Gene SIK (Mouse)

SIK

Species: Mouse
Alias: SIK, Snf1lk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: QIK

Sequence

Name Sequence Type Origin Length Description Download
SIK.AA Protein Sugen 779 None Fasta, JSON
SIK.NA RNA Sugen 4512 None Fasta, JSON
SIK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of SIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SIK.AA QIK 27-278 69 6.9e-205 686.95 In-house 1-272 (272) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-272/272
Sequence Identity: 69% (188 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH------
||.|||.||||||||||||||.|||.||||||||..||..||.|.|||||.||.|.||.||||||||||.||.|||||...||||||||...|.      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLD
              ..|||||..||||.|||.|||...|||||||.||.|||.||.||.|||||.|..|.|..|.||||||||||||.||||||.||..|
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

VWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
.||.||||||||||.|||||..|..||||||.|.||||||||||||.|||.||||||..|.||.||.|||||
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase SIK.AA CAMKL 27-278 46 4.5e-165 530.85 In-house 1-297 (297) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-297/297
Sequence Identity: 46% (139 aa)

YDVERTLGKGNFAVVKLARH-RVTKTQVAIKIID--KTRLDSSNLEK-----------IYREVQLMKLLN---HPNIIKLYQVMETKDM------LYIVT
|....|||||.|..||||.| | |...|||||||  |...|  .. .           |.||.|.||.||   ||||||||.|.||...      .|.|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFAKNGE--MFDYLTSNGH----LSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMD--IKLADFGFGNFYKP-----GEPLSTWCGSPPYA
| . .||  .|||. ..||    ..|.|||. |.||.|||.|||.|.|||||.| ||.|||.|..  ||..||||.|.|.|     |. |.|.||||||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVFEG--KEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLP---------TLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
|||.|.|  |.|.||. |.||.||.||..||| ||||.....          ...... ....|....| ||. |||.||.|.| ||.|| ||..|.||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase SIK.AA AMPK 27-278 51 5e-151 451.56 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-254/254
Sequence Identity: 51% (130 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPNIIKLYQVM-ETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN
| .. |.|.| |  ||.. |  |...|||||..|... |..  |.| ||....||..||.||.||.|  ||.. ...|.|.. .|| ||| ...| |.| 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPF
||.  | ||.|.|||||.| ||||||| |||||| |. ||..|||  | .| || |.| |||| |||||. .|| |.||. |.|| ||.||...|| |||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

DGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
| .| ||| .....|.. || |.|.... ||..|| ||| ||||| .||.| | 
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase SIK.AA MARK 27-278 47 3.2e-150 494.08 In-house 1-262 (262) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-262/262
Sequence Identity: 47% (125 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDS-SNLEKIYREVQLMKLLNHPNIIKLYQVME--TKDM-LYIVTEFAKNGEMFDYLTSN--GH
| . .|.|.|..|.||||.|. |...|||||..|..|.   ......||...||.|.|||||||..|.|  |.   .|.. | | .||..||. .   |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNM--DIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLV
|.|.|||. | ||.|||.|||...|||||.| ||.|.|.|.  .||..||||..  .||. |.| ||.|||.|||.|..|.|.||  |.||||||||..|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

CGSLPFDGPN--LPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
||..|||| .  . .|....| |...||...| .|. ||.|.|.|.| .|.|| .| .|.||
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase SIK.AA CAMK 32-278 30 1.3e-142 462.73 In-house 1-425 (425) Show / Hide 
Range on Protein: 32-278
Range on HMM: 1-425/425
Sequence Identity: 30% (129 aa)

TLGKGNFAVVKLARHRVTK------------TQVAIKIIDKTRLD--------------------------SSNLEKIYREVQLMKL-------LNHPNI
|||.|.|..|||..|. |.            ..||||||||..|.                           .......||...||.       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYQVME------------TKDM--------LYIVT---EFAKNGEM----FDYLTSNGH---------------LSENEARQKFWQILSAVEYCHNHH
||||.|.|            | ..        .|.|.   |.. .||.    |||....|.               ..| |||. |.||.|||.|||.|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKTENLLLDSNM-----------------DIKLADFGFGNFYKP------------------------GEPLSTWCGSPPYAA-PEVFEG-----
||||||| ||.|||.|.                 .||..|||| |...|                        |....|.||.|.|.| |||..|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KEYEGPQLDVWSLGVVLYVLVCGSLPFDGP-------------NLPTLRQRVLEGRFR-IPFFMS-----------------------QDCE
        |.| ||. |.||.||.||...|| .||.|.             |.. | .....|... .|...|                       |.| 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

TLIRRMLVVDPAKRITIAQIRQHRWM
 |||.||.||| ||.||.|. .| ||
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SIK.AA NuaK 27-278 47 2.8e-134 355.63 In-house 1-252 (252) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-252/252
Sequence Identity: 47% (121 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENE
|....||||| .  ||||. . |  .|||| | | .  |   . .| ||...|  ||||.||. | | | || . || |.|  ||..||. . . |.|.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFD
||. | || ||| ||| | |.||||| || ||| | ..| ||||  |.|. .. | | |||| || ||. .|. |.||  | |||||.||..| |..|||
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
| .  .| . . .|... |   |. | .||| || |.| .| || .| .| |.
GHDFKHLVKQISQGAYYEPCKPSDAC-MLIRWMLMVNPRRRATIYDICHHWWV
Kinase SIK.AA NIM1 27-278 42 9.3e-112 329.56 In-house 1-258 (258) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-258/258
Sequence Identity: 42% (109 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIID--KTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN
| .   .| |||  |||. |  ||  |||||.|  || .|   .    ||.| |  ..||||..|| | ||   .. |.|.|  || . . .  | |.| 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

EARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKP----GEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCG
..   | ||.|||   |   |||||.| || .. ||  .|..||||    |     .. | | |||||||||| |    | |.  ||| ||. ||  . |
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTG

SLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
  ||  .  | .   .|.| . || . |  |  |||.||  .|. | || |. .| ||
VMPFRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase SIK.AA S_TKc 27-278 37 2e-105 357.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-231/231
Sequence Identity: 37% (99 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKN--GEMFDYLTSNGH----
|.. |..||| |..|...||. |. .||||||.         |.|.||.|..|  .||||.||| |... | ||.|.|.. .  |..|||. ..|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLV
  ..| .||  ..||..|.||||.|.|.||||| ||.|||.   ||..|||.  ..      .| ||.| | ||||.    | ..  |.||.|..|| ..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

CGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQ-------HRWM
||  ||.  .. .. ....          |...  .||..|..||.||.|. .. |       | |.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SIK.AA BRSK 27-278 49 4.4e-105 355.42 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-254/254
Sequence Identity: 49% (126 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLD--SSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSEN
| .|.|||||    |||  | ||   |||||| | .|    | | |. ||. .||| .||...|.| | |.|  || . |.   ||.||||   | |   
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPF
|||. | || ||...|| | | ||||| ||||||    || |||| .     .  | | |||| || |||  | .| | . |||| ||.|| |  | |||
EARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPF

DGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
|  ||  |  .|  | | .| |  .||  | | |. |||.|||....|..| | 
DDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase SIK.AA TSSK 27-278 38 2.4e-104 343.39 In-house 1-289 (289) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-289/289
Sequence Identity: 38% (111 aa)

YDVERTLGKGNFAVVKLARHRVTKTQ----------------VAIKIIDKTRLDSSNLEK-IYREVQLMKL-LNHPNIIKLYQVMETKD-MLYIVTEFAK
|.|....|.|..| |..|... .|                  |||||||...  . .|.| . || | |.  |.|||||..|.  || . . |.| |.| 
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

NGEMFDYLTSN------GHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEP------LSTWCGSPPYAAPEVF
.| ...|   .      | |.| .||. |.|. |||.|||.|..|||||| ||.||| .  |||.||||..  ....|      ..| |||  |||||..
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEIL

EGKEYEGPQLDVWSLGVVLYVLVCGSLPFDG--PNLPTLRQRVL--EGRFRI--PFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
 |..| . . ||||.||.||..|||..|||    |.... ...   .  |..    . ||.|  |||.||  .| .|..| .|  | ||
RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase SIK.AA Pkinase 27-278 35 1.6e-102 351.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-293/293
Sequence Identity: 35% (105 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYR--EVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNG----EMFDYLT--SN
| ..|..|.|.|..|....|. |  .||.|||.| . .|. ..   |  |.|.|| ||||||..|| ..|.|| .|.|.|.. .|    . |||..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GHL--SENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDI----KLADFGFGNF--YKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSL
| .  ||.|..  ..|||...||||.. |.||||| ||.|.|.|..|    |..|||.  .  | ... ..| ||.|.|.||||  | .| ||  |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLYVLVCGSLPFDGP------NLPTLRQRVLEGRFRIPFF---------------------MSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
|..|| ..|| .||.|       .   . .|....... ...                     .|..|  .|...| .||.||.|..|| || |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SIK.AA SNRK 27-278 45 8e-100 327.57 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-254/254
Sequence Identity: 45% (116 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH-LSENE
||.|.|||.| |||||||||  |  .||.|.||||..|     ....||. |||  ||||..|| |..|.  ||.. |    ..|.||.    . |.|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMD-IKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPF
||. | ||. |..|||  |.|||||| || .    .  .|| |||| | ..||| | | |||  |.|||.  | .|. | .|.|||||.||.|||| .||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

DGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
.  |      .... .. .|  .|..|  || .||| || || .. .|  | |.
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase SIK.AA Pkinase_Tyr 27-169 31 9e-29 98.07 Pfam 1-156 (270) Show / Hide 
Range on Protein: 27-169
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

YDVERTLGKGNFAVVKLARHR----VTKTQVAIKIIDKTRLDSSN--LEKIYREVQLMKLL-NHPNIIKLYQVME-TKDM--LYIVTEFAKNGEMFDYLT
    ..||.|.| .|.... .     ||..||.|.. |   ....  .|.  ||...|| | .||||..|| |    ..   .|||.|....| . ||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----NGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFG
.    ...|.  .  |  ||| .. || ......|||| . | |...|. .| .|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase SIK.AA TyrKc 27-278 24 3.7e-22 80.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLL--NHPNIIKLYQVMETK-------DMLYIVTEFAKNGEMFDYLTS
   ...|| |.| .| ... .   .|||.| . .       .| ..|| ..|. |  .||||..|| |  ..       . |.||.|....|   ||| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NGH-LSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPG-------EPLSTW---CGS--PPYA--APEVFEGKEYEG
... |.  .  .  ||| .  || | ....|||| . | |...|  .| .|||   . . .       .  ..    .|    |.   |||..  ...  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-T

PQLDVWSLGVVLY-VLVCGSLPFDG-----PNLPTLRQRVLEG-RFRIPFF--------MSQDCETLIRRMLVVDPAKRITIAQIRQHRWM
.. |||| ||... ..  |  |  |      .   ....| .| | ..|          ....  .....    ||..| | ..|  |. .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SIK.AA Pkinase_Tyr 206-244 29 0.230861 5.24 Pfam 196-236 (270) Show / Hide 
Range on Protein: 206-244
Range on HMM: 196-236/270
Sequence Identity: 29% (12 aa)

DVWSLGVVLYVLVC-GSLP-FDGPNLPTLRQRVLEGRFRIP
|||| ||... ..  |  | . |     . ... | . | |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMP
UBA_CAMKL SIK.AA UBA_CAMKL 305-342 46 3.1e-14 49.17 In-house 1-41 (41) Show / Hide 
Range on Protein: 305-342
Range on HMM: 1-41/41
Sequence Identity: 46% (19 aa)

NEQVLGIMQAL--GIDRQRTIESLQNSSY-NHFAAIYYLLL
.|... .|...  |.||. .||||.| .| ||  |.|||||
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
UBA SIK.AA UBA 305-342 21 0.000516 20.0 SMART 1-38 (38) Show / Hide 
Range on Protein: 305-342
Range on HMM: 1-38/38
Sequence Identity: 21% (8 aa)

NEQVLGIMQALGIDRQRTIESLQNSSYNHFAAIYYLLL
.|. .  .  .|.||.. ...|... .|  .|...|. 
YEEKIDQLMEMGFDREECVQALRACNWNVEMAMNWLFS