Gene SgK307 (Mouse)
SgK307
Sequence
Protein domains of SgK307.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Ank | SgK307.AA | Ank | 55-87 | 30 | 1.3e-05 | 24.49 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 55-87 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) QGQSALFVAALLGHVKLVDVLVDYGSDPNHRCF |...| .|.. ||.. | |...| |.|.. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | SgK307.AA | Ank | 88-120 | 36 | 0.00141 | 17.16 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 88-120 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) DGSTPVHAAAFSGNQWILSKLLTAGGDLRLHDE || || | |...|. ... || .| |. ..| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | SgK307.AA | Ank | 27-54 | 28 | 20.839699 | 2.12 | Pfam | 6-33 (33) | Show / Hide |
Range on Protein: 27-54 Range on HMM: 6-33/33 Sequence Identity: 28% (8 aa) LHEYAKQGNCVKLKKILKKGVCVDAVNT || ... |. .| |..| .|.|.. LHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Kinase | SgK307.AA | NKF5 | 334-509 | 80 | 8.99999999999e-162 | 492.89 | In-house | 1-176 (176) | Show / Hide |
Range on Protein: 334-509 Range on HMM: 1-176/176 Sequence Identity: 80% (141 aa) ERRSQFPVLHMEVIVHLLLQVADALIYLHSRGFIHRSLSSYAVHIVSAGEARLTNLEYLTESQDSGAHRNVTRMPLPTQLYNWAAPEVVLQKAATVKSDI ||||||||||||||||||||.||||.|||..||||||||||||||.|.||||||||||.|||||.|.||.||||||||||||||||||..|...|||||| ERRSQFPVLHMEVIVHLLLQIADALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMTESQDRGVHRDVTRMPLPTQLYNWAAPEVICQDMPTVKSDI YSFSVIIQEILTDSIPWNGLDGSLVKETIALGNYLEADVRLPEPYYDIVKSGIHAKQKNRTMNLQDIRYILKNDLK |||..|.|||.||.|||.|.||..||..|..|||.|||.|||.|||||||.|||.|||.|.||||||||||||||| YSFCIIMQEIFTDEIPWAGRDGPEVKAKIEAGNYPEADPRLPAPYYDIVKAGIHLKQKDRWMNLQDIRYILKNDLK |
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| Kinase | SgK307.AA | Frk | 286-493 | 26 | 4.4e-17 | 55.43 | In-house | 41-246 (260) | Show / Hide |
Range on Protein: 286-493 Range on HMM: 41-246/260 Sequence Identity: 26% (56 aa) LIAEQEHSSNLRHPNLLQLMAVCLSRDLEKIRLVYERITVGTLFSVLHERRSQFPVLHMEVIVHLLLQVADALIYLHSRGFIHRSLSSYAVHIVSAGEAR ...| .|||| |.|| ||| | | .. | . |.| | . ..|. .| . ||| . || |. .||| | | . . FLREAQIMKKLRHPKLIQLYAVCTVE--EPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICK LTNLEYLT----ESQDSGAHRNVTRMPLPTQLYNWAAPEVVLQKAATVKSDIYSFSVIIQEILT-DSIPWNGLDGSLVKETIALGNYLEADVRLPEPYYD . . .| | |.|. | ||| . . |.|||..|| ... ||.| .|. |. . | . .. | . |. .|. IADFGLARVLMKDNEDIYESRHGARFPI-----KWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYE IVKSGIHAKQKNR |. |.. ..| IMLECWHSDPMKR |
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| Kinase | SgK307.AA | TK-Unique | 297-445 | 21 | 1.8e-15 | 49.88 | In-house | 62-234 (294) | Show / Hide |
Range on Protein: 297-445 Range on HMM: 62-234/294 Sequence Identity: 21% (38 aa) RHPNLLQLMAVCLSRDLEKIRLVYERITVGTLFSVLHERRS-QFPV---------------------LHMEVIVHLLLQVADALIYLHS--RGFIHRSLS .|||..|.. .| . | | ...| . |.| . |...| .... . .. .| . |.| .. ||.| ....|| |. DHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLC SYAVHIVSAGEARLTNLEYLTESQDSGAHRNV-TRMPLPTQLYNWAAPEVVL--QKAA-TVKSDIYSFSVIIQEILT . | . . ... .... .. .. |.. . .. ..| | |||. . .. . | |||..|| |.. ||.| ARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR---WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT |
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| Kinase | SgK307.AA | Src-Echino1 | 286-502 | 22 | 6.2e-15 | 47.78 | In-house | 41-252 (252) | Show / Hide |
Range on Protein: 286-502 Range on HMM: 41-252/252 Sequence Identity: 22% (49 aa) LIAEQEHSSNLRHPNLLQLMAVCLSRDLEKIRLVYERITVGTLFSVLHERRSQFPVLHMEVIVHLLLQVADALIYLHSRGFIHRSLSSYAVHIVSAGEAR ..|| . .|| ...|. ||| | | | .| | . | | . | . ... . | .. . ..| . || |. ..|| |. | . . FLAEANVMKKCRHEGIVQIYAVC--SDKEPIYIVTELMSNGNLQDYLKRGKCKH--VKMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCK LTNLEYLT-ESQDSGAHRNVTRMPLPTQLYNWAAPEVVLQKAATVKSDIYSFSVIIQEILT-DSIPWNGLDGSLVKETIALGNYLEADVRLPEPYYDI-- . .. .| .. ..|. | ||| .| |.|||..|| ... |..| .|..|. | . ...| . . |. |.. IADFGLARMMQKDVYCGKQGAKLPI-----KWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCM VKSGIHAKQKNRTMNLQDIRY .| |. |.. . MKCWHKDPQQRPTFEFLHDFF |
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| Kinase | SgK307.AA | TKL | 281-373 | 24 | 1.6e-12 | 41.42 | In-house | 67-168 (364) | Show / Hide |
Range on Protein: 281-373 Range on HMM: 67-168/364 Sequence Identity: 24% (27 aa) RLADLLIAEQEHSSNLRHPNLLQLMAVCLSRDLE-----------KIRLVYERITVGTLFSVLHERRSQFPVLHMEVIVHLLLQVADALIYLHS------ .. . .. | . |.|||||..|.|..|.. . .. .|.| . |.|...|| ....... |..| .. |||| WFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWC --RGFIHRSLSS .. ||| | | TKPPIIHRDLKS |
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| Kinase | SgK307.AA | TKL-Unique | 293-373 | 25 | 2.2e-11 | 36.56 | In-house | 49-140 (290) | Show / Hide |
Range on Protein: 293-373 Range on HMM: 49-140/290 Sequence Identity: 25% (24 aa) SSNLR-HPNLLQLMAVCLSRDLEKI--RLVYERITVGTLFSVLH---------ERRSQFPVLHMEVIVHLLLQVADALIYLHSRG--FIHRSLSS ...|. |||....|..| . .| | . |.| .||| .. . .. |...|.. ...|....|||... ||| | | MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLN---MQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKS |
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| Kinase | SgK307.AA | TK | 296-369 | 15 | 5.4e-11 | 32.32 | In-house | 100-264 (486) | Show / Hide |
Range on Protein: 296-369
Range on HMM: 100-264/486
Sequence Identity: 15% (25 aa)
LRHPNLLQLMAVCLSRDL----------EKIRLVYERITVGT----LFSVLHERRSQFPV----------------------------------------
..|||...| .||. . | . .| | | | . |...| |
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD
--------------------------------LHMEVIVHLLLQVADALIYLHSR------GFIHR
|.|. . .|.|... ||||. .|.||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHR
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| TyrKc | SgK307.AA | TyrKc | 252-503 | 21 | 1.2e-10 | -50.43 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 252-503 Range on HMM: 1-280/280 Sequence Identity: 21% (64 aa) MVMTNL------------VWNRSRVTVKELNLPTRPHCSRLRLADLLIAEQEHSSNL--RHPNLLQLMAVCLSR-----DLEKIRLVYERITVGTLFSVL .. .|. | || |. . .. | . ..| .|||...| .||.. | . .| | | | . | ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL HERRSQFPVLHMEVIVHLLLQVADALIYLHSRGFIHRSLSSYAVHIVSAGE---------ARLTNLE-YLTESQDSGAHRN--VTRMPLPTQLYNWAAPE ...| . | |. .. .|.|. ||||...||| | . |... .| . ||.| .. ....|| . | ||| RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNC-LVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP---IRWMAPE VVLQKAATVKSDIYSFSVIIQEILTD-SIPWNG-----LDGSLVKETIALGNYLEADVR--------LPEPYYDIVKSGIHAKQKNRTMNLQDIRYI . . | |||..|| | . ||.|. |. | .. . | | . |.... |. |.| |. |.. ..| . .... CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| S_TKc | SgK307.AA | S_TKc | 251-512 | 13 | 2.6e-10 | -25.67 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 251-512 Range on HMM: 1-231/231 Sequence Identity: 13% (41 aa) YMVMTNL----------VWNRS---RVTVKELNLPTRPHCSRLRLADLLIAEQEHSSNLRHPNLLQLMAVCLSRDLEKIRLVYERITV--GTLFSVLHER | .. . ..... .| .|... . .. | . .. .|||. .| |. . ... .| | . |.||.....| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR RSQFP--VLHMEVIVHLLLQVADALIYLHSRGFIHR------------------SLSSYAVHIVSAGEARLTNLEYLTESQDSGAHRNVTRMPLPTQL-- ... . ... .. ... |...|| |.||.|.||| |. | . GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----------------------------------TTFCG -YNWAAPEVVLQKAATV-KSDIYSFSVIIQEILTDSIPWNGLDGSLVKETIALGNYLEADVRLPEPYYDIVKSGIHAKQKNRTMNLQDIRYILKNDLKEF .. ||||. . |.|..|. .|. | |. |. . .. . | ... |... . ..| . .. .. . .. TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW I . F |
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| Kinase | SgK307.AA | Pkinase_Tyr | 294-369 | 30 | 2.4e-09 | 32.26 | Pfam | 58-135 (270) | Show / Hide |
Range on Protein: 294-369 Range on HMM: 58-135/270 Sequence Identity: 30% (24 aa) SNL-RHPNLLQLMAVCLSRDLE-KIRLVYERITVGTLFSVLHERRSQFPVLHMEVIVHLLLQVADALIYLHSRGFIHR ..| .|||...|..||.... .| .| | | | . |...|.. . | |. ... .|.|... ||.|...||| KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHR |
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| Kinase | SgK307.AA | UTK | 294-369 | 30 | 1.2e-08 | 25.7 | In-house | 64-142 (296) | Show / Hide |
Range on Protein: 294-369 Range on HMM: 64-142/296 Sequence Identity: 30% (25 aa) SNLR-HPNLLQLMAVCLSRDLEKIRLVYERITVGTLFSVLHERRSQFP----VLHMEVIVHLLLQVADALIYLHSRGFIHR .... |||.|.| .||.. . .|.| | | |.| | ..| | .. .. ...|... ||||.||.|| KQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHR |
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| Kinase | SgK307.AA | LRRK | 294-369 | 28 | 1.3e-08 | 26.52 | In-house | 112-190 (351) | Show / Hide |
Range on Protein: 294-369 Range on HMM: 112-190/351 Sequence Identity: 28% (24 aa) SNLRHPNLLQLMAVCLSRDLEKIRLVYERITVGTLFSVLHERR-SQF----PVLHMEVIVHLLLQVADALIYLHSRG--FIHR |.|.|||...|. .| .. ...| | .. |.| ..||... ..| ... .. . ||.|... ||||. .||| SHLNHPNIVSLKGFC----IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHR |
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| Kinase | SgK307.AA | Dicty4-Unclassified | 296-373 | 27 | 3.6e-08 | 24.05 | In-house | 55-137 (263) | Show / Hide |
Range on Protein: 296-373 Range on HMM: 55-137/263 Sequence Identity: 27% (23 aa) LRHPNLLQLMAVCLSR--DLEKIRLVYERITVGTLFSVLH-ERRSQFPVLHMEV--IVHLLLQVADALIYLHSRGFIHRSLSS . ||||... |. . | | . |.|| | | | . .. |. . .| . .||.| |||| . | IQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKS |
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| Kinase | SgK307.AA | TKL-Unique | 414-463 | 32 | 7.1e-08 | 24.05 | In-house | 190-247 (290) | Show / Hide |
Range on Protein: 414-463 Range on HMM: 190-247/290 Sequence Identity: 32% (19 aa) YNWAAPEVVLQ--KAATVKSDIYSFSVIIQEILTDSI------PWNGLDGSLVKETIA ..|.|||| . . . |||.|||... ||.| | | |.| ..|... FRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVH |
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| Kinase | SgK307.AA | LRRK | 416-462 | 29 | 7.7e-07 | 20.22 | In-house | 245-302 (351) | Show / Hide |
Range on Protein: 416-462 Range on HMM: 245-302/351 Sequence Identity: 29% (17 aa) WAAPEVVL---QKAATVKSDIYSFSVIIQEILTDS-IPWNGLD-------GSLVKETI | |||.. . | |.|.||| .|. |.|| . .| ..| ..... | WMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKI |
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| Kinase | SgK307.AA | Pkinase | 295-369 | 27 | 9e-06 | 21.5 | Pfam | 56-132 (293) | Show / Hide |
Range on Protein: 295-369 Range on HMM: 56-132/293 Sequence Identity: 27% (22 aa) NLRHPNLLQLMAVCLSRDLEKIRLVYERITVG----TLFSVLH-ERRSQFPVLHMEVIVHLLLQVADALIYLHSRGFIHR .|.||| ..| .. . .| .| | | ||.... .|. | . .... . ..|.. .| |.||.|.||| RLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHR |
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| Kinase | SgK307.AA | TKL | 414-445 | 29 | 2.4e-05 | 15.2 | In-house | 237-284 (364) | Show / Hide |
Range on Protein: 414-445 Range on HMM: 237-284/364 Sequence Identity: 29% (14 aa) YNWAAPEVVLQK----------------AATVKSDIYSFSVIIQEILT ..| |||| .. .. |.|.||| ... |||| PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT |
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| Kinase | SgK307.AA | Pkinase | 414-452 | 30 | 8.2e-05 | 18.09 | Pfam | 175-214 (293) | Show / Hide |
Range on Protein: 414-452 Range on HMM: 175-214/293 Sequence Identity: 30% (12 aa) YNWAAPEVVL-QKAATVKSDIYSFSVIIQEILTDSIPWNG ....||||.. .. . |.|..|. .|. | |. |. | PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG |
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| Kinase | SgK307.AA | Dicty4-Unclassified | 416-445 | 33 | 0.000248 | 10.7 | In-house | 174-203 (263) | Show / Hide |
Range on Protein: 416-445 Range on HMM: 174-203/263 Sequence Identity: 33% (10 aa) WAAPEVVLQKAATVKSDIYSFSVIIQEILT | .||. . . |||.||. .. | .| WESPECLMHESYNQKSDVYSYAMMLYELAT |
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| Kinase | SgK307.AA | TK | 416-445 | 35 | 0.003108 | 5.84 | In-house | 351-389 (486) | Show / Hide |
Range on Protein: 416-445 Range on HMM: 351-389/486 Sequence Identity: 35% (14 aa) WAAPEVVLQKA---------ATVKSDIYSFSVIIQEILT | |||... . | |||..|| | . ||.| WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT |
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| Kinase | SgK307.AA | UTK | 416-445 | 45 | 0.005045 | 6.19 | In-house | 205-235 (296) | Show / Hide |
Range on Protein: 416-445 Range on HMM: 205-235/296 Sequence Identity: 45% (14 aa) WAAPEVVLQK-AATVKSDIYSFSVIIQEILT | |||.. . | |||..|| | ||.| WMAPEALTHHTRFTTKSDVWSFGVVCWEIWT |
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| Kinase | SgK307.AA | Pkinase_Tyr | 416-470 | 34 | 0.011358 | 9.67 | Pfam | 180-237 (270) | Show / Hide |
Range on Protein: 416-470 Range on HMM: 180-237/270 Sequence Identity: 34% (20 aa) WAAPEVVLQKAATVKSDIYSFSVIIQEILTDS-IP-WNGLDGSLVKETI-ALGNYLEA | |||. . |.|||..|| | . ||.| .| . |.. . |.| | |. ... WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC |
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