smMLCK

Species: Mouse
Alias: Mylk, smMLCK
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: MLCK

Sequence

Name Sequence Type Origin Length Description Download
smMLCK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 256 Kinase domain by global Sugen HMM Fasta, JSON
smMLCK.NA RNA Sugen 7809 None Fasta, JSON
smMLCK.AA Protein Sugen 1950 None Fasta, JSON

Protein domain

Protein domains of smMLCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set smMLCK.AA I-set 42-132 42 2.3e-32 112.32 Pfam 1-92 (92) Show / Hide
Range on Protein: 42-132
Range on HMM: 1-92/92
Sequence Identity: 42% (39 aa)

PAFILPPRNLCVKEGATAKFEGRVRGYPEPQVTWHRKGQAITN-GGRFLLDCGVRGTFSLVIHTVREEDKGKYTCEASNGSGARQVTVELTV
| |. .|... |.|| ||.|| .|.|.|.|||.|...|| ... . |.  ..  .|| .| |  |  .| ||||| |.| .|  ..|.||||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IGc2 smMLCK.AA IGc2 54-122 28 4.7e-13 50.61 SMART 1-56 (56) Show / Hide
Range on Protein: 54-122
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

KEGATAKFEGRVRGYPEPQVTWHRKGQAITNGGRFLLDCGVRGTFSLVIHTVREEDKGKYTCEASNGSG
.|| .. .. ...|.|.|...| . || .             .  .| |  |..|| |.|||.|.|  |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG

IG smMLCK.AA IG 48-133 24 5.8e-13 50.32 SMART 1-58 (58) Show / Hide
Range on Protein: 48-133
Range on HMM: 1-58/58
Sequence Identity: 24% (22 aa)

PRNLCVKEGATAKFEGRVRGYPEPQVTWHRKGQAITNGGRFLLDCGVRGTFSLVIHTVREEDK---GKYTCEASNGSGARQV--TVELTVE
|. . |||| |....  |      |..|.                       |.|  |..||    | |.|.|.  .|  .   ...|||.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

V-set smMLCK.AA V-set 42-128 16 0.00272 13.18 Pfam 1-128 (128) Show / Hide
Range on Protein: 42-128
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

PAFILP--PR----NLCVKEGATAKFEGRVR-GY----PEPQVTWHR-KGQ-------------AITN-----------GGRFLLDCGVRGTFSLVIHTV
. .. .  ||     . |.||......  .. .|    .. ...| |   .               .|           | ...  .. ...||| |. .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

REEDKGKYTCEASN-----GSGARQVTV
...| | |.| ..|       .  ..||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV

C2-set_2 smMLCK.AA C2-set_2 67-80 64 0.962758 5.11 Pfam 32-45 (101) Show / Hide
Range on Protein: 67-80
Range on HMM: 32-45/101
Sequence Identity: 64% (9 aa)

GYPEPQVTWHRKGQ
|||.||.||.. ||
GYPPPQITWYLNGQ

I-set smMLCK.AA I-set 165-254 44 9.3e-34 117.06 Pfam 1-92 (92) Show / Hide
Range on Protein: 165-254
Range on HMM: 1-92/92
Sequence Identity: 44% (41 aa)

PKFATKLGRAVVKEGQMGRFSCKITGRPPPQVTWLKGNVPLQP-SARVSMSEKN-GMQILEIRGVTRDDLGVYTCMVVNGSGKASMSAELSI
||| .|. ...|.||.  ||.|..|| |||||.|.|.. ||.| | |..|.... | . |.|..|..|| |.||| ..| .|.|. .||| .
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IG smMLCK.AA IG 171-255 17 3.9e-14 54.2 SMART 1-58 (58) Show / Hide
Range on Protein: 171-255
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

LGRAVVKEGQMGRFSCKITGRPPPQVTWLKGNVPLQPSARVSMSEKNGMQILEIRGVTRDDL---GVYTCMVVNGSGKASM--SAELSIP
 .  .||||.  ...| ..     |..|.                      |.| .|...|    |.|.|..   .|....  ...|.. 
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IGc2 smMLCK.AA IGc2 177-244 33 2e-13 51.84 SMART 1-56 (56) Show / Hide
Range on Protein: 177-244
Range on HMM: 1-56/56
Sequence Identity: 33% (23 aa)

KEGQMGRFSCKITGRPPPQVTWLKGNVPLQPSARVSMSEKNGMQILEIRGVTRDDLGVYTCMVVNGSG
.|||  .. |. ||.| |...|.| . ||.           . . |.|. ||..| |.||| . |  |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG

V-set smMLCK.AA V-set 165-265 13 2.8e-05 20.04 Pfam 1-128 (128) Show / Hide
Range on Protein: 165-265
Range on HMM: 1-128/128
Sequence Identity: 13% (19 aa)

PKFATK--LG----RAVVKEGQMGRFSCKITGRP----PP-QVTWLK-GNV-------------------------PLQPSARVSMSEKNGMQILEIRGV
. . |    .      .|.|||. ...|. .  .    .. ...| . ..                          . . . ..|..  ..   | |. .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TRDDLGVYTCMVVNGSGKASMSAELSIPGLDNAARLAV
...| |.|.| | |.          .. .  .  || |
QPSDSGTYYCAVWNC----------NEDYFGHGTRLTV

C2-set_2 smMLCK.AA C2-set_2 190-218 25 0.034242 10.28 Pfam 32-67 (101) Show / Hide
Range on Protein: 190-218
Range on HMM: 32-67/101
Sequence Identity: 25% (9 aa)

GRPPPQVTWLKGNVPL-------QPSARVSMSEKNG
|.||||.||.....|.       . .  ... . .|
GYPPPQITWYLNGQPMVPNEKTEAITTTSEQDPETG

I-set smMLCK.AA I-set 411-501 36 1.5e-29 102.8 Pfam 1-92 (92) Show / Hide
Range on Protein: 411-501
Range on HMM: 1-92/92
Sequence Identity: 36% (34 aa)

PRFESQPQSQEVTEGQTVKFICEVSGIPKPDVGWFLEGIPVRRREGITEVYEDG-VSHHLCLLRARTRDSGRYSCTASNSLGQVSCSWSLLV
|.|. .|...||.||.|..| |.|.| |.|.| ||  | |.| ..    . .||   . |  ...  .|.| |.|.|.||.|...|. .| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IG smMLCK.AA IG 417-502 23 1.2e-13 52.53 SMART 1-58 (58) Show / Hide
Range on Protein: 417-502
Range on HMM: 1-58/58
Sequence Identity: 23% (21 aa)

PQSQEVTEGQTVKFICEVSGIPKPDVGWFLEGIPVRRREGITEVYEDGVSHHLCLLRARTRDS---GRYSCTASNSLGQVSC--SWSLLVD
|. ..| ||.||.. | ||      . |.                       | . ...  ||   | | |.|.   ||...  .  | | 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IGc2 smMLCK.AA IGc2 423-491 28 8.2e-12 46.49 SMART 1-56 (56) Show / Hide
Range on Protein: 423-491
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

TEGQTVKFICEVSGIPKPDVGWFLEGIPVRRREGITEVYEDGVSHHLCLLRARTRDSGRYSCTASNSLG
 |||.| . |...| | |.. |.  | |.              . .| . ...  |||.|.|.|.|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG

V-set smMLCK.AA V-set 415-501 16 0.56417 5.19 Pfam 5-128 (128) Show / Hide
Range on Protein: 415-501
Range on HMM: 5-128/128
Sequence Identity: 16% (20 aa)

SQ--PQ----SQEVTEGQTVKFICEVS-GI----PKPDVGWFL-EGI---------------PVRRREGITEVYEDGV---------SHHLCLLRARTRD
.|  |     . .| |||.|.. | .| .     .  .. |.                    .. .. . .... . |         . .| .  ..  |
TQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSD

SGRYSCTASNS-LGQVSCSWSLLV
|| | | ..|.  ..   .  | |
SGTYYCAVWNCNEDYFGHGTRLTV

I-set smMLCK.AA I-set 511-597 36 3.3e-28 98.25 Pfam 1-92 (92) Show / Hide
Range on Protein: 511-597
Range on HMM: 1-92/92
Sequence Identity: 36% (34 aa)

PSFSSVLKDSVVIEGQDFVLRCSVQGTPAPRVTWLLNGQPIQF---AHSICEAG--VAELHIQDALPEDRGTYTCLAENAMGQVSCSATVTV
|.|. ..|| .| ||..  . | |.|.| | |.|. .|||..     |.. . |   . | |... |.| |.||| |.|  |...|.|..||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IGc2 smMLCK.AA IGc2 523-587 36 1.7e-20 75.36 SMART 1-56 (56) Show / Hide
Range on Protein: 523-587
Range on HMM: 1-56/56
Sequence Identity: 36% (24 aa)

IEGQDFVLRCSVQGTPAPRVTWLLNGQPIQFAHSICEAGVAELHIQDALPEDRGTYTCLAENAMG
.|||...|.| . | |.| ..|.  |||..        .  .|.|... |||.|.|||.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG

IG smMLCK.AA IG 517-598 26 3.3e-16 61.08 SMART 1-58 (58) Show / Hide
Range on Protein: 517-598
Range on HMM: 1-58/58
Sequence Identity: 26% (23 aa)

LKDSVVIEGQDFVLRCSVQGTPAPRVTWLLNGQPIQFAHSICEAGVAELHIQDALPEDR---GTYTCLAENAMGQVSC--SATVTVQ
 .  .| ||.. .|.| |.     ...|.                   |.| .. |||    |||.| |.   ||...  ..|.|||
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

C2-set_2 smMLCK.AA C2-set_2 515-550 32 0.00135 15.29 Pfam 1-46 (101) Show / Hide
Range on Protein: 515-550
Range on HMM: 1-46/101
Sequence Identity: 32% (15 aa)

SVLKDS-VVIEGQ-----DFVLRC----SVQGTPAPRVTWLLNGQP
  .. . . .|.|       |..|    |  | |.|..||.|||||
PEIEPPPTQLEWQYQENMEVVATCVFPWSCGGYPPPQITWYLNGQP

V-set smMLCK.AA V-set 513-597 17 0.008751 11.43 Pfam 1-128 (128) Show / Hide
Range on Protein: 513-597
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

FSSVLK--------DSVVIEGQDFVLRCSVQGTP----AP-RVTWLL----NGQPIQFA---------------HSICEAGVA-----E-----LHIQDA
 |.|            .| |||.  |.|... ..    .. ...|      ...| . .               .. .   |            |.|...
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

LPEDRGTYTCLAENA-MGQVSCSATVTV
 |.| |||.| . |  ...   . ..||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV

I-set smMLCK.AA I-set 620-709 40 2.2e-33 115.78 Pfam 1-92 (92) Show / Hide
Range on Protein: 620-709
Range on HMM: 1-92/92
Sequence Identity: 40% (37 aa)

PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHDGNEIQE-SEDFHFEQKG-GWHSLCIQEVFPEDTGTYTCEAWNSAGEVRTRAVLTV
| |.| ..|..|. |. .. ..||.|.|||.| |..|| .... |. ... ..| | ..| |..|.|.|.|.||| | ||.||. ..| |||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IG smMLCK.AA IG 626-710 26 1.1e-13 52.67 SMART 1-58 (58) Show / Hide
Range on Protein: 626-710
Range on HMM: 1-58/58
Sequence Identity: 26% (24 aa)

LSDLKVMDGSQVTMTVQVSGNPPPEVIWLHDGNEIQESEDFHFEQKGGWHSLCIQEVFPEDT---GTYTCEAWNSAGEVRT--RAVLTVQ
 . . |. |. ||.|  ||     .. |.                      | | .| |||.   |||.|.|.  .|..     . ||||
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IGc2 smMLCK.AA IGc2 632-699 33 3.2e-09 37.9 SMART 1-56 (56) Show / Hide
Range on Protein: 632-699
Range on HMM: 1-56/56
Sequence Identity: 33% (23 aa)

MDGSQVTMTVQVSGNPPPEVIWLHDGNEIQESEDFHFEQKGGWHSLCIQEVFPEDTGTYTCEAWNSAG
  | .||.|  ..||| |.. |.. | ...           .  .| |..| ||| |.|||.| |..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG

V-set smMLCK.AA V-set 620-709 16 0.000176 17.28 Pfam 1-128 (128) Show / Hide
Range on Protein: 620-709
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

PIFLQG--LS----DLKVMDGSQVTMTVQVSGNP----PP-EVIWLH-DGN-----------------------EIQESEDFHFEQKGG--WHSLCIQEV
......   .     . |  |  ||.. ..| ..    ..  . |                             . . .. ..| . ..    || |. .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

FPEDTGTYTCEAWNS-AGEVRTRAVLTV
 |.|.|||.| .||.  .   .   |||
QPSDSGTYYCAVWNCNEDYFGHGTRLTV

C2-set_2 smMLCK.AA C2-set_2 644-659 37 6.417991 2.17 Pfam 31-46 (101) Show / Hide
Range on Protein: 644-659
Range on HMM: 31-46/101
Sequence Identity: 37% (6 aa)

SGNPPPEVIWLHDGNE
.|.||| ..|. .|..
GGYPPPQITWYLNGQP

I-set smMLCK.AA I-set 1129-1218 39 4.7e-27 94.31 Pfam 1-92 (92) Show / Hide
Range on Protein: 1129-1218
Range on HMM: 1-92/92
Sequence Identity: 39% (36 aa)

PVFKEKLQDVHVAEGEKLLLQCQVISDPPATVTWSLNGKTLKT-TKFIVLAQEG-SRFSVSIEKALPEDRGLYKCVAKNSAGQAECSCQVTV
|.|  |..|| | ||| . ..|||. ||| .|.|  .|. |.. .. ..  ..|  . .  |... |.| | |.|||.||.|.|||....||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

I-set smMLCK.AA I-set 718-808 33 3.1e-22 77.98 Pfam 1-92 (92) Show / Hide
Range on Protein: 718-808
Range on HMM: 1-92/92
Sequence Identity: 33% (31 aa)

PWFISKPRSVTATLGQSVLISCAIAGDPFPTVHWLRDGRALSKDSGHFELLQNE-DVFTLVLKNVQPWHAGQYEILLKNRVGECSCQVSLML
| |. ||..|... |...  .| . ||| |.| |..||. |. || ..   ... .  ||  .||||  .|.|..  .|..||..| ..|  
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IGc2 smMLCK.AA IGc2 1141-1208 26 1.2e-13 52.54 SMART 1-56 (56) Show / Hide
Range on Protein: 1141-1208
Range on HMM: 1-56/56
Sequence Identity: 26% (18 aa)

AEGEKLLLQCQVISDPPATVTWSLNGKTLKTTKFIVLAQEGSRFSVSIEKALPEDRGLYKCVAKNSAG
 ||. . |.| .  .| ....|   |. |            .. ...|. . |||.|.| |.| |..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG

IG smMLCK.AA IG 1135-1219 23 1.4e-13 52.35 SMART 1-58 (58) Show / Hide
Range on Protein: 1135-1219
Range on HMM: 1-58/58
Sequence Identity: 23% (21 aa)

LQDVHVAEGEKLLLQCQVISDPPATVTWSLNGKTLKTTKFIVLAQEGSRFSVSIEKALPEDR---GLYKCVAKNSAGQAEC--SCQVTVD
 . | | ||| . |.| |      ...|.                        | .. |||    | | |.|.  .||...  . ..|| 
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IG smMLCK.AA IG 724-809 17 9.2e-10 39.68 SMART 1-58 (58) Show / Hide
Range on Protein: 724-809
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

PRSVTATLGQSVLISCAIAGDPFPTVHWLRDGRALSKDSGHFELLQNEDVFTLVLKNVQPWHA---GQYEILLKNRVGECSC--QVSLMLH
|. ||. .|..| ..| ..     ...|.                       |.. |||| ..   | |    .   |. ..   . |  .
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IGc2 smMLCK.AA IGc2 730-798 31 7.2e-08 33.39 SMART 1-56 (56) Show / Hide
Range on Protein: 730-798
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

TLGQSVLISCAIAGDPFPTVHWLRDGRALSKDSGHFELLQNEDVFTLVLKNVQPWHAGQYEILLKNRVG
  |||| . |  .|.| |..||.. |  |.            .  || .|||.| ..| |. .  |..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG

V-set smMLCK.AA V-set 718-783 18 7.5e-05 18.56 Pfam 1-102 (128) Show / Hide
Range on Protein: 718-783
Range on HMM: 1-102/128
Sequence Identity: 18% (19 aa)

PWFISK--PR----SVTATLGQSVLISCAIAGDP----FP-TVHWLR-DGR------------ALSKD----------SGHFELLQNED--VFTLVLKNV
. ...   ||    .||. .||||...|    |.     . ...| |                 .. .          .| ... .| .   |.| ..|.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

QP
||
QP

V-set smMLCK.AA V-set 810-1218 6 0.000285 16.56 Pfam 1-128 (128) Show / Hide
Range on Protein: 810-1218
Range on HMM: 1-128/128
Sequence Identity: 6% (27 aa)

NSPSRA-PPRGREPASCEGLCGGGGVGAHGDGDRHGTLRPCWPARGQGWPEEEDGEDVRGLLKRRVETRLHTEEAIRQQEVGQLDFRDLLGKKVSTKTVS
 |.  . ||||  |                                                                                      
QSQVTQHPPRGC-PW-------------------------------------------------------------------------------------

EDDLKDIPAEQMDFRANLQRQVKPKTISEEERKVHSPQQVDFRSVLAKKGTPKTPVPEKAPPKAATPDFRSVLGGKKKSPSENGGNSAEVLNVKAGESPT
                                                                                                    
----------------------------------------------------------------------------------------------------

PAGDAQAIGALKPVGNAKPAETPKPIGNAKPTETLKPVGNTKPAETLKPIANAQPSGSLKPVTNAQPAEPQKPVGNAKSAETSKPAGKEEVKEVKNDVNC
                                                                                                    
----------------------------------------------------------------------------------------------------

KKGQVGATGNEKRPESQGSAPVFKEKLQDVHVAEGEKLLLQCQVISDP----PA-TVTWSLNGKTL-KTTKFIV------------------------LA
                             |.|.||....|.|.. .|.    .  ...|.    .. .. ..|.                        ..
----------------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFS

QEGS--RFSVSIEKALPEDRGLYKCVAKNS-AGQAECSCQVTV
. .|  .||..| .. |.| | | |...|.  .. . . ..||
GNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV

I-set smMLCK.AA I-set 1269-1358 27 7.8e-19 66.42 Pfam 1-92 (92) Show / Hide
Range on Protein: 1269-1358
Range on HMM: 1-92/92
Sequence Identity: 27% (25 aa)

PQIIQFPEDQKVRAGEPVELFGKVAGTQPITCKWMKFRKQIQE-SEHIKVENGE-SGSKLTILAARQEHCGCYTLVVENKLGSRQAQVNLTV
|...| | |..|. || ...  .| |. | .  | |  ..... |..... . .   ..|||. . ..  | || |..|..|. .. ..|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IG smMLCK.AA IG 1275-1359 20 1.2e-09 39.27 SMART 1-58 (58) Show / Hide
Range on Protein: 1275-1359
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

PEDQKVRAGEPVELFGKVAGTQPITCKWMKFRKQIQESEHIKVENGESGSKLTILAARQEHC---GCYTLVVENKLGSRQA--QVNLTVV
|. . |..||.|.|   |.     . .|.                      |||  .. |.    | |. ...   |. ..   ..||| 
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IGc2 smMLCK.AA IGc2 1281-1348 22 0.002153 7.43 SMART 1-56 (56) Show / Hide
Range on Protein: 1281-1348
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

RAGEPVELFGKVAGTQPITCKWMKFRKQIQESEHIKVENGESGSKLTILAARQEHCGCYTLVVENKLG
. |..|.|  ...|    . .| |  ....           ... |||  .. |. | || ...|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG

V-set smMLCK.AA V-set 1326-1358 29 0.012138 10.94 Pfam 95-128 (128) Show / Hide
Range on Protein: 1326-1358
Range on HMM: 95-128/128
Sequence Identity: 29% (10 aa)

LTILAARQEHCGCYTLVVENK-LGSRQAQVNLTV
|||  .. .. |.|. .| |   .. .. ..|||
LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV

FN3 smMLCK.AA FN3 1362-1444 24 1.3e-13 52.48 SMART 1-69 (69) Show / Hide
Range on Protein: 1362-1444
Range on HMM: 1-69/69
Sequence Identity: 24% (24 aa)

PDPPAGT--PCASDIRSS------SLTLSWYGSSYDGGSAVQSYNVEIWDTEDKVWKELATCRSTSFNVQDLLPD----REYKFRVRAVNV--YGTS
|.|| .   . ..|. |.      |.||||          . .|                      . | .| |.     ||.|||||||   .| .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Kinase smMLCK.AA MLCK 1495-1750 66 8.3e-245 653.55 In-house 1-257 (257) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-257/257
Sequence Identity: 66% (170 aa)

YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECI
|.|.| || ||||.|.| .||.|||.|| ||.|....|.|.|...||.|||.||||.|.|| ||||.| ..||..|..|||||||||.||||.|||||.|
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

KYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGS-LKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFM
.||||| |||...|.|.|||||||||||||...|...||.|||||||....... .||.|||||||||||.||.|.|..|||||.|||||.| |||||||
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM

GDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL
||||.||..||||. ||||||.||.|||.||||||.||.||...|.....|||||||
GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL

Kinase smMLCK.AA DAPK 1497-1750 43 4e-133 369.1 In-house 1-264 (264) Show / Hide
Range on Protein: 1497-1750
Range on HMM: 1-264/264
Sequence Identity: 43% (115 aa)

IEERLGSGKFGQVFRLVEKKTGKIWAGKFFK--AYSAK----EKDNIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIID--EDFE
. |.||.|.|  | .  .|.|||  |.|| |   . .        .|  ||.|   .  ||...   ...| .  ....|| |||||||  .    |.  
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREEC-

LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR--IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYIL
|.| . .. |.|| ||| | | . |.||||||.|||  ..      ||.|||||.|...|.  ..  .||||.||||..||||.. |||||||||| ||.
LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM

VSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL
 || ||| ||.  ||..|..    ||..| |.  |  |||||  || || . |.  ..||||||.
LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI

Kinase smMLCK.AA DAPK 1495-1750 47 2.8e-124 360.39 In-house 1-264 (264) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-264/264
Sequence Identity: 47% (127 aa)

YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAK------EKDNIRQEISIMNCLH-HPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFE
||. |..||| |  | .  ||.|||  |.|| |    .        ..|  |.||   .  ||  .   |..| |  .|..|| |||||||  . ...  
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKE-C

LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR--IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYIL
|.| |  ..  || .|| ..|   |.|.||||||||  ..      ||.||||||.| |     | .||||||||||..|||| | .||||||||| |||
LNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYIL

VSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL
 || |||.||.  |||||.|    .||.| | . |  |||||  || || | |.   .|||||| 
LSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI

Kinase smMLCK.AA CAMK 1500-1750 24 2.5e-119 386.34 In-house 1-425 (425) Show / Hide
Range on Protein: 1500-1750
Range on HMM: 1-425/425
Sequence Identity: 24% (105 aa)

RLGSGKFGQVFRLVEKKTG------------KIWAGKFFKAY----------------------------SAKEKDNIRQEISIMNC-------LHHPKL
 ||.| ||.|.. ..|.|.            . .| |. .                              ..| ..|.|.||.||.        |.|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQCVDAFEE-------------------KANIVMVL---EIVSGGEL----FERIIDE--------------DFELTERECIKYMRQISEGVEYIHKQGI
... ...|                    . ...||.   | .|||||    |..|..               .. .||||. .|.||| ..|.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHLDLKPENIMCVNKTG---------------TRIKLIDFGLARRLENAG------------------------SLKVLFGTPEFVA-PEVINY------
||.|||||||..... .                 ||.||||.|....                            .|  .||||..| |||.|.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EPIGYATDMWSIGVICYILVSGLSPFMGD-------------NDNETLANVTSATWDFDDEAFDE------------ISDD--------AKD
        ...|...||||.|||.||...| .|| ||             ||.|.. ..... .||... |..            |||.        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FISNLLKKDMKNRLDCTQCLQHPWL
.|...|..| ..|. ..|||.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM

Kinase smMLCK.AA CAMK1 1495-1750 38 1.1e-108 317.13 In-house 1-276 (276) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-276/276
Sequence Identity: 38% (106 aa)

YDIEERLGSGKFGQVFRLVEKKT---GKIWAGKFF--KAYSAKEK----DNIRQEISIMN-C--LHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERII
| . ...|.| |..|.. ..|.|   || .| | .  |   .|..    .....||.||  .  ..||  ... . .|..  . .|.| |.|||||.||.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

DEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNK-TGTRIK--LIDFGLARRLENAG-SLKVLFGTPEFVAPEVINY---EPIGYATDM
. .   ||..  . |.|| . |||.|..|||| ||||||. ...|  .  ||  ..||||......    .|  .|||..|||||...   .| ..| ||
EKG-NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSIGVICYILVSGLSPFMGDN-DNETLANVTSATWDFDDEAFDEISDD-AKDFISNLLKKDMKNRLDCTQCLQHPWL
|||||| |||  | .|| ..| ||| .. .... ..|.   .|.|||  |||||...|..| |.|..|.|||.|||.
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase smMLCK.AA Trio 1495-1750 36 1e-107 277.13 In-house 1-258 (258) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-258/258
Sequence Identity: 36% (94 aa)

YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECI
|.. | .| | |. | | ..| ||.  | ||   | .. |.  ..| ...  |.|| ...  |..|     . .||  ..||| ... .  ....|.| .
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFI-PYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRW-GSYCESEVK

KYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTG--TRIKLIDFGLARRLENA--GSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLS
 ||.|. |.| | | ..| |||.||||.| .   .   .||..||| |  |  .    .  . |.|||.|||.|. .|..|.|| |||||. |.. || |
TYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGIS

PFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL
|| ...| ||..|.     .| .. |  .| .||.||  .|  |   |    .||||||.
PFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF

Kinase smMLCK.AA Pkinase 1495-1750 35 9.79999999999e-103 352.41 Pfam 1-293 (293) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-293/293
Sequence Identity: 35% (106 aa)

YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQ----EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGG----ELFERII-DED
| |....||| ||.|.. ..|.||||.| | .|  ..|.. ...     ||.||. |.||  |.. |.||.| .| ||.| . ||    .||..|  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

FEL--TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR---IKLIDFGLARR--LENAGSLKVLFGTPEFVAPEVIN-YEPIGYATDMWS
  .  .|.||..||.|| .|.||.|..||.| |||||||... ..|.    .|..|||||.   . | . .... |||...|||||. ....|.. ||||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGVICYILVSGLSPFMGD------NDNETLANVTSATWDFDDEAFDEIS-----------------DDAKDFISNLLKKDMKNRLDCTQCLQHPWL
.|.|.|....|  || |.      .... .... .. ..|| .  ..||                 ...||||...|.||.| |. ..|.|||||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase smMLCK.AA S_TKc 1495-1750 34 2.5e-97 330.54 SMART 1-231 (231) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSG--GELFERIIDEDFE-----
|.| . .|.| ||.|.. ..||||.| | |  |       ..||.||.|.   ||| .|.. |.|..  .. ||.| ..|  |.||..| .   .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY-ATDMWSIGVICYILV
..| .. .||.|| ...||.|..||.| |||||||.. .    .||..||||||.|      . . |||...||||.   . |. . |.||.|.| |...
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQ-------HPWL
.|  ||   ...... ..               |..|||||...|.|| ..|. . ..||       |||.
CGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase smMLCK.AA Ciliate-E2a 1495-1750 34 1.1e-93 276.12 In-house 1-275 (275) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-275/275
Sequence Identity: 34% (96 aa)

YDIEERLGSGKFGQVFRLVEKKTGKI-WAGKFFKAYSAKE--KDNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDED-FELTE
|...  .|.|.||.|.    |.|||   . || |... ..  | .. .||.|| .| || . .  . .| . |. .|.| ..||||...|.  . |   .
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

RECIKYMRQIS-EGVEYIHKQGIVHLDLKPENIMCV--NKTG---TRIKLIDFGLARRL--ENAGSLKVLFGTPEFVAPEVINYEPI------GYATDMW
 |  ..|.|.  .|..|.|...|.| |||||||.    .|..   . ||.||||||..        ...  ||| .|||||.|.. .      ..  |||
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEA-FDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL
|.||| |||..| .|| | . ||.| ..     ||..   . ..|...||... .|.|| |.|....|.|.||| 
SCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase smMLCK.AA DRAK 1498-1750 38 2e-91 284.33 In-house 2-259 (259) Show / Hide
Range on Protein: 1498-1750
Range on HMM: 2-259/259
Sequence Identity: 38% (99 aa)

EERLGSGKFGQVFRLVEKKTGKIWAGKFFKA--YSAKEKDNIRQEISI-MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFE-RIIDEDFELTEREC
   .| |||  | . ..| ||. .| || |        . .| .|| . |.|   |...   . .| . ....|||  .|||.|.  . |..  ..|.. 
AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDV

IKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTR-IKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPF
.. |||| ||| | |.. |||||||| ||.    .    ||..|||..| ..|.  .  . |||..||||. ||.||  |||||||||. |.. ...|||
QRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISPF

MGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL
.||   ||  |.     |. .| |. .|. | |||  |. ..   |.  ..||.||||
VGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL

Kinase smMLCK.AA Ciliate-E2 1495-1750 22 1.6e-82 280.44 In-house 1-365 (365) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

YDIEERLGSGKFGQVFRLVEKKTGKIW------------------AGKF--FKAYSAKEKDNIRQEISIMNCLH----------------HPKLVQCVDA
|.. . .|.| ||.|..   .|..|                    ..|.   | .. ... .| |||.||....                || .......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--EKANIVMVLEIVSGGELFERIIDEDFE----------LTERECIKYMRQISE---------------GVEYIHKQG-IVHLDLKPENIMCVNKTGT
|.   . || .|.| ..||.||..|.. .            .||.|....|.|| .               ..||.|... |.| |.|||||.       
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

RIKLIDFGLARRLEN----------AGSLKVLF-----------------------GTPEFVAPEVINYEP---------IGYATDMWSIGVICYILVSG
 ||.|||||.... .          .. ..  .                       |||...|||..|...          .|. |.||.||| |....|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

LSPFMGDNDNETLANVTSATWDFDDE--------------AFDEISDDAKDFISN----LLKKDMKNRLD-CTQCLQHPWL
  ||        . .     .||. .               ....|...||.|..    .|.|| ..|..   |.|.|||.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase smMLCK.AA CDPK 1495-1750 36 6.1e-82 251.13 In-house 1-271 (271) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-271/271
Sequence Identity: 36% (101 aa)

YDIEERLGSGKFGQVFRLVEK-KTGKIW-AGKFFKAY--SAKEK-DNIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLE--IVSGGELFERIIDEDFE
|.|.. ||.| ||||.. ..| ||. .  | |  .    . ||. ..  .|| |.  | ||  ..    .. . |.  |.|  ...|||||..||..   
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH-

LTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIM-CVNKTGT----RIKLIDFGLARRLENA-----GSLKVLFGTPEFVAPEVINYEPIGYATDMWS
.||.|  ..||||   | |.|...||| |||||||. . .|...     ||.||.|.... . .       ..  .|||  .||||..     .  | ||
FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWS

IGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL
.||| ||| .|  || |.||.|....|     .|... .|.|||.||| |...| .| |.|. . |.||||| 
CGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF

Kinase smMLCK.AA TyrKc 1495-1750 20 5.3e-14 3.71 SMART 1-280 (280) Show / Hide
Range on Protein: 1495-1750
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKDNIRQEISIMNCL--HHPKLVQCVDAFEEK-------ANIVMVLEIVSGGELFERIIDED
   .. ||.| ||.|.. . |      | |  |...   .  ...|..||  |  ||| .|... .  ..         . .|.| ...| | ... .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

FELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENA-------GSLKVLF--GTPEFV-----APEVINYEPIGY
 .|. .. .... ||..| ||.|.....| ||   |..  ..   ..|  ||||.| ...           ..    |.   .     |||.|||     
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

ATDMWSIGVICY-ILVSGLSPFMG-----DNDNETLANVTSA-TWDFDDEAFDE-----ISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL
..| || || .. |.  | .|  |      .. | ...| .    .  ...  .      .|.  . ..   . | ..|   ...  |  .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase smMLCK.AA Pkinase_Tyr 1495-1617 25 4.2e-09 31.47 Pfam 1-137 (270) Show / Hide
Range on Protein: 1495-1617
Range on HMM: 1-137/270
Sequence Identity: 25% (35 aa)

YDIEERLGSGKFGQVFRLVEK----KTGKIWAGKFFKAYSAKE---KDNIRQEISIMNCL-HHPKLVQCVDAFE-EKAN--IVMVLEIVSGGELFERIID
  . . ||.| ||.|.. . |    .|.   | |  | .. .|   ..   .|..||  | |||..|... .   ..    | .|.| . .| | .   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---DFELTERECIKYMRQISEGVEYIHKQGIVHLDL
    .  ||  . ... .||..| || . ....| ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

I-set smMLCK.AA I-set 1840-1930 53 1e-48 167.81 Pfam 1-92 (92) Show / Hide
Range on Protein: 1840-1930
Range on HMM: 1-92/92
Sequence Identity: 53% (49 aa)

PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRE-SRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV
|.|.....|.|| ||..|||.|...|.|.|.|.||||.| .|. |...|..||.||...|.||.|. ||  ||||.|.||.|||.|||||.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IGc2 smMLCK.AA IGc2 1852-1920 30 3e-17 64.56 SMART 1-56 (56) Show / Hide
Range on Protein: 1852-1920
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

VEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLG
 || .... |. .|.|||.. |.| .|..             .| .| |..|  .|. .|||.| |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG

IG smMLCK.AA IG 1846-1931 16 8e-13 49.85 SMART 1-58 (58) Show / Hide
Range on Protein: 1846-1931
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

IRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDD---AKYTCKAVNSLGEATC--TAELIVE
 . ..|.||. ... | ..     .. |.                       |.| .|  .|    . |.| |    |....  ...|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

V-set smMLCK.AA V-set 1847-1930 15 0.079769 8.12 Pfam 10-128 (128) Show / Hide
Range on Protein: 1847-1930
Range on HMM: 10-128/128
Sequence Identity: 15% (19 aa)

R----DLEVVEGSAARFDCKIE-GY----PDPEVVWFKDDQSI---------------------------RESRHFQIDYDEDGNCSLIISDVCGDDDAK
|     ..|.||  ... |.   .|    ..  . |... |.                            .....|. . . ....|| ||..  .| . 
RGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPS-KNDFSLTISNLQPSDSGT

YTCKAVNS-LGEATCTAELIV
|.| . |.  .      .|.|
YYCAVWNCNEDYFGHGTRLTV