Gene PKCh (Mouse)

PKCh

Species: Mouse
Alias: PKCeta, Prkch, PKCh
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: PKC
Subfamily: PKCh

Sequence

Name Sequence Type Origin Length Description Download
PKCh.NA RNA Sugen 3301 None Fasta, JSON
PKCh.AA Protein Sugen 683 None Fasta, JSON
PKCh.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of PKCh.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD PKCh.AA C2_PKD 9-167 28 1.3e-30 104.43 In-house 1-183 (183) Show / Hide 
Range on Protein: 9-167
Range on HMM: 1-183/183
Sequence Identity: 28% (53 aa)

NGYLRVRIGEAVGLQPTRWSLRHSLF---KKGHQLLDPYLTVSVDQVR----VGQTSTKQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANC
 | .|||...| || |.    .| |      . .. |||. | || .     .||| .| ||  |  |..| ..|..| |......|   .. . .||.|
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

TLQFQELLRTAGT-SDTFEGWVDLEPEGKVFVVITLTGSFTEATLQR---------------DRIFKHFTRKRQRAMR-RRVH
|  . ..  ...| |.. . |..||| |||.| | .  . |..  .                 | .  |.|.|  ||| ...|
TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C2 PKCh.AA C2 12-102 26 1.8e-17 62.05 Pfam 1-90 (90) Show / Hide 
Range on Protein: 12-102
Range on HMM: 1-90/90
Sequence Identity: 26% (26 aa)

LRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRV----GQTSTKQKTNKPTYNEEFCAN--VTDGGH-LELAVFHETPLGYDHFVANCT
|||.. || .| |. |        ..  . ||| .|.......     .|.....|  |..||.|  .  . |. | |.. |...  .| |.|.  |.
LRVHVIEARNLPPMDW--------DKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC
C2 PKCh.AA C2 11-117 17 5.3e-16 60.41 SMART 1-92 (92) Show / Hide 
Range on Protein: 11-117
Range on HMM: 1-92/92
Sequence Identity: 17% (22 aa)

YLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTN---KPTYNE---EFCANVTDGGHLELAVFHETPLGYDHFVANCTLQ
 |.|.| || .|                   ||| .|.       .|.....|.    |..||   .|  .|..   |.. |...       |.  |.. 
TLTVHIIEARNLP------------------DPYVKVY-------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH------DFIGHCCIP

--------------FQELLRTAGTSDT
              ....|   ..   
PNNPHWHQWDGCIHLSDIL-GYRH-WW
C1_1 PKCh.AA C1_1 172-225 41 2e-20 78.67 Pfam 1-55 (55) Show / Hide 
Range on Protein: 172-225
Range on HMM: 1-55/55
Sequence Identity: 41% (23 aa)

HKFMAT-YLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQ
|.....  ..|||.|.||.||.|| .|.||..||.|  ..|.|||.. .. | |.
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCh.AA C1 172-222 35 4.4e-16 60.68 SMART 1-61 (61) Show / Hide 
Range on Protein: 172-222
Range on HMM: 1-61/61
Sequence Identity: 35% (22 aa)

HKFMATYLRQPTYCSHCREFIWGVFG----KQGYQCQVCTCVVHKRCHHLIVT-------AC
|.....   .||||.|||..|||.|     .|||.|..|  ..||.||. .         .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PKCh.AA C1_1 246-298 47 6.7e-22 83.87 Pfam 1-55 (55) Show / Hide 
Range on Protein: 246-298
Range on HMM: 1-55/55
Sequence Identity: 47% (26 aa)

HKFNVH-NYKVPTFCDHCGSLLWG-IMRQGLQCKICKMNVHIRCQANVAPNCGVN
|.. .| |.| ||||.|||...|| . .||..|  |..|.| ||. .|.|.|| |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCh.AA C1 246-295 27 1.3e-17 65.71 SMART 1-61 (61) Show / Hide 
Range on Protein: 246-295
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HKFNVHNYKVPTFCDHCGSLLWGIMRQ-----GLQCKICKMNVHIRCQANVAP-------NC
|..  ...  ||.|.||....||. .|     |..|  ||...| .|...|..       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCh.AA PKC 355-614 71 7.6e-214 699.79 In-house 1-262 (262) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-262/262
Sequence Identity: 71% (188 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
|.|..|||||||||||||. |.| |.||.||||||||.|||||||||||||.|.||..|||||.|.|||||.||||||||.|||||||||||..|||.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
.|||||||||.||.||||||||||||||||||||||||.|.||||||||...||.||.|||||||||||||||.. ||..|||||.|||.|||..|..||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQG--GEHEILRHPFF
..|.||.||..|..|...|| ||...|..|.|.||||||..|||. .|.  ||..| .||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCh.AA Eta 355-614 79 1.1e-210 706.2 In-house 1-261 (261) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-261/261
Sequence Identity: 79% (208 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
|.||.|||||||||||||..|.|.|.||.||||||||.|||||||||||||||||||.|||||||.|||||.||||||||.||||||||.||..|.|||.
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
||||||||...||||||..|.|||||||||.||||||||||||||||||||.||.||.||||||||||||||||| |||.|||||||||.|||.||..||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT-QGGEHEILRHPFF
||.|||||||.||.|.|.||.|||..|..|||.||||||..|||..| |||||.|..||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCh.AA AGC 355-614 35 9.90000000001e-197 514.52 In-house 1-395 (395) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-395/395
Sequence Identity: 35% (141 aa)

FEFIRVLGKGSFGKVMLARIK------ETGELYAVKVLKKDV-ILQDD--DVECTMTE------------KRILSLARN---------HPFLTQ-LFCCF
|||..|.||||||||.|.| |       ||..||.|||||.. |....  .||.||||            ..||.....         |||... |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPDR--LFFVME----FVN-----GG-DLMFHIQ---KSRRFDEARARFYAAE-------IISALMFLHE-KGIIYRD-LKLDNVLLDHEGHCKLADFG
|..|.  |.||||    .||     || .|..|.|   |..|||| ||||||||       |..|| .||. .|||.|| ||..|.|||..||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGICNG--------------------------------------------------VTTATFCG--TPDYIAPEILQEMLYGPAVDWWA--MGVLLY
.||||. .|                                                  ..| ||||  ||.|.|||||    ||.|.|||.  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLCGHAPFEAEN----------EDDLFEAIL------NDEVVYP----------TWLHEDATGILKSFMTKNPTMRLGSLTQG----GEHEILRHPFF
|||.|. || ..|          ....|. |.      |..| .|           |. ..|  ..| ...|.|. |||.. ..    |  || .||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCh.AA Alpha 355-614 64 5.5e-163 547.75 In-house 1-259 (259) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-259/259
Sequence Identity: 64% (167 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
| |. |||||||||||||  | | ||||.|.|||||| |||||||||.|||.| |    |||.|.  ||||.|||.||||.|||||||.|||.  .| | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
 | ||||||  .| |||||||||||||||||.|| ||| |.||||||||.. ...|| |||||||||||||     || .||||| |||||||. | .||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF
. | ||.||.|| . .|.||  .   |  | |.|.||.|  |||. .. ||..|  ||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGC-GPDGEQDIREHPFF
Kinase PKCh.AA Delta 355-614 60 3.2e-146 492.05 In-house 1-259 (259) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-259/259
Sequence Identity: 60% (157 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
| | .||||||||||||| .|.. . ||.| |||||.|.|||||||| |.|.|.|| .||||..||| ||| . ||||||..||||||.|||...||||.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
||||||.|||..| |||.||||||||||||||||..|| |.|||||||| .    .. |||||||||||||..  .|  .||||. |||.|||| | .||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF
. |.||.||..|.||.  || |. ..|...||  . ..|. |||.  .  . .| .|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGV-QYCPKGDIRQHCFF
Kinase PKCh.AA Akt 355-614 48 7.29999999999e-140 449.82 In-house 1-264 (264) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-264/264
Sequence Identity: 48% (130 aa)

FEFIRVLGKGSFGKVMLARIKETGELY-AVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE
|.|..||||||||||.|.. | |...| | ||||||.|.| . || |.||..||   . |||...|   |||.|.|.|||...|||.| .|.|. |||.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

ARARFYAAEIISALMFLHEKGIIYRD-LKLDNVLLDHEGHCKLADFGMCKEG-ICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWA-MGVLLYEMLCG
 |||||.||||.|. .||.|.||||| ||. |.|.|..|| .|.|||.|||. | .. .| |||||| |.|||||.   .. |||||.  |...|||.||
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

HAPFEAENEDDLFEAILNDEVVYP--TWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF
  || ... . .|. |.| .| .|   |.  ..  ....  .|.|..|||. . .. .|| |||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGG-GPNDAQEIKRHPWF
Kinase PKCh.AA SGK 355-614 42 5.5e-132 410.07 In-house 1-283 (283) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-283/283
Sequence Identity: 42% (122 aa)

FEFIRVLGKGSFGKVMLARIKET------------------GELYAVKVLKKDVIL-------QDDDVECTMTEK-RILSLARNHPFLTQLFCCFQTPDR
|.|. |.||||||||.... |..                  . .||.|||.|. |.       .   .  .|.|.  ||..  .|||. .|   |||.. 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNM-KHPFIVNLHYAFQTKWK

LFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE
|.|||..||||.. .|.|. ..| | |||||||||..||  ||.. ||||||| .|.||||.|||.| ||| |||||    || |||||| | |||.|. 
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF
  .. .|||| .| .||||. |  ||.  |   ... |.| .   |.    ||  ...   .|.|. |||  |  .  || .||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG--TKRDFMEIKNHPFF
Kinase PKCh.AA Iota 355-614 55 6.8e-124 414.72 In-house 1-271 (271) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-271/271
Sequence Identity: 55% (150 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
|| |||.|.||. ||.... |.|  .||.||.||... .|.|..   ||| .   | |||||  |  ||||. |||||.|||||||||||.|. |.  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

RARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
 ||||.|||. || ||||.||||||||||||||||||| || |.||||||| .| ||.|||||| |||||||    || .|||||.|||..||. | .||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

---------EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQG--GEHEILRHPFF
         .   || ||  ||  ..  |  |   |...||.|. |.|. |||   |   | ..|  ||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCh.AA PKN 355-614 52 2.7e-111 376.07 In-house 1-260 (260) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-260/260
Sequence Identity: 52% (137 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFD
| .| |||.| ||||.|.. |.|||.||.|.|||  |.  |.||  |.||||.  .    |||| .|| |||| .  .||||.. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHED-VFS

EARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHA
|.||.|||| ..  | .|||. ||||||||||.|||.||. |.||||.||||.  |  |.||||||...|||.| .  |  ||||| .|||.|||| | .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFF
||  ..|...|..|.||.| || .|  .|  |..  . |||  |||.  .  | .|  .|||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAE-DIKMQPFF
Kinase PKCh.AA AktR 355-614 40 5e-104 351.9 In-house 1-268 (268) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-268/268
Sequence Identity: 40% (109 aa)

FEFIRVLGKGSFGKVMLARIK-ETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE
|.....|||| ||||.|.. | .....|| |..||  | .    . | ||. |.    ||||. .|. |||| . |||.||.. ||.| .|..|...|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ARARFYAAEIISALMFLHEK-GIIYRDLKLDNVLLDHEGHCKLADFGMCK-EGIC-NGVTTATFCGTPDYIAPEILQE-MLYGPAVDWWAMGVLLYEMLC
 .||||.|.|. || .||..  ||||||| .| ||| .|| |..|||. | ...  .  .. .||||| |.|||....   .. .||||| |...|||. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GHAPFEAENEDDLFEAILNDE---VVYPTWLHEDATGILK-SFMTKNPTMRLGSLTQGGEHEILRHPFF
|. ||...|  ..|. |.. .   . ||. . . .  ...   . |||..|||. . | | || .||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWE-EIKSHPWF
Kinase PKCh.AA S_TKc 355-614 37 3.5e-102 346.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-231/231
Sequence Identity: 37% (100 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNG--GDLMFHIQKSRR--
.|..|..|||.||||...| |.||...|.|..|          | .. | .||.   .||.. .|. .||. |.|..|||...|  |||. .|.| .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGP-AVDWWAMGVLLY
    |.| .||||...|..|| ..|..|||.|||| .|.|||.  | |..|||....         ||||||.|.|||.|    ||. ..|||. |..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGG-EHEILRHPFF
|||||  ||.  ... .|. |.           ..|  ...  ..|.|. |..       | .|  ||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCh.AA Pkinase 355-614 31 5.4e-86 296.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTM-TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGG----DLMFHIQ--K
....|..|.||||.| ... | ||...|||..||. .  . |.. .  .| .|.    |||.  .|...|...|.. .|||...||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SRRF--DEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHC----KLADFGMCKEG-ICNGVTTATFCGTPDYIAPEILQ-EMLYGPAVDWWA
...|  .|  ..||. .|...| ..|..|||.||||..|.|.|..||.    |..||| .|   . |.. . ||||||.|.|||...    |||.||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

MGVLLYEMLCGHAPFEAE------NEDDLFEAILNDEVVYPTWLH---------------------EDATGILKSFMTKNPTMRLGSLTQGGEHEILRHP
.|..|||||||. ||  .      ... ... |.  .. .. .                       |..  ..|.  .|.|. |..       ..|| ||
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------AEQILQHP

FF
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WF
Kinase PKCh.AA S_TK_X 615-678 40 4.4e-27 97.21 SMART 1-79 (79) Show / Hide 
Range on Protein: 615-678
Range on HMM: 1-79/79
Sequence Identity: 40% (32 aa)

KEIDWAQLNH--RQLEPPFRPRIK----SREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDE---------FRNFSYVS
..||| .| .  ...||||.|.||    | .|.|||||.| .|.|.|||.|.. .. ..|.|         ||.|.|| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCh.AA Pkinase_C 634-680 44 1.1e-18 69.0 Pfam 1-46 (46) Show / Hide 
Range on Protein: 634-680
Range on HMM: 1-46/46
Sequence Identity: 44% (21 aa)

RIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE
..||..|.|||||.| .| |..|| |.  .. ..|..||.|.||.|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCh.AA TyrKc 355-609 21 5.7e-16 35.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 355-609
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLA-RNHPFLTQLFCCFQTP-------DRLFFVMEFVNGGDLMFHIQ
 .....|| | ||.|.... |   .  |||.||.|       .|  | | ||..    .|| . .|. .  ..       . |. |||.. .|||  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSRR-FDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICN-------GVTTATFCGTPD------YIAPEILQEMLYG
|.|. .  .    ..  | .   .||.|..| |||   |.|.......| .|||.....           . ...  .  .        ||| ...  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PAVDWWAMGVLLYEML-CGHAPFEA-----ENEDDLFEAILNDEVVYPTWL----------HEDATGILKSFMTKNPTMRLGSLTQGGEHEIL
.. | |. ||...|..  |  | .       . ....| . . .   .              |  . | |.    .| .|    .    ||..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI---HECF
Kinase PKCh.AA Pkinase_Tyr 421-502 25 9.1e-08 26.93 Pfam 72-159 (270) Show / Hide 
Range on Protein: 421-502
Range on HMM: 72-159/270
Sequence Identity: 25% (22 aa)

CCF-QTPD-RLFFVMEFVNGGDLMFHIQK----SRRFDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCK
.|  |    ... |||.. .|||  . .|     ....  .   ....| ... .|..|..| |||   |.|.......| .|||...
VCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCh.AA Pkinase_Tyr 355-389 35 1e-06 23.08 Pfam 1-39 (270) Show / Hide 
Range on Protein: 355-389
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

FEFIRVLGKGSFGKVMLARIK----ETGELYAVKVLKKD
 .|...||.|.||.|.... |    .|.   |||.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase PKCh.AA Pkinase_Tyr 522-566 27 0.748433 3.51 Pfam 182-228 (270) Show / Hide 
Range on Protein: 522-566
Range on HMM: 182-228/270
Sequence Identity: 27% (13 aa)

APEILQEMLYGPAVDWWAMGVLLYEMLC-GHAP-FEAENEDDLFEAI
||| .... .  . | |. |||..|..  |  | ..     ...|.|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI