Gene RIPK1 (Mouse)

RIPK1

Species: Mouse
Alias: RIPK1, Ripk1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: RIPK

Sequence

Name Sequence Type Origin Length Description Download
RIPK1.NA RNA Sugen 2268 None Fasta, JSON
RIPK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
RIPK1.AA Protein Sugen 656 None Fasta, JSON

Protein domain

Protein domains of RIPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIPK1.AA RIPK 24-286 41 2.2e-157 529.14 In-house 1-290 (290) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-290/290
Sequence Identity: 41% (120 aa)

DS-GGFGKVSLCYHRSHGFVILKKVYTGPNRAEY-----NEVLLEEGKMMHRLRHSRVVKLLGIIIEE-----GN-YSLVMEYMEKGNLMHVLKTQID--
.. ||||.|....||..|....||..........     .. ..||.|.||.||....|...|....|     .. |..||||||.|.|.|.|.|...  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---VPLSLKGRIIVEAIEGMCYLHDKG--VIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINA
   .|..|..|.|.| ..||||||...  .||.||||||||||..||.||||.|.|....||.......| |.||.|...||..|||.||.|||....|.
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCN-QREVYSMKSKNRWGTLSYMPPEHFRTDNK

KP----TEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCP-----REIISLMERCWQAIPEDRPTFLGIEEEF
||    |.|.|||||.||.|.....|.|||...|......|.|.|.||..... ||.|     ...|.||.||||. |.|||.|...||..
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase RIPK1.AA TKL 23-286 25 1.3e-87 297.38 In-house 1-364 (364) Show / Hide 
Range on Protein: 23-286
Range on HMM: 1-364/364
Sequence Identity: 25% (93 aa)

LDSGGFGKVSLCYHRSHG--------FVILKKVYTGPNRAE--------------------------YNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGN-
. |||||.|   ..| .|         ..  |..   |  |                          ... . || .||.||||  .|...|. ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLHD--------KGVIHKDLKPENILVDRDFH--------------IK
            . .||||...|.| |.|       .... |.. ..  ||.|||         ...|| |||..|||||....              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IADLGVASFKTWSKLTKEKDNKQKE-----VSSTTKKNNGGTLYYMAPEHLNDINA--------------KPTEKSDVYSFGIVLWAIFAKKEPYENVIC
|.|.| . |...|.  .   ....|     ....|. . .||...|||| |.. .               . .||.|||||||||| |.. ..||..  .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

T---------EQFVICIKSGNRPNVEEILEY---------CPREIISLMERCWQAIPEDRPTFLGIEEEF
          | |..... |.|| . .| ..         ||.....||..||.. ||.||.|. | ...
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc RIPK1.AA S_TKc 17-290 23 1.8e-52 181.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-290
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

LLEKTDLDSGGFGKVSLCYHRS-HGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEK--GNLMHVLKTQID----
      . .|.|||| .|.|.. .  | .|..          | .. | ..... .|  .|||.... . ... .||||..   |.|....| .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPT
   |     ... . .... |.|..|.|| ||||||||.|.  ||||.| |.| .                      .   ||..||||| |     . .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------TTFCGTPWYMAPEVL-----GYG

E-KSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEF-----RPFY
  |.|..|.|..|.  .. . |..    ..| .. .               ..| ......|.|  ||.|||   . ..       |. 
KCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase RIPK1.AA Pkinase 17-279 22 1.2e-48 172.76 Pfam 1-284 (293) Show / Hide 
Range on Protein: 17-279
Range on HMM: 1-284/293
Sequence Identity: 22% (68 aa)

LLEKTDLDSGGFGKVSLCYHRSHG-FVILKKVYTGPNRAEYNEVLLE--EGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKG----NLMHVLK--TQ
.  .  . ||.||.| .|.|.. |  | .|..    .. . .. ..   | ..|.||.|  .|.|...  ..... .||||.|.|     |.....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IDV--PLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHI----KIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLND
  .  .     ... . ..|. |.|..|.|| ||||||||.|.. ||    ||.| |.| ..              . ...  .   ||..||||| .. 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------Y-NNS-MTTFCGTPWYMAPEVIR-

INAKPTEKSDVYSFGIVLWAIFAKKEPYENV----ICTEQFVICIKSGNRPNVEEILEYCP-------------------REIISLMERCWQAIPEDRPT
 . . . |.|..|.|..|.  . .. |. .        .| ..  . . .|. ... . |.                   .| ......|..  |..|||
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

F
.
A
Kinase RIPK1.AA TK 17-286 16 1.9e-46 153.3 In-house 1-486 (486) Show / Hide 
Range on Protein: 17-286
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

LLEKTDLDSGGFG---KVSLCYHRSHGF----------------------------VILKKVYTGPNRAEYNE--------------VLLEEGKMMH-RL
.     | .| ||   .| ..  |...                             |  .|  .. . .|  .               ..|. .|.|  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHSRVVKLLGIIIEEGN------------YSLVMEYMEKGN----LMHVLKTQID---------------------------------------------
.|  .|.|.|.. ....            . .|||||..|.    | . |..  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPLSLKGRIIVEAIEGMCYLHDK------GVIHKDLKPENILVDRDFH-----------IKIADLGVAS
                               ...  .  . . . .|| |||.|      ...| ||   |.||... .           .|||| | . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

FKTWSKLTKEKDNKQKEVSSTTKKNNGGTLY----------------------YMAPEHLND-I------NAKPTEKSDVYSFGIVLWAIFAKK-EPYEN
 ..   |... ....  ....... ...                         .|||| ||| .      . | |.||||.|||...| ||    |||  
QGS-GVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

VICT---------EQFVICIKSGNRP-----------NVEEILEYCPR-------------EIISL-MERCWQAIPEDRPTFLGIEEEF
 .           .... ....| |.           .  .  ..||              |.. . | .||.. |||||||  . |..
GMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RIPK1.AA TKL-Unique 65-286 28 6.7e-45 155.49 In-house 47-290 (290) Show / Hide 
Range on Protein: 65-286
Range on HMM: 47-290/290
Sequence Identity: 28% (72 aa)

KMMHRLR-HSRVVKLLGIII----EEGNYSLVMEYMEKGNLMHVLK----------TQIDVPLSLKGRIIVEAIEGMCYLHDKG--VIHKDLKPENILVD
. | .|. |  .|.. |. .     ..|...||||.. |.|. ||             .. ..... ...  .  ||.||| ..  .|| |||. |.|||
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD

RD-----FHIKIADLGVASFKTWS--KLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKE------PYENVIC
..     . |||.| | . |.. .  . ..|. .         .  . |.. .|||| |.. ... .||||||||||||| |.  |       ||...  
NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR-------NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQ

TEQFVICIK--SGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEF
.. . .  .   . ||   .| . || |.  |...||   |..||.|  | .. 
EQWCEMVHYMEENYRP---PIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase RIPK1.AA TyrKc 17-286 26 1.1e-43 152.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-286
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

LLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRL--RHSRVVKLLGIIIEE-------GNYSLVMEYMEKGNLMHVLKTQ
.  .  | .| ||.| ..  .    |  |..  .       | ...| ..|..|  .|  .|.|.|.....       . . .|||||..|.| . |.  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ID-VPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNK------QKEVSSTTKKNNG--GTLYYMAPEH
 . .... .  . . . .|| |||.|..|| ||   |.||......||.| |         |... ...      ..  .....|.      .  |||| 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG---------LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LNDINAKPTEKSDVYSFGIVLWAIFAK-KEPYENV----ICTEQFVICIKSGNRPNVEEILEY--------CPREIISLMERCWQAIPEDRPTFLGIEEE
.     | |.||||.|||...| ||   ..||...    .  .. . ..|.|.|.   .. ..        || |. ..|..||.. |||||||  | |.
I--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM---PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

F
|
F
Kinase RIPK1.AA MLK 17-286 24 2.1e-43 148.47 In-house 1-291 (291) Show / Hide 
Range on Protein: 17-286
Range on HMM: 1-291/291
Sequence Identity: 24% (75 aa)

LLEKTDLDSGGFGKVSLCYHRSHG----FVILKKVYTGP----NRAEYNEVLLEEGKMMHRLRHSR----VVKLLGIIIEEGN-YSLVMEYMEKGNLMHV
..... . ||.|||| . . |        | .|.| . .       .  . . .| .   .|.|      .....|....... . .||||.|.| | .|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L---KTQID-----------VPLSLKGRIIVEAIEGMCYLHDKG---VIHKDLKPENILVDR------DFHIKIADLGVASFKTWSKLTKEKDNKQKEVS
|   .....           ...... .. .   .|| ||| .    .|| |||. |||.|.      . . ||.| |.. ...             .  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWH-------------QMC

STTKKNNGGTLYYMAPEHLND-INAKPTEKSDVYSFGIVLWAIFAKKEPYE-NVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPT
 |.. .| ||. .|||| .    . | .||.||.|.|.||| ......||.  . . . .   .  |.|| ..     ||. . .||..||.. |..||.
-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPS

FLGIEEEF
|  | ...
FRQIVQHL
Kinase RIPK1.AA Dicty4 65-282 32 6.1e-40 130.99 In-house 50-269 (277) Show / Hide 
Range on Protein: 65-282
Range on HMM: 50-269/277
Sequence Identity: 32% (77 aa)

KMMHRLRHSRVVKLLGIII----EEGNYSLVMEYMEKGNLMHVLKT-------QIDVPLSLKGR---IIVEAIEGMCYLHDKG--VIHKDLKPENILVDR
. |  .||  .....|  .    . |  . |.||| ||||  .|          |  ...|  |   .   |  || .||     .|| |||. |.||| 
HIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDK

DFHIKIADLGVAS-FKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYE-NVICTEQFVICIKS-G
.. .|..|.| .  .|      |..|.|..   .|..    ||  .|||| .   .   .||.|||||||||| |. ..|||    . ..|||. . . .
NWRVKVCDFGLSQYMK------KHEDHKDN--QMTAC----GTPCWMAPEVM--MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKK

NRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGI
.||   .|  .||  ...|...||   |. ||.| .|
LRP---PIPDWCPPSWKHLIQWCWDHDPQHRPSFEEI
Kinase RIPK1.AA STE 18-278 19 2.6e-34 118.57 In-house 1-347 (359) Show / Hide 
Range on Protein: 18-278
Range on HMM: 1-347/359
Sequence Identity: 19% (69 aa)

LEK-TDLDSGGFGKVSLCYHRSHG----------------FVILKKVYTGPNRA---------------EYNEVLLEEGKMMHRLR--HSRVVKLLGIII
.|.   . .|.||.| .....  .                ..  |..   ....               |  . .|.| |.|....  |  .|| .|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EEG-------NYSLVMEYMEKGNLMHVLK----TQID----------VPLSLKGRIIVEAIEG-MCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVAS
 ||       .  ..||||. | |  ..|    .. .          .| |. ..|... ..| . |||....|| |.|| |||.     .|..| ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

FKTWSKLTKEKDNKQKEVS-------STTKKNNGGTLYYMAPEHLND-I---NAKPTEKSDVYSFGIVLWAIFAKKEPYEN-VICTEQFVICIKS-----
  | |   .   .     .       .   .   ||  .|||| ..      . . ..|.|..|.|....     | |. .       | | ...     
QLTDSMANI-Q-S--NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

--------GNRPNVEEILE----------------YCPREIISLMERCWQAIPEDRPT
        |. |  .. |.                 .  | .  ...| |  |..|||
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase RIPK1.AA LRRK 66-288 27 1.6e-33 115.96 In-house 110-351 (351) Show / Hide 
Range on Protein: 66-288
Range on HMM: 110-351/351
Sequence Identity: 27% (72 aa)

MMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLK----TQ-----IDVPLSLKGRIIVEAIEGMCYLHDKG--VIHKDLKPENILV---D----
.|..|.|. .|.|.|. |.   . .||||.  |.| |.|.    ..     .. . .|| .| ..  .|| |||..   .|| |||..|||.   .    
IMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHS

-----RDFHIKIADLGVAS-FKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDI-NAKPTEKSDVYSFGIVLWAIFAKK-EPYENVI----C-
      . ..|||| |  . |..              . ..  |  .|.  .|||| ...  .   |||.|.||||..|| .   .  |...        
PNYPNAHVCAKIADFGISRMFQC--------------FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQ

-TEQFVICIKSGNRPNVEEILEYCPR-----EIISLMERCWQAIPEDRPTFLGIEEEFRP
 .||.  .|..| || . .   |||.     .  .|.. |||. |..||.|  | .    
WMEQIEDKIIEGLRPTIPQH--YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase RIPK1.AA Ciliate-E2 17-284 17 2.6e-31 104.72 In-house 1-358 (365) Show / Hide 
Range on Protein: 17-284
Range on HMM: 1-358/365
Sequence Identity: 17% (65 aa)

LLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPN---------------------RAEYNEVLLEEGKM---------------MHRLRHSRVVKLLG
      . .|.||.| .| ... .  . .|. .  .                       . .... |.  |               . .| |  ..|.  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

III--EEGNYSLVMEYMEKGNLMHVLKTQ---------------IDVPLSLKGRIIV-----------EAIEGMCYLHDKG-VIHKDLKPENILVDRDFH
  .   . |. ||||| . |.|.. .| .               .   . .   |.            . |... ||| |. .|| |.||||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNG-----------------------GTLYYMAPEHLNDIN-------AKPTEKSDVYSFGIVLWA
|||.|.| . . .    ...... .  . .  ... .                       ||..||||| ||  .          ..|.|..|.|..|  
IKIIDFGLSKKYD----DDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

IFAKKEPYENVICTEQFVICIKSGNRPNVEEIL---------------EYCPREIISLMER----CWQAIPEDRPTFLGIEE
   .| |.          . ..  .  .  .                 .... | . |. .    . |  || |.|  |.|.
MLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQ
Kinase RIPK1.AA Pkinase_Tyr 17-160 26 8.5e-21 71.06 Pfam 1-158 (270) Show / Hide 
Range on Protein: 17-160
Range on HMM: 1-158/270
Sequence Identity: 26% (42 aa)

LLEKTDLDSGGFGKVSLCYHR-----SHGFVILKKVYTGPNRAEY--NEVLLEEGKMMHRL-RHSRVVKLLGIII-EEGN--YSLVMEYMEKGNLMHVLK
.     | .| ||.| ... .      .  |  |..       |    | ...| |.|. | .|  .|.|.|... ...   . .|||||..|.| . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

T----QIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVA
.    .  .... .  . ..  .|| ||..|. || ||   |.||......||.| | |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase RIPK1.AA Pkinase_Tyr 207-286 42 4.8e-18 61.75 Pfam 192-270 (270) Show / Hide 
Range on Protein: 207-286
Range on HMM: 192-270/270
Sequence Identity: 42% (35 aa)

TEKSDVYSFGIVLWAIFA-KKEP-YENVICTEQFVICI-KSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEF
|.||||.|||...| ||   ..| |...   |...  | ..|.|    .. |.|| || .|| .||.. |||||||  | |..
TTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR---MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RIPK1.AA UTK 58-160 28 1.2e-17 56.94 In-house 48-175 (296) Show / Hide 
Range on Protein: 58-160
Range on HMM: 48-175/296
Sequence Identity: 28% (37 aa)

E---VLLEEGK---MMHRLR-HSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQID----VPLSLKGR----IIVEAIEGMCYLHDKGVIHKDLKPE
|    ..|| .   || ... |  |..|.|.   |.   .|.||||.|.| ..| .. .     |..|. .      .   .|| ||| .|..| ||   
EPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAAR

NILVDRD-------FHIKIADLG---VA
|.||...         .||||.|    .
NCLVHMHRMMWHCMMVCKIADFGRGGMS
Kinase RIPK1.AA UTK 194-220 55 1.6e-08 25.3 In-house 206-231 (296) Show / Hide 
Range on Protein: 194-220
Range on HMM: 206-231/296
Sequence Identity: 55% (15 aa)

MAPEHLNDINAKPTEKSDVYSFGIVLW
|||| |..   ..|.||||.|||.|.|
MAPEALTHHT-RFTTKSDVWSFGVVCW
Kinase RIPK1.AA UTK 257-286 36 3.2e-07 20.76 In-house 267-296 (296) Show / Hide 
Range on Protein: 257-286
Range on HMM: 267-296/296
Sequence Identity: 36% (11 aa)

CPREIISLMERCWQAIPEDRPTFLGIEEEF
||...  || |||.. |..||.|  .....
CPHPVYRLMHRCWHYDPQERPDFEDLVQQM
RHIM RIPK1.AA RHIM 520-538 68 9.8e-12 38.34 In-house 1-19 (19) Show / Hide 
Range on Protein: 520-538
Range on HMM: 1-19/19
Sequence Identity: 68% (13 aa)

YTIFNSSGIQIGNHNYMDV
..|.|.||||||||||| .
IHIYNCSGIQIGNHNYMWI
Death RIPK1.AA Death 569-654 32 2.8e-23 80.42 Pfam 1-87 (87) Show / Hide 
Range on Protein: 569-654
Range on HMM: 1-87/87
Sequence Identity: 32% (29 aa)

DEHLNPI--RENLGRQWKNCARKLGFTESQIDEIDHDYERDG-LKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRAS
.. .. .  ....|..|. .|||||.....||.| || .. . |....||||.|| .|   |.|||..|..||... |.|..  . ...
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQR-HGKNATVDHLIEALRKMGRRDCAEKIQSWL