Gene PEK (Mouse)

PEK

Species: Mouse
Alias: Eif2ak3, PEK
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK

Sequence

Name Sequence Type Origin Length Description Download
PEK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 487 Kinase domain by global Sugen HMM Fasta, JSON
PEK.AA Protein Sugen 1114 None Fasta, JSON
PEK.NA RNA Sugen 4512 None Fasta, JSON

Protein domain

Protein domains of PEK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ PEK.AA PQQ 100-138 33 0.000427 16.85 Pfam 1-37 (37) Show / Hide 
Range on Protein: 100-138
Range on HMM: 1-37/37
Sequence Identity: 33% (13 aa)

SLVIISTLDGRIAALDAENDGKKQWDLDVGSGSLVSSSL
  |.. | ||.| ||||.. ||. |  ..|..    .  
GDVYVHTWDGYIYALDADT-GKVKWKFKTGPPDWW-PMT
PQQ PEK.AA PQQ 230-259 20 10.266071 2.24 Pfam 1-30 (37) Show / Hide 
Range on Protein: 230-259
Range on HMM: 1-30/37
Sequence Identity: 20% (6 aa)

DILLLQRTQKTVRAVGPRSGSEKWNFSVGH
... .     ...|.  ..| .|| | .|.
GDVYVHTWDGYIYALDADTGKVKWKFKTGP
PQQ PEK.AA PQQ 380-392 30 31.611338 0.61 Pfam 1-13 (37) Show / Hide 
Range on Protein: 380-392
Range on HMM: 1-13/37
Sequence Identity: 30% (4 aa)

NSVYLGMYRGQLY
. ||.. ..|..|
GDVYVHTWDGYIY
Kinase PEK.AA PEK 589-1075 34 1.8e-301 1007.79 In-house 1-758 (758) Show / Hide 
Range on Protein: 589-1075
Range on HMM: 1-758/758
Sequence Identity: 34% (258 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPN--------RELAREKVMREVKALAKLEHPGIVRYFNAWLETP----------------------
||.|||.|.|||||||.||||||..|||||||..||        ||.|||||||||..||.|.|..||||||||||||                      
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

-------------------------------------------PEKWQEEMDEIWLKDESTDWP-----LSSPSPMDAPSVKIRRMD-------------
                                           |.||||.||..|....|..|.     |..|..||.....||.||             
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENEDDNPCNRFVNKIPKKWQEKMDKCWNNNISNNWKKKLHQLKYPFKMDDDISFIRNMDQTMQNDQSRYKMQ

----PFSTKEQIEVIAPSPERSRSFSVGISCGQTSSS-------------------ESQFSPLEFSGTDCGD---NSDSADAAYNLQDSCLTDCEDVEDG
    ||..|.....|...|.|..|||....|.|..|.                   ||||.|.||||||...   .....|..||.|..|.|.|......
YSHDPFFKKFNKQIIIREPMRNSSFSKESYCDQDDSNDIYSNEVDFFFTPKKCYFSESQFMPSEFSGTDDEEQSWMDSNNDTMYNAQQKCMTKCFGHHKH

TVD---GNDEGHSFELCPSEASPYTRSREGTSSSIVFEDSGCGNASSKEEPRGNRLHDGNHYVNKLTDLKCSSSRSSSEATTLSTSPTRPTTLSLDFTKN
..|   .|.|.|.|..||||||.|........|||.||||.|.....||.......|......|..|..|||||.|..|...|.||.............|
MMDFSKDNKEEHTFFDCPSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNN

TVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--------------------
.. ...|.....|.||||||||||.|||||..||..|.|.. ..||.|.||.|.|...||||..|||||||||||.||..                    
KNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDG

----VKVGDFGLVT--------------------------------------------------------------------------------------
    .|.|||||||                                                                                      
GHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTITTISVSPSKPSSIS

------------------------AMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGN----------------NYSHKVDIFSLGLILFELLYP
                        |.||..|..|....||....||.||||.|||||||.|..                .|.|||||.|||||.|||..|
TPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHP

-FSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIF
 |||||||.|...|.||...| .||||||||....|.|.|..|.|||.|..|.....|
GFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF
Kinase PEK.AA PEK 589-1075 30 8.70000000001e-221 739.77 In-house 1-655 (655) Show / Hide 
Range on Protein: 589-1075
Range on HMM: 1-655/655
Sequence Identity: 30% (203 aa)

FEPIQCMGRGGF-GVVFEAKNKVDDCNYAIKRIRLPNRE----------------LAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEIWL
|| |||.|.||| |.|....||.|.|.||||||.|....                ...|||.||||.||.|.||.||||.|||.|.|.||||...||.|.
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

KDESTDWP----LSSPSPMDAPSVKIRRMD-----------------PFSTKEQIEVIAPSPERSRSFSVGISCGQTSSS------ESQFSPLEFSGTDC
.|.|||||    .|...... |..|.. .|                 ....|...|....|.......|.. ||...|.|      |.||| ..| ||..
LDSSTDWPNGKHKSKDYNFH-PFEKEW-DDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFS-INF-GTEN

GD------NSDSADAAYNLQDSCLTDCEDVEDGTVDGNDEGHSFELCPSEASPYTRSREGTSSSIVFEDSGCGNASSKEEPRGNRLHDGNHYVNKLTDLK
 .      .|.| ..... .... .......|.| ...||.|||. |.|..|..|.... ..||....|.||.|....|.. ....|..|.. .|..| |
ENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSK

CSSSRSSSEATT----------------LSTSPTRPTTLSLDFTKNTVGQLQPS--SPKVYLYIQMQLCRKENLKDWMNRRC------------------
..|.....|.|                  |... . .. . ...||.. | ...  ... ||||||..|.|..|.||.....                  
NQSHKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYN

-----------------------SLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV-----VKVGDFGLVT----------------
                        .. ... .|..|| ||.|.....||.|..||||||||||...|.      ||.|||||.|                
NYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQD

-------AMDQDEEEQTVLTPMPAYAT----------------------HTGQVGTKLYMSPEQIHGN-----NYSHKVDIFSLGLILFELLYPFSTQM-
       |.|.  . .|  ...|...                       |||.||| |||||||..|.     .| ||||..|||.|.||..|||.|.| 
QSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMM

ERVRILTDVRN------LKFP-LLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIF
|||..|||.|.       .||  .|..|||... ..|.|||..|..||.| .| ..  |
ERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase PEK.AA GCN2 875-1075 31 1.7e-51 177.4 In-house 275-511 (511) Show / Hide 
Range on Protein: 875-1075
Range on HMM: 275-511/511
Sequence Identity: 31% (77 aa)

PSSPKVYLYIQMQLCRKENLKDWMNRR-CSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT---------------
....  ||||||  | . .|..      . ....       .| || |.. ..||.|  ||||||||||.. .. ||.|||||.|               
KPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQ

--------------AMDQDEEEQTVLTPMPA----YATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSL-GLILFELLYP-FSTQMERVRILTDVRNLKFP
              . |. ...|.. ...        .||| ||| .||.|||     |  |||..|| |.|.||..|| |.|||||| ||.. |...||
QQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFP

LLFTQ----KYPQEHMMVQDMLSPSPTERPEATDIIENAIF
  |      ... .  |.. .|.. |..|| | .. .    
QDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase PEK.AA PKR 882-1073 39 5.2e-44 152.53 In-house 96-272 (272) Show / Hide 
Range on Protein: 882-1073
Range on HMM: 96-272/272
Sequence Identity: 39% (76 aa)

LYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTG
|.|||  | |  |  ||..|   |  .  . | .. || . |...|||.|.||||||||||   .  .|.||||||||.. |    |  .          
LFIQMEFCDKGTLEQWMRNRRQ-EKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVTALKNDGKSRTRRK----------

QVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVRNLKFP-LLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENA
  ||  |||||||   .|   |||. ||||| |||    |..|...  .|.|.  |   .| .|   |  ..| .||  | .||.  .|.   
--GTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDNK---EKTLLQKLLSKKPKDRPNTSEILRTL
Kinase PEK.AA S_TKc 589-1075 13 4.4e-42 147.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 589-1075
Range on HMM: 1-231/231
Sequence Identity: 13% (66 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDA
.| ..  |.|.||.|. ...| ..  .|||.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

PSVKIRRMDPFSTKEQIEVIAPSPERSRSFSVGISCGQTSSSESQFSPLEFSGTDCGDNSDSADAAYNLQDSCLTDCEDVEDGTVDGNDEGHSFELCPSE
                                                                                                    
----------------------------------------------------------------------------------------------------

ASPYTRSREGTSSSIVFEDSGCGNASSKEEPRGNRLHDGNHYVNKLTDLKCSSSRSSSEATTLSTSPTRPTTLSLDFTKNTVGQLQPSSPKVYLYIQMQL
                                                      .  .|   |.           ..  .  .  |      .||. | .
-----------------------------------------------------EHIRREIQILKK--------HHPNIVKLYDVFQD----DHLYMVMEY

CRK--ENLKDWMNRRCSLED---REHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQV
|     .|.| . .| .          .. ... ||..|.|..||.| .||||||.||...   ..|..|||| . .                   | ..
CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFC

GTKLYMSPEQIHGNNYSH-KVDIFSLGLILFELLY---PFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIE-------N
||  ||.|| .    |.. |.|. |.| ||.|.|.   ||.   .  ...  ..            |.   ... .|   |..|| | .. .        
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

AIF
  |
PWF
Kinase PEK.AA Ciliate-E2 881-1075 22 2e-40 136.45 In-house 108-365 (365) Show / Hide 
Range on Protein: 881-1075
Range on HMM: 108-365/365
Sequence Identity: 22% (61 aa)

YLYIQMQLCRKENLKDWMNRRCSLEDRE--------HGVCLHIFLQIAE---------------AVEFLHSKG-LMHRDLKPSNIFFTMDDVVKVGDFGL
..|. | .|   .|.|... ..  .. |        .  ...|. ||..               |.|.||||.  .|||.||.||.|     .|. ||||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGL

VTAMDQDEEEQTVLTPMPAYATHTG---------------------QVGTKLYMSPEQIHGNN---------YSHKVDIFSLGLILFELL---YPFSTQM
 .  |.|....|   ..    .  .                     ..||  ||.|| . | .         |..|.||.||| ||.|.|   .||    
SKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----

ERVRILTDVRNLKFPLLFT------------------QKYPQE--HMMVQ---DMLSPSPTERPE-ATDIIENAIF
          ... .. |                   .| .||  ... .    ||   | .|.  . .|... .|
-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PEK.AA Pkinase 881-1016 31 2.6e-39 140.09 Pfam 74-206 (293) Show / Hide 
Range on Protein: 881-1016
Range on HMM: 74-206/293
Sequence Identity: 31% (46 aa)

YLYIQMQLCRKE----NLKDWMN--RRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVV----KVGDFGLVTAMDQDEEEQTVL
..|. | .|..      |.|..   |....   .  .| ....||....|..||.| .||||||.||..  ....    |..||||   .|         
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------

TPMPAYATHTGQVGTKLYMSPEQIH-GNNYSHKVDIFSLGLILFELL
     .   |. .||  ||.|| |  |. |..|||..|.|.||.|.|
--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML
Kinase PEK.AA HRI 881-1075 35 2.9e-37 128.86 In-house 393-613 (613) Show / Hide 
Range on Protein: 881-1075
Range on HMM: 393-613/613
Sequence Identity: 35% (80 aa)

YLYIQMQLCRKENLKDWM---NRR---------CSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV----VKVGDFGL-----VTA
.|.||||||    |.||.   |.|         |        |   || || | . . | .. .|||.|| |||    |     ||.|||||     .. 
MLHIQMQLC-ELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACEDILQE

M--------DQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMM
         |||  . |   |     |||  ||| .| ||||  | .|  | | .|.|.|||||  || | |||  .|| ||  . |     . |     
PKTPMRFRRDQDFDW-TNRNPCVT-QTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKY

VQDMLSPSPTERPEATDIIENAIF
.| .       || |  ..   .|
IQHLTRRNASQRPSAIQLLQSELF
Kinase PEK.AA STE-Unique 882-1075 23 6e-30 103.25 In-house 369-616 (616) Show / Hide 
Range on Protein: 882-1075
Range on HMM: 369-616/616
Sequence Identity: 23% (58 aa)

LYIQMQLCRKENLKDWMNRRCS---------LEDREHGVCLHIFLQIAEAVEFLHSKG--LMHRDLKPSNIFFTMDD-----VVKVGDFGLVTAMDQDEE
..|.| .| .  |..  .| .          ..  |    . . .||.|. |.|||..    ||||||.|||.. |.      ||..|||. | .  |. 
VWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETE---VIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHF

EQ----------------------TVLTPMPAY----ATHTGQVGTKLYMSPEQIHGN-----NYSHKVDIFSLGLILFELLYPFSTQMERVRI--LTDV
|                          |||        | .. .||  ||.|| | ..      |..||||.||| ..|...  . ....| ..  . . 
EKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEM

R-NLKFPLL-------FTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIF
. .......       . .  |.     .  |.. |. || | .  .    
CIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase PEK.AA GCN2 589-668 40 1.3e-26 89.98 In-house 1-84 (511) Show / Hide 
Range on Protein: 589-668
Range on HMM: 1-84/511
Sequence Identity: 40% (34 aa)

FEPIQCMGRGGFGVVFE-AKNKVDDCNYAIKRIRLP--NRELARE-KVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDE
|| |.| |.|||| |   ..|..| ..||||.....  .|.| .. | ||||| |..| |...|||..||.| . |.  .. ..
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNN
Kinase PEK.AA WEE 914-1015 27 4.1e-25 81.23 In-house 115-229 (297) Show / Hide 
Range on Protein: 914-1015
Range on HMM: 115-229/297
Sequence Identity: 27% (36 aa)

HIFLQIAEAVEFLHSK-GLMHRDLKPSNIFFTMDD--------------------VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQV---GTKLYM
.|...|.... ..||. |..| |.||.|||.....                    . | ||||.|| |.                ..  ..   |   ||
QILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNS--------------NNNNPHQEQEGDSRYM

SPEQIHG-NNYSHK--VDIFSLGLILFEL
.|| ..|  .|.|    ||||||. ..||
APEILQGYYHYTHLYKADIFSLGITIYEL
Kinase PEK.AA PEK-Unclassified 589-665 33 4e-22 73.62 In-house 1-86 (835) Show / Hide 
Range on Protein: 589-665
Range on HMM: 1-86/835
Sequence Identity: 33% (29 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLP------NRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKW---QEE
|  .| .|.|||..|.   .|.|.  ||.|.|..             || ..|| ..|.. || |.||.  | |    |    |||
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEIKKNSQKQEE
Kinase PEK.AA WEE 589-657 38 7.5e-22 70.14 In-house 1-77 (297) Show / Hide 
Range on Protein: 589-657
Range on HMM: 1-77/297
Sequence Identity: 38% (30 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLE-------HPGIVRYFNAWLET
|. .|  |.| || |. .....| | ||||... | |..  |.   |||.|...|        || ||||..|| |.
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEED
Kinase PEK.AA HRI 589-656 44 9.3e-20 65.77 In-house 1-69 (613) Show / Hide 
Range on Protein: 589-656
Range on HMM: 1-69/613
Sequence Identity: 44% (31 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAR-EKVMREVKALAKLEHPGIVRYFNAWLE
||    .|.||.| |.  ..| |   ||||.|.   |      |..|||| || |.|. ||||  ||.|
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase PEK.AA PEK-Unclassified 980-1074 30 1.8e-19 64.07 In-house 731-835 (835) Show / Hide 
Range on Protein: 980-1074
Range on HMM: 731-835/835
Sequence Identity: 30% (32 aa)

TGQVGTKLYMSPEQI-----------HGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATD
|  .|| .| |.||             ...| |. ||.|.| |.|... .. | ||||. .  ..    |  |  |.|    ...| ||  |  ||    
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSK

IIENAI
 ||  .
-IEQTL
Kinase PEK.AA PKR 589-654 46 1e-17 59.9 In-house 1-61 (272) Show / Hide 
Range on Protein: 589-654
Range on HMM: 1-61/272
Sequence Identity: 46% (31 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAW
|. |  .| |||| || || ..|   |.|||..  |     ||  .||.|||||.|  ||.|   |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNN-----EKAEHEVQALAKLDHVNIVHYHSCW
Kinase PEK.AA NEK 913-956 35 5.5e-16 53.13 In-house 117-169 (286) Show / Hide 
Range on Protein: 913-956
Range on HMM: 117-169/286
Sequence Identity: 35% (19 aa)

LHIFLQIAEAVEFLHSK-----GLMHRDLKPSNIFFTMDDV----VKVGDFGL
...| |.. |. ..|..       .|||.||.||| | ..     ||.||||.
WDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGI
Kinase PEK.AA STE-Unique 590-656 31 1.3e-15 51.45 In-house 1-72 (616) Show / Hide 
Range on Protein: 590-656
Range on HMM: 1-72/616
Sequence Identity: 31% (23 aa)

EPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAR-----EKVMREVKALAKLEHPGIVRYFNAWLE
. .|  |||.||.|. ..||.|  ..||| |.| ..   .     ..  .|. ....| |..||.|  .||.
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase PEK.AA NEK 589-656 32 9.4e-14 45.18 In-house 1-75 (286) Show / Hide 
Range on Protein: 589-656
Range on HMM: 1-75/286
Sequence Identity: 32% (24 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCN-----YAIKRIRLPNR-ELAREKVM-REVKALAKLEHPGIVRYFNAWLE
.| |.  |.| ||.|. .. | |        |..|.| . |  |  ... .  ||. |..| || ||.|.....|
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE
Kinase PEK.AA Pkinase 589-656 23 5.4e-13 47.04 Pfam 1-71 (293) Show / Hide 
Range on Protein: 589-656
Range on HMM: 1-71/293
Sequence Identity: 23% (17 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNREL-AREKVMR--EVKALAKLEHPGIVRYFNAWLE
.. ... |.|.||.|.....| . . .|.|.|......   ..   |  |.. ...| || |||.. .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED
Kinase PEK.AA PEK-Unclassified 912-962 39 2.1e-12 38.68 In-house 615-667 (835) Show / Hide 
Range on Protein: 912-962
Range on HMM: 615-667/835
Sequence Identity: 39% (21 aa)

CLHIFLQIAEAVEFLHSKG-LMHRDLKPSNIFFTMD-DVVKVGDFGLVTAMDQ
|  |  ||  |  . |. . . |||.|| ||| .     .|.||||||. ...
CREITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKKIEK
Kinase PEK.AA TyrKc 589-1073 12 4e-12 -26.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 589-1073
Range on HMM: 1-280/280
Sequence Identity: 12% (65 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL--EHPGIVRYFNAWLE--------TPPEKWQEEMDEIWLKD-----
 . ..  |.| ||.|.... |    . |.| ..       ||  ||| . . ||  .|| ||| . . ..         |.    | |.   |||     
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ESTDWPLSSPSPMDAPSVKIRRMDPFSTKEQIEVIAPSPERSRSFSVGISCGQTSSSESQFSPLEFSGTDCGDNSDSADAAYNLQDSCLTDCEDVEDGTV
. .                                                                                                 
RPK-------------------------------------------------------------------------------------------------

DGNDEGHSFELCPSEASPYTRSREGTSSSIVFEDSGCGNASSKEEPRGNRLHDGNHYVNKLTDLKCSSSRSSSEATTLSTSPTRPTTLSLDFTKNTVGQL
                                                                                                    
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QPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQD------EEEQ
                                   .   |.. .|||.  |.||||.. ||||   |.  . . .||..||||  . . |      ..  
---------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYY

TV----LTP--MPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELL----YPFSTQ----MERVRILTDVRNLKFPLLFTQ--------KY
..     .   .|              |.|| |  . ...| |..| |  ..|..     | . .    |.  ... .|.. . .               
RKKEHKGGKTMLPIR-----------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP

PQEHMMVQDMLSPSPTERPEATDIIENA
.  ... ..     | .||  ..|.|  
DEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PEK.AA NEK 982-1015 52 1.1e-09 30.62 In-house 184-217 (286) Show / Hide 
Range on Protein: 982-1015
Range on HMM: 184-217/286
Sequence Identity: 52% (18 aa)

QVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFEL
||||  |||||....  |..|.|| ||| .|.|.
QVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEM
Kinase PEK.AA Ciliate-E2 589-654 17 4.2e-09 27.37 In-house 1-101 (365) Show / Hide 
Range on Protein: 589-654
Range on HMM: 1-101/365
Sequence Identity: 17% (18 aa)

FEPIQCMGRGGFGVVFEAKNKVDDCN-----------------------YAIKRI--RLPNRELAREKVMREVK----------ALAKLEHPGIVRYFNA
.. |.. |.|.||.|...|.. ....                       ||.|..  .  .  .  ...|||..           | .| || |.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

W
.
F
Kinase PEK.AA Pkinase_Tyr 913-974 35 8.9e-05 16.8 Pfam 114-177 (270) Show / Hide 
Range on Protein: 913-974
Range on HMM: 114-177/270
Sequence Identity: 35% (23 aa)

LHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAM-DQDEE-EQTVLTPMP
|.. .|||.. |.|.||.. ||||   |.  | . |||..||||  .. . |.   ..  ...|
LQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLP
Kinase PEK.AA NEK 1049-1075 25 0.000442 10.72 In-house 260-286 (286) Show / Hide 
Range on Protein: 1049-1075
Range on HMM: 260-286/286
Sequence Identity: 25% (7 aa)

HMMVQDMLSPSPTERPEATDIIENAIF
..... || ..|..|| ...|.|. . 
QNLISQMLQKDPEQRPSCNQILEMPFI
Kinase PEK.AA Pkinase_Tyr 589-650 28 0.018658 8.94 Pfam 1-69 (270) Show / Hide 
Range on Protein: 589-650
Range on HMM: 1-69/270
Sequence Identity: 28% (20 aa)

FEPIQCMGRGGFGVVFEAKNK----VDDCNYAIKRIRLPNRELA--REKVMREVKALAKL-EHPGIVRY
 . ..  |.| ||.|.... |     ...  |.| ..    . .  ||. |||.| . .|  || |||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase PEK.AA WEE 1051-1075 20 0.211016 0.55 In-house 273-297 (297) Show / Hide 
Range on Protein: 1051-1075
Range on HMM: 273-297/297
Sequence Identity: 20% (5 aa)

MVQDMLSPSPTERPEATDIIENAIF
... |. | |. || . .. .. . 
LIKWMMHPDPEQRPTCQQLLQHPVL
Kinase PEK.AA Pkinase_Tyr 989-1016 32 7.549835 0.11 Pfam 181-208 (270) Show / Hide 
Range on Protein: 989-1016
Range on HMM: 181-208/270
Sequence Identity: 32% (9 aa)

MSPEQIHGNNYSHKVDIFSLGLILFELL
|.|| |. . ...| |. | |  ..|..
MAPECINYGKFTTKSDVWSFGVLMWEIF