..||||.||||.| ||. ||| .. |.  .||.
KHR--------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK

WMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQP-YYGMAHEEVIYYV-RDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRIL
||.||.|.|...||.||||..||..||||.|| || |.||  |||. |. .||. ..|||||| |.|.||..|| . |.|||.|  ||..|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase MUSK.AA TyrKc 584-865 40 9.1e-143 481.51 SMART 1-280 (280) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-280/280
Sequence Identity: 40% (126 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEF--DNPNIVKLLGVCAVG-------KPMCLLFEYMAYGDLNE
|.  . .||||||.|.....         ..||||||||.|    ..|| ||| .| ..  ..||||.|.|||  .       .|.....|||..|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSA-------DYYKA
.||.  |.                       |. .. | .. |.|.||.||......|||||.|||||||  .|||.||||||.||.        |||..
YLRKHRPK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

----DGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG-----MAHEEVIYYVRDGNILACPEN--------CPLELYNLMRLCWSK
    .|.. .|||||.||.|.|...||.||||..||..||||.|| |||.|     |  .||| ||..|. . .|.|        || |.|..|. ||  
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

LPADRPSFCSIHRIL
 |.|||.|  ||...
DPEDRPTFSEIHECF

Kinase MUSK.AA TK 584-865 26 5.9e-125 421.11 In-house 1-486 (486) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-486/486
Sequence Identity: 26% (131 aa)

IEYVRDIGEGAFG---RVFQARAPGLLPYEPF--------------------TMVAVKMLKEEASADMQADFQ-------------REAALMAEFD----
|.... .|||.||   .|..... |. |...                     | ||||||||........ |.             .||. |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NPNIVKLLGVCAVG------------KPMCLLFEYMAYGD----LNEFLRSMSPHTVCSLSHSDLSTRARVSS--------------------------
  ||||.|.|||  |            .|.... |||..||    | ..||. .|.. ......| . . ...|                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------PGPPPLSCAEQLC-------------------IARQVAAGMAYLSER------KFVHRDLATRNCLVGETMV-----------VKIADFG----
      . ||||. ...|.                   ...|.|.||.||...      .|||||||.||||||| .|           .||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSRNIYS------------------------ADYYKADGNDAIPIRWMPPESIF---------YNRYTTESDVWAYGVVLWEIFSYGLQPYYG-MA
    |.| |||                         |||... .. .|||||.||...         |...||.||||..||..||||.|| .|||| | 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

H---------EEVIYYVRDG--------------NILACPENCP--------------LELYNLMRLCWSKLPADRPSFCSIHRIL
.         .||. |.|.|              . ...|..||               |.| ||. ||.. |.|||.|  .|. |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase MUSK.AA Trk 584-865 45 1.1e-124 420.56 In-house 1-275 (275) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-275/275
Sequence Identity: 45% (129 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|   ...||||||.|| |    |.| .  .||||| || .|| .   |||||| |. . . ..|||. |||  ..|. . ||||  ||||..||.  |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLK-DASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYS-ADYYKADGNDAIPIRWMPPES
.| .   .   .         ||   . | ||.|.|.|| |. .  |||||.||||||||.  .|||.|||.|| .||  |||. ..  . |||||||||
MCYAQYQPRQAPG--------PLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPES

IFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNI-LACPENCPLELYNLMRLCWSKLPADRPSFCSIHRIL
| | ..|.||||| .|||.||.|.|| ||.|..   ||| ..  |   | .|. || |.|..|. || . |  | .  .|| |.
IMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII

Kinase MUSK.AA Ror 584-862 48 1.4e-123 416.84 In-house 1-272 (308) Show / Hide
Range on Protein: 584-862
Range on HMM: 1-272/308
Sequence Identity: 48% (136 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
..    .||..|| |.     |... .. . ||.| .|..||   ..||..|. |||... ||||.|||||   .|.| |||||. ||| ||| . ||| 
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESI
    |  |   |   ||     |. .. | || |.|||| ||| . |||||||.|||||||. .|||.||||.| |||.|||.  ..   |||||.||.|
DHGCSSDD--DRMVKSS-----LDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAI

FYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIH
 | . ...||.| .|||||||.|||.|||||    |||  .|   .| ||.|||   | ||  ||.  |. || |  ||
MYGKFSEDSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIH

Kinase MUSK.AA UTK 584-868 36 2.7e-104 352.77 In-house 1-296 (296) Show / Hide
Range on Protein: 584-868
Range on HMM: 1-296/296
Sequence Identity: 36% (115 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQAD----FQREAA---LMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEF
..  |..|.|||| |. ||.    . ..   |||| ....|.|  . .    | .||.   .|. |.  ||...|.|||  ..|.... |||. |||  .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGET-------MVVKIADFG---LSRNIY-----
||. .| .                 . |  |.  ..|| |...|.||.||....||||||| |||||..        ||.||||||   .||...     
LRRHRPTPP----------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFS

----SADYYKADGNDAIPIRWMPPESIFYN-RYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDG--NILACPENCPLELYNLMRLCWSKLPA
    ...||.|...|..||||| ||.. .. |.|| ||||..|||.|||...| .|| ||....|.  |..|    ..||. ||...|.||. || . |.
NRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQ

DRPSFCSIHRILQRM
.||.|   ....|.|
ERPDF---EDLVQQM

Kinase MUSK.AA InsR 584-867 41 3.2e-100 337.35 In-house 1-278 (278) Show / Hide
Range on Protein: 584-867
Range on HMM: 1-278/278
Sequence Identity: 41% (120 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFT--MVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSP
|.  |  |.|.|| |    | |..| |. .   .|.| ..|.||.    .|  ||  | ||.  ..|.|||||  | ||    | |.||||  .|||  |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

HTVCSLSHSDLSTRARVSSPGPP----PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRW
  .                || .    . .  . .  | ... |||||  .|||||||| |||.| .   |||.|||. | ||  |||.  |    |.||
EEEF-------------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRW

MPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV-RDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQR
|.|||.    .|| |||| .||||||. . | ||| |   |.|  |. .|||.|  |||||  .. ||. ||   | .||.|  |  .|. 
MAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD

Kinase MUSK.AA DDR 584-865 38 4.4e-92 312.22 In-house 1-306 (306) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-306/306
Sequence Identity: 38% (120 aa)

IEYVRDIGEGAFGRVFQARAPGLL-------PYE----PFTMVAVKMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAY-G
   |  |||| || |    . |..       . .      |.||||||...|.    .|| .|.. |.     ||||.|.||| . .|.|.. ||| . |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNEFLRSMSPHTVCSLSHS-DLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFG--LSRNIYSADYYKA
||| |.    . ....   . |..   . .      .| .  . |. |.|.||.||.   ||||||||||||||.   .||.|||  .||| || |||. 
DLNQFWMEHEAENSGLMNCKADTQNCQKPT------ISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRV

DG-----NDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYG-LQPYYGMAHEEVI-----YYVRDGN--ILACPENCPLELY-NLMRLCWSKLPA
.|         ||||| .|||  .  || ||||| || .||.|.    |||  .  | ||      .  .|.  .|. | .|| |.| .||  ||.  . 
EGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQS

DRPSFCSIHRIL
 ||||  ||. |
QRPSFEEIHKFL

Kinase MUSK.AA TK-Unique 584-865 36 6.8e-89 301.63 In-house 1-294 (294) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-294/294
Sequence Identity: 36% (114 aa)

IEYVRDIGEGAFGRVFQARAPGLL-PYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGK-PMCLLFEYMAYGDLNEFLRSMS
.|  . ||||||| |. . . |.  . . .. |||||||..|.   ..|| .|...| | .  ||||..||.|     |.....||...|.|  .||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PHTVCS---------------------LSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSE--RKFVHRDLATRNCLVGETMVVKIADFGLSR
| .. .                     .|  || .                   .| |.| ||.||..  .|.|||||..||.|..|  |.||.|||..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH-------------------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMAR

NIY-SADYYKADGNDAIPIRWMPPESIF--YNRY-TTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENC-PLELYNLMRLCWSKLP
 .|   .| . ..   ||||||.|||.   .. | ||.||||..||..||||..| .||.||  ....  .||| ..  ||.| . |.||||. ||.. |
DVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEP

ADRPSFCSIHRIL
 .|||| .|  .|
EERPSFRQIKHRL

Kinase MUSK.AA Src 584-865 37 3.8e-87 295.84 In-house 1-255 (255) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-255/255
Sequence Identity: 37% (106 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|  .| .|.| || |...       .   | |||| ||.      ...|..|| .| ... ...|.|. ||  ..|     |||. | | ..|.      
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSA-DYYKADGNDAIPIRWMPPES
                ..    |.  ... .| |||.|||||......||||| || ||||. |.|.||||| | |    | | |     .||.|. || 
----------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEA

IFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYN-LMRLCWSKLPADRPSFCSIHRIL
| |.|.|. |||| .|. |.||..||  || ||  .||.  |  |  . ||.||| |||. .|. || | | .|| |  ..  |
INYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase MUSK.AA CTKA 584-865 39 1.1e-86 291.28 In-house 1-290 (290) Show / Hide
Range on Protein: 584-865
Range on HMM: 1-290/290
Sequence Identity: 39% (119 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPF---------TMVAVKMLKEEASADMQADFQREAALMA--EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDL
      |||| .| ||.|    .|  .|          . |||||||..|       |  || . .   |. ||.. |||||   ||.    |.| ||||
HCIMFKIGEGHYGQVFRA----WLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDL

NEFLRSMSPHT--VCSLSHSDLSTRARVSSP---GPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSA-DYYK
  .||   |    ||         ||| | |    |  ..  ||   |.|.|||| ||.|. ||||||| ||||.|   ..||||||..|   .   || 
HCYLRACRPADGQVC-------PARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYY

ADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDG--NILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRI
      .|.||| || .  ..... |||||.||.||||.| |  |. .|   ||   .  .    |  | |||  || .| .||   |. ||.|  . | 
VSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRM

L
|
L

Kinase MUSK.AA S_TKc 584-868 21 7e-42 146.38 SMART 1-231 (231) Show / Hide
Range on Protein: 584-868
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY--GDLNEFLRSMSP
 | .| ||.||||.|...|  .         ||.|..|         ...|| ... . . ||||||..|.   . ... .||.    ||| ...... .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

HTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPE
|  ..                  |..  .  ....|.. ...|. .....||||   | |. |  ..||.||||.| .                 .|.||
HGLRF------------------PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPE

SIFYNRYTT-ESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHR------ILQRM
 .    |.. ..|.|. |..|.| .. |  |..   ...... .            . |. ...| |. | |..||.   . .      . . .
VL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase MUSK.AA Pkinase 584-868 21 2.8e-39 139.95 Pfam 1-293 (293) Show / Hide
Range on Protein: 584-868
Range on HMM: 1-293/293
Sequence Identity: 21% (70 aa)

IEYVRDIGEGAFGRVFQARAPGL-LPYEPFTMVAVKMLKEEASADMQAD--FQR--EAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYG----DLNE
.. .| ||.|.||.|....  |         .|||| .| . ..... |    |  |...|.... ||||.|....  .. ... .||.  |    || .
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FLRSMSPHTVCSLSHSDLSTRARVSSPGPPPL--SCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVV----KIADFGLSRNIYSADYYKAD
...                           ..  |  |  ....|.. |..|. .....||||   |.|. .....    ||.||||.. ..   | .  
YIST----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS

GNDAIP--IRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYGM------AHEEVIYYVRD-GNILACPENCP-------------------LE
 .. .   ...|.|| |  .. |....|.|..|..|.| .. |  |..|        . ..|. ...  .   .|. |.                    |
-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

LYNLMRLCWSKLPADRPSFCSIHRILQR--M
.  ... |. | |..||.   .. |||   .
CKDFIKWCLCKDPKKRPT---AEQILQHPWF