PDHK2

Species: Mouse
Alias: PDHK2, Pdk2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: PDHK
Subfamily: PDHK

Sequence

Name Sequence Type Origin Length Description Download
PDHK2.AA Protein Sugen 407 None Fasta, JSON
PDHK2.NA RNA Sugen 2207 None Fasta, JSON
PDHK2.kin_dom Protein Kinase Domain None 124 None Fasta, JSON

Protein domain

Protein domains of PDHK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BCDHK_Adom3 PDHK2.AA BCDHK_Adom3 29-193 40 1.4e-88 305.38 Pfam 1-199 (199) Show / Hide
Range on Protein: 29-193
Range on HMM: 1-199/199
Sequence Identity: 40% (81 aa)

SPLSMKQFLDFGSSNACEKT---SFTFLRQELPVRLANIMKEINLLPDRVLGTPSVQLVQSWYVQSLLDIME-F---------------LDKDPED----
.|||..|...||..|.||||   |. |...|||.|||....|...||. .. .|..|.|..||.||. ...| |               . |..||    
TPLSLRQMMQFGRPNPCEKTLFKSAQFCHEELPIRLAHRIRELQNLPYGLNKMPHIQQVYNWYYQSFEELRECFPKPISELKHLRYYEPPPKTLEDWLHD

-HRTLSQFTDALVTIRNRHN-DVVPTMAQGVLEYK-DTYGDDPVSNQ----NIQYFLDRFYLSRISI---RMLINQHTLIFD-GSTNPAH---PKHIGSI
 ..    |.| | .|..||. .|||||||||||.| ..|| |.....    .|||||||||.|||.|   ||||.||...|. ...||.|   |...|.|
YNEK---FCDMLRDIKDRHDRNVVPTMAQGVLEWKCRYYGQDNQPDDLHWFQIQYFLDRFYMSRIGINFIRMLIGQHIALFEFNYHNPHHFEHPDYVGII

DP
..
CT

Kinase PDHK2.AA PDHK 240-363 81 9.40000000001e-102 344.35 In-house 1-125 (125) Show / Hide
Range on Protein: 240-363
Range on HMM: 1-125/125
Sequence Identity: 81% (102 aa)

YVPSHLYHMLFELFKNAMRATVESHESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYAK
|||||||||||||||||||||||.||... .||||.||.||.|||.|||||||||||||||.|||.|||||||.||..|. ..|||||||||||.|||||
YVPSHLYHMLFELFKNAMRATVEHHENRKIYPPIKVMVTLGKEDLTIKMSDRGGGVPLRKIDRLFNYMYSTAPRPQMETSRAAPLAGFGYGLPICRLYAK

YFQGDLQLFSMEGFGTDAVIYLKAL
||||||.|.||||.|||||||||||
YFQGDLKLYSMEGYGTDAVIYLKAL

Kinase PDHK2.AA PDHK 240-363 70 9.7e-97 327.7 In-house 1-140 (140) Show / Hide
Range on Protein: 240-363
Range on HMM: 1-140/140
Sequence Identity: 70% (98 aa)

YVPSHLYHMLFELFKNAMRATVESHESSL-TLPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPT----PQP----------GTG-GTPL
|||.|||||||||||||||||.|.||...  .||||.|||||.|||.|||||||||||.|||.|||.|||||||.    |..          .|. ..|.
YVPMHLYHMLFELFKNAMRATMEHHEDRPYNYPPIKVMVALGDEDLTIKMSDRGGGVPHRKIDRLFNYMYSTAPRSTQDPRMSPLFGHLDMHETSRAAPM

AGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKAL
.||||||||.|||||||||||||.||||.|||||||||||
HGFGYGLPICRLYAKYFQGDLQLYSMEGYGTDAVIYLKAL

Kinase PDHK2.AA HATPase_c 240-363 24 2.1e-22 80.2 Pfam 1-120 (120) Show / Hide
Range on Protein: 240-363
Range on HMM: 1-120/120
Sequence Identity: 24% (32 aa)

YVPSHLYHMLFELFKNAMRATVESHESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPL------RKIERLFSYMYSTAPTPQPGTGGTPLAG--FGYGLP
 .| .|.... .|  ||...| |.       . |.. |   .....|  .| | |.|        .|.|.|   |.| |      .     |  .|.|| 
GDPDRLHQVVWNLVDNAIKHTPEG-------GHITVRVHRDDDHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPD----SR-RKYGGGLTGLGLY

ISRLYAKYFQGDLQLFSMEGFGTDAVIYLKAL
|.| ... ..|.... | .| ||  ...|.  
ICRRIVEQHGGTIWVESEPGGGTTFTFTLPLE

Kinase PDHK2.AA HATPase_c 240-364 21 3.8e-16 60.9 SMART 1-130 (130) Show / Hide
Range on Protein: 240-364
Range on HMM: 1-130/130
Sequence Identity: 21% (30 aa)

YVPSHLYHMLFELFKNAMRATVESHESS----LTLPPIKIMVALGEEDLSIKMSDRGGGVPL------RKIERLFSYMYSTAP---TPQPGTGGTPLAG-
  | .|...| .| .|| ..| |.| ..       .  .| | .     .|  .| | |.|        .|.|.|  .|.|..   .. |. . .   | 
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH----RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYGGG

-FGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALS
 .|.||.|.. ... ..|....       |  ...|.   
LTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER