Gene RIPK3 (Mouse)

RIPK3

Species: Mouse
Alias: RIPK3, Ripk3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: RIPK

Sequence

Name Sequence Type Origin Length Description Download
RIPK3.AA Protein Sugen 486 None Fasta, JSON
RIPK3.NA RNA Sugen 1899 None Fasta, JSON
RIPK3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 271 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of RIPK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIPK3.AA RIPK 28-288 37 3.5e-148 498.6 In-house 1-290 (290) Show / Hide 
Range on Protein: 28-288
Range on HMM: 1-290/290
Sequence Identity: 37% (110 aa)

VGKGGFGVVFRAHHRTWNHDVAVKIVN------------SKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSG-QALVTRFMENGSLAGLLQPEC---
||.|||| ||.|.||.|...||.|...            ......|.|.| .||.|... ..|.... .||.... ...|...||||||...|....   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

--PRPWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGS-------GSGSGSRDSGGTLAYLDPELLFDVNLK
  |.||||.||...|...||||||| |||..||||||.|||.|...|.|.|||||.|....|.|..       .....|....|||.|..||.....| |
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK

A----SKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKT
.    ....|||||.|..|.||....... .|........|....||.|...|. .||.|..|...||| .|| .....||.||.||..|
PIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase RIPK3.AA TKL 28-288 23 1.3e-82 280.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 28-288
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

VGKGGFGVVFRAHHRTWN--------HDVAVKIVNS---------------------------------KKISWEVKAMVNLRNENVLLLLGVTEDLQWD
.|.||||.|.....| |.         |||||. .|                                 ...  |.. | .|| .|.....|.  . ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

FVSGQ--------ALVTRFMENGSLAGLLQPECPRPWPLLCRLLQEVVLGMCYLHSLN------PPLLHRDLKPSNILLDPELH--------------AK
 |...        ..|. ....|||  .|.      |...||. ... .||.|||| |      ||..|||||..|||.|  ..              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LADFGLSTFQGGSQSGSGSGSG-------------SRDSGGTLAYLDPELLFDV--------------NLKASKASDVYSFGILVWAVLAGREAELVDKT
..|||||.|  .|.. . ....             .   .||.... ||.| .               ....|...|||||||. | .|.... .  .. 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

S---------LIRETVCDRQSRPPLTELPPG----SPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKT
.         .. . |||.. |||. . ..     .|... .. .|.|| .|| .  |.|||||..  . 
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase RIPK3.AA Pkinase 22-223 25 5.1e-40 142.57 Pfam 1-209 (293) Show / Hide 
Range on Protein: 22-223
Range on HMM: 1-209/293
Sequence Identity: 25% (57 aa)

LKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW----------EVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENG----SLAGLL
..... .|.|.||.|...||.  .. |||||.. .....          |.. | .|. .|.. |... ||   | .    .|. ..|.|    .|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIY---MVMEYCEGGLYVMDLFDYI

Q--PECPR--PWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHA----KLADFGLST-FQGGSQSGSGSGSGSRDSGGTLAYLDPELLFD
.   ...   ..  ... . ... |. |.||     .||||||.|||.| . |     |..||||.  |.        ..|   .  ||. |. ||..  
STWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR-

VNLKASKASDVYSFGILVWAVLAGR
 . . ....|..|.|.... .| ||
GGQYYGPKVDMWSCGCILYEMLCGR
S_TKc RIPK3.AA S_TKc 22-292 21 4.9e-36 126.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-292
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

LKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMEN--GSLAGLLQPECP------R
 ..|. .|||.||.|....|.  .. ||.||.. ..|  |.. . . . .|.  |..| .|      .   .|. ....  |.|  ...   .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASK-ASDVYSF
|    ........... |.||..   .||||||.|||||   | |..||||...              .   ||. |. ||.|     . .| ..|..|.
PE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSC

GILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEP-----KTNEVY
|....  |.|.     .   ...  .                      . .|... .|.    |.||.  ..       |  .  
GCILYEMLCGYPPFP-QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RIPK3.AA TKL-Unique 24-217 28 7.9e-36 123.87 In-house 1-219 (290) Show / Hide 
Range on Protein: 24-217
Range on HMM: 1-219/290
Sequence Identity: 28% (63 aa)

KLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN-----SKKISW----EVKAMVNLR-NENVLLLLGVTEDLQWDFVSGQ--ALVTRFMENGSLAGLLQ---
 .. .| ||.|.|... .|.   .||.|. .     |....     ||. | .|.  .|.... |.. | |   |.     .|. ... |||  .|.   
FWNKIGEGGYGQVYKGKWRG--YPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQ---VYPPNMCIVMEYCPGGSLYDVLHQNN

-------PECPRPWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPE-----LHAKLADFGLSTFQGGSQSGSGS---GSGSRDSGGTLAYLDP
       ..|. .. .  .. . ...||.|||...|| .|||||.||.|.| .     . .|..|||||.|.  .  .. .   |..  .  |.. .. |
NNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

ELLFDVNLKASKASDVYSFGILVW
|.| ... . |. |||||||| .|
EVLRMNFCQYSEKSDVYSFGIVLW
Kinase RIPK3.AA MLK 22-224 24 8.4e-31 104.14 In-house 1-234 (291) Show / Hide 
Range on Protein: 22-224
Range on HMM: 1-234/291
Sequence Identity: 24% (62 aa)

LKKLEFVGKGGFGVVFRAHHRTWNHD-----VAVKIVN------------SKKISWEVKAMVNLRNEN----VLLLLGVTEDLQWDFVSGQALVTRFMEN
.. .|..|.|.||.|...  |  | |     ||||.|.            ....  |..    |. .|    .  ..||  . . .|.    .|. ..|.
IQFHEWIGSGSFGKVWKGRWR--NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFC----IVMEYCEG

GSLAGLL-----QPE---------CPRPWPLLCRLLQEVVLGMCYLHSLNP-PLLHRDLKPSNILLDP------ELHAKLADFGLSTFQGGSQSGSGSGS
|||. .|     ...            .  .. .    .  || ||||. | |. |||||..|||.|       ....| .|||.|..            
GSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW-----------

GSRD-----S-GGTLAYLDPELLFD-VNLKASKASDVYSFGILVWAVLAGRE
 ..      |  ||.|.  || .    . | |...||.|.|.. | .|....
-HQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase RIPK3.AA TK 22-217 15 1.8e-26 85.11 In-house 1-385 (486) Show / Hide 
Range on Protein: 22-217
Range on HMM: 1-385/486
Sequence Identity: 15% (61 aa)

LKKLEFVGKGGFG---VVFRAHHR---TWN----------------------HDVAVKIVN---SKKISW-----------------EVKAMVNLR----
.. ..  |.| ||   .|...  |    ||                      ..||||..    .                      |. .|  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NENVLLLLGVTEDLQ------WDFVSGQ---ALVTRFMENGS----LAGLLQPECP-------------------------------------------
  .|.. |.||  . .        . ..|    .|. .|..|.    |   |.   |                                           
HHPNIVRLYGVCTQGEPKPCFEV-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQ

---------------------------------RPWPLLCRLLQEVVLGMCYLHSLNP----PLLHRDLKPSNILLDPELH-----------AKLADFGL
                                  . . |.   . .  || ||||.|      . ||||   |.|.. ...           .|.|||||
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

STFQG--GSQSGSGSGSGSRDSGGTLAY--------------------------LDPELLFDV-------NLKASKASDVYSFGILVW
|  .    .     ..   |.|... .                           . || |.|        . | . .|||.|||.|.|
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW
Kinase RIPK3.AA STE 22-217 19 2.1e-26 90.29 In-house 1-259 (359) Show / Hide 
Range on Protein: 22-217
Range on HMM: 1-259/359
Sequence Identity: 19% (52 aa)

LKKLEFVGKGGFGVVFRAHHRT---------------WNHDVAVKIVN-----------------------SKKISWEVKAMVNLR--NENVLLLLGVTE
....|..|||.||.|..| ..                 .  .|.|..|                        ..|  |.| | ...   .|.   .|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DL----QW-DFVSGQALVTRFMENGSLAGLLQ--PECPRP------------WPLLCRLLQEVVLG-MCYLHSLNPPLLHRDLKPSNILLDPELHAKLAD
.     .. | .    ..  .|..|||  ...   .|..|             ..... ..... | . ||||..    |||.||.||||     .||.|
KEGHNHKNDDELW---ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCD

FGLSTFQGGSQSGSGSGS------------GSRDSGGTLAYLDPELLF--DVN--LKASKASDVYSFGILVW
||...    | ... . |             .    ||  .  || .   . .   . .  .|..|.|....
FGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII
Kinase RIPK3.AA IRAK 29-223 30 2.7e-22 75.93 In-house 8-221 (317) Show / Hide 
Range on Protein: 29-223
Range on HMM: 8-221/317
Sequence Identity: 30% (69 aa)

GKGGFGVVFRAHHRTWNHD--VAVK-IVNSKKISW------------EVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQ---PE
|.||||.|.|.. .  | .  .||| . . ...||            |.|..  .| .|.. |.|    .. .. .   ||  .| ||||   |.   . 
GEGGFGCVYRGQWK--NTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYC--TERQCHC---LVYPYMPNGSLEDRLWCQDGQ

CP---RPWPLLCRLLQEVVLGMCYLHSLNP--PLLHRDLKPSNILLDPELHAKLADFGLSTFQ---GGSQSGSG---SGSGSRDSGGTLAYLDPELLFDV
||    .|.  |  ..   .|  .||.. |  |. |.| |..|||||  . .|..||||  |    ... ...      |  |   ||..|. || . | 
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVR---GTTWYMPPEFIRDP

NLKASKASDVYSFGILVWAVLAGR
  . .| .||||||| .  ||.|.
QGQLTKKTDVYSFGIVLLEVLTGC
Kinase RIPK3.AA LRRK 92-290 23 3.1e-22 75.46 In-house 131-351 (351) Show / Hide 
Range on Protein: 92-290
Range on HMM: 131-351/351
Sequence Identity: 23% (55 aa)

ALVTRFMENGSLAGLLQ-PE-CP------R-PWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILL---D---------PELHAKLADFGLST----
..|. .. .|.|  .|. ..  .      . .| |. ..  ..  || |||| |||..|||||. ||||   .         .. .||.||||.|.    
CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQC

FQGGSQSGSGSGSGSRDSGGTLAYLDPELLFDV-NLKASKASDVYSFGILVWAVLAGR-EA--ELVDK-----TSLIRETVCDRQSRPPLTELPPGSPET
|. |         . ....|.  .. || . .  .   .  .|.||||.. |  | ..  .  |.. .     ...|.. . . . ||.. .     |..
FHMG---------VAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIE-GLRPTIPQH-Y-CPPC

PGLEKLKELMIHCWGSQSENRPSFQDCEPKTNE
     ...|. |||  . ..||.|..   .  .
QPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase RIPK3.AA Dicty4 94-172 34 5.2e-20 63.58 In-house 80-169 (277) Show / Hide 
Range on Protein: 94-172
Range on HMM: 80-169/277
Sequence Identity: 34% (31 aa)

VTRFMENGSLAGLLQP-------ECPRPWPLLCR---LLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLST-FQGGSQ
|| .|  |.|. ||         . . .|||  |   .   ...|| .||. ||  .|||||..|.| |  . .| .|||||. .. ...
VTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHED
Kinase RIPK3.AA TyrKc 22-291 20 3.3e-16 39.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-291
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

LKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN---SKKISWEVKAMVNL--RNENVLLLLGVTEDLQWDF--VSGQALVTRFMENGSLAGLL-QPECPR
.....  | | ||.|.... .    .|||| ..    . .  | . | .|  ...|.. |.||  . .  |  .    .|. .|..|.|   |  ..   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

PWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGS-------QSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASKA
... |.     .  || ||||   .. ||||   |.|.. ....| .||||| . .         .  . ........   .  . || .     | . .
CMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTK

SDVYSFGILVW------AVLAGREAE--LVDKTSLIRETVCDRQSRPPLTELPPGSPETP-----GLEKLKELMIHCWGSQSENRPSFQDCEPKTNEV
|||.|||.. |      .     ...  . ..  . .    .|  .||  .        |       ... ..|  ||  . |.||.|...     . 
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase RIPK3.AA CAMKL 119-444 6 5.9e-16 47.27 In-house 130-186 (297) Show / Hide 
Range on Protein: 119-444
Range on HMM: 130-186/297
Sequence Identity: 6% (21 aa)

CRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPEL--HAKLADFGLSTFQG-GSQSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASKASDVYSFGIL
.|. . .| .. |.||..    |||.|| |||||      .|..|||.|...  .                                             
RRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC---------------------------------------------

VWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQHRS
                                                                                                    
----------------------------------------------------------------------------------------------------

SGRNLSAREPSQRGTEMDCPRETMVSKMLDRLHLEEPSGPVPGKCPERQAQDTSVGPATPARTSSDPVAGTPQIPHTLPFRGTTPGPVFTETPGPHPQRN
                                                                                                    
----------------------------------------------------------------------------------------------------

QGDGRHGTPWYPWTPPNPMTGPPALVFNN
                         .|..
-------------------------IFGP
Kinase RIPK3.AA CAMKL 22-84 27 7.2e-11 30.76 In-house 1-88 (297) Show / Hide 
Range on Protein: 22-84
Range on HMM: 1-88/297
Sequence Identity: 27% (24 aa)

LKKLEFVGKGGFGVVFRAHH-RTWNHDVAVKIVNSKKISW---------------------EVKAMVNLR---NENVLLLLGVTEDLQ
 . ..  |||.||.|  |.| || .. ||.||.. |||.                      |.. |  |.    .|.  |. | |. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPE
Kinase RIPK3.AA RHIM 440-458 42 1.5e-07 24.46 In-house 1-19 (19) Show / Hide 
Range on Protein: 440-458
Range on HMM: 1-19/19
Sequence Identity: 42% (8 aa)

LVFNNCSEVQIGNYNSLVA
.. .|||..||||.|..  
IHIYNCSGIQIGNHNYMWI
Kinase RIPK3.AA Dicty4 206-290 25 1e-06 18.4 In-house 197-277 (277) Show / Hide 
Range on Protein: 206-290
Range on HMM: 197-277/277
Sequence Identity: 25% (23 aa)

ASDVYSFGILVWAVLAGREAEL--VDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPK--TNE
..|||||||. |  | . |  .   . .  ... ||. . |||.           .. ..|.|.  ||    ..||||. . ..   ..
KADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDW--------CPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase RIPK3.AA MLK 261-288 35 1.9e-05 15.02 In-house 264-291 (291) Show / Hide 
Range on Protein: 261-288
Range on HMM: 264-291/291
Sequence Identity: 35% (10 aa)

EKLKELMIHCWGSQSENRPSFQDCEPKT
| .|.||  || . ...||||. . .. 
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase RIPK3.AA Dicty4 22-78 28 2e-05 14.25 In-house 1-65 (277) Show / Hide 
Range on Protein: 22-78
Range on HMM: 1-65/277
Sequence Identity: 28% (19 aa)

LKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS----------WEVKAMVNLRNENVLLLLG
... .. |||.|| |...  |    .||||. |....            ||. | ..|. |..|..|
INIEQRIGKGSFGEVYKGTWRG--KEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMG
Kinase RIPK3.AA Pkinase_Tyr 128-165 44 0.000159 15.95 Pfam 123-158 (270) Show / Hide 
Range on Protein: 128-165
Range on HMM: 123-158/270
Sequence Identity: 44% (17 aa)

GMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLS
|| ||.| |  . ||||   |.|.. ....| .||||.
GMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLA
Kinase RIPK3.AA Pkinase_Tyr 22-79 23 0.000277 15.13 Pfam 1-72 (270) Show / Hide 
Range on Protein: 22-79
Range on HMM: 1-72/270
Sequence Identity: 23% (17 aa)

LKKLEFVGKGGFGVVFRAHHR----TWNHDVAVKIV--NSKKIS-------WEVKAMVNL-RNENVLLLLGV
.....  |.| ||.|.... .      . .||||..  .. .          |.| | .| ...|.. |.||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV
Kinase RIPK3.AA TKL-Unique 261-283 30 0.000403 10.64 In-house 263-285 (290) Show / Hide 
Range on Protein: 261-283
Range on HMM: 263-285/290
Sequence Identity: 30% (7 aa)

EKLKELMIHCWGSQSENRPSFQD
. ...|.  || .....||||..
KEYRDLIQQCWHHDPSQRPSFDE
Kinase RIPK3.AA LRRK 22-54 25 0.00044 10.32 In-house 1-60 (351) Show / Hide 
Range on Protein: 22-54
Range on HMM: 1-60/351
Sequence Identity: 25% (16 aa)

LKKLEFVGKGGFG-VVFRAHHRTWN-----------------------------HDVAVKIVN
||. | .|.|||| .|.||   .|.                              .||.|. |
LKIEEQIGRGGFGTFVYRA---KWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWN
Kinase RIPK3.AA TK 251-288 25 0.002173 6.37 In-house 440-486 (486) Show / Hide 
Range on Protein: 251-288
Range on HMM: 440-486/486
Sequence Identity: 25% (12 aa)

PPGSPETPGL----------EKLKELMIHCWGSQSENRPSFQDCEPKT
||. |. . .          | . .||  ||  . | ||.|...  . 
PPHCPDWM-RYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RIPK3.AA Pkinase_Tyr 261-284 33 0.007657 10.25 Pfam 243-266 (270) Show / Hide 
Range on Protein: 261-284
Range on HMM: 243-266/270
Sequence Identity: 33% (8 aa)

EKLKELMIHCWGSQSENRPSFQDC
... .|| .||  . |.||.|...
DEIYDLMKQCWHYDPEDRPTFSEI
Kinase RIPK3.AA Pkinase_Tyr 206-217 66 0.07779 6.84 Pfam 194-205 (270) Show / Hide 
Range on Protein: 206-217
Range on HMM: 194-205/270
Sequence Identity: 66% (8 aa)

ASDVYSFGILVW
.|||.|||.| |
KSDVWSFGVLMW