Gene PKCd (Mouse)

PKCd

Species: Mouse
Alias: Prkcd, PKCd
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: PKC
Subfamily: PKCd

Sequence

Name Sequence Type Origin Length Description Download
PKCd.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
PKCd.AA Protein Sugen 674 None Fasta, JSON
PKCd.NA RNA Sugen 2536 None Fasta, JSON

Protein domain

Protein domains of PKCd.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD PKCd.AA C2_PKD 2-154 32 9.5e-77 261.29 In-house 1-183 (183) Show / Hide 
Range on Protein: 2-154
Range on HMM: 1-183/183
Sequence Identity: 32% (60 aa)

APFLRISFNSYELGSL-------------QVEDEASQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKTTFDAHIYEGRVIQIVLMRAA----EDPVSEV
..|.|. ..... ...             ....||..|.|.|...|...........|||.|.||||. .||.|.||||.||||.|..|    ...|.|.
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

TVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMCVQYFLEDGD----CKQ-------SMRSEEEAKFPTMN-RRG-AIKQAKIH
|.......|.||.|.|....|..|.||.||.. ...| ||.|    |..       .|..| ....|..| ||| |...||||
TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C1_1 PKCd.AA C1_1 159-211 40 4.1e-18 70.14 Pfam 1-55 (55) Show / Hide 
Range on Protein: 159-211
Range on HMM: 1-55/55
Sequence Identity: 40% (22 aa)

HEFIAT-FFGQPTFCSVCKEFVWG-LNKQGYKCRQCNAAIHKKCIDKIIGRCTGT
| .... .| |||||..|.||.|| | .||.||..|.  .|..|  |    | . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCd.AA C1 159-208 33 7.1e-16 59.98 SMART 1-61 (61) Show / Hide 
Range on Protein: 159-208
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HEFIATFFGQPTFCSVCKEFVWGLNKQ-----GYKCRQCNAAIHKKCIDKIIG-------RC
| .... | .||.|..|....||. ||     ||.|. |. ..|||| ||.          |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCd.AA C1_3 170-201 25 2.1e-07 20.35 Pfam 1-30 (30) Show / Hide 
Range on Protein: 170-201
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCI
 .|..|.. . .    .|.| ||.  .|..|.
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1_1 PKCd.AA C1_1 231-283 47 3.9e-26 97.93 Pfam 1-55 (55) Show / Hide 
Range on Protein: 231-283
Range on HMM: 1-55/55
Sequence Identity: 47% (26 aa)

HRFKVY-NYMSPTFCDHCGSLLWG-LVKQGLKCEDCGMNVHHKCREKVANLCGIN
|....  |. .||||.|||...|| | .||.||..|..|.||.| .||...|| |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCd.AA C1 231-280 30 1.7e-20 75.37 SMART 1-61 (61) Show / Hide 
Range on Protein: 231-280
Range on HMM: 1-61/61
Sequence Identity: 30% (19 aa)

HRFKVYNYMSPTFCDHCGSLLWGLVKQ-----GLKCEDCGMNVHHKCREKVAN-------LC
|... ... .||.|.||....||. ||     |..|..|....|.|| .||..        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCd.AA PKC 347-601 69 5.6e-207 677.18 In-house 1-262 (262) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-262/262
Sequence Identity: 69% (182 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELY
|.|.|||||||||||.|||.||.|.|.|||.|||||.. ||||||||.|||||||||. |||||| |.|||.|.||||||..||||||||||. .||...
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPF
.|.||||||||.|||||.|||||||||||||.||..||||||||||||||.... ..||||||||||||||||. .|..|||||.||||.|||..|||||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

HGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGV-------TGNIRIHPFF
||.||||||.||. |.||||||..||...|........| ||||.       ...|| ||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCd.AA Delta 347-601 79 1.3e-190 639.54 In-house 1-259 (259) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-259/259
Sequence Identity: 79% (206 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELY
|.|.|||||||||||.|||||||.||.|||||||||||.||||||||||.||||||||.|||.||.||||||.|||||||.|||||||.|||...||...
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPF
||.|||.||||||||||.|||||||||||||.||.|||||||||||||||..||..|||||||||||||||..| ||..||||||||||.||||||||||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

HGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGV----TGNIRIHPFF
||.||||||.||..|.|.||||||||.||...|||||||.|||||    .|.||.|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKCd.AA AGC 347-601 33 6.6e-184 480.6 In-house 1-395 (395) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-395/395
Sequence Identity: 33% (135 aa)

FTFQKVLGKGSFGKVLLAELK------GKDKYFAIKCLKKDV-VLIDD--DVECTMVE------------KRVLALAWE---------SPFLTH-LICTF
| | ||.|||||||| |.. |      . .||.|.|.|||.. ..|..  .||.||.|            ...|...           .||... | ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKDH--LFFVME----FLN-----GG-DLMFHIQ---DKGRFELYRATFYAAE-------IICGLQFLHS-KGIIYRD-LKLDNVMLDRDGHIKIADFG
|.|||  |.||||    ..|     || .|..|.|   ..|||.  || |||||       |...|..||| .|||.|| ||..|..||.|||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKENIFGE--------------------------------------------------GRASTFCG--TPDYIAPEILQGLKYSFSVDWWS--FGVLLY
.|||.. ..                                                   |..||||  ||.|.|||||    |....||||  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLIGQSPFHGD----------DEDELFESIR------VDTPHYP----------RWITKESKDIMEKLFERDPDKRLGVTGN---------IRIHPFF
|||.|..||.||          ...|.|..|.       . ...|          ||...| ||...||...||.||||  ||         |. ||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCd.AA Alpha 347-601 62 1.5e-149 503.1 In-house 1-259 (259) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-259/259
Sequence Identity: 62% (163 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELY
| | .||||||||||.||| || |  .||| |||||.  ||||||||||||||||    |||. .  .||| | |.||||. ||||||.|||  |.|   
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPF
 | ||||||  || |||.||||||||||||||||..||||||||||||||....    |||||||||||||     |. |||||.||||||||. || ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

HGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTG----NIRIHPFF
 |.||||||..|   .. ||. . ||..||   .  . | |||| ..    .|| ||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCd.AA Eta 347-601 61 1.3e-142 480.11 In-house 1-261 (261) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-261/261
Sequence Identity: 61% (161 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELY
|.| |||||||||||.|||.||.|  .||| |||||.. |||||||| |||.|.|| . |||| | |.||||| ||||||. |||||||.||   .|.  
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPF
|| |||||..| |.||| .|.|||||||||..||..|| |.|||||||| |  .   .||||||||||||||| ..|  ||||| .|||.|||. ||.||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

HGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTG------NIRIHPFF
  | ||.|||||  |   || |. ||   |.   . . |.|||| .       .|| ||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCd.AA Akt 347-601 47 2.1e-124 399.64 In-house 1-264 (264) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-264/264
Sequence Identity: 47% (125 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYF-AIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFEL
|.| |||||||||||.|.. |  .|.. |.| ||||. .  . || |. |...|     .||.. |   |||.|.|.|||.. |||.| .|.| |.||  
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

YRATFYAAEIICGLQFLHSKGIIYRD-LKLDNVMLDRDGHIKIADFGMCKEN-IFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWS-FGVLLYEMLIG
 || ||.||||.....||||.||||| ||. |...|.||||...|||.|||| |    .. |||||| |.|||||.|  .. .||||. .|...|||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QSPFHGDDEDELFESIRVDTPHYP--RWITKESKDIMEKLFERDPDKRLGVTGN----IRIHPFF
. ||. .| ...|. |      .|  .|| .| ||. ..| ..||.|||| . |    |. ||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCd.AA SGK 347-601 38 4.2e-112 347.56 In-house 1-283 (283) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-283/283
Sequence Identity: 38% (109 aa)

FTFQKVLGKGSFGKVLLAELKGK------------------DKYFAIKCLKKDVVL-------IDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHL
| | ||.||||||||.... |..                  || .|.| |.|. ..           .  .| |. |.     .||.  |   ||||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGL
.|||...|||.. .|.|  ..|   || ||||||.| |  |||. ||||||| .|..|| .||... ||| |||.|  .   .|||||| | |||.|.. 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

KYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVT---GNIRIHPFF
 .. .||||. | .||||..|  ||   .  .... |.      |. .. . .|... | ..||.||||     . |. ||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase PKCd.AA PKN 347-601 49 1.1e-107 364.12 In-house 1-260 (260) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-260/260
Sequence Identity: 49% (129 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALA--WESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFE
| .  |||.| ||||||...|. ..|.||| |||  ..  |.||  |.|||... .     |||  |.  |||..| .||||.. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHED-VFS

LYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQS
  || |||| .. |||.|| . ||||||||||..||..|..||||||.|||..    | |||||||...|||.|    |   ||||  |||.||||.| .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTG----NIRIHPFF
|| ||||.|.|..|  |   |||..  |. .|| .|  . |..||| .     .|...|||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCd.AA S_TKc 347-601 35 7.1e-100 339.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNG--GDLMFHIQDKGR--
... ...|||.|||| ..  |. ....|||..|          | .. | ..|      |.. .|. .||. |||..|||...|  |||. .|...||  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSF-SVDWWSFGVLLY
    |   .| ||...|.|.|...||.|||.|||| .|..||.  ||||.|||....        .||||||.|.|||.|   .|.. ..||||.|..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTGNIR------IHPFF
||| |. ||.  .....|. |.          ..| ||...|....||.||...    .      .||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCd.AA RSK 350-601 37 1.3e-97 330.63 In-house 1-278 (278) Show / Hide 
Range on Protein: 350-601
Range on HMM: 1-278/278
Sequence Identity: 37% (103 aa)

QKVLGKGSFGKVLLAELK---GKDKYFAIKCLKKDVVLIDD-DVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGR---
 ||||.|..||| |   .    .....| | ||| ..   . |.. || | ..|..   .||. .|  .|||...|. .||...||.|  |.| ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDR---DGHIKIADFGMCKENIFG-EGRASTFCGTPDYIAPEILQ---GLK-YSFSVDWWSFGV
|   .| ||.|||.. ...||..|||.||||..|...|    .||||. ||| ||..    .... |||.| .|.|||.|    . . .. ..||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMLIGQSPFHG---DDEDELFESIRVDT--PHYPRW--ITKESKDIMEKLFERDPDKRLGV----TGNIRIHPFF
|.|||| |..||.|   .. .|... |.  .  .  |.|  ...| ||.  |...||| ||||     .  |. ||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKCd.AA AktR 347-601 38 4.5e-96 325.48 In-house 1-268 (268) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-268/268
Sequence Identity: 38% (104 aa)

FTFQKVLGKGSFGKVLLAELK-GKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFEL
|.. |.|||| |||| |.. |   .|..|.| .||         . |  |. ...     ||.  |  .||||..|||.||.  ||.| .|.. |..|. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

YRATFYAAEIICGLQFLHSK-GIIYRDLKLDNVMLDRDGHIKIADFGMCK-ENIF-GEGRASTFCGTPDYIAPEILQG-LKYSFSVDWWSFGVLLYEMLI
 .| ||.|.|. .|..||..  ||||||| .| .|| |||.||.|||. | ...   . .| .||||| |.|||...    . .|||||.||...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQSPFHGDDEDELFESIRVDT---PHYPRWITKESKDIME-KLFERDPDKRLG-V---TGNIRIHPFF
|. ||  ..  ..|..|.  .   . ||  .... ||. . ||. ..| ||||     .  |. ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKCd.AA Pkinase 347-601 32 4.6e-86 297.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 347-601
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTM-VEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGG----DLMFHIQ--D
... ...|.||||.| ..  ||  | .|.|..||.    . |.. .   | ....    .|.   |...|..|||. .|||...||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KGRF--ELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHI----KIADFGMCKE--NIFGEGRASTFCGTPDYIAPEILQ-GLKYSFSVDWW
.|.|  .   . ||. .|..||...||.|||.||||..|...|..|||    ||.||| .|   .  ..  ..||||||.|.|||... | .|. .||.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVLLYEMLIGQSPFHGD------DEDELFESIRVDTPHYPRWIT---------------------KESKDIMEKLFERDPDKRLGVTGNIRIHPFF
|.|..||||| |. || |.      |...... |.   .|.... .                     .| ||........|| ||..    |  ||.|
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-AEQILQHPWF
Kinase PKCd.AA S_TK_X 602-665 41 4.6e-27 97.16 SMART 1-79 (79) Show / Hide 
Range on Protein: 602-665
Range on HMM: 1-79/79
Sequence Identity: 41% (33 aa)

KTINWSLLEK--RKVEPPFKPKVK----SPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEA---------FHGFSFVN
. |.|  |..  ...|||||||.|    || | ||||||| .|.| |.  |..|..||.|..         | ||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCd.AA Pkinase_C 621-667 53 3.2e-19 70.86 Pfam 1-46 (46) Show / Hide 
Range on Protein: 621-667
Range on HMM: 1-46/46
Sequence Identity: 53% (25 aa)

KVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHGFSFVNPK
.|||| | ||||||| .|.|.....|.. . |.|||.|.||..|||.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCd.AA TyrKc 347-608 23 1.6e-16 44.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 347-608
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

FTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHL------------ICTFQTK-----DHLFFVMEFLN
 |. |.|| | ||.| ....|      |.|.||.|                . ..  |   ...|            .|| |       . |. |||.  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP

GGDLMFHIQDKGR-FELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKEN----IFGEGRASTFC-----GTPD-----YIA
.|||  ....... . .     ..  | || ..||||..| |||   |.........||.|||....       |  . ..       |. .       |
HGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMA

PEILQGLKYSFSVDWWSFGVLLYEML-IGQSPFHG-----DDEDELFESIRVD----TPHY--PRW----ITKESKDIMEKLFERDPDKRLGVTGNIRIH
|| ..  |...  | |||||...|..  ||.|  |      . .|..| ..       |..  |       ..|  .||..  ..||..|          
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDR----------

PFFKTINWSL
| |..|   .
PTFSEIHECF
Kinase PKCd.AA Pkinase_Tyr 420-494 27 9.4e-09 30.27 Pfam 81-159 (270) Show / Hide 
Range on Protein: 420-494
Range on HMM: 81-159/270
Sequence Identity: 27% (22 aa)

HLFFVMEFLNGGDLMFHIQD----KGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCK
... |||.  .|||  . ..    |... . .   ....| .|...|.||..| |||   |.........||.|||...
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCd.AA Pkinase_Tyr 347-381 35 9e-06 20.16 Pfam 1-39 (270) Show / Hide 
Range on Protein: 347-381
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

FTFQKVLGKGSFGKVLLAELK----GKDKYFAIKCLKKD
 || |.||.|.||.| ....|    ...   |.|.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase PKCd.AA Pkinase_Tyr 514-546 40 5.2e-05 17.58 Pfam 182-216 (270) Show / Hide 
Range on Protein: 514-546
Range on HMM: 182-216/270
Sequence Identity: 40% (14 aa)

APEILQGLKYSFSVDWWSFGVLLYEMLI-GQSP-F
||| ..  |..   | ||||||..|..  |..| .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY