Gene PKCt (Mouse)

PKCt

Species: Mouse
Alias: Prkcq, PKCt
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: PKC
Subfamily: PKCd

Sequence

Name Sequence Type Origin Length Description Download
PKCt.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
PKCt.AA Protein Sugen 707 None Fasta, JSON
PKCt.NA RNA Sugen 3313 None Fasta, JSON

Protein domain

Protein domains of PKCt.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD PKCt.AA C2_PKD 2-155 29 1.4e-40 139.56 In-house 1-183 (183) Show / Hide 
Range on Protein: 2-155
Range on HMM: 1-183/183
Sequence Identity: 29% (54 aa)

SPFLRIGLSNFDCGTCQAC------------QGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKN----VDLISET
..|.|. |   | .   .              .||  |||.| |.| .|.. .    |||.|.|| |...||.|.  ||. ||..  .      . ..|.
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

TVELYSLAERCRKNNGRTEIWLELKPQGRMLMNARYFLEMSD----TKD---------MSEFENEGFFALHQRRG-AIKQAKVH
|. |  ..|.| .|.| |.||..|.|||. ... ..| |  |     ..         |.||... . ..  ||| |...||.|
TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQ-RPGFNRRRGNAMRHAKIH
C1_1 PKCt.AA C1_1 160-212 40 5.2e-19 73.45 Pfam 1-55 (55) Show / Hide 
Range on Protein: 160-212
Range on HMM: 1-55/55
Sequence Identity: 40% (22 aa)

HEFTAT-FFPQPTFCSVCHEFVWG-LNKQGYQCRQCNAAIHKKCIDKVIAKCTGS
| . .. .|.|||||..| ||.|| | .||..|..|.  .|..|  || ..| ..
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCt.AA C1 160-209 35 1.8e-17 65.32 SMART 1-61 (61) Show / Hide 
Range on Protein: 160-209
Range on HMM: 1-61/61
Sequence Identity: 35% (22 aa)

HEFTATFFPQPTFCSVCHEFVWGLNKQ-----GYQCRQCNAAIHKKCIDKVIA-------KC
| . .. | .||.|..|....||. ||     ||.|. |. ..|||| ||| .        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCt.AA C1_3 171-202 25 9.6e-05 13.57 Pfam 1-30 (30) Show / Hide 
Range on Protein: 171-202
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCI
 .|..| . . .    .| | ||.  .|..|.
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1_1 PKCt.AA C1_1 232-284 50 2.3e-25 95.37 Pfam 1-55 (55) Show / Hide 
Range on Protein: 232-284
Range on HMM: 1-55/55
Sequence Identity: 50% (28 aa)

HRFKVY-NYKSPTFCEHCGTLLWG-LARQGLKCDACGMNVHHRCQTKVANLCGIN
|....  |.|.||||.||| ..|| |..||.||..|..|.||||..||...|| |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCt.AA C1 232-281 27 1.2e-19 72.57 SMART 1-61 (61) Show / Hide 
Range on Protein: 232-281
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HRFKVYNYKSPTFCEHCGTLLWGLARQ-----GLKCDACGMNVHHRCQTKVAN-------LC
|... ... .||.|.||. ..||...|     |..| .|....|..|..||..        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKCt.AA C1_3 243-274 21 1.008168 3.34 Pfam 1-30 (30) Show / Hide 
Range on Protein: 243-274
Range on HMM: 1-30/30
Sequence Identity: 21% (7 aa)

TFCEHCGTLLWGLARQGLKCDACGMNVHHRCQ
 .|. ||. . .  . . .|  |  ..| .| 
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
Kinase PKCt.AA PKC 380-634 66 1.8e-202 662.35 In-house 1-262 (262) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-262/262
Sequence Identity: 66% (173 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLS
| ..|.|||||||||.||| |.|....|||.|||||...||||||||.|||||.|||.||||||..|.|||...|||||||.||||||.|||....|...
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQSPF
.|.|||||.|..|||||.|||.||||||||.|||..|||||||||||||||.....|.|||||||||||||| .|.|..|||||.|||| |||..|||||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

HGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGV-------RGDIRQHPLF
||.||.|||.||..|||.|||||..||.... ... ..||||||.       ..|||.||.|
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCt.AA Delta 380-634 77 2.4e-188 632.02 In-house 1-259 (259) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-259/259
Sequence Identity: 77% (201 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLS
|..||.|||||||||.|||.|..|...|||.|||||||.||||||||||.|||.||||||||.|.||||||||.||||||||||||||||||.||.||..
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQSPF
||.|||.|.|.||||||.|||.||||||||.|||.||||||||||||||||.|..|..|||||||||||||. ||||||||||||||||.||||||||||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

HGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGV----RGDIRQHPLF
||.||.|||.||..|.|.||||...||||.|.|||.|.|||||||    .||||||..|
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKCt.AA AGC 380-634 32 1.4e-183 479.76 In-house 1-395 (395) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-395/395
Sequence Identity: 32% (130 aa)

FILHKMLGKGSFGKVFLAEFK------RTNQFFAIKALKKDV-VLMDD--DVECTMVE------------KRVLSLAWE---------HPFLTH-MFCTF
| ..|..||||||||.|.. |       |....|.| |||.. .....  .||.||.|            ...|...           |||... ....|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKEN--LFFVMEYLN---------GG-DLMYHIQ---SCHKFDLSRATFYAAE-------VILGLQFLHS-KGIVYRD-LKLDNILLDRDGHIKIADFG
|.|..  |.|||||..         || .|..|.|    . .|| .|| |||||       ..|.|..||| .||..|| ||..|||||.|||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKENMLGD--------------------------------------------------AKTNTFCG--TPDYIAPEILLGQKYNHSVDWWS--FGVLVY
.|||.| ..                                                  ..|.||||  ||.|.|||||    |....||||  .|.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLIGQSPFHGQ----------DEEELFHSIR------MDNPFYP----------RWLEREAKDLLVKLFVREPEKRLGVRGD---------IRQHPLF
|||.|..||.|.          ...|.|..|.      .... .|          ||.  |||||. ||....|||||| .|.         |..|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCt.AA Alpha 380-634 61 2.8e-144 485.63 In-house 1-259 (259) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-259/259
Sequence Identity: 61% (159 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLS
|   . ||||||||| ||| | |.  .||| |||||.  |||||||||||||| |    |||. |  .|||   |.||||| ||||||||||   ||  .
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQSPF
 | |||||.  || |||.|||.||||||||..||..||||||||||||||| .|. | ||||||||||||| . | |  |||||.|||| |||. || ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

HGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGV----RGDIRQHPLF
 | ||.||| .|   |. ||. . .||.|.   . ...| ||||     . |||.|| |
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKCt.AA Eta 380-634 60 4.3e-139 468.4 In-house 1-261 (261) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-261/261
Sequence Identity: 60% (158 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLS
|   |.||||||||| ||| | |.. .||| |||||.. |||||||| |||.|||| .||||| ..|.||||. ||||||| ||||||..||   ||| .
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQSPF
|| ||||||.. |.||| .|..||||||||||||..|| |.|||||||| .. .  | ||||||||||||||  ..|  ||||| .|||.|||. ||.||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

HGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGVRG------DIRQHPLF
  . |..|| ||  |.  || ||..||  .|   . . |.||||         .||||| |
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCt.AA Akt 380-634 46 2.9e-129 415.41 In-house 1-264 (264) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-264/264
Sequence Identity: 46% (124 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFF-AIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDL
| . |.|||||||||||.. | |.... |.|.||||. .. . || |. |...|     |||.. .   |||...|.|||.| |||.| ||.| . .|. 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

SRATFYAAEVILGLQFLHSKGIVYRD-LKLDNILLDRDGHIKIADFGMCKEN-MLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWS-FGVLVYEMLIG
.|| ||.||.||....||||.|.||| ||. |||.|.||||...|||.|||| .  . ||.|||||| |.|||||.|. .  .||||. .|.. |||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QSPFHGQDEEELFHSIRMDNPFYP--RWLEREAKDLLVKLFVREPEKRLG-VRG---DIRQHPLF
. ||. || ...|. | . .  .|  .|.  |.|||. .|  . |.||||   .   .|..|| |
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKCt.AA SGK 380-634 37 2e-109 339.15 In-house 1-283 (283) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-283/283
Sequence Identity: 37% (107 aa)

FILHKMLGKGSFGKVFLAEFKRT------------------NQFFAIKALKKDVVL-------MDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENL
|.. | .||||||||.... | .                   .|.|.| |.|. ..           .  .| |. |.     |||.      ||||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ
.|||.|.|||.. ||.|   .|  .|| |||||... |  |||. |.||||| .||||| .||... ||| |||..    .| |||||| | |||.|..|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

KYNHSVDWWSFGVLVYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGVR---GDIRQHPLF
 .  .||||. | . |||..|  ||  .. ....  |.      |.    .|.||.  |  ..|.|||| .   ..|..|| |
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase PKCt.AA PKN 380-634 50 4.2e-109 368.75 In-house 1-260 (260) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-260/260
Sequence Identity: 50% (133 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLA--WEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFD
| .  .||.| |||| |...| |....|||||||  ..  |.||  |.|||..  .    ||||  .|  |||.|  .|||||. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

LSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQS
  || |||| |.||||.|| . |.||||||||.|||..|..||||||.|||.|    .| ||||||...|||.|  . |   ||||  |||.||||.| .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGVRG----DIRQHPLF
|| | ||||.| .|  |.  |||.|  || ... .|  . ||.|||       ||. .| |
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKCt.AA AktR 380-634 41 6e-105 354.97 In-house 1-268 (268) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-268/268
Sequence Identity: 41% (110 aa)

FILHKMLGKGSFGKVFLAEFK-RTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDL
| ..|.|||| ||||.|.. |  .....|.| .||         . |  |. ..     |||.  .. .|||||.|||.|||  ||.| .|.....||. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SRATFYAAEVILGLQFLHSK-GIVYRDLKLDNILLDRDGHIKIADFGMCK-ENML-GDAKTNTFCGTPDYIAPEILLG-QKYNHSVDWWSFGVLVYEMLI
..| ||.|...|.|..||..  |.||||| .||||| |||.||.|||. | ..|   | |...||||| |.|||...  . .| |||||.||...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQSPFHGQDEEELFHSIRMDN---PFYPRWLEREAKDLLV-KLFVREPEKRLG-V---RGDIRQHPLF
|. ||  .. ...|..|.  .   . ||  .  ..|||.  ||. . |.||||       .|. || |
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKCt.AA S_TKc 380-634 34 7.1e-100 339.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNG--GDLMYHIQSCHK--
. ... .|||.||||...  |.|.. .||| .|          | .. | ..|.    ||.. ... .||. ..|..||||..|  |||. .|... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDLSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNH-SVDWWSFGVLVY
    |.  .| ||.......|...||.||..|||| .|||||.  ||||.|||....        .||||||.|.|||.|   .|.. ..||||.|...|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGVRGDIR------QHPLF
||| |. ||.  .....|. |.           .||||.. |.....||||...    .      .|| |
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCt.AA RSK 383-634 40 6e-99 335.02 In-house 1-278 (278) Show / Hide 
Range on Protein: 383-634
Range on HMM: 1-278/278
Sequence Identity: 40% (112 aa)

HKMLGKGSFGKVFLAEFK---RTNQFFAIKALKKDVVLMDD-DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK---
.|.||.|..|||||  ..    |.| .| | ||| ..   . |.. || | ..|..   |||. . . .|||.. |. .|||..||.| .|.|       
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDLSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDR---DGHIKIADFGMCKENMLG-DAKTNTFCGTPDYIAPEILL---GQK-YNHSVDWWSFGV
|. ..| ||.||..| ...||..||..||||..|||.|    .||||. ||| ||.. .    .|.|||.| .|.|||.|    .|. .....||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LVYEMLIGQSPFHG---QDEEELFHSIRMDN--PFYPRW--LEREAKDLLVKLFVREPEKRLGV----RGDIRQHPLF
| |||| |..||.|   .. .|..  |.  .  .  |.|  | .|||||. |.. |.|.||||       .|.||| |
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKCt.AA Pkinase 380-634 30 1.6e-82 285.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 380-634
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTM-VEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGG----DLMYHIQ--S
. ... .|.||||.|...  | |.. .|.| .||.   .. |.. .   | ...     ||.   ....|..| .. .||||..||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

CHKF--DLSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHI----KIADFGMCKEN-MLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDWWS
  .|  .   . ||. ... ||...||.||..||||..|||.|..|||    ||.||| .|      .  ..||||||.|.|||... ||.| ..||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGVLVYEMLIGQSPFHGQ------DEEELFHSIRMDNPFYPRWLE---------------------REAKDLLVKLFVREPEKRLGVRGDIRQHPLF
.|...|||| |. || |.      |. ...  |..  . .... .                     .|.||.. ... . |.||..   .| ||| |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-AEQILQHPWF
Kinase PKCt.AA S_TK_X 635-698 43 1.4e-28 102.18 SMART 1-79 (79) Show / Hide 
Range on Protein: 635-698
Range on HMM: 1-79/79
Sequence Identity: 43% (34 aa)

REINWEELER--KEIDPPFRPKVK----SPYDCSNFDKEFLSEKPRLSFADRALINSMDQNM---------FSNFSFIN
|.|.|. |..  ||| |||.||.|    || | ||||.|| .|.|.|. .|..|.|||.||.         | .|....
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCt.AA Pkinase_C 654-700 44 7.9e-17 62.45 Pfam 1-46 (46) Show / Hide 
Range on Protein: 654-700
Range on HMM: 1-46/46
Sequence Identity: 44% (21 aa)

KVKSPYDCSNFDKEFLSEKPRLSFADRALINSMDQNMFSNFSFINPG
.|||| | ||||.|| .|.|.... |.  . |.||. | .|.. || 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCt.AA TyrKc 380-628 24 5.3e-16 36.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 380-628
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

FILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW-EHPFLTHMF--CTFQTK-----ENLFFVMEYLNGGDLMYHIQ
  | |.|| | ||.|.... |   .  |.| ||.|       .|  | | |...    .|| .  ..  || |       | |. ||||  .|||  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SCHK-FDLSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLG-------DAKTNTFCGTPD------YIAPEILLGQKYN
.... . ..    ..  .  | ..||||... |||   |.|.......||.|||....   .       | .. .  .  .        ||| .   |..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

HSVDWWSFGVLVYEML-IGQSPFHG-----QDEEELFHSI----RMDNPFY--PRW----LEREAKDLLVKLFVREPEKRLG---VRGDI
.  | |||||. .|..  ||.|  |      . .|... .    ||. | .  |         |  ..  .   ..||.|     .. ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKCt.AA Pkinase_Tyr 451-527 26 5.6e-10 34.41 Pfam 77-159 (270) Show / Hide 
Range on Protein: 451-527
Range on HMM: 77-159/270
Sequence Identity: 26% (22 aa)

KEN--LFFVMEYLNGGDLMYHIQSC----HKFDLSRATFYAAEVILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCK
.|   .. ||||  .|||  . ..     .......   .....  |...|.||... |||   |.|.......||.|||...
GEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCt.AA Pkinase_Tyr 547-592 36 6.4e-05 17.29 Pfam 182-230 (270) Show / Hide 
Range on Protein: 547-592
Range on HMM: 182-230/270
Sequence Identity: 36% (18 aa)

APEILLGQKYNHSVDWWSFGVLVYEMLI-GQSP-FHGQDEEELFHSI-R
||| .   |...  | |||||| .|..  |..| . | . ||... | .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE
Kinase PKCt.AA Pkinase_Tyr 380-398 36 0.000846 13.49 Pfam 1-19 (270) Show / Hide 
Range on Protein: 380-398
Range on HMM: 1-19/270
Sequence Identity: 36% (7 aa)

FILHKMLGKGSFGKVFLAE
 .. |.||.|.||.|....
ITFGKKLGEGAFGEVYKGT