Gene RON (Mouse)

RON

Species: Mouse
Alias: Mst1r, RON
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
RON.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
RON.AA Protein Sugen 1411 None Fasta, JSON
RON.NA RNA Sugen 4805 None Fasta, JSON

Protein domain

Protein domains of RON.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Sema RON.AA Sema 60-509 24 2.9e-161 546.82 Pfam 1-484 (484) Show / Hide 
Range on Protein: 60-509
Range on HMM: 1-484/484
Sequence Identity: 24% (120 aa)

TAAYEDS-TNSAVFVATRNHLHVL-GPDLQFIENLTTGPIGNPGCQTCASCGPGPHGP---PKDTDTLVLVMEPGLPALVSCGSTL-QGRCFLHELEPRG
  .....  .....|..|||..|| ...|. ............||..| .| .... |   . .... .... .. . |..||. . ...|..|.|....
FHTLLHDEDRDRLYVGARNHVYVLNLNNLSERCYQKIHWPSSHGCEHCEECYMKGKDPPVWTECQNYIRVLHPYNDTHLYVCGTNAFHPVCWYHNLGHHH

KALHLAAPACLFSA-NNNKPEACTDCVASPLGTRVTVVEQGHASYFYVASSLDPELAASFSPRSVSIRRLKSDTSGFQPGFPS--LSVLPKYLASYLIKY
.|.|.|...||||. . .... | .|...|......|..|......|.....|...|.||..|...|.|.| . ..|.... .  . ..|.. .||.|.|
TADHQAEEHCLFSYDHDKEEDGCGRCPYDPKHNTTSVMVQDRFGELYSGTYIDSKVAYSFMGRDPWIYRSKGSHHPFRTEQHDSKWLNEPNFVDSYPIHY

VYSFHSGDFVYFLTVQPISVTSPP--SALHTRLVRLNAVEPEIGDYRELVLDCHFAPKRRRR--GAPEGTQ-PYPVLQAAHSAPVDAKLAVELSISEGQE
|..| ..|||||....... .|..  .. |.|..|. . ...  .|.|....|.|...|...  ..|.|.. ....||... .|.|. ||.||.||. ..
VHDF-DDDFVYFFFRETAVEYSMNCGKTIHSRVARVCKNDMGGHRYLEMNKWCTFLKARLNCSVPGPDGYPFYFNELQDVFVLPTDNWLAHELGISWRNP

VLFGVFVTVKDGGSGMGPNSVVCAFPIYHLNILIEEGVEYCCHSSNSSSLLSRGLDFFQTP-SFCPNPPGG---------EASGPSSRCHYFPLMVHASF
|..|||.| .....|...|| ||||.. ..|  ...|.. .. ..|.  |  |||.... .  .|||.|..         ... .  ||| .. .|....
VIYGVFTTPWNIFRGPMHNSAVCAFHMNDINQVFNNGPFKHQEGCNHQWLPYRGLRVPYPRPGQCPNDPNHGNMSTKDLPDNTCNFIRCHPLMYEVVYPV

TRVDLFNGLLGSVKVTALHVT---RLGN---VTVAHMGTVDGRVL--QVEIARSL--NYLLYVSNFSLGSSGQ-PVHRDVSRLGN
....||.. .. ...|...|.   |.|.   .||...|| ||||.  ||.. |.   .|. .|...... ... |..... ....
HNRPLFMRQSVNYRFTQIAVDPRVRAGDGQWYTVMFIGTDDGRVHKKQVVVSRDSWPHYHEVVLEEIHVFPDPEPIQNMEISQKQ
Sema RON.AA Sema 57-510 20 3.6e-118 399.78 SMART 1-532 (532) Show / Hide 
Range on Protein: 57-510
Range on HMM: 1-532/532
Sequence Identity: 20% (109 aa)

VQATAAYEDSTNSAVFVATRNHLHVLG-PDLQFIENLTTGPIG-NPGCQT-------CASCGPGPH---GP---PKDTDTLVLVMEPG---LPALVSCGS
 .. . .||..|. ..|. |||...|  |.|. .... ||| . .| |..       |  |  . .   ..   ..|... ||.  .    .. |..||.
YNHMLLDEDRGNWRLYVGARNHIYQLSLPNLSKEWEHVTGPVIDWPSCPEPNEKCIKCQECQMKGKHFCPHNETWCDNYIRVLQPYNDHYYDTHLYVCGT

TLQGR---CFLHELEPRGKAL-----HLAAPACLFSANNN-KPEACTDCVASPLGTRVTVVEQGHA---SYFYVASSLDPEL-AAS-FSPRSVSIRRLKS
  .|    |..|.|. ....      . . ..|..|...| ... | .|...||.. ..|...|..   ...|.... |    |.| ........|||. 
NAFGPDVMCWYHNLGNHEPWDEMEQEDQIFTHCPHSKQHNRSESGCGKCPYDPLHNSTSVFVDGYNPDGGELYSGTVADFSGVAQSYHRSDPIIYRRLGM

DTSGFQPGFPS--LSVLPKYL--ASYLIKYVYSFHS-----GDFVYFLTVQPISVT-----SPPSALHTRLVRLNAVE--------PEIGDYRELVLDCH
...||...|..  . ... ..   .| ...|..|..     ||||||..... .       . ... |.|..|.   .        ..   |... |.|.
FQDGFHFWFHPSRTDQYDSKWGYDLYEPHFVHAFEIPESNDGDFVYFFFRERAHEHMNRDCGYEKHYHSRVARVCKNDMGGQRLLQKKWTSYLKARLNCS

FAPKRRRRGAPEGTQ-PYPVLQAAHSAPVDAKLAVELSISEGQEVLFGVFVTVKDGGS----GMGPNSVVCAFPIYHLNILIEEGVEYCCHSS--NSSSL
. .|.||.      . ....||... .|..| || .... |...||.||| .... .|    .  |.| ||||..   |  ..||.  |....  .  ..
VPDKGRRP------EFYFNELQDVFVLPPGA-LAQDWGW-EQDDVLYGVFTQGQQWSSRDAANPWPGSAVCAFSMKDINRVFNEGPFKCYEGPNHQWHPY

LSRGLDFFQTPSF----------CPNPPGGEASGP-SSRCHYFPLMVHASFTRVDLFNGLLGSVKVTALHVTRLGN-------VTVAHMGTVDGRVLQVE
 .... ...  .           |....   .. .   ..|  ....  ......||.. .. ...|.. |.| .|       .||...|| |||...| 
NGNKVPWPRPGTCPSNHFREQRNCCHTKDLPDDVLCFIKHHPLMDEAVQPIHGRPLFVKTNTDYRFTHIAVDRVHNLDGHHNWYTVMFLGTDDGRIHKVV

IARSLN-------YLLYVSNFSLGSSGQPVHRDVSRLGND
. || .       . . ...|.... |....||..  .  
VWRSRHNQSWHGWESHVYEEFQVFPHGSEPIRDMQFSHKQ
IPT RON.AA IPT 685-769 26 1.3e-25 92.29 SMART 1-111 (111) Show / Hide 
Range on Protein: 685-769
Range on HMM: 1-111/111
Sequence Identity: 26% (29 aa)

EPVLTSIKPDFGPRAGGT-YLTLEGQSLSV-GTSRAVLVN------GTQCRLEQV------NEEQILCVTPPGA----GTARVPL----HLQIGGAEVPG
.|| |.|.| .||..|||  .|..|. . . ...| | ||      .. | ....      ...||.|.|||..    ... ||.    ..|.....|..
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNVRT

S----WTFHYK
.    ..| | 
QLSWPQPFTYV
IPT RON.AA IPT 570-684 22 6.2e-21 76.79 SMART 1-111 (111) Show / Hide 
Range on Protein: 570-684
Range on HMM: 1-111/111
Sequence Identity: 22% (28 aa)

PPEISEFYPHSGPLRGTT-RLTLCGSNFYLRPDDVVPEGTHQITVG----QSPCRLLPKDSSSPRPGSLKEFIQELECELEPLVTQ--AVGTTNISLVIT
.|.|... |..||..| | |.|.||.||       . . .....||    ..|| ..| |...      |..  ...|.. |  .|   .|. ..... .
DPVITRIHPNCGPCSGGTERITICGKNFDS----DIQVRFVRVNVGGRVWEVPCTFQPWDYHG------KDSQTQIVCCTPPYHNQSPIPGQVPVRVTQE

NMPAGKHFRVEGISVQEGFSFV
 .  ....|... | .. |..|
VQFCNDNVRTQL-SWPQPFTYV
TIG RON.AA TIG 686-768 30 3.7e-14 50.29 Pfam 1-82 (82) Show / Hide 
Range on Protein: 686-768
Range on HMM: 1-82/82
Sequence Identity: 30% (26 aa)

PVLTSIKP-DFGPRAGGTYLTLEGQSL-SVGTSRAVLVNGTQCRLEQVNEEQILCVTPPGAGTARVPLHLQIGGAEVPGSWTFHY
|..||| |   || .||| .|. || . .   .  ....||.|    ... || |.|||.. .  ... . ..|. .... ||.|
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHT-PGTHNVSV-VNGQWSSNPTTFTY
PSI RON.AA PSI 528-570 31 5.1e-12 38.93 Pfam 1-57 (57) Show / Hide 
Range on Protein: 528-570
Range on HMM: 1-57/57
Sequence Identity: 31% (18 aa)

GCRHFLTCWRCLRAQRFMGCGWCGD--RCDRQK-----ECPGSW-------QQDHCP
.|... .| .||.|.....||||..  || |.      .||..|        |..||
NCSQHTSCSSCLSARDPFYCGWCSSQHRCTRGHAYTYGQCPRWWQWMWWSWSQSQCP
PSI RON.AA PSI 528-570 28 4e-06 27.63 SMART 1-56 (56) Show / Hide 
Range on Protein: 528-570
Range on HMM: 1-56/56
Sequence Identity: 28% (16 aa)

GCRHF--LTCWRCLRAQRFMGCGWC--GDRCDRQKECP------GSWQQ---DHCP
.|.|.   .|  || |. ...||||  . || .. .|.       .| .   ..||
NCSHYGVTSCSECLSARDPYRCGWCSWQHRCTHRHRCDERRFWRQNWEHGPHKQCP
TIG RON.AA TIG 571-628 25 2.3e-05 20.51 Pfam 1-49 (82) Show / Hide 
Range on Protein: 571-628
Range on HMM: 1-49/82
Sequence Identity: 25% (15 aa)

PEISEFYP-HSGPLRGTTRLTLCGSNFYLRPDDVVPEGTHQITVGQSPCRLLPKDSSSP
| |. ..|  .||  | |..|. |.||           . ....| .||      ..|.
PTITSISPNTTGPPSGGTTITITGQNF------GNDS-DTKCYFGGTPCTVI---WWSS
IPT RON.AA IPT 771-873 23 3.1e-14 54.55 SMART 1-111 (111) Show / Hide 
Range on Protein: 771-873
Range on HMM: 1-111/111
Sequence Identity: 23% (27 aa)

DPIVLDISPKCGY--SGS-HIMIHGQHLTS-AWHFTLSFH-DGQSTVESRCAGQFV------EQQQRRCRLPEYVVRNPQGWATGNLSVWGDGAAGFTLP
||....|.|.||.   |  .| |.|... |  .  . ... .|. ..|..|  | .       | | .|..|.| ...|    .|.  |.... ..|.. 
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGR-VWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSP---IPGQVPVRVTQEVQFCND

GFRFL-PPPSPLRAG
..|.. ..|.|..  
NVRTQLSWPQPFTYV
TIG RON.AA TIG 772-863 22 1.7e-12 44.63 Pfam 1-82 (82) Show / Hide 
Range on Protein: 772-863
Range on HMM: 1-82/82
Sequence Identity: 22% (22 aa)

PIVLDISP-KCGYS--GSHIMIHGQHL-TSAWHFTLSFHDGQSTVESRCAGQFVEQQQRRCRLPEYVVRNPQGWATGNLSVWGDGAAGFTLPGFRF
|.. .||| ..| .  |..| |.||.. ... . .  | . . ||       ..  .| .|..|...        |.|.||  .|. . .   |..
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVI------WWSSTQIVCTTPPHT------PGTHNVSV-VNGQWSSNPTTFTY
IPT RON.AA IPT 878-972 14 0.012864 7.3 SMART 1-111 (111) Show / Hide 
Range on Protein: 878-972
Range on HMM: 1-111/111
Sequence Identity: 14% (16 aa)

KPEEHSVKVEYVGLG----AVADCVTVNMT-VGGEVCQHELRGDV--VICPLPPSLQLGKDGVPLQVCVDGGCH----ILSQVVRSSPGRASQRILLIAL
 |. .... ..  .      .  | ..  . .  ....... |.|  | | . |. . |||     ||. . .|    | .||  . ..... ..  .  
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNVRT

-----LVLILL
     . .  .
QLSWPQPFTYV
Kinase RON.AA Met 1093-1345 64 1.5e-209 693.66 In-house 1-271 (271) Show / Hide 
Range on Protein: 1093-1345
Range on HMM: 1-271/271
Sequence Identity: 64% (176 aa)

HTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLS--RITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEG-LPRVLLPYMRHGDLLHFIRSPQRN
|.|.|||.||||.||||.|.|...|..|||.|||.  |||..|....|||||..|....|||.|.||||.|.||| .|.|.||||.||||..|||.||.|
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

PTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGV-LDKEYYSVRQHRH-ARLPVKWMALESLQ--------TYR-FTTKS
|.|.||..|..|||.||.|.|.|||||||||.|||||||.||||||||||.|.. .||||||...|.| |||||||||.|.||        ||| |||||
PCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKS

DVWSFGVLLWELLTRGAPPYPHIDP-FDLSHFLAQG--RRLPQPEYCPDSLY-HVMLRCWEADPAARPTFR
|||||||..|||.|||||||||.|. ||..|.|.||  |||||||||||.|| .|||.||.|.|..||.| 
DVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Pkinase_Tyr RON.AA Pkinase_Tyr 1092-1351 40 2.4e-141 479.35 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1092-1351
Range on HMM: 1-270/270
Sequence Identity: 40% (110 aa)

IHTDQVIGKGHFGVVYHGEYT-DGAQNQTHCAIKSLSRITEVQE--VEAFLREGLLMRGL-HHPNILALIGIMLPPEGL--PRVLLPYMRHGDLLHFIRS
|. ....|.|.||.||.|... |. ......|.|.|   .  ..   |.|.||  .|. | |||||. |.|. .. ..   . . ..|| |||||.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P---QRNPTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWS
.   ....|.|||... .|.|.|||||......|||||||||...|...||..|||||| . ...|| .|.. ...||.||||.|......|||||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVLLWELLTRGAPP-YPHIDPFDLSHFL-AQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEV
||||.||..|.|. | || ...... ...  .|.|.|.||.||| .|..|..||..||. ||||.... . 
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc RON.AA TyrKc 1092-1351 37 2.6e-136 460.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 1092-1351
Range on HMM: 1-280/280
Sequence Identity: 37% (110 aa)

IHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGL--HHPNILALIGIMLPPE------GLPRVLLPYMRHGDLLHFI
|. ....| |.||.||.|...      . .|.|.|   .    .|.|.||  .|. |  |||||..|.|. . ..      . . ... || ||||....
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RSPQRNPTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDK-------EYYSVRQHRHAR--LPVKWMALESLQTYRF
|..... ..|||.|| .|.|||||||......|||||||||...| .|||..||||.| . |.       .||....|....  ||..|||.|......|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTKSDVWSFGVLLWELLTRGAPPYPH-----IDPFDLSHFLAQGRRLPQPEY--------CPDSLYHVMLRCWEADPAARPTFRALVLEV
|||||||||||..||..|.|..|||      ...... ... ||.|.|||..        ||| .| .|..||..||. ||||.... . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RON.AA TK 1092-1351 21 2.3e-110 371.33 In-house 1-486 (486) Show / Hide 
Range on Protein: 1092-1351
Range on HMM: 1-486/486
Sequence Identity: 21% (107 aa)

IHTDQVIGKGHFG---VVYHGEYTDGA----------------------QNQTHCAIKSLSR--ITEVQEVEA--------------FLREGLLMRG--L
|.  ...|.|.||   .|| ||. ..                       ...| .|.| |     .. .| ..              ...|  .|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNILALIGIMLPPE-----------GLPRVLLPYMRHGD----LLHFIRSPQRN--------------------------------------------
|||||. |.|. . .|           . . ... || |||    |... |.  ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PTVKDLVSFGLQVACGMEYLAEQ------KFVHRDLAARNCMLDESFT-----------VKVADFG---
                               .|...|. . .|.|||||||...      .|||||||||||...|. .           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARGVLDKEYYSVRQHR----------------------HARLPVKWMALESLQ---------TYRFTTKSDVWSFGVLLWELLTRG-APPYPHI
     ||| . ....| ... .                       ..||..||| |.|.         . .|||||||||||||.||..|.| .|.|. .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DP---------FDLSHFLAQG--------------RRLPQPEYCP--------------DSLYHVMLRCWEADPAARPTFRALVLEV
.           ..  .| .|               |.|||..||              . .| .|..||..||. ||||..|. . 
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RON.AA UTK 1092-1351 33 3.8e-95 322.42 In-house 1-296 (296) Show / Hide 
Range on Protein: 1092-1351
Range on HMM: 1-296/296
Sequence Identity: 33% (100 aa)

IHTDQVIGKGHFGVVYHGEYTDGA--QNQTHCAIKSLS-RITEVQEVE---AFLREGL---LMRGLH-HPNILALIGIMLPPEGLPRVLLPYMRHGDLLH
..  . .|.|.||.|.....|. .    . ..|.| .. . .  || |    |..|     .|  .| |||.| |.|. .  |. . ... ||. |||..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

FIRSPQRNPT-------VKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDES-------FTVKVADFG---LARGVL-------DKEYYSVRQHRHA
. |.  ..|          ..... ...|.||.||....||||||||||| ....        ..|.||||   ..|.|        ..|.| ....   
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

RLPVKWMALESLQTY-RFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQG--RRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEV
|.|..||| |.|    |||||||||||||..||..|.|. |||..   .. |..  |  .|.|.|. ||...| .|.|||..||. ||.|. || ..
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RON.AA Axl 1092-1349 42 2.2e-84 286.67 In-house 1-267 (267) Show / Hide 
Range on Protein: 1092-1349
Range on HMM: 1-267/267
Sequence Identity: 42% (114 aa)

IHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLS-RITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEG-----LPRVLLPYMRHGDLLHF---
.   ...|.| || |  |.           |.| .   |   .|.| ||.|   |.   |||.. |||. .          | |.||.|.||||  |   
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

--IRSPQRNPTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDV
  .     .  .. || | . .|||||||....|.||||||||||| |  || ||||||.. . . .||  || . |..||||.|.|||    .| ||||
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYY--RQGCIAKMPVKWIAIESLADRVYTSKSDV

WSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVL
|.||| .||. |||  ||| ..  ..  .| .| || ||| | | ||..| .||||||  ||.|  | .
WAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase RON.AA TK-Unique 1092-1351 35 4.4e-84 285.66 In-house 1-294 (294) Show / Hide 
Range on Protein: 1092-1351
Range on HMM: 1-294/294
Sequence Identity: 35% (105 aa)

IHTDQVIGKGHFGVVYHGEYTD--GAQNQT-HCAIKSLSRITEVQEVEAFLREGLLMRGLH-HPNILALIGIMLPPEGLPRVLLPYMRHGDLLHFIRSPQ
.  ..|||.| || |..||..   . .... . |.| | .    ... .||.|  .|. |  ||||. ..|.   ... .  ...|.. |.|.|..|. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

RN-------------------------PTVKDLVSFGLQVACGMEYLAE--QKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLP
..                          . |||..|. |.||||||||.  .|.|||||.|||..| | ...|..|||.|| | . . ||  . .. |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG-RIP

VKWMALESLQ--TYRF-TTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYC-PDSLYHVMLRCWEADPAARPTFRALVLEV
..|||.|||.  .  . ||||||||||||.||..| ||.||| ... |.   . .| |.||||.| .. .| .| .||  .|  ||.||... . 
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RON.AA EGFR 1092-1352 37 3.3e-81 269.35 In-house 1-258 (258) Show / Hide 
Range on Protein: 1092-1352
Range on HMM: 1-258/258
Sequence Identity: 37% (98 aa)

IHTDQVIGKGHFGVVYHGEYT-DGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDLLHFIRSPQRNP
.  ..| | | || || | .  .| . .   ||| |   |. .  |..|.| . | .. ||... |.|. . .. . ..   || .| || ..|  . | 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-M-QLVTQYMPYGCLLDYVRQHKDNI

TVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWEL
  ..|. ...|.| ||.|| |.. ||||||||| ..     ||..|||||. .|...  .. ..  ...|.||||||...  ..| .|||||.|| .|||
GSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAK-LLEHDEKEY-HAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

LTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEVK
.| |. ||  |   . . .| .| |||||. |   .| ||..|| .|.. ||||. |. | |
MTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase RON.AA Src 1173-1349 44 1.8e-73 248.95 In-house 75-255 (255) Show / Hide 
Range on Protein: 1173-1349
Range on HMM: 75-255/255
Sequence Identity: 44% (81 aa)

YMRHGDLLHFIR--SPQRNPTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLD--KEYYSVRQHRHARLPVKWMALES
||.|| || . .  .  |.  ...|.... ||| ||.|| .....||||||||   .|.  .||||||||| ...  .. |. |.   |..|.||.| | 
YMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARH--GAKFPIKWTAPEA

LQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYH-VMLRCWEADPAARPTFRALV--L
..  |||.||||||||.||.|. |.|  |||  .  .    . .| |.|.|. |||.||. .||.||..||  ||||  |   |
INYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RON.AA Csk 1092-1351 40 6.3e-71 241.25 In-house 1-251 (251) Show / Hide 
Range on Protein: 1092-1351
Range on HMM: 1-251/251
Sequence Identity: 40% (107 aa)

IHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRI--TEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDLLHFIRSPQRN
.|  . ||.| || |  |||    ||.   |.| ...   . .|   ||| |   | .| |||  .|||. |   .   . . ||  | |. ..||  |.
LHLGECIGHGEFGDVMQGEY----QNR-KVAVKCIKCDGNGMAQ---AFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRH

P-TVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLW
  | ..|  | . |. ||.|| . |||||||||||  ..|    || |||||.    .| .   .    ..|.|| | | |   .|.|||||||||.|||
VITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK----EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLW

ELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEV
|.   |  ||| |   | ..    | |   || ||.. | ||  ||...|| ||||| ..   
EIYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase RON.AA FGFR 1191-1351 49 9.6e-71 240.34 In-house 134-293 (293) Show / Hide 
Range on Protein: 1191-1351
Range on HMM: 134-293/293
Sequence Identity: 49% (80 aa)

TVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWEL
| |||||.  ||| |||||| .| .||||||||    . .  |..||||||.. . .||  |     |||.||||.|.|.   .|..|||||.|||||| 
TQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYY--RKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

LTRGAPPYPHID-PFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEV
.| |  |||||    .|  .|  |.|.  |. |.  .||.|  || . | .||||  || . 
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RON.AA S_TKc 1092-1355 24 1.8e-48 168.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 1092-1355
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

IHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRH--GDLLHFIRSPQRN
 .  ..|||| ||.|| .  ..    . ..||| ..        | ..||  ...  |||||  |....    .   . . |. .  |||...|.. .|.
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

P-----TVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTT-KSDVWSF
.     .  .  ..  |..|..||. .....||||   | .|||  ..|..|||||| .           ..      .|| | |    ... |.|.||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVL-----EVKQVV
|..|.|.|. | ||.|  ... . . .            .... . . .|.. ||. |||   .          . .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RON.AA Ryk 1260-1351 55 1.3e-46 145.23 In-house 201-292 (292) Show / Hide 
Range on Protein: 1260-1351
Range on HMM: 201-292/292
Sequence Identity: 55% (51 aa)

PVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEV
|||||.|||||   . . ||||||||..||| | |  ||  |||| . |.|. | ||.||  ||| |. ||. ||  .|. ||||  ||   
PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDELFTVMACCWHCMPEERPTFQQLVQCL
Kinase RON.AA Pkinase 1092-1351 21 2.6e-40 143.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1092-1351
Range on HMM: 1-293/293
Sequence Identity: 21% (64 aa)

IHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIK--SLSRITEVQEVEAFL-REGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHG----DLLHFIR
.|. ..||.| ||.||..   .  .     |.|  ..... . ....... .|  .|. |.||||. |....  .  .  . ..|...|    || ..|.
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYIS

-SPQRNP--TVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTV----KVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQ-TYRFTT
 . ...   . ... .. .|...|.||. .....||||   |...|.  ..    |..|||||. .    | . .   .      .|| | ..     ..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVWSFGVLLWELLTRGAPPYPHI----DPFDLSHFLAQGRR----LPQPEYCP-------------------DSLYHVMLRCWEADPAARPTFRALVL
|.|.||.|..|.|.|. | ||.|.     .  |  . ... ..     . |. |.                   ... ... .|.. ||. |||.. .. 
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

E--V
   .
HPWF
Kinase RON.AA Ryk 1092-1241 25 2.6e-30 92.86 In-house 1-184 (292) Show / Hide 
Range on Protein: 1092-1241
Range on HMM: 1-184/292
Sequence Identity: 25% (46 aa)

IHTDQVIGKGHFGVVYHGEYT--DGAQ------------NQTHCAIKSLSRITEVQEVEAFLREGLLMRGLH-HPNILALIGIM--------LPPEGLPR
|    ..  | || .||| .   |.              ..    .| .        |  .| |..|..|.. |.|||.. ..             . | 
IQYSCLVQEGTFGRIYHGIWNQVDDVNNGDVDDEEDTFCDCQDVFVKTVKDHASQMQVHCMLQESCLLYGISPHQNILPVLHVCSFGRFDRPIEDHDPPF

VLLPYMR-HGDLLHFIRS-----PQRNPTV--KDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDES---FTVKVADFGLAR
|..|.|   | |  | .      |.   ..  ..||....|...||..|.    ||.|.|.||| .||      ||  |  | |
VCYPHMNNWGNLKQFLQDCRHDKPKCHQAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSR
Kinase RON.AA Src 1092-1156 32 3.5e-10 30.73 In-house 1-59 (255) Show / Hide 
Range on Protein: 1092-1156
Range on HMM: 1-59/255
Sequence Identity: 32% (21 aa)

IHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILAL
|.  . .|.|.|| |. | .    ...|. |.|.|.. |   ..||||.|  .|  | |.....|
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQL