Gene NIK (Mouse)

NIK

Species: Mouse
Alias: NIK, Map3k14
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE-Unique

Sequence

Name Sequence Type Origin Length Description Download
NIK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON
NIK.AA Protein Sugen 942 None Fasta, JSON
NIK.NA RNA Sugen 4173 None Fasta, JSON

Protein domain

Protein domains of NIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NIK.AA STE-Unique 465-655 35 2.8e-105 356.05 In-house 367-616 (616) Show / Hide 
Range on Protein: 465-655
Range on HMM: 367-616/616
Sequence Identity: 35% (89 aa)

PWVNIFMELLEGGSLGQLIKQMGC---------LPEDRALYYLGQALEGLEYLHTRR--ILHGDVKADNVLLSSDG----SRAALCDFGHALCLQPDGLG
.||.||||..|.|.|.|.||..||         .||.....|..|.||||||||...  |.|.|.|..|.....||    .....|||||| |.|||...
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE

K---------------------------------SLLTGDYIPGTETHMAPEVVMGK-----PCDAKVDIWSSCCMMLHMLNGCHPWTQYFRG----PLC
|                                 ...|..|..||...|.|||....     |.|.||||||..||..||..||.||.|....    ..|
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMC

LKIASEPP--PIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGK
..|...||  ||..|||.|.|...|.|...|...|.||.||..|.... .
IHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase NIK.AA STE 402-649 22 3.4e-68 232.87 In-house 1-351 (359) Show / Hide 
Range on Protein: 402-649
Range on HMM: 1-351/359
Sequence Identity: 22% (80 aa)

MTHQPRVGRGSFGEVHRMKDK------QTGFQ---------CAVKKVRLEVFRV----------------------EELVACAGLS--SPRIVPLYGAVR
 ... ..|.|.||.|.. ...      .||..         .|.|...||  .                       .|.  .  ..  .| ||  ||.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------PWVNIFMELLEGGSLGQLIKQM--------------GCLPEDRALYYLGQALEG-LEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHA
 .        ...|.||...|||| ..||.               ...||.   |.. | |.| |.|||  .| | |.|..|.||      . |||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

LCLQPDGLGK----------SLL-TGDYIPGTETHMAPEVVMG------KPCDAKVDIWSSCCMMLHMLNGCHPWTQ-YFRGPLCLKIAS----------
 .|.... ..          .     . . ||  .|||||...      |..|.|.||||  |....|..|..||   .    . ... .          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-----EPPPIREI----------------PPSCAPLTAQAIQEGLRKEPVHRASAMEL
     .|||. .                 | .. |   . |.  |.|.| .|..| .|
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQL
Kinase NIK.AA S_TKc 402-657 26 2e-44 154.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 402-657
Range on HMM: 1-231/231
Sequence Identity: 26% (72 aa)

MTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEG--GSLGQLIKQMGC------LPEDR
 .    .|.|.||.|.. ..| || ..|.|...       |.  .     | || ||.. ..   . ..||...|  |.| ..||..|.      .|| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

ALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDA-KVDIWSSCCMMLHML
| .|. | ...|||.| ..|.| |.| .|.||..   .  .|||| |  |            . . ||   |||||.   . .  |.|.||  |..  ||
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

NGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRR-----KVGKAL
 |. |.       . .|.               |   . |.  |.|.| .| .| |. .     |    .
CGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NIK.AA Pkinase 402-598 30 1e-40 145.05 Pfam 1-212 (293) Show / Hide 
Range on Protein: 402-598
Range on HMM: 1-212/293
Sequence Identity: 30% (67 aa)

MTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE----------ELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGG----SLGQLIK--Q
 .   ..|.||||.| . ..| || . |||.....  . .          |.   . |..| || ||......... . ||..|||    .|  .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

MGCL--PEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRA---ALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVM-GKPCDAKV
 ||.  .|. .  |. | |.||||.| ..|.| |.| .|.|....|  .    .|||| | ...   . ..  . ..  ||   |||||.. |.. . ||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFC-GTPWYMAPEVIRGGQYYGPKV

DIWSSCCMMLHMLNGCHPW
|.||  |..  ||.|  |.
DMWSCGCILYEMLCGRPPF
Kinase NIK.AA TKL 408-653 19 2.1e-34 120.65 In-house 1-364 (364) Show / Hide 
Range on Protein: 408-653
Range on HMM: 1-364/364
Sequence Identity: 19% (71 aa)

VGRGSFGEVHRMKDKQ--------TGFQCAVKKVRLEV--------------------------------FRVEELVACAGLSSPRIVPLYGAVREGPW-
.|.|.||||.. | ..        ||   |||| . .                                 |..||.. .  |. | ||...|.. ..|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VNIFMELLEGGS-LGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRR--------ILHGDVKADNVLLSSDGS-------------RA
              | ||. .||| | .|.        .. .    ..  |..|||...        |.| | | .|.|. ...              ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

ALCDFGHALCLQPDGLGKSLL--------------TGDYIPGTETHMAPEVVMGK----------------PCDAKVDIWSSCCMMLHMLNGCHPWT-QY
 .|||| . .....|  .                 |   . ||  .||||| .|.                . . |.|..|   ..  .| .|.|.  . 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

FRGPL---------CLKI-ASEPPPIREIPPS---------CAPLTAQAIQEGLRKEPVHRASAMELRRKV
.. ..          . .  ...||| .|...         | |  .. .|.    .|  | |. |.  . 
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase NIK.AA CAMK 407-598 17 1.6e-31 98.27 In-house 1-334 (425) Show / Hide 
Range on Protein: 407-598
Range on HMM: 1-334/425
Sequence Identity: 17% (60 aa)

RVGRGSFGEVHRMKDKQTG------------FQCAVKKVR---------------------------------LEVFRVEELVACAGLS-------SPRI
  ||||||.|.. ..|.|.             ..|.| .                                   . .   |.  .  |.        | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VPLYGAVR------------EGPW--------VNIFM---ELLEGG----SLGQLIKQMGC---------------LPEDRALYYLGQALEGLEYLHTRR
. || .                          . ..|   |. .||     | . |.. ||               ..|. | .|  | .....|.| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHGDVKADNVLLSSDG----------------SRAALCDFGHALCLQPD--------GLGKSLLTGD------------YIPGTETHMA-PEVVMG---
| | | | .|.||....                    ..||| |  ..|.        . |.. .  .               ||   || |||. |   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------KPCDAKVDIWSSCCMMLHMLNGCHPW
           .... |.|.||  ...  || |. |.
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase NIK.AA STE11 409-601 30 1.8e-29 103.8 In-house 8-241 (303) Show / Hide 
Range on Protein: 409-601
Range on HMM: 8-241/303
Sequence Identity: 30% (72 aa)

GRGSFGEVHRMKDKQTGFQCAVKKVRL-----------EVFRV--------EELVACAGLSSPRIVPLYGAVR---EGPWVNIFMELLEGGSLGQLIK-Q
|.|.|| |..  .. ||   |||....           .  .         ||.    .|. ..||  ||. .   .   ||||||  .|||| ....  
GKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHK

MGC--LPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGD-----YIPGTET--------HMAPEVV
 |.  ..|    .|  | |||| |||  .| | |.|..|.|| ||| .  | ||| |  |. ... ..   ..      ..||           |||||.
WGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVI

MGKP---CDAKVDIWSSCCMMLHMLNGCHPWTQY
.. .    ..|.||||  | .. |. | .||  |
KQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNY
Kinase NIK.AA STE20 403-583 30 2.7e-29 103.66 In-house 2-212 (288) Show / Hide 
Range on Protein: 403-583
Range on HMM: 2-212/288
Sequence Identity: 30% (66 aa)

THQPRVGRGSFGEVHRMKDKQTGFQ----CAVKKVRL---------EVFRVEELVACAGLSSPRIVPLYGAVREG----PWVNIFMELLEGGSLGQLIKQ
. . ..|.||.|.|..  .|.|| .    .|.||. |         .   . | .  . . .| ||  ||.   .     .  | ||...|||| ...|.
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKH

M---GC------LPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTG---DYIPGTETHMAPEVVMG-
.   |.      . |.   | . ..|.||.||| ..| | |.||||.||..|| .. |.||| .  |.. | .     .   . . ||   |||||... 
CMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDG-EVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEVIQCM

----KPCDAKVDIWS
    |. | |.||||
EGPDKGYDYKCDIWS
Kinase NIK.AA STE-Unique 403-464 31 2e-26 90.47 In-house 1-73 (616) Show / Hide 
Range on Protein: 403-464
Range on HMM: 1-73/616
Sequence Identity: 31% (23 aa)

THQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR-----------VEELVACAGLSSPRIVPLYGAVREG
..|...||||||.||....|...|.||.|...|..|.           ..|......|....||..||....|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG
Kinase NIK.AA MEKK2 401-655 31 8.2e-26 90.56 In-house 1-262 (262) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-262/262
Sequence Identity: 31% (83 aa)

WMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE----------ELVACAGLSSPRIVPLYGAVREGP--WVNIFMELLEGGSLGQLIKQMGC
|   .  .| | || |    |  ||   |||.|. .    |          |.     |  .|||  || .|.     . |||| . |||.   .|  | 
WRRGK-LLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGA

LPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMM
| |     |  | |||..|||   | | |.|  |.|  | |    | ||| .  ||   .  .      . ||   |.|||. |     | |.||  | .
LTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSG-NVKLGDFGASKRLQ--TICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTV

LHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGK
  ||    || .|       ||| . |   ..|.. .  . . ..   ..    | || || |    
VEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase NIK.AA Ciliate-E2 409-583 18 5.5e-24 79.2 In-house 8-281 (365) Show / Hide 
Range on Protein: 409-583
Range on HMM: 8-281/365
Sequence Identity: 18% (51 aa)

GRGSFGEVHRMKDKQTGF------------------QCAVKKVRLEVFRVEELVACAGLSSPR-----------------------IVPLYGAVR--EGP
|.|.|| | ..|.....                   ....|.. .....  .. .     .                         |. .| .       
GQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDN

WVNIFMELLEGGSLGQLIKQM-----------GCLPEDRALYYLGQALE---------------GLEYLHTRR-ILHGDVKADNVLLSSDGSRAALCDFG
 . . ||...||.| ..||..           ... |  ..|.  | |.               .||||| .  |.| | | .|.|.        ..|||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFG

HAL----------------CLQPDGLGKSLLTGDY-----------IPGTETHMAPEVVMGKP---------CDAKVDIWS
 .                  ..  .  .|  .|..           | ||   ||||...||.          | |.||||
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS
Kinase NIK.AA MEKK15 454-655 30 8.3e-23 79.52 In-house 63-264 (264) Show / Hide 
Range on Protein: 454-655
Range on HMM: 63-264/264
Sequence Identity: 30% (62 aa)

IVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSL-
||   |   |   |||||. . |||.  .|   | |.|     |  | |.| .|||   ..| |.|  ||.| . |    | ||| |  |   |. ..  
IVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGI-IKLIDFGCAKRLCWQGINRTHS

LTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRK
     . ||   |||||.|      | ||||  | .  |  .  || .  |      | ..  |. ..|   .   .. ..  | ..   |..|..| . 
DMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKH

VGK
   
PFI
Kinase NIK.AA PAKA 471-594 36 1.1e-20 69.44 In-house 77-199 (260) Show / Hide 
Range on Protein: 471-594
Range on HMM: 77-199/260
Sequence Identity: 36% (47 aa)

MELLEGGSLGQLIKQMG-----CLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHM
|| .|||.|  .|.|.       ..|. . | . . | |||..| . . | |.| ||.|| .|||   . ||| .  |..  . ..        ||   |
MEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGS-VKITDFGFCAQLTQEQQKRNTMV-----GTPYWM

APEVVMGKPCDAKVDIWSSCCMMLHMLNG
||||. .|  | ||||||   |.. |. |
APEVIRRKQYDEKVDIWSLGIMAIEMIEG
Kinase NIK.AA TyrKc 402-653 21 4.5e-12 -27.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 402-653
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

MTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR---VEELVACAGL--SSPRIVPLYGAVREG-------PWVNIFMELLEGGSLGQLIKQMGC-
 |     |.| ||||.. . |    |.|||... .  |    .|.     |  . | || |||.....       . . | ||. ..|.| . ..  .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPD---GLGKSLLTGDYIPGTE---TH-------MAPEVVMGKPC
|. .  |..  |. .| |||| ... | |  | |.|..... ..  .||| .  .  |   |       .||.  .|   ..       ||||. . . .
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DAKVDIWSSCCMMLHMLNGCHPWTQY----FRGPLCLKIASEPPPIREIPPS--------CAPLTAQAIQEGLRKEPVHRASAMELRRKV
  | |.||   .|  ..  . .        .  .  .    .    ...||.        | .   | ...  . .|  | .  |.... 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase NIK.AA Pkinase_Tyr 409-538 28 1.4e-10 36.5 Pfam 8-156 (270) Show / Hide 
Range on Protein: 409-538
Range on HMM: 8-156/270
Sequence Identity: 28% (43 aa)

GRGSFGEVHRMKDK----QTGFQCAVKKV----------RLEVFRVEELVACAGL-SSPRIVPLYGAVR--EGP-WVNIFMELLEGGSLGQLIKQM----
|.|.||||.. . |    .|. ..|||..          | . .|  |.     | . | || |||..   ..|  . | ||. ..|.|    ..     
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR--EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

GCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFG
. |.  . | .  |  .|.|||. ... | |. | |.|.....  .  ||||
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFG
Kinase NIK.AA PAKA 403-436 22 0.000531 10.11 In-house 2-37 (260) Show / Hide 
Range on Protein: 403-436
Range on HMM: 2-37/260
Sequence Identity: 22% (8 aa)

THQPRVGRGSFGEVHRMKDKQTGFQ--CAVKKVRLE
.    .| |. ||| . ....|. .  .|.|. ...
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMK