Gene SYK (Mouse)

SYK

Species: Mouse
Alias: SYK, Syk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Syk

Sequence

Name Sequence Type Origin Length Description Download
SYK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
SYK.NA RNA Sugen 5148 None Fasta, JSON
SYK.AA Protein Sugen 629 None Fasta, JSON

Protein domain

Protein domains of SYK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 SYK.AA SH2 14-91 34 1.7e-36 108.98 Pfam 1-81 (81) Show / Hide 
Range on Protein: 14-91
Range on HMM: 1-81/81
Sequence Identity: 34% (28 aa)

YFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNR---KAHHYTIERELNGTYAISGGRAHASPADLCHYH
...|.|.|.|||..| ..|..|| .|.|.|... |...||| ..    . .|| | |. ||.| |.|.. ..| ..|....
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 SYK.AA SH2 12-97 37 1.8e-28 101.8 SMART 1-87 (87) Show / Hide 
Range on Protein: 12-97
Range on HMM: 1-87/87
Sequence Identity: 37% (33 aa)

LTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAISG--GRAHASPADLCHYHSQEPDG
  ...|||.|||||. | ..|| || .|.|.|..  |...||| ...| .|| |.|. .| | | .  .| . |  .| ..... |.|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 SYK.AA SH2 167-243 39 6.9e-37 110.12 Pfam 1-81 (81) Show / Hide 
Range on Protein: 167-243
Range on HMM: 1-81/81
Sequence Identity: 39% (32 aa)

WFHGNISRDESEQTVLIGSKTNGKFLIRARD-NSGSYALCLLHEG---KVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHY
|.||.||| | |.  . . ...| ||.| .. . |.|.|.....|   .| |||| |...|.. | ...||..|..|||||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 SYK.AA SH2 165-249 44 2.1e-31 111.58 SMART 1-87 (87) Show / Hide 
Range on Protein: 165-249
Range on HMM: 1-87/87
Sequence Identity: 44% (39 aa)

MPWFHGNISRDESEQTVLIGSKTNGKFLIRARDN-SGSYALCLLHEGKVLHYRIDRDKTGKLSIPE--GKKFDTLWQLVEHYSYKPDG
.||.||||||.| ||  . ... .| ||.| ...  |.|.|.. ..||| |||| |...|| .| |  ..||..| .||.||.  |.|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase SYK.AA Syk 365-614 66 5.6e-208 697.22 In-house 1-257 (257) Show / Hide 
Range on Protein: 365-614
Range on HMM: 1-257/257
Sequence Identity: 66% (171 aa)

TLEDNELGSGNFGTVKKGYYQMK-----KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-
...|||.|.||||.|.||.|.||     |....||.|.||...|.||.|.|...||.||.|||.|.||||||||.||..|.|||||||||..|||||.| 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

HIKDKNIIELVH-QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW
.|...|..||.| ||.|||.||||..||||||||||||||..|||||||||.||||.||..||.|.|||||||||||||||.|||||.|||||||||.||
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFT
|.||||||||..|||.||....|.|.||.||.|||.|||.|||.||.|....||.| 
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Pkinase_Tyr SYK.AA Pkinase_Tyr 364-620 43 5.4e-127 430.72 Pfam 1-270 (270) Show / Hide 
Range on Protein: 364-620
Range on HMM: 1-270/270
Sequence Identity: 43% (118 aa)

LTLEDNELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPA-LKDELLAEANVMQQL-DNPYIVRMIGICE--AES--WMLVMEMAELGPLNKYLQ
.|.   .||.|.||.|.||..   ...   .||||.||. | ... .......||..| || ..| |||..|.|    |.  ...||| ...| | .||.
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

Q----NRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY-KAQTHGKWPVKWYAPECINYYKFSSKSDVW
.    ..... | ...  .|...|| |||. |..||||||||.|.  .. .||.||||....  .. || .....||.|.||.|||||||.||..|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGVLMWEAFSYGQKP-YRGMKGSEVTAML-EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRL
|||||||| |.||..| | ||. .|| ... |.|.|| || .|| |.|||| .|| || |.|| |...  .|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase SYK.AA TyrKc 365-620 39 2.3e-122 413.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 365-620
Range on HMM: 1-280/280
Sequence Identity: 39% (115 aa)

TLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL--DNPYIVRMIGICEA--------ESWMLVMEMAELGPLNKYL
   . .||.|.||.| || .       .|||| ||..|     . ... ||..| .|  ..| |||..|.|          |  |.||| ...| |..||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QQNRH-IKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD------ENYYKAQT--HGK--WPVKWYAPECINYYKF
. .|. .. |  ..  .|.. || ||.. |..||||||||.|.  .| .||||||||...  |      . ||....  .||  .|..|.|||||||.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SSKSDVWSFGVLMWEAFSYGQKPYRG-----MKGSEVTAMLEKGERMGCPAG--------CPREMYDLMNLCWTYDVENRPGFTAVELRL
..|||||||||.||| |.|||.|| |     |. .|| . ...|.|| .|.         || |||..|  || .| |.|| |...  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SYK.AA TK 365-620 23 1.2e-104 351.84 In-house 1-486 (486) Show / Hide 
Range on Protein: 365-620
Range on HMM: 1-486/486
Sequence Identity: 23% (116 aa)

TLEDNELGSGNFG---TVKKGYYQMK-----------------------KVVKTVAVKILK--NEANDPALKD----------ELLAEANVMQQLD----
    ..||.|.||   .| || ....                       ... .||||.||  ..... . .|          . |.||..|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NPYIVRMIGICEAES-------------WMLVMEMAELGP----LNKYLQQNRH---------------------------------------------
  | |||..|.|  .              ||.|||....|     | .||...|.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IKDKNIIELVHQVSMGMKYLEES------NFVHRDLAARNVLLVTQHY-----------AKISDFG---
                               .  .  .   .|.. || ||..       |||||||||||.|.  ..            .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKALRADENYYKAQ-----------------------THGKWPVKWYAPECIN---------YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK
     |....  |..||...                       . ||.|..|.||||.|         | ||..||||||||||||| |.|||.|| |. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

G----------SEVTAMLEKG--------------ERMGCPAGCP--------------REMYDLMNLCWTYDVENRPGFTAVELRL
            ||  .|..|               || .|..||               |.||||  || || | || |...  .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase SYK.AA UTK 369-620 33 1.8e-94 320.19 In-house 5-296 (296) Show / Hide 
Range on Protein: 369-620
Range on HMM: 5-296/296
Sequence Identity: 33% (97 aa)

NELGSGNFGTVKKGYYQMKK---VVKTVAVKILKNEANDPALKD---ELLAEAN---VMQQLD-NPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQN
..||.|.||.| |. ..  .    .  |||| ....|...  ..   ... ||.   .|.|..  |...|..|.|   | ||.|.|..| | | .||. .
RQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRH

RH--------IKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH-------YAKISDFG---LSKALRA--------DENYYKAQTHGKWPVK
|.         ..   .. . ... || ||.. .||||||||||.|.  ..        .||.|||   .|... .        . .||.||  ..||..
RPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIR

WYAPECINYY-KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG--ERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRL
|.|||....  .|..|||||||||..|| ...|..|| ||   .|.. ...|   || ||..||...|.||. ||.||...|| |  .. ..
WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase SYK.AA Ack 364-620 38 2.6e-85 287.74 In-house 1-266 (266) Show / Hide 
Range on Protein: 364-620
Range on HMM: 1-266/266
Sequence Identity: 38% (104 aa)

LTLEDNELGSGNFGTVKKGYYQM--KKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRH
.||   .||.| || |..|       |..  ||||.|. .  . |   |..| |...| .|| | .||  |.  .    |.|.|.|..| |   | .  |
ITLC-EKLGDGCFGVVWRGEWTNPGGKHIQ-VAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK--H

IKDKNI-IELVH----QVSMGMKYLEESNFVHRDLAARNVLLVTQ-HYAKISDFGLSKALRADENYYKAQTHG--KWPVKWYAPECINYYKFSSKSDVWS
 ..    | . .    |. ||| ||| ....||||||||.|| ..   .||.||||. ||   |.||. . |   | |  | ||||... .||..||||.
CRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWM

FGVLMWEAFSYGQKPYRGMKGSEVTAMLE-KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRL
||| .|| ||||..|. |. |...   .. .|||   |  ||.. |..|  ||. ... || | |..  |
FGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase SYK.AA FAK 366-625 38 3.9e-85 285.21 In-house 2-285 (285) Show / Hide 
Range on Protein: 366-625
Range on HMM: 2-285/285
Sequence Identity: 38% (110 aa)

LEDNELGSGNFGTVKKGYYQMKKV-------------------------VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWML
     .| | || | .| |   |                          .  ||.|  |..  |.  |.. ..|| .|.|.| | ||..||||| .   .
TLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCC-DDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

VMEMAELGPLNKYLQQNR-HIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN
.||....| | .||| |.   |    |    |..| | |||  .||||| |||||| . .   |  |||||  .  |. ||||   || |.|| .|| ||
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMH-DHSYYKASPKGKLPIKWMSPESIN

YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRLRNYYY
.  | . |||| ||| |||  .|| ||. ..| ..|   .|.|||.  |. ||  .| || .|| ||   || |. .  .|.. | 
FRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase SYK.AA Fer 364-621 35 1.2e-84 287.51 In-house 1-283 (283) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-283/283
Sequence Identity: 35% (100 aa)

LTLEDNELGSGNFGTVKKG------YYQMKKVVKTVAVKILKN--EANDPALKDELLAEANVMQQ-LDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKY
 ||..  ||.|.||.|.||      . ... ||  ||||  |.  |. . . . |...||..|.. .| |..|. .|.|   .  |.|||..  | | .|
VTLGK-KLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LQQNRH--IKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT-QHYAK--ISDFGLSKALRADENYYKAQ-THGKWPVKWYAPECINYYKFSSKS
|. | .  ..|. .|. ..|.. ||.||.. | .|||.||||.|.   ... |  |||||.|.... ... ||   .. | |..| |||....  .|.|.
LKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKT

DVWSFGVLMWEAFSYGQKPYRG----MKGSEV-----TAMLEKGERMGCPAGCPREMYDLMN-LCWTYDVENRPGFTAVELRLR
|||||||..|| |. |..|| |    ||  .|      .  .|| .| .| ..| |.. .|   ||..| |.|| .. .  .|.
DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase SYK.AA Src 364-620 40 3.1e-84 286.08 In-house 1-255 (255) Show / Hide 
Range on Protein: 364-620
Range on HMM: 1-255/255
Sequence Identity: 40% (107 aa)

LTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQ---QNRH
..|.. .||.|.|| | .||.  .. .| |||| ||         . .|.||..| .|. . .|..  .|  |     | |  . | | .||.   . ||
IKLCR-KLGQGQFGEVWMGYW--NGNTK-VAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

IKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEA
.. .. |..  ||. ||.|||. |..||||||||||  ..  .|. |||| . .  |.. | |..  | |.|| |||.||| .|. ||||||||.|..| 
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

FSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD-LMNLCWTYDVENRPGFTAVELRL
..||. ||.||.  ||  ..|.| || ||..|| |.|. .|  ||  | | || |      |
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase SYK.AA EGFR 365-621 41 5.3e-82 272.03 In-house 1-258 (258) Show / Hide 
Range on Protein: 365-621
Range on HMM: 1-258/258
Sequence Identity: 41% (108 aa)

TLEDNELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HIK
.  .  |||| |||| || .  . ..|   ||.|.| .|. .|  ..|.| || ||  .|.|..||..|.| ... .||  .  .| |  |..|.. .| 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVL-REQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIG

DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS
 .. .    |.  ||.||||   |||||||||||. .    || ||||.| | .||. |.||  || |.|| | ||| . .. ..|||||.|| .||   
SQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQ-GGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMT

YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRLR
.||||| |.. .|.  .||||||.  |  |   .| .|  ||  | . ||.|     ...
FGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase SYK.AA Frk 369-624 39 2.1e-78 266.78 In-house 5-260 (260) Show / Hide 
Range on Protein: 369-624
Range on HMM: 5-260/260
Sequence Identity: 39% (103 aa)

NELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVM-EMAELGPLNKYLQ----QNRHIKDK
 .|||| || |  | .    .   |||| ||  . ||    ..|.|| .|..|  | ....  .|  |  .... |. . | | .|||    . |... .
RRLGSGQFGEVWEGLWN---NTTPVAVKTLKPGTMDPN---DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQ

NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN-YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY
 ....  ||  || |||. |..||||||||||.  .   || |||| . |  |.   | ...  . |.|| ||| .|| ||. ||||||||.|. |   |
QLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITY

GQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRLRNYY
|. || || . ||  |...| || .|..|| ..|..|  ||  | ..|| |  .. .| .|.
GRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase SYK.AA Csk 364-620 41 2.7e-77 263.08 In-house 1-251 (251) Show / Hide 
Range on Protein: 364-620
Range on HMM: 1-251/251
Sequence Identity: 41% (110 aa)

LTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES--WMLVMEMAELGPLNKYL--QQNRH
|.| . . | |.|| |. | || .|    |||| .|...|  |  . .|||| || ||  |  |..||.   .     .|||    | |  ||      .
LHLGE-CIGHGEFGDVMQGEYQNRK----VAVKCIKCDGNGMA--QAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHV

IKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA-QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWE
|. .  .     |  || |||. .||||||||||.|.  .  ||.|||||.|    .|..     | || |.|| |||     |||.||||||||.|.||
ITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK----EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWE

AFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELRL
 .|.|  ||  .  ..| .  ||| ||  | ||| . | .|. ||  .  .|| |  |  .|
IYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase SYK.AA S_TKc 365-624 21 2.1e-46 161.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 365-624
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

TLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAEL--GPLNKYLQQNRH---
    ...|.| ||.|.|..       . ||.||.|         . .. | ..... . |.||....... ..  .|||...   | | .|......   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KSDVWSFGVL
   .    .  ...|.  ...|. . ...||||   |.|| .    ||.||||.. |          |.      . ||| .   ...  |.|.||.|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

MWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVEL-----RLRNYY
..| .. |. |..     .. .|..|          ..|. |... |...| |.||.   .       ..  . 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SYK.AA Pkinase 371-616 23 4.4e-36 128.68 Pfam 7-287 (293) Show / Hide 
Range on Protein: 371-616
Range on HMM: 7-287/293
Sequence Identity: 23% (68 aa)

LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA--EANVMQQLDNPYIVRMIGICEAESWML-VMEMAELG----PLNKYLQ--QNRHI-
.|||.||.|.|..   |.  |.|||||.| . ...  . ...   |. .|. |. |.|||.....| ....  ||| .| |     |  |..  ... . 
IGSGSFGCVYKCHH--KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

-KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA----KISDFGLSKALRADENYYKAQTHGKWPV---KWYAPECIN-YYKFSSKSDVWS
  .. ..  . |.  |..|. . ...||||   |.|.. . .     ||.||||.| ..     |  ..  ....    . ||| |. . . ..|.|.||
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGVLMWEAFSYGQKPYRGM----KGSEVTAMLEKGERMGCPAGCP-----------------------REMYDLMNLCWTYDVENRPGFTAV
.|....| .. |. |..|     .  .  .|...  .   .  .|                       .|. |... |...| . ||... .
CGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI