Gene PKN3 (Mouse)

PKN3

Species: Mouse
Alias: PKN3, BC034126
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: PKN

Sequence

Name Sequence Type Origin Length Description Download
PKN3.AA Protein Sugen 882 None Fasta, JSON
PKN3.NA RNA Sugen 2987 None Fasta, JSON
PKN3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of PKN3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HR1 PKN3.AA HR1 19-86 33 4.3e-18 68.02 Pfam 1-74 (74) Show / Hide 
Range on Protein: 19-86
Range on HMM: 1-74/74
Sequence Identity: 33% (25 aa)

DEKEMVRRAIQKELKIKEGMENMRRV---ATDRRH----LGHVQQLLRASNRRLEQLHGELRELHAQVLLPASAE
. .. .|. |..|.||||| |||||.   .||..     . ..|| || ||...|.|. .|..|....    ...
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN3.AA HR1 102-174 30 2.5e-20 76.01 Pfam 1-74 (74) Show / Hide 
Range on Protein: 102-174
Range on HMM: 1-74/74
Sequence Identity: 30% (23 aa)

RLSEALHRQLQVELKVKQGAENMIHTC--ASGTPKERKLLAAAQQMLKDSQLKVALLRMKISSLESSGSPEPGPD
.  ..|......|.|.|.|||||.. .  ... .| ||.....||||..|. |...|||..  |... ..  .|.
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN3.AA HR1 175-247 26 1e-18 70.29 Pfam 1-74 (74) Show / Hide 
Range on Protein: 175-247
Range on HMM: 1-74/74
Sequence Identity: 26% (20 aa)

LLAEELQHRLRVEAAVAAGAKNVVKLL---GGQRMQDRKALAEAQAQLQESSQKLDLLRLALELLLERLPPTHSLR
.  ..|......| ..  ||.|.....   .. ... ||.....|..|.||.||...|| .|| | .|... |. .
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKH-RKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
C2_PKD PKN3.AA C2_PKD 316-435 18 6.2e-07 20.96 In-house 20-174 (183) Show / Hide 
Range on Protein: 316-435
Range on HMM: 20-174/183
Sequence Identity: 18% (28 aa)

QQR-------GGGELASEVLAVLKVDNRV----VGQTGW-GLVAEKSWDQSFIISLDRARELEIGVHWRDW---RQLCGVAFLKLEDFLD-----NACHQ
|..       .... |...  |..||...    .|||          |.. |.  ....|...| .  ..    .  .. .  ||||        ..   
QHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAECTMKLEDCIEMCKTNSGITH

LSLSLVPQGRLFAQVTFCEPVIERRPRL---------------QRQRCIFSKRRG
. . | |||....|.    .. .... .               .|||  |  |||
IWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRG
Kinase PKN3.AA PKN 552-811 75 5.3e-196 657.45 In-house 1-260 (260) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-260/260
Sequence Identity: 75% (195 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHEDVFPE
|||.|||||||||||||.|||.||.||||||||||....|||..||.|||||.|.|.|..||||..|.||.||..|.|||.|...|||||..||||||.|
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDVFSE

PQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECP
|.||||.||||||||.|||..||||||||||||||..|..|||||||||||.|.||||||||||||||||||||...|||||||||||||.|||||||||
PRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGECP

FPGDTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFF
||||.|||||.|||..||..|.||||........||.|.||.||||||||||.||.||||
FPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKN3.AA AGC 552-811 32 1.1e-167 437.64 In-house 1-395 (395) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-395/395
Sequence Identity: 32% (130 aa)

FRCLAVLGRGHFGKVLLVQYK------GTGKYYAIKALKKQE-VLGRD--EIDSLYCE------------KRILETVGRTG-------HPFLLS-LLACL
|. | |.|.|.|||| ||. |      .||||||.| |||.. .. ..  ...  . |            ..|||..  |.       |||. . |  . 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTSSH--ACFVTEFLP---------GG-DLMAQIHED----VFPEPQACFYLAC-------VVLGLQFLHE-KRIIYRD-LKLDNLLLDAQGFLKIADFG
|. .|   .|| |..|         || .|. .....    .|.|..|.||.|.       .||.|..||. . ||.|| ||..|.|||..| .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGIGFG--------------------------------------------------DRTSTFCG--TPEFLAPEVLTQEAYTRAVDWWG--LGVLLY
|||||.. |                                                  |||.||||  |||..|||.|    |..|.|||.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGECPFPGDT----------EEEVFECIV------SADVPCP----------HFLSVQGLELIQKLLQKSPEKRLGAGERD-----AEEIKVQPFF
|||.|  || ||.          ..|.|. |       . .|. |           ..|..   ||.|||.| ||||||.|..|     |||||  |.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKN3.AA PKC 552-811 48 7e-130 423.26 In-house 1-262 (262) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-262/262
Sequence Identity: 48% (127 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHED-VFP
|. | |||.| ||||.|.  ||| .|||||.|||  ..  | ... ..|||.|.. ..  |||| .|  | || ..  || |.. ||||| .| .   |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWK--HPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFK

EPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
|..| || | ....||||||| |||||||||| |||. |  ||||||.|||..  ||.||||||||...|||.|  . |. .|||| .|||.|||..|  
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFPGDTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERD---AEEIKVQPFF
|| |..|.|.|..|   ..  |  ||.   ........| ||||||.....   ...|.  |||
PFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKN3.AA Akt 552-811 43 2.5e-111 357.14 In-house 1-264 (264) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-264/264
Sequence Identity: 43% (116 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYY-AIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQI-HEDVF
|. | |||.| ||||.||. | |.|.| |.|.|||.  . ....     |..||...    |||. .|    ||. . .||... .||.|   . .. .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN---HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

PEPQACFYLACVVLGLQFLHEKRIIYRD-LKLDNLLLDAQGFLKIADFGLCKEG-IGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWG-LGVLLYEML
.|..| || | ..|....||.| ||||| ||. |.|.|..| ....|||||||. |  .|.| ||||||| ||||.| .  .|.|||||| ||...|||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

VGECPFPGDTEEEVFECIVSADVPCP--HFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFF
 |  ||  .  .. |. | ...|  |  ...| .   || .||.| |.||||.|. ||.|||  |.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKN3.AA Delta 552-811 46 7.4e-102 344.69 In-house 1-259 (259) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-259/259
Sequence Identity: 46% (122 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHEDV-FP
|  ..|||.| ||||.|.  ||. ||||||.|||. ||  |.... . |.|.|     . ||||  |.   || .|  || |.| |||||  | .   | 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALA--WEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFD

EPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
|  | || . ...||||||.| ||||||||||.||| .| .||||||.||| .    ..|||||||...|||..  . |...||||  |||.||||.|  
EKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQS

PFPGDTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFF
|| |. |.|.|..|.      |.... .  ....||... ||||||  .  . .|.  .||
PFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKN3.AA Alpha 552-811 47 2.5e-100 339.62 In-house 1-259 (259) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-259/259
Sequence Identity: 47% (124 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHE-DVFP
|  | |||.| ||||.|   |||   |||| |||  .   | ..    |||.|   |.   ||| ..  | ||     || |.  ||||| .|     | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGK--PPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFK

EPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
||.| || | .  || ||||| |||||||||| .||| |  ||||||.|||..  .. | ||||||...|||.   . | ..||||  |||||||..|  
EPHAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQP

PFPGDTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFF
|| |. |.|.|. |    |  |  .|.   .... .| | | ||||.|  . ..|.  |||
PFDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKN3.AA Eta 552-811 47 2.8e-100 339.47 In-house 1-261 (261) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-261/261
Sequence Identity: 47% (124 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHED-VFP
|  . |||.| ||||.| . |||.  |||| |||. ..  |...   .|||||    .  |||| .| .| ||.    || |.  ||||| ||     | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARK--HPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFD

EPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
|| | || | |.. |.|||.. .|||||||||.|||..|  |.||||.|||||  |  |.||||||...|||.|    |  .|||| .|||.|||. |. 
EPRARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQP

PFPGDTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGE--RDAEEIKVQPFF
||  | |...|| |.  ||  | .|. .  ....  . | |.||||. .   . ..|.  |||
PFEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKN3.AA SGK 552-811 41 1e-97 302.34 In-house 1-283 (283) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-283/283
Sequence Identity: 41% (118 aa)

FRCLAVLGRGHFGKVLLVQYKGT------------------GKYYAIKALKKQEVL-------GRDEIDSLYCEK-RILETVGRTGHPFLLSLLACLQTS
|. | |.| | ||||..|. |..                  .| ||.| |.|| ..        . |      |.  ||  .    |||. .|    || 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNM---KHPFIVNLHYAFQTK

SHACFVTEFLPGGDLMAQIH-EDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVL
    || ... ||..   .  |  |||..| || | .|. |  ||.. ||||||| .|.|||.|| ... |||||||||   | |.||||||| ||||||
WKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

TQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFF
  . . |.|||| || .||||..|  ||     .. .. | . .   |.. |..  .||| |||| |.||||.  ||..|||  |||
RKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase PKN3.AA S_TKc 552-811 35 1.5e-95 324.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPG--GDLMAQIHEDV-
.. | ..|.| |||| ... |.||...||| .|          .... | .||.     .||..  |. . |. .| ..|.|...|  |||.  |..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTR-AVDWWGLGVL
      ||| .|.||.. ....|...|...||.|||| .|.|||    .||.||||...        .||||||...|||||    |.. ..||| .|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYEMLVGECPFPGDTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDA--EEIKVQPFF
|||||.|. |||  .....|. |.          | .....|.|.||| ||||..| |  .  ..||  |.|
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKN3.AA RSK 555-811 38 5.4e-95 321.89 In-house 1-278 (278) Show / Hide 
Range on Protein: 555-811
Range on HMM: 1-278/278
Sequence Identity: 38% (108 aa)

LAVLGRGHFGKVLLVQYK---GTGKYYAIKALKKQEVLGRDE-IDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHEDVF-
| |||.| .||| |.. .    ||..|| | ||| ..  |.  .     | .|||...  .|||. .|    || ..   ..|...||.|   . . .. 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQ--QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

---PEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDA---QGFLKIADFGLCKEG-IGFGDRTSTFCGTPEFLAPEVLT----QEAYTRAVDWWGL
    |  ||||.| .|| ...||.. ||.||||..| |.|    .| .|. |||.||.. . .. .| |||.| |..|||.|.    |.....|.||| |
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLLYEMLVGECPFPG---DTEEEVFECIVSAD--VPCP--HFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFF
|||.||||.|  || |   .. .|... | ...  .. |  ..||    .||.|.|.. |.||||.| .||||||  |.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKN3.AA Iota 552-811 45 2.5e-87 290.89 In-house 1-271 (271) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-271/271
Sequence Identity: 45% (123 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGGDLMAQIHED-VFP
|. . |.||| . |||.|..| | . ||.| .||. |   ..||    || . |.     ||||  | .| || |   || || .|||||  .      |
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQA--SNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLP

EPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC
|  | || | ..| |.||||. |||||||||| |||..| .|. |.|.|||||  || |||||||| ..|||.|  | |  .|||| ||||..||. |  
EEHARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRS

PFP--G-------DTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERD---AEEIKVQPFF
||   |        ||. .|  |.   .  | .|||.  ....  | | |. |||         ..||  |||
PFDIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKN3.AA Pkinase 552-811 29 1.2e-79 275.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 552-811
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLY-CEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLPGG----DLMAQIH-
.... ..|.| ||.| . . ||||| .|.| .||..     ..  .   | .|.  ..   ||. . |. . ....| ..|.|...||    ||.. |. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--EDVF--PEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFL----KIADFGLCKEG-IGFGDRTSTFCGTPEFLAPEVLT-QEAYTRAVDW
  . .|  .| ...||.  .. ||...|...||.||||..|.|.| .| .    ||.||||.|   .  .  ..||||||...||||.  .. |...||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WGLGVLLYEMLVGECPFPGD------TEEEVFECIVSADVPCPHFLS---------------------VQGLELIQKLLQKSPEKRLGAGERDAEEIKVQ
|..|..||||| |. ||||.      .. .... | ..... . . .                       ....| ..|.| |.||..     ||.|.  
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

PFF
|.|
PWF
Kinase PKN3.AA S_TK_X 812-876 29 5.1e-18 67.1 SMART 1-79 (79) Show / Hide 
Range on Protein: 812-876
Range on HMM: 1-79/79
Sequence Identity: 29% (23 aa)

RTTNWQALLA--RTVQPPFVPTLC----GPADLRYFEGEFTSLPPTLTPPVSQSSLTARQQA--------AFRDFDFVS
| ..|..|..  ....|||.|...    .| |...|. |||. .|.|||. . .| .. |..         ||.|..| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKN3.AA TyrKc 552-805 21 9e-15 16.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 552-805
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FRCLAVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVG-RTGHPFLLSLLACLQTS-------SHACFVTEFLPGGDLMAQ
 . . .||.|.||.| . ..|      |.| ||.        .  .. | ||.  .| .  || .. |...  ..          . |.|. |.|||   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGH--HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

I--HEDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGF---GDRTSTFCG----TPEF------LAPEVLTQEA
.  |.. .. .. . .   .  | ..||.|..| |||   | |.....  ||.||||....      | ....          .      .|||..    
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTRAVDWWGLGVLLYEML-VGECPFPG-----DTEEEVFECIVSADVPCPHFL--------SVQGL-ELIQKLLQKSPEKRLGAGERDAEEI
.| . | |  ||...|..  |. | ||      . .||.|.. . . . .             . . .....  .  ||.|    |   |..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PKN3.AA Pkinase_C 831-878 31 2.6e-12 46.57 Pfam 1-46 (46) Show / Hide 
Range on Protein: 831-878
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

TLCGPADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVSEQ
....| | ..|. |||. ||..|| .... ... .|..||.| .|.. 
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase PKN3.AA Pkinase_Tyr 552-700 24 3.4e-09 31.78 Pfam 1-159 (270) Show / Hide 
Range on Protein: 552-700
Range on HMM: 1-159/270
Sequence Identity: 24% (40 aa)

FRCLAVLGRGHFGKVLLVQYK----GTGKYYAIKALKKQEVLGRDE--IDSLYCEKRILETVGRTGHPFLLSLLACLQ-TSSH--ACFVTEFLPGGDLMA
 . . .||.|.||.| .  .|    .|.   |.| ||  |    ..  ....  | .|. . |.  || ...|...    . .   . |.|. |.|||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--EGAMHEQNCREDFMREAKIMKQLGH--HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

QIHED-----VFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCK
  ..       .. .. . . . .  |...|..|..| |||   | |.. ... ||.||||..
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKN3.AA Pkinase_Tyr 719-764 41 0.001787 12.39 Pfam 181-228 (270) Show / Hide 
Range on Protein: 719-764
Range on HMM: 181-228/270
Sequence Identity: 41% (20 aa)

LAPEVLTQEAYTRAVDWWGLGVLLYEMLV-GECP-FPGDTEEEVFECI
.|||..    .| . | |  |||..|..  || | .|| . |||.| |
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI