Gene SPEG (Mouse)

SPEG

Species: Mouse
Alias: SPEG, Apeg1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: CAMK, Secondary Family: Trio,

Classification

Group: CAMK
Family: Trio

Sequence

Name Sequence Type Origin Length Description Download
SPEG.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 254 Kinase domain by global Sugen HMM Fasta, JSON
SPEG.NA RNA Sugen 10795 None Fasta, JSON
SPEG.AA Protein Sugen 3262 None Fasta, JSON
SPEG.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of SPEG.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set SPEG.AA I-set 45-127 34 2.4e-23 81.75 Pfam 1-92 (92) Show / Hide 
Range on Protein: 45-127
Range on HMM: 1-92/92
Sequence Identity: 34% (32 aa)

PVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLSWFRDGQLLPPP------APEP---SCLWLRSCGAQDAGVYSCSAQNERGQASCEAVLTV
|.|....|.. |  |...|. . |.|.|.|. |||.||| |.|.        .    . |. . . . |.|.|.| |.|. |.|.|.| |||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 51-128 21 3.9e-09 37.6 SMART 1-58 (58) Show / Hide 
Range on Protein: 51-128
Range on HMM: 1-58/58
Sequence Identity: 21% (18 aa)

LKNAAVCAGSDVRLRVVVSGTPQPSLSWFRDGQLLPPPAPEPSCLWLRSCGAQDA---GVYSCSAQNERGQASC--EAVLTVL
 .   | .|..|.|.  ||     ...|.               | . .  ..|.   |.| | |.   ||...  .. |||.
PP-VTVKEGETVTLTC-VS-----QIWWY---------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 57-117 31 9.3e-05 20.49 SMART 1-56 (56) Show / Hide 
Range on Protein: 57-117
Range on HMM: 1-56/56
Sequence Identity: 31% (19 aa)

CAGSDVRLRVVVSGTPQPSLSWFRDGQLLPPPAPEPSCLWLRSCGAQDAGVYSCSAQNERG
  | .|.|.  ..| | |. .|.. || ||      . | ...    |.|.|.|.|.|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set SPEG.AA V-set 104-127 32 0.870719 4.54 Pfam 104-128 (128) Show / Hide 
Range on Protein: 104-127
Range on HMM: 104-128/128
Sequence Identity: 32% (8 aa)

DAGVYSCSAQNE-RGQASCEAVLTV
| |.| | . |.  ..   .  |||
DSGTYYCAVWNCNEDYFGHGTRLTV
I-set SPEG.AA I-set 727-816 36 4.2e-39 135.22 Pfam 1-92 (92) Show / Hide 
Range on Protein: 727-816
Range on HMM: 1-92/92
Sequence Identity: 36% (34 aa)

PVFEIPLQNMVVAPGADVLLKCIITANPPPQVSWKKDGSMLHS-EGRLLIRAEG-ERHTLLLREAQAADAGSYTATATNELGQATCASSLAV
|.|........|  | .. ..| .| .|||||||.|||..|.. . |  ....|  ..||  ...|..|.|.|| .|||..|.|.|  .| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 SPEG.AA IGc2 739-806 30 1.1e-11 46.06 SMART 1-56 (56) Show / Hide 
Range on Protein: 739-806
Range on HMM: 1-56/56
Sequence Identity: 30% (21 aa)

APGADVLLKCIITANPPPQVSWKKDGSMLHSEGRLLIRAEGERHTLLLREAQAADAGSYTATATNELG
 .| .| |.|. |.|| |...|.| |..|             . || ..... .|.| || .|.|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG SPEG.AA IG 733-817 20 1.9e-10 41.94 SMART 1-58 (58) Show / Hide 
Range on Protein: 733-817
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

LQNMVVAPGADVLLKCIITANPPPQVSWKKDGSMLHSEGRLLIRAEGERHTLLLREAQAADA---GSYTATATNELGQATC--ASSLAVR
 . ..| .| .| |.| ..     |..|.                      | . ..|..|.   | |. .||   ||...     | |.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set SPEG.AA I-set 874-964 38 1.4e-31 109.68 Pfam 1-92 (92) Show / Hide 
Range on Protein: 874-964
Range on HMM: 1-92/92
Sequence Identity: 38% (35 aa)

PTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEG-GLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEV
|.|   . |. |.||...  . .|.|.|.|.|||... ||.||| .|.   ..| | ..|.|. ....|.| |||.|.|..|  .|.|.|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 880-965 17 1e-11 46.19 SMART 1-58 (58) Show / Hide 
Range on Protein: 880-965
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

LMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDA---GFYTCKAVNEYGARQC--EARLEVR
   ..|.||..| ..  |.      ..|.                       |.|  ... |.   | |.| |   .|  ..  ...|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 886-954 28 2.2e-10 41.77 SMART 1-56 (56) Show / Hide 
Range on Protein: 886-954
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

REGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYG
.|||.|..  .. | | | ..|..  ||.             .  .|.|  ....|.| |||.| |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set SPEG.AA V-set 826-964 13 0.013872 10.74 Pfam 1-128 (128) Show / Hide 
Range on Protein: 826-964
Range on HMM: 1-128/128
Sequence Identity: 13% (24 aa)

SSPITS-DEEYLSPPEEFPEPGETWPRTPTMKLSPSQDHDSSDSSSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEP----KP-VVSWLRNRQPV-----
.|..|  ... . |                                             .| |||.| ..  ..  .     .  ..| |  ||      
QSQVTQHPPRGC-PW------------------------------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQ

-------RPDQR--------RFAEEAE------GGLCRLRILAAERGDAGFYTCKAVNE-YGARQCEARLEV
       . ...        || .  .      .. . |.|  ... | | |.| . |. ..  . . || |
WIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set SPEG.AA I-set 973-1063 35 7.3e-12 42.76 Pfam 1-92 (92) Show / Hide 
Range on Protein: 973-1063
Range on HMM: 1-92/92
Sequence Identity: 35% (33 aa)

LAVLAPLQDVDVGAGEMALFECLVAGPADVEVDWLCRGRLLQPALL--KCKMHFDG-RKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTV
  .. ...|| |  || | ||| | |  . .| |.. |. |.|     ...|..||   ..|  . |  ||.|.|||. .    | .|.|.|||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP--DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 979-1064 18 2.8e-09 38.07 SMART 1-58 (58) Show / Hide 
Range on Protein: 979-1064
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

LQDVDVGAGEMALFECLVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDS---GVYTCKLSTAKDELTC--SARLTVR
 . | | .|| . ..| |.     .. |.                       | . .| ..||   |.|.|  .  . . ..  ...|||.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 985-1053 21 9e-06 26.35 SMART 1-56 (56) Show / Hide 
Range on Protein: 985-1053
Range on HMM: 1-56/56
Sequence Identity: 21% (15 aa)

GAGEMALFECLVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKD
  |. . ..| ..|  | .. |.  |  |.             .  | ...| ..|||.|||. . .. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set SPEG.AA V-set 1031-1063 32 6.8e-05 18.7 Pfam 95-128 (128) Show / Hide 
Range on Protein: 1031-1063
Range on HMM: 95-128/128
Sequence Identity: 32% (11 aa)

LLLTSVHEDDSGVYTCKLSTA-KDELTCSARLTV
| .......|||.|.|  ..  .|    . ||||
LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set SPEG.AA I-set 1069-1158 43 5e-32 111.19 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1069-1158
Range on HMM: 1-92/92
Sequence Identity: 43% (40 aa)

PLFTRLLEDVEVLEGRAARLDCKISGTPPPSVTWTHFGHPVNE-GDNLRLQQDG-GLHSLHIARVGSEDEGLYEVSATNTHGQAHCSAQLYV
| ||. . |||| || .||..|...|.|||.|.|.. | |... .|  . ..|| | ..| | .| ..||| |.. |||  |.| |.|.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 1075-1159 24 6.4e-15 56.82 SMART 1-58 (58) Show / Hide 
Range on Protein: 1075-1159
Range on HMM: 1-58/58
Sequence Identity: 24% (22 aa)

LEDVEVLEGRAARLDCKISGTPPPSVTWTHFGHPVNEGDNLRLQQDGGLHSLHIARVGSEDE---GLYEVSATNTHGQAHC--SAQLYVE
 . |.| ||  ..| | .|     ...|.                      |.| .|  ||.   | |   ||  |||...  ...|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 1081-1148 29 1.1e-11 46.01 SMART 1-56 (56) Show / Hide 
Range on Protein: 1081-1148
Range on HMM: 1-56/56
Sequence Identity: 29% (20 aa)

LEGRAARLDCKISGTPPPSVTWTHFGHPVNEGDNLRLQQDGGLHSLHIARVGSEDEGLYEVSATNTHG
.||....| |. .| | |...|.. | |..           .  .|.| .|  ||.|.|. .|.| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set SPEG.AA V-set 1067-1158 13 0.027046 9.74 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1067-1158
Range on HMM: 1-128/128
Sequence Identity: 13% (17 aa)

LAPLFTRLLE----DVEVLEGRAARLDCKISGTP----PP-SVTWTH-FGH-----------------------PVNEGDNLRLQQDGG--LHSLHIARV
  .. ..  .     |.| ||  ..| |. | ..    .. ...|                             .    .. .......    ||.|  .
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

GSEDEGLYEVSATNT-HGQAHCSAQLYV
 ..|.| |   ..|  ... . . .| |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set SPEG.AA I-set 1193-1282 38 5.2e-20 70.43 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1193-1282
Range on HMM: 1-92/92
Sequence Identity: 38% (35 aa)

PDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQS-SDDRRMTQYR-DIHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYV
| |.....|.||   . | .|||||| | |..|||..|  ... ||  .||.   ....| .  | |  .|.|. |  |..|.| | |.| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 SPEG.AA IGc2 1205-1272 23 3.1e-05 24.62 SMART 1-56 (56) Show / Hide 
Range on Protein: 1205-1272
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

GLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDIHRLVFPAVGPQHAGVYKSVIANKLG
     . |.| .|| | |.|.|.. | ...           .  .| .  | | ..|.|  .  |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG SPEG.AA IG 1199-1283 15 0.000182 22.08 SMART 1-58 (58) Show / Hide 
Range on Protein: 1199-1283
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

LQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDIHRLVFPAVGPQHA---GVYKSVIANKLGKAAC--YAHLYVT
 . ..| .   . |.| |.     .|.|.                      |..  | |...   |.|  .     |.. .   ..|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
FN3 SPEG.AA FN3 1287-1373 23 7.3e-07 30.04 SMART 1-69 (69) Show / Hide 
Range on Protein: 1287-1373
Range on HMM: 1-69/69
Sequence Identity: 23% (24 aa)

PGPPDGA--PEVVAVTGR------MVTLSWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPAWAATGLKKG----IQHIFRVLSSSG--KSS
|||| .   ..|..|| .       |||||.||           ..|.                         |||| |     .  |||   .|  . .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

S
.
G
IG SPEG.AA IG 1401-1487 19 7e-06 26.79 SMART 1-58 (58) Show / Hide 
Range on Protein: 1401-1487
Range on HMM: 1-58/58
Sequence Identity: 19% (18 aa)

QDIVYVVEGQPACVTVTFNHVEAQVVWRSCRGALLEARTGVYELSQPDDDQYCLRICRVSRRDL---GPLTCSARNRHGTKAC--SVTLELA
.  |.|.||...  |  ..    |. |.                         |.| .|.. |    |  .| |.  ||.. .  ..||.  
PP-VTVKEGETVTLTC-VS----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set SPEG.AA I-set 1448-1486 35 0.054691 9.26 Pfam 53-92 (92) Show / Hide 
Range on Protein: 1448-1486
Range on HMM: 53-92/92
Sequence Identity: 35% (14 aa)

DD-DQYCLRICRVSRRDLGPLTCSARNRHGTKACSVTLEL
|. . | |.| .| ..| |  || |.|. |.  |...|. 
DGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
I-set SPEG.AA I-set 1490-1579 40 4.2e-36 125.03 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1490-1579
Range on HMM: 1-92/92
Sequence Identity: 40% (37 aa)

PRFESIMEDVEVGPGETARFAVVVEGKPLPDIMWYKDEVLLAE-SNHVSFVYEE-NECSLVLLSAGSQDGGVYTCTARNLAGEVSCKAELSV
|.|.    ||||  |||||| . |.|.| |.. |.||.  |.. |......|.. ....|  . . . | |.|||.|.| .||..|.||| |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG SPEG.AA IG 1496-1580 20 3.5e-10 41.06 SMART 1-58 (58) Show / Hide 
Range on Protein: 1496-1580
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

MEDVEVGPGETARFAVVVEGKPLPDIMWYKDEVLLAESNHVSFVYEENECSLVLLSAGSQDG---GVYTCTARNLAGEVSC--KAELSVL
 . |.| .|||...   |.      | ||                      |.. ..  .|    |.|.|.|.  .|....   ..|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 SPEG.AA IGc2 1502-1569 27 6e-09 36.97 SMART 1-56 (56) Show / Hide 
Range on Protein: 1502-1569
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

GPGETARFAVVVEGKPLPDIMWYKDEVLLAESNHVSFVYEENECSLVLLSAGSQDGGVYTCTARNLAG
 .|.....   ..|.| |.|.||| .  |.           .. .| . ..   | |.|||.||| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
Kinase SPEG.AA Trio 1606-1859 47 1.3e-227 591.25 In-house 1-258 (258) Show / Hide 
Range on Protein: 1606-1859
Range on HMM: 1-258/258
Sequence Identity: 47% (123 aa)

YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHGCVLYFHEAFERRRGLVIVTELCT-EELLERMARKPTVCESETRTY
|....|||||.||..||......|...||||||.....|.....|...|..||| ||...|...|..|......|||. .|||....|....||||..||
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

MRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPG--EPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPF
|.|.||...|||..|.||||.||||...|....|..|..|||||.||.|.|.  |||..|||.|||.||||....|||..||||..||.....|.|||||
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

VGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
..|.||.|.|||......|.|..|...|..|..|..|||..| . ||.|.|.|.||||
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase SPEG.AA MLCK 1606-1859 39 1.7e-100 265.39 In-house 86-342 (257) Show / Hide 
Range on Protein: 1606-1859
Range on HMM: 86-342/257
Sequence Identity: 39% (103 aa)

YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPS-QAKPKASARREARLLARLQHGCVLYFHEAFERRRGLVIVTELCT-EELLERMA-RKPTVCESETR
|.|| |.|||.|.  .|..|.|.|...|||||.   .| |.  ..|   .  |.|  ..  |.|||  .  | . |. . .||.||   .. .  |.|..
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

TYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEP-QYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISP
.||||..||. ..|. ...|||.|||| .  .  .   |. | ||| |... |.|.   . .|||||||||.||  ||.  ||.| |||.... |.|.||
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTS--HQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSP

FVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDR-LRPTAEETLEHPWF
| |.||| |. |... .  |.. .|   | ||. |  . ||.|.  |.||.| |.|||.
FMGDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase SPEG.AA CAMK 1611-1859 18 1.3e-82 265.86 In-house 267-691 (425) Show / Hide 
Range on Protein: 1611-1859
Range on HMM: 267-691/425
Sequence Identity: 18% (78 aa)

EIGRGAFSYLRRVVERSSG------------LEFAAKFIPSQ-----------------------------AKPKASARREARLLARLQ-------HGCV
..|||.|.  .........             ..|.|.|. .                             .| ... ||| ... .||       | ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LYFHEAFE--------RRRG------------LVIVT---ELCTE-EL----LERMARK---------------PTVCESETRTYMRQVLEGICYLHQSH
. ..|..|        .. .            ...|.   |.|.  ||    ...  ..                 ..|.|.|.|.||..... |.|. .
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VLHLDVKPENLLVWDGAGGEE-------------QVRICDFGNAQELTP------------------------GEPQYCQYGTPEFVA-PEIVNQ-----
. |.| ||||.|. |  ....             .. |.||| |....|                        |.. . . ||||..| ||..|.     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------SPVSGVTDIWPVGVVAFLCLTGISPFVGE-------------NDRTTLMNIRNYNVAFEETTFLS--------------------LSREAR
          ...  .|.| .||. . .|.| .|| |.             ||. .. .|.. .  |..  |                      .| |..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

GFLIKVLVQD-RLRPTAEETLEHPWF
 .. | |. |   |.|.|. |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SPEG.AA DAPK 1608-1859 36 6.6e-81 222.48 In-house 1-264 (264) Show / Hide 
Range on Protein: 1608-1859
Range on HMM: 1-264/264
Sequence Identity: 36% (96 aa)

IHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKAS----AR----REARLLARLQ-HGCVLYFHEAFERRRGLVIVTELCT-EELLERMAR--KPT
. .|.||| |.  |.. ..|.|...|||||    . ..|     |    .| . |  .. |  |   ||..| |   ... |. .  ||    .   .  
MGEELGRGQFAVVRKCRHKSTGKHYAAKFI-KKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREEC

VCESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLC
.|| . .  |.|.|||. |||. .. ||| ||.| .  |    .  . |.||| . .. .||      ||||.|||||||  | |  ||.| .||..   
LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM

LTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
|.|||||.|..   |. ||   |. |.| .| ..| .|. |  . || | . |.|||| |.||| 
LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase SPEG.AA DAPK 1606-1859 36 2e-69 199.39 In-house 1-264 (264) Show / Hide 
Range on Protein: 1606-1859
Range on HMM: 1-264/264
Sequence Identity: 36% (97 aa)

YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASAR--------REARLLARLQ-HGCVLYFHEAFERRRGLVIVTELCT-EELLERMARKPT
||. .||| | |.  ... |.| |.|.|||||    . .|| |        || . |  .. |  .   |...| .   |.. || .  ||   .. |  
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFI-KKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKEC

VCESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLC
. | |   .  |.|.|. ..|  |. |.| ||||    |    . ...| ||| | .  ||.      ||||||||||||  | .  || | .||. .  
LNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYIL

LTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
| | ||| |..   || ||   |  |.|  | . |  |  |  . ||.| . | | .| |.||| 
LSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase SPEG.AA S_TKc 1606-1859 27 5e-65 223.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 1606-1859
Range on HMM: 1-231/231
Sequence Identity: 27% (74 aa)

YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHGCVLYFHEAFERRRGLVIVTELCTE---ELLERMARKPT------V
|.|...||.|||.  ........| ..| | |.       ..||| ..| . .|  .  ....|.    | .|.|.|     .|.... ....       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

CESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSG-VTDIWPVGVVAFLC
 | ..| ||.|..... |.|. ...| |.||||.|. .      .. ||||| | .|      . . |||...|||..   . ..   |.| .|.. . .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLE-------HPWF
|.|  ||   .. ... .|.              |.||. |. | |. | . |||| | |.       ||||
LCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SPEG.AA DRAK 1609-1859 35 1.3e-61 189.98 In-house 2-259 (259) Show / Hide 
Range on Protein: 1609-1859
Range on HMM: 2-259/259
Sequence Identity: 35% (92 aa)

HQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASAR---REARLLARLQH-GCVLYFHEAFERRRGLVIVTELCT-EELLE--RMARKPTVCESET
 .| ||| |   |. .....| .|||||.    . . . .   .| . |   |    |   || .| |  .. | |. .  |. .     .   .|| . 
AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDV

RTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISP
.  |||.|||. ||||  . ||| || | |       |. ..||||| .  .  ||      |||..||||| |  |..  ||.| .||.... ||.|||
QRCMRQILEGVHYLHQRNIVHLDLKPQNILLTS-EYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP

FVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWF
|||.    | .||   |. . | .| ..| .|. |  ...| .   |.|||| |.||| 
FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase SPEG.AA Pkinase 1606-1859 26 2.5e-52 184.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1606-1859
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPK---ASARR--EARLLARLQHGCVLYFHEAFERRRGLVIVTELCTE-----ELLERMA--RK
| |.. ||.|.|.  .. .....| ..| | |. . . .    ..||  |.....||.| ... ....||... . .|.|.|       .| ...   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PTV--CESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVW-DGAGGEEQVRICDFGNAQE--LTPGEPQYCQYGTPEFVAPEIVN-QSPVSGVTDIWP
 ..   | | . ||.|.|.|. |.|.  ..| |.||||.|.  .|  ..  |.||||| |    . ...  .   |||...|||... ... .   |.| 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVVAFLCLTGISPFVGE------NDRTTLMNIRNYNVAFEETTFLSLS-----------------REARGFLIKVLVQDR-LRPTAEETLEHPWF
.|.. .  |.|  || |.      ...  . .|.   . |.. .  | |                 .|.. |. . | .|   |||||. |.||||
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SPEG.AA Ciliate-E2 1606-1859 19 1.3e-43 147.52 In-house 136-500 (365) Show / Hide 
Range on Protein: 1606-1859
Range on HMM: 136-500/365
Sequence Identity: 19% (73 aa)

YDIHQEIGRGAFS--YLRRVVER---------------------SSGLEFAAKFI----PSQAKPKASARREAR----------LLARLQHGCVLYFHEA
|.... ||.|.|.  |. .| .                        . ..| | .      | | . .  || .          .| .|.|  .. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--RRRGLVIVTELCTE-ELLERMARKPTVC-----------ESETRTYMRQVLE---------------GICYLHQSH-VLHLDVKPENLLVWDGAGG
|.   .  . .|.|.|   .|....  ... .           | | ...|.|.|.               .. |||. . ..| | ||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

EEQVRICDFGNAQELTPGEPQYC--------------------------------QYGTPEFVAPEIVNQSP---------VSGVTDIWPVGVVAFLCLT
   . |.|||....... . ..                                 ..|||...||||.|  .          .   ||| .||. . .|.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GISPFVGENDRTTLMNIRNYNVAFEET--------------TFLSLSREARGFLIK----VLVQD-RLRPT-AEETLEHPWF
|  ||        . .| . .. | .                ....| |.  .. |     |. |   |.| .|. |.||||
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase SPEG.AA CAMKL 1606-1859 22 1.3e-43 137.01 In-house 182-478 (297) Show / Hide 
Range on Protein: 1606-1859
Range on HMM: 182-478/297
Sequence Identity: 22% (68 aa)

YDIHQEIGRGAFSYLRRVVE-RSSGLEFAAKFIP--SQA-KPKASAR-------------REARLLARLQ---HGCVLYFHEAFERRRG------LVIVT
|.| ...|.|.|.  .  .  |  | . | |.|       .|.....             ||.... .|.   |  .  ..| .| ..       ...|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCTEE---LLERMARKPT----VCESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTP-----GEPQYCQYGTPE
|.|      |...  ...       |.|.| | ||..... |.|. .. | | ||||.|. |  | . .. |.||| . . .|     |.    . |.|.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL-DENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

FVAPEIVNQ---SPVSGVTDIWPVGVVAFLCLTGISPFVGEND------RTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHP
. ||||..    .     .|||  ||. .  ..|  || ....       . ..  ..    .... ....| ..| .. | |. .   |||... ..||
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

WF
|.
WM
Kinase SPEG.AA CAMK-Unique 1606-1859 19 2.7e-40 130.6 In-house 1-363 (363) Show / Hide 
Range on Protein: 1606-1859
Range on HMM: 1-363/363
Sequence Identity: 19% (70 aa)

YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPS----QAKPKA-----------------SARREARLLARLQHGCVLYFHEA----FERRR-------
|. |. || |.|. ....  |. | ..| | .        | |.                 ...||.... .. | . . . .     |. |.       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------GLVIVTELCTEE-LLERMAR--------------------KPTVCE--SETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGG----
         ..||.|.|..  |.. ...                    .    |  ..|...|...|. . |.|.  . | | |.||..|          
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------EEQVRICDFGNAQELT-PGEP----QYCQYGTPEFVAP--------------EIVNQSPVSGVT----DIWPVGVVAFLCLTGISPFVGEND
           . .|||| . ..    ..     .|  |||...||              |..|... ..      |||  ||.... |.|..|| .|..
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMC--GTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECE

R--------TTLMNIRNYNV-AFEETTFLS---LSREARGFLIKVLVQD-RLRPTAEETLEHPWF
          .. .|.  ..  |..  . .    | ||  |... .. |   | .|.| |||.|.
DRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase SPEG.AA RSK 1608-1859 25 1.9e-35 124.08 In-house 1-278 (278) Show / Hide 
Range on Protein: 1608-1859
Range on HMM: 1-278/278
Sequence Identity: 25% (72 aa)

IHQE--IGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASAR------REARLLARLQ-HGCVLYFHEAFERRRGLVIVTELCT-EELLERMARKPT--
. .   .| |...  |... . .| ..| | . ..|| .....      .| . |.| | |  .   |.||.    | ...|.|   ||...  .. .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVL-KKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-VCESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPG--EPQYCQYGTPEFVAPEIVN----QSPVSGVTDIWPV
  .|.| . ||...   . .||| .. | | |||| |  |   .|. ....||| . .. .   .. .   .| |..|||...    |.  .   |.|  
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVVAFLCLTGISPFVG---ENDRTTLMNIRNYN--VAFEETTFLSLSREARGFLIKVL-VQDRLRPT-----AEETLEHPWF
||. .  ||| .|| |   .|   .. .|.. .  . ...  .  ||.||. .. | | .    |..     ||| ..||||
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQY--LSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
I-set SPEG.AA I-set 2587-2677 33 7.1e-21 73.35 Pfam 1-92 (92) Show / Hide 
Range on Protein: 2587-2677
Range on HMM: 1-92/92
Sequence Identity: 33% (31 aa)

PVFHIKLKDQVLLEGEAATLLCLPAACPAPRISWMKDKQSLRS-EPSVVIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAV
|.| .|.||..  |||.|.. |    .| | .|| || | ||. .  ....  .||.. | | .. .. .| |.| ||| .|. ...... |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 SPEG.AA IGc2 2599-2667 28 1e-11 46.14 SMART 1-56 (56) Show / Hide 
Range on Protein: 2599-2667
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

LEGEAATLLCLPAACPAPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLG
.||...|| |  .. |.| |.| |  |.|             ... |.| .. . ..|.|.|.|.|  |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG SPEG.AA IG 2593-2678 20 1.3e-10 42.53 SMART 1-58 (58) Show / Hide 
Range on Protein: 2593-2678
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

LKDQVLLEGEAATLLCLPAACPAPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRAGKRHA---GLYECSATNVLGSITS--SCTVAVA
 . ..  ||| .|| |  .     .|.|.                       | | .. . ..   | | | ||   |...|  . |. | 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
FN3 SPEG.AA FN3 2681-2760 20 0.000135 22.52 SMART 1-69 (69) Show / Hide 
Range on Protein: 2681-2760
Range on HMM: 1-69/69
Sequence Identity: 20% (19 aa)

PGKLAP---PEVPQTYHD------TALVVWKPGDGRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTQLPVG----VTVRFRVACSNR--AGQG
||       ..|  .  .      .. . |||         ... |                  | || |  |     . .|||.. |.  ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase SPEG.AA Trio 2961-3213 48 1.4e-225 585.96 In-house 1-258 (258) Show / Hide 
Range on Protein: 2961-3213
Range on HMM: 1-258/258
Sequence Identity: 48% (125 aa)

YTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATY
|||.||..||||.|||.|...|||||..||..||....|..|..|||.|..|.|....|||..|.|||...||.|.|...||||.|.....|.|..|.||
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

VVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNA----LKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTYIMLSGYSPF
..|.|....|||..|.|||||||.|......||    .||.|||.||...|....|..|..|..||||||...|.|....||||..|||||.||||.|||
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

YEPDPQETEARIVGGRFDAFQLYPN-TSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
|.....||...|..|.|.....|.. .||.|..|..|||...||.||....||.|||.
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase SPEG.AA MLCK 2961-3213 35 1e-105 279.42 In-house 1-257 (257) Show / Hide 
Range on Protein: 2961-3213
Range on HMM: 1-257/257
Sequence Identity: 35% (92 aa)

YTFLEEKARGRFGVVRSCRENATGRTFVAKIVPY-AAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGLS-DRFRYSEDDVA
| ..|| .||.||.|. |.| .||.|..||...   .. |. |..|.|....|||..|. .|.|. |..  |.| |     ||.     ..| ..| .|.
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

TYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAA--DNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTYIMLSGYSPF
.|. |.. |....|.....|||.||.| .. .   . .||.||| |. |.|   | .    || || |||.|. ||.| .||.|. ||..|..|||.|||
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKK-VKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPF

YEPDPQETEARIVGG--RFD--AFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
   . .|| . .  .  .||  .|.   . |. |. | .. |  .. .|.. ..||.||||
MGDNDRETMNNVTSCEWDFDDECFD---DISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase SPEG.AA CAMK 2966-3213 20 1.2e-86 279.19 In-house 1-425 (425) Show / Hide 
Range on Protein: 2966-3213
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

EKARGRFGVVRSCRENATG------------RTFVAKIVPYA-----------------------------AEGKRRVLQEYEVLRT-------LHHERL
.  ||.||.|. |..  |.            . . .||..                               .. ...|..|.|....       |.|. .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

MSLHEAYITPRY-------------------LVLIA---ESCGNRELLCGLSDRF-------------------RYSEDDVATYVVQLLQGLDYLHGHHV
 .|.|.| .|.|                   ....    | | . ||.. | |.                    |..|.....|. |......|.| |..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHLDIKPDNLLLAAD-----------------NALKIVDFGSAQPYNPQAL----------------------KPLGHRTGTLEFMA-PEMVKG------
 |.|.||.|.||  .                 | .||.||| |. ..|                         ...  . ||.|.|| ||...|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------DPIGSATDIWGAGVLTYIMLSGYSPFYEP-------------DPQETEARIVGGRFD-AFQLYPNTS--------------------QSATL
        ...| ..|.| .||..||||.||.|||..             ...|.  .|  |..|      ...|                    |..  
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLRKVLSVHPWSRPSLQDCLAHPWL
..|| | | |. |.....||.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SPEG.AA S_TKc 2961-3213 27 2.7e-68 234.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 2961-3213
Range on HMM: 1-231/231
Sequence Identity: 27% (75 aa)

YTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGN--RELLCGLSDRFR------Y
|..|..  .| ||.|. ||.. ||| .  ||..      .....| ..|.  ||. .  |.... .  .| .. | |..   .|.  . .| |      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGS-ATDIWGAGVLTYIMLS
.| ... |. |....|.|.| |...| |.||.|.||     .|| |||.|  .         .  ||...||||..   . |  . |.|  |.. |.||.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GYSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLA-------HPWL
|| ||.    ...  ...|            |..|  |.|| | . |  ||.  ..|.       |||.
GYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SPEG.AA Pkinase 2961-3213 24 1.3e-62 219.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2961-3213
Range on HMM: 1-293/293
Sequence Identity: 24% (72 aa)

YTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGK----RRVL-QEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNR----ELLCGLS--DR
|....   .| ||.|. |..  ||.... ||...  | .    .... .| .... |.|.    |.... ..... .. | |..     .|   .|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

FRY--SEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNAL----KIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVK-GDPIGSATDIWGA
 ..  ||...  |. |.|.||.|.| . ..| |.||.|.|.  .. .    || |||.|  ..    ... ...||...|||| .. | ..|.. |.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLTYIMLSGYSPFYEP------DPQETEARIVGGRFDAFQLYP------------------NTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
|.. |.||.|. ||..       |...  .|| |....    ..                  |.|...  |... | . | .||. ...| |||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SPEG.AA CAMKL 2961-3213 24 4.4e-52 164.43 In-house 1-297 (297) Show / Hide 
Range on Protein: 2961-3213
Range on HMM: 1-297/297
Sequence Identity: 24% (72 aa)

YTFLEEKARGRFGVVRSCRE-NATGRTFVAKIVPYAAEGKRRVLQ----------------EYEVLRTLH---HERLMSLHEAYITPRY------LVLIA
|.....  .| ||.|. ..    ||.    ||.      .. . .                |.. .. |.   |.  ..|.| . ||..      ..|. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ESCGNRE--LLCGLSDRFR----YSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADN--ALKIVDFGSAQPYNP---QALKPLGHRTGTLEFM
| |.. |  |.  .  . .     .|..   |  |.. ...|.| |.. | ||||.|.||  ..   .||.||| .  | |   .  . |  . |....|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEMVKG--D-PIGSATDIWGAGVLTYIMLSGYSPFYEPDP-------QETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
|||...|  .  .| ..||| .||. | |. || || ...        . .. ... .    .  ..  | ..  ..|| | | |. ||.... . |||.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase SPEG.AA DRAK 2965-3213 33 1.1e-48 149.12 In-house 3-259 (259) Show / Hide 
Range on Protein: 2965-3213
Range on HMM: 3-259/259
Sequence Identity: 33% (87 aa)

EEKARGRFGVVRSCRENATGRTFVAKIVP---YAAEGKRRVLQEYEVLRTLHHE-RLMSLHEAYITPRYLVLIAE--SCGNRELLCGLSDRFRYSEDDVA
 |..||.| ||| | .  ||. | || .     . . .. .|.|  ||   . . ..  ||| | |   ..|. |  . |    .| .      .| || 
KERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDVQ

TYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNA---LKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTYIMLSGYSP
  . | |.|. |||   . ||| || | ||.       .||.||| .   . ..   .    || ...|||  . |||  |||.|  |||||.||.. ||
RCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYIC-NGEE-VREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP

FYEPDPQETEARIVGGRFD-AFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
|   | |||   |     | .  ..   |..|. | ....   |  |.. . || ||||
FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase SPEG.AA Ciliate-E2 2961-3213 17 1.2e-48 165.08 In-house 1-365 (365) Show / Hide 
Range on Protein: 2961-3213
Range on HMM: 1-365/365
Sequence Identity: 17% (68 aa)

YTFLEEKARGRFGVVRSCRENATGRTF------------------------VAKIVPYAAEGKRRVLQEYE-------------VLRTLHHERLMSLHEA
| |..   .| ||.|. |.   ... |                        .  . ..  | . ......              .|..| |  .. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--TPRYLVLIAESCGNRELLCGLSDRF-----------RYSEDDVATYVVQLLQ---------------GLDYLHGHH-VLHLDIKPDNLLLAADNAL
..  .  .. |. | |   .|.  . ..            ...|  ....  |.||               .| |||  . ..| ||||.|.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIVDFGSAQPYNPQ----------ALKPLGH---------------------RTGTLEFMAPEMVKGDP---------IGSATDIWGAGVLTYIMLSGYS
||.||| .. |...           ...  .                       ||...||||...| .          . . ||| .||. |.||.|. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFYEPDPQETEARIVGGRFDAFQL---------------YPNTSQSATLFLRK----VLSVHPWSRPS-LQDCLAHPWL
||        .  |  . .| ..                . . ||..  ...|     | . |  |..  ...| |||.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase SPEG.AA DAPK 3053-3213 37 6.5e-48 129.86 In-house 101-264 (264) Show / Hide 
Range on Protein: 3053-3213
Range on HMM: 101-264/264
Sequence Identity: 37% (62 aa)

SEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAA--DNA--LKIVDFGSAQPYNP-QALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTY
.|.|..  . | |.|. |||  .. |||.|| | .|.   .    .||.||| .   ..   ..      || |. ||| |  .|.. |||.|  ||.||
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDI---MGTPEYVAPEIVNYEPLSLATDMWSIGVITY

IMLSGYSPFYEPDPQETEARIVGGRFD-AFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
||||| |||   . ||| . |   . | .  .  .||..|. | |. |   |  |.. ..|| |||.
IMLSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase SPEG.AA RSK 2964-3213 27 3.2e-46 159.88 In-house 1-278 (278) Show / Hide 
Range on Protein: 2964-3213
Range on HMM: 1-278/278
Sequence Identity: 27% (76 aa)

LEEK---ARGRFGVVRSCRENATGRTFVAKIVPYAAEGKR-----RVLQEYEVLRTLH-HERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFR---
|...   . | . ..| |.  .||. .  |..  |   .|     ....| ..| .   |  . .||.|. |. .| || | |   ||.  |. . .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

YSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAA---DNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVK---GDP-IGSATDIWGAGV
 |||... |  ..   ...|| ... | |.||.| |..    .  .|..||| .   ...  ...    .|.|.|||||.|   ..   . | |.|  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYIMLSGYSPFYE---PDPQETEARIVGGRFDAFQLY--PNTSQSATLFLRKVLSVHPWSRPS-----LQDCLAHPWL
| | ||.|..||.     ...|. .||  |.|. . .   .. || |  ..|| | ..|  |..     ... ..|||.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFS-LTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase SPEG.AA CAMK-Unique 2961-3213 18 7.8e-44 142.46 In-house 1-363 (363) Show / Hide 
Range on Protein: 2961-3213
Range on HMM: 1-363/363
Sequence Identity: 18% (69 aa)

YTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEG-KRRVLQ--------------------EYEVLRTLHHERLMSLHEA----YITPR-------
|....    | ||.|. |   .||  .. |.|  .. | |....|                    | ...... |...  | .     . ...       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YLVLIAESCGNRELLCGLSD--------------------RFRYSE--DDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAAD-------
        |.... | |  ..|.  . .                    . ..||   |..... .||. . |.|   . | |.|..|...          
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

---------NALKIVDFGSAQPYNPQALKP-LGHRTGTLEFMAP--------------EMVKGDPIGSAT----DIWGAGVLTYIMLSGYSPFYEPDPQ-
         . .|. ||| .  ||     . .  . ||...|||              |.........      |||  ||..|.||.|..||....   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ETEARIVGGRF-----DAFQL--YPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
       |....|  |..     .....  |   ||.|. |. . . | | .| |.   | |.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDY--ISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase SPEG.AA DAPK 3005-3213 36 3.2e-37 104.82 In-house 52-264 (264) Show / Hide 
Range on Protein: 3005-3213
Range on HMM: 52-264/264
Sequence Identity: 36% (79 aa)

EYEVLRTLH-HERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNALK----IVDF
|  .|| .  |.   .||..| .    ||| |     ||   | ..   .|.  . .. | |.|. ..|  |. |.|.|| |  |   |. .    |.||
EVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECLNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDF

GSAQPYNP-QALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTYIMLSGYSPFYEPDPQETEARIVGGRFDAFQLY-PNTSQSATLFLRKVLSVH
| |    | .  | .    || || ||| |   | | .|| |  || |||.||| |||     ||| | |   ...    |  |||. |  | |. |   
GLAHRIEPGNEFKNI---FGTPEFVAPEIVNYEPLGLETDMWSIGVITYILLSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKD

PWSRPSLQDCLAHPWL
|  |   |.|| ||| 
PKKRMTIQECLQHPWI
Kinase SPEG.AA TyrKc 2961-3213 17 1.7e-12 -20.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 2961-3213
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

YTFLEEKARGRFGVVRSCRENATGRTFVA--KIVPYAAEGKRRVLQEYEVLRTL--HHERLMSLHEAYITP-------RYLVLIAESCGNRELLCGLSDR
 |....  .| ||.|. .. .    . ||  .. ..|   ..  ..| .... |  ||. .  |. . ...         | .. | . .  |.  | ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

FR-YSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNALKIVDFGSAQPYNPQ-------ALKPL----GHRT-GTLEFMAPEMVKGDPIGSA
 .  . .|   . .|  .| .||| ... | |.   | |.....  || ||| .               .      | .|   .  ||||  .     ..
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

TDIWGAGVLTY-IMLSGYSPFYE-----PDPQETEARIVGGRFDAFQLY------PNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL
.|.|  ||. . |.  | .| ..      ..||  ...  |.      .      .  ..      ..     | .||. ...  |  .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SPEG.AA DAPK 2963-3024 30 3.8e-07 15.4 In-house 1-70 (264) Show / Hide 
Range on Protein: 2963-3024
Range on HMM: 1-70/264
Sequence Identity: 30% (21 aa)

FLEEKARGRFGVVRSCRENATGRTFVAKIV---PYAAE----GKRRVLQEYEVLRTLH-HERLMSLHEAY
  ||  ||.| ||| ||.  ||. . || .    ...          . |  .|. .  | .. .|||.|
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVY
Kinase SPEG.AA DAPK 2961-2990 46 0.000914 6.63 In-house 1-30 (264) Show / Hide 
Range on Protein: 2961-2990
Range on HMM: 1-30/264
Sequence Identity: 46% (14 aa)

YTFLEEKARGRFGVVRSCRENATGRTFVAK
|   ||   | | ||. |||  ||  . ||
YDMGEEIGSGQFAVVKKCREKSTGKEYAAK