RAF1

Species: Mouse
Alias: Raf1, RAF1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
RAF1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
RAF1.NA RNA Sugen 3066 None Fasta, JSON
RAF1.AA Protein Sugen 648 None Fasta, JSON

Protein domain

Protein domains of RAF1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD RAF1.AA RBD 56-131 49 4.8e-40 141.57 Pfam 1-77 (77) Show / Hide
Range on Protein: 56-131
Range on HMM: 1-77/77
Sequence Identity: 49% (38 aa)

NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIG-EELQVDFL
....|.|||.||.||.||.||...|.|||..|..||.|.||.|.|.  .|.|.|..|||.||...| | .||.|..|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL

RBD RAF1.AA RBD 56-131 51 2.6e-37 131.17 SMART 1-76 (76) Show / Hide
Range on Protein: 56-131
Range on HMM: 1-76/76
Sequence Identity: 51% (39 aa)

NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFL
....|.||..|||||.||.||..||.|||..|.|||.||||.|||.  .|.|.| .|||......| |.||.|...
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR

C1_1 RAF1.AA C1_1 139-187 30 7.9e-18 69.1 Pfam 1-55 (55) Show / Hide
Range on Protein: 139-187
Range on HMM: 1-55/55
Sequence Identity: 30% (17 aa)

HNFARK-TFLKLAFCDICQKFL-----LNGFRCQTCGYKFHEHCSTKVPTMCVDW
|.. .. .| . .||. |..|.     . |..||.|.|..|..|..|||..| ..
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN

C1 RAF1.AA C1 139-184 30 6.2e-16 60.17 SMART 1-61 (61) Show / Hide
Range on Protein: 139-184
Range on HMM: 1-61/61
Sequence Identity: 30% (19 aa)

HNFARKTFLKLAFCDICQKFLLN---------GFRCQTCGYKFHEHCSTKVPT-------MC
|.. ...| | ..|..|.|..           |.||. |.||.|..|..|||        ||
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC

C1_3 RAF1.AA C1_3 150-177 23 0.000492 11.76 Pfam 1-30 (30) Show / Hide
Range on Protein: 150-177
Range on HMM: 1-30/30
Sequence Identity: 23% (7 aa)

AFCDICQKFLL--NGFRCQTCGYKFHEHCS
 .|..|.. .   ....| .| . .|| | 
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA

Kinase RAF1.AA RAF 349-608 69 2.1e-202 662.51 In-house 1-282 (282) Show / Hide
Range on Protein: 349-608
Range on HMM: 1-282/282
Sequence Identity: 69% (195 aa)

VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQA---FRNEVAVLRKTRHVNILLFMGYMTKDN---LAIVTQWCEGSSLYKHLHVQET--KF
||..||||||||||||.|.||||||||.|.|.||||||.||   |.|||||..||||.|||||||||.|..   .||||||||.||||.|.|||||  ||
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS--GSQQVEQPTGSVLWMAPEVIR-----------MQDDNPFSF
.|..||||.||..|||||||||||||||.|||||||||..|||||||||.|||.|||  |.||.||||...|||||||||           |||.||.||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYSYGIVLYELMAGELPY-AHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIEL
||||||.|||.||||....|| .||.||||||||.||||..||||.....|||||.||..||.|. .||||||.|||..|..
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV

Kinase RAF1.AA RAF 349-606 59 1.3e-186 626.27 In-house 1-275 (275) Show / Hide
Range on Protein: 349-606
Range on HMM: 1-275/275
Sequence Identity: 59% (163 aa)

VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP-EQLQAFRNEVAVLRKTRHVNILLFMGYMTKD---NLAIVTQWCEGSSLYKHLHVQET-KFQMF
|.. .|||.|.|||||.|.||||||||.|....||| .|||||.|||....||||.||.|||||..|.   ..|||||||.||.||.|.|||.| ||.| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

QLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK-SRWS--GSQQVEQPTGSVLWMAPEVIRMQ---------DDNPFSFQSDV
..|.||.|..|||||||||||||||.||.|||||.|..|.|.||||.||| .||.  ..||..||.|...|||||||||.         |.|||||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
|..|.|.|||||||.||.||....|||.||.|||...|.|. ...|||.||.|...|... .||||.|.||...|
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI

Kinase RAF1.AA TKL 355-606 26 1.9e-96 326.74 In-house 1-364 (364) Show / Hide
Range on Protein: 355-606
Range on HMM: 1-364/364
Sequence Identity: 26% (100 aa)

IGSGSFGTVYKGKWHG-----------DVAVKILKVV------------------------DPTPEQLQAFRNEVA-VLRKTRHVNILLFMG--------
||||.||.||||||.|           |||||..|.                         ||...... |..|.. .....|| ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YMTKD-----NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHA--------KNIIHRDMKSNNIFLHEGLT--------------V
 .. .      .|.||...|.| ||. .||       . |....|...|.||.|||.        ..||||| ||.||...| .|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVKS------------------RWSGSQQVEQPTGSVLWMAPEVIRMQDD-------------NPFSFQSDVYSYGIVLYELMAGELPYAHI
||.||||....|                  . .....   . |.  ||||||.|.|..              ..| ..||||.||||.|......||...
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

NNRDQI------IFMVGRGYASPDLSRL----Y-------KNCPKAMKRLVADCVKKVKEERPLFPQILSSI
.....|      ........ .  . .     .       ..||. ||.|  || .   |.|| | .||. .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase RAF1.AA Pkinase 349-606 25 7.9e-83 286.27 Pfam 1-293 (293) Show / Hide
Range on Protein: 349-606
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

VMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQLQAFRN--EVAVLRKTRHVNILLFMGYM-TKDNLAIVTQWCEGS----SLYKHLH-VQE
  .  .|||||||.|||....|.   |||||.|...  ....|. |.  |...... .| ||. . ... .||.. .|. .|||     .|. ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKF--QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTV----KIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDV
..|  .. .......|...|..|.|...|||||.|. ||....  ..    ||.||||| ... .  ..    ..|.  .|||||||  .... .  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YSYGIVLYELMAGELPYAHI----NNRDQIIFMVGRGYASPDLSRLYKNC------------------PKAMKRLVADCVKKVKEERPLFPQILSS--I
.|.|..|||.. |..|. .     | .||.  .. .... .. .. ....                  ....| .. .| .|  ..|| ..||| .  .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase RAF1.AA KSR 349-606 36 1.2e-69 236.59 In-house 1-272 (272) Show / Hide
Range on Protein: 349-606
Range on HMM: 1-272/272
Sequence Identity: 36% (100 aa)

VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVV--DPTPEQLQAFRNEVAVLRKTRHVNILLFMGY-MTKDNLAIVTQWCEG-SSLYKHLHVQETKFQMFQ
. .  .|| | ||.|..| |||.||.|..     .     | .|. ||. ...||| || ||||. |   .||||.  | |  .|| |.||. .|..|  
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK---SRWSGSQQVEQPTGSVLWMAPEVIR--------MQDD-NPFSFQSDVY
 ..||.| .||| ||||| ||| | || |||.     | | ||||  ..       .. .   | |    .||| ||         |.. .||| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

SYGIVLYELMAGELPYAHINNRDQIIFMVGRG-YASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
..| ..||...||.|...     .||. ...|    ..|. .   | . || .   |    ..||| | .|.. .
AFGTIWYEMICGEWPFKY-QCAESIIWQMCQGEGMRQVLRNV--QCGREMKEILMMCWSYEPQERPTFQDIMKML

Kinase RAF1.AA TKL-Unique 351-606 33 1.6e-67 230.6 In-house 1-290 (290) Show / Hide
Range on Protein: 351-606
Range on HMM: 1-290/290
Sequence Identity: 33% (100 aa)

LSTRIGSGSFGTVYKGKWHGD-VAVKILKV-VDPTPEQLQAFRNEVAVLRKTR-HVNILLFMGYMTK-----DNLAIVTQWCEGSSLYKHLH--------
 .  ||.|..|.||||||.|. ||.|....  |. .| .| |.||| .. | . | ||...||| ..      |. ||.  |.|.|||..||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKSNNIFLHEG-----LTVKIGDFGLATVKSRWSGSQQV-------EQPTGSVLWMAPEVIRM
  ...|. | | ...|.. ||||.||| ..  |||||.|| |. . ..     . .|| ||||....|. . .          . . || .||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QDDNPFSFQSDVYSYGIVLYELMAGEL------PYAHINNRDQIIFMVGR--GYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
   . .| .|||||.||||.|.  ...      || .. ...|.. ||        | ..    .|||  . |  .| .   ..|| | .|....
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase RAF1.AA Dicty4 349-608 34 3.5e-63 209.6 In-house 1-277 (277) Show / Hide
Range on Protein: 349-608
Range on HMM: 1-277/277
Sequence Identity: 34% (97 aa)

VMLSTRIGSGSFGTVYKGKWHG-DVAVKIL--KVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMT-----KDNLAIVTQWCEGSSLYKHLHV-----
     |||.||||.||||.| | .||||.|  . ..   . |..||.||. . | || ||.||||. |     .  . |||  .   .||. ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QETKFQMFQLID---IARQTAQGMDYLHAKN--IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ-VEQPTGSVLWMAPEVIRMQDDNPFSFQ
 |..| .    .    .|. .|.|| .||. |  ||||| || |.   . ..||..||||.... . .  ..    . |...|||||| . |   |.   
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ---PYNEK

SDVYSYGIVLYELMAGELPYA-HINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS--IEL
.||||.||||.|.  .. ||. |. . .|... |..    | ..   ..||.  |.|...|  .  . || |..|..    | 
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIP---DWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase RAF1.AA MLK 349-606 31 5.4e-61 208.95 In-house 1-291 (291) Show / Hide
Range on Protein: 349-606
Range on HMM: 1-291/291
Sequence Identity: 31% (93 aa)

VMLSTRIGSGSFGTVYKGKWHG-D-----VAVKILK----VVDPTPEQLQAFRNEVAVLRKTRHVN----ILLFMGYMTKD-N-LAIVTQWCEGSSLYKH
  ... ||||||| |.||.|.. |     ||||. .     .  | .. ..|. |.  ||. .| |    |  |.|  ... . ..||...|||.|||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHVQETKFQ-------------MFQLIDIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHE------GLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL
|| ...|               . .....| | |.||.|||..    ||||| || || ..|      ..|.|| |||... ...   .    .. |.. 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

WMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
|||||||     ...|  .||.|.|.||.|....|.||. ...  .|...|.     | .      ||. .|.|  .| .   ..|| | ||..  
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase RAF1.AA TK 349-606 16 2.1e-60 200.91 In-house 1-486 (486) Show / Hide
Range on Protein: 349-606
Range on HMM: 1-486/486
Sequence Identity: 16% (81 aa)

VMLSTRIGSGSFG---TVYKGKWHG----------------------------DVAVKILKVV-DPTPEQLQA--------------FRNEVAVLR--KT
. |   .|.| ||   .||||.|.|                            .||||.||   . ..|. ..              . .| ....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHVNILLFMGYMTKDN-------------LAIVTQWCEGSS----LYKHLHVQETK--------------------------------------------
.| ||. . |. |..              . ||. .... .    | ..|.    |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FQMFQLIDIARQTAQGMDYLHAK------NIIHRDMKSNNIFLHEGLT-----------VKIGDFGLAT
                               . | ||. ...| |.|| |||.|      |..|||    |. ..|...           .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKS----RWSGSQQVEQPTGS----------------------------VLWMAPEVIRMQD------DNPFSFQSDVYSYGIVLYELMA-G-ELPYAHI
..|    |  .| .    ..|                            . |||||... .       .. |. .|||.|.|....|..  | | .|  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN--------RDQIIFMVGRG-----------YASPDLSRLYKNCP-------------KAMKRLVADCVKKVKEERPLFPQILSSI
.|         .... .. ||                . .    ..             ... .|  .| ..  |.|| | |... .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase RAF1.AA S_TKc 349-609 24 5.6e-57 196.52 SMART 1-231 (231) Show / Hide
Range on Protein: 349-609
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

VMLSTRIGSGSFGTVYKGKWHG---DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEG--SSLYKHLHVQETK----
  .   ||.|.||.|||.....    ||.||.|         . .|.|...|.| .| ||  . ...  |.| .|.  |.|   .|..... . ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSF-QSDVYSYGIV
 |   .   ...|......|.| ..||||| |  ||.| |  ..||.|||||..              |.  .|||||.      ....  .|..| |..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

LYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILS------SIELL
|||...|. |.    . .... ..|               .. .| ..  | .|  |.||   ..|       . . .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase RAF1.AA STE 350-597 21 6e-51 175.59 In-house 1-346 (359) Show / Hide
Range on Protein: 350-597
Range on HMM: 1-346/359
Sequence Identity: 21% (74 aa)

MLS-TRIGSGSFGTVYKGKWH----GD--------------VAVKILKVVDPTP---------------EQLQAFRNEVAVLRKTR--HVNILLFMGYMT
     .||.|.||||||.. |    ..              .|.|.... . ..               |..| . .|. ...| .  | ||  . |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD--------NLAIVTQWCEGSSLYKHLH-VQETKFQM------------FQLIDIARQTAQG-MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
|.        .| |.  ...| || . .. . ......             |.. |.||. .| ..||| ..||||| |. ||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

--VKSRW------------SGSQQVEQPTGSVLWMAPEVIRMQD---DNPFSFQSDVYSYGIVLYELMAGELPYAHINNRD---QIIFMVGRG-------
  ..|              ...|.    .|.  |||||||. ..   |.. ....|..| |... |.  |. |..  ..     .|.|. . .       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---YASPDLSR----------------LYKNCPKAMKRLVADCVKKVKEERP
     .| |                  . ... . .|  .. | .|  ..||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP

Kinase RAF1.AA TyrKc 349-606 30 3.6e-49 170.59 SMART 1-280 (280) Show / Hide
Range on Protein: 349-606
Range on HMM: 1-280/280
Sequence Identity: 30% (88 aa)

VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKT--RHVNILLFMGYMTK--------DNLAIVTQWCEGSSLYKHLHVQET
. |   .|.| ||.||||.|  .|||| ||        ...|..|  ...|   .| ||. . |. |.        . | ||.  ... .| ..|.  . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW-----SGSQQVE----QPT--GSVLWMAPEVIRMQDDNPFSF
|..| .|.... | |.||.||| ||.||||    |. ..|..||||.||||.           |..  .     .      . |||||.|   ... |..
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYSYGIVLYELMA-GELPYAH-----INNRDQIIFMVGRGYASPDLSRLYKN-----CPKAMKRLVADCVKKVKEERPLFPQILSSI
.|||.|.|....|..  |. ||       ..|.. .|  | .||  |     |       ||..| ..  .| .   |.|| | .| . .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase RAF1.AA Src 349-606 31 6.2e-48 160.91 In-house 1-255 (255) Show / Hide
Range on Protein: 349-606
Range on HMM: 1-255/255
Sequence Identity: 31% (84 aa)

VMLSTRIGSGSFGTVYKGKWHG--DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLH-VQETK-FQMF
. |  ..|.| || |..|.| |  .|||| ||  .    . .||  |  .. | || ...      ...    |||   .  || . |.  .|..  .. 
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLP

QLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKS----RWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLY
||||.| | |.||.|| ..|.||||    |.   |.. .|..||||| .        . ..    |   . |.||| |. .    |.  ||| |.|| |.
QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFP---IKWTAPEAINYGR---FTIKSDVWSFGILLT

ELMA-GELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKR-LVADCVKKVKEERPLFPQILSSI
|..  |  ||   .|. . . .| |||  |  .     ||. .   .   |..|  |.|| |  . .  
EIVTYGRVPYPGMTNH-EVLQQVERGYRMPCPHN----CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase RAF1.AA Pkinase_Tyr 349-490 32 9.5e-47 158.95 Pfam 1-158 (270) Show / Hide
Range on Protein: 349-490
Range on HMM: 1-158/270
Sequence Identity: 32% (52 aa)

VMLSTRIGSGSFGTVYKGKWH-------GDVAVKILKVVDPTPEQ--LQAFRNEVAVLRKT-RHVNILLFMGYMT--KDN--LAIVTQWCEGSSLYKHLH
. .   .|.|.||.||||.|.        .||||.||  . ..||  ...| .|......  .| ||. ..|  |  ..   . ||.  ... .|...|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VQ---ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA
 .   . .. | .|.....| |.||.||..||.||||    |. ..|...|||.|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA

Kinase RAF1.AA Pkinase_Tyr 511-606 30 1.8e-16 56.4 Pfam 180-270 (270) Show / Hide
Range on Protein: 511-606
Range on HMM: 180-270/270
Sequence Identity: 30% (30 aa)

WMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMA-GELP-YAHINNRDQIIFMV-GRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
|||||.|.      |. .|||.|.|....|..  || | |. . | . .. ..  .||    . .  .|||. . .|  .| ..  |.|| | .|.. .
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYR---MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL