TBK1

Species: Mouse
Alias: Tbk1, TBK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: IKK

Sequence

Name Sequence Type Origin Length Description Download
TBK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 296 Kinase domain by global Sugen HMM Fasta, JSON
TBK1.AA Protein Sugen 729 None Fasta, JSON
TBK1.NA RNA Sugen 3031 None Fasta, JSON

Protein domain

Protein domains of TBK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TBK1.AA IKK 9-293 54 1.1e-186 626.55 In-house 1-297 (297) Show / Hide
Range on Protein: 9-293
Range on HMM: 1-297/297
Sequence Identity: 54% (162 aa)

WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHK-------NIVKLFAIEEE---TTTRHKVLIMEFCPCGSLYTVL
| ..|.|||||..||...||||||. .|||..|..|..|. .|..||||..|.|||.       ||..|..|||.   ......|..||.|..|.||..|
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPVIVMEYCTGGDLYKYL

EEPSNAYGLPE-SEFLIVLRDVVGGMNHLR-ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQK
..|.|..||.| .|||.|.||.. ||.||. .||||||||||||||...||||...||.||||.|||..|||.|.|.|||||||||||||||||||.|||
NSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQK

KYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCW
.|.||||.||.||||||.|||.|||.|...|||..|.|..|.|.||||...|||...|||..||...| .|.|.|.......|.....||..|..||
PYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW

Kinase TBK1.AA S_TKc 9-310 22 1e-52 182.38 SMART 1-231 (231) Show / Hide
Range on Protein: 9-310
Range on HMM: 1-231/231
Sequence Identity: 22% (70 aa)

WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPC--GSLYTVLEEPSNA--
. . ...|.|| . |...|||||| ..|.|. .        .  .|| ..||| .|.|||||. . ..    |  ..||.|.   |.|......      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-YGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGA-TV
 ...|| .   ... .. ..... ..||.|||.|| ||.         . |..||| ||.|       .. || .|. | .            .||   .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------GYGKCKC

DLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAET
| ||.|...|  ..|  ||.       . ..|.|.|                                   . ..   . ..|. | || ..  . ... 
DWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG---------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDE

SDVL-HRMV
.|.  |  .
WDIKCHPWF

Kinase TBK1.AA Pkinase 9-243 25 1.5e-45 162.15 Pfam 1-236 (293) Show / Hide
Range on Protein: 9-243
Range on HMM: 1-236/293
Sequence Identity: 25% (65 aa)

WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMR---EFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCG----SLYTVLE-E
. .  ..|.|. . |....||.||...|||...  .    .|.. |   | ...|.|||.|||.|. . |. .  .  ..||.|..|    .|..... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYISTW

PSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQS---VYKLTDFGAARE--LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ
 .... ..| |   ... .. |.... ..||.|||.|| ||.  | ..|.    | |..||| |.   .  .. . .. || .|. |   |   .|  ..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--IDNNGHIDACV-KICDFGLAKQFDY-NNS-MTTFCGTPWYMAP---EV--IR--GG

KKYGATVDLWSVGVTFYHAATGSLPFRPF---EGPRRNKEVMYKIITGKPS
..||  || ||.|...|  ..| .||.     .. .. ......|  ....
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLH

Kinase TBK1.AA CAMK 14-222 19 1.6e-45 144.21 In-house 1-335 (425) Show / Hide
Range on Protein: 14-222
Range on HMM: 1-335/425
Sequence Identity: 19% (67 aa)

ILGQGATANVFRGRHKKTG------------DLYAVKVFNN----------------ISFL---------RPVDVQ--MREFEVLKK-------LNHKNI
.||.|. . |....||.|.              .|.|. .                 |..          ||.| .  .|| |..||       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFAIEEE-----------TTTR-------HKVLIM---EFCPCG----SLYTVLEEPSN------------AYGLPESEFLIVLRDVVGGMNHLRENG
.||. . |            | ..       | ...|   |.|. |     |.  . | ..               ..|.|   . | .. ..... ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKPGNIMRVIGEDGQ-------------SVYKLTDFGAARELED------------------------DEQFVSLYGTEEYLH-PDMYER-----
|||||.|| ||. .  .|..                |..||| |.....                        .. .    || ||   | . ..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

----AVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFR
         . .. ||  .| ||.||  |   .| .||.
MQNAT---DEEKPYYGPKCDMWSCGVILYIMLCGYPPFY

Kinase TBK1.AA ULK 9-176 26 4e-38 130.69 In-house 1-214 (329) Show / Hide
Range on Protein: 9-176
Range on HMM: 1-214/329
Sequence Identity: 26% (56 aa)

WLLSDILGQGATANVFRGRHKKT----GDLYAVKV-----FNNISFLRP----VDVQMREFEVLKKLN----HKN----IVKLFAIEEETTTRHKVLIME
. |...||.|. . |..||.|||    . ..|.|.     .|... ...     .  ..| ...|||.    |||    ||||. . |...  .  .|||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCPCGSLYTVLE------EPS-NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGE---------DGQSVYKLTDFGAARELEDD----
.|. | | . ..      |.  .   |.|.| ...... . |. .|....|.|||||| ||.   |            . |.|..||| |. ...|    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ

EQFVSLY------GT
.....        ||
QMMMTCVNEKRLCGT

Kinase TBK1.AA STE 9-224 21 4.4e-38 132.1 In-house 1-274 (359) Show / Hide
Range on Protein: 9-224
Range on HMM: 1-274/359
Sequence Identity: 21% (62 aa)

WLLSDILGQGATANVFRGRHKK---------------TGDLYAVKVFN----------------NISFLRPVDVQMREFEVLKKLN--HKNIVKLFAIEE
| . ...|.||.  |......|               ||...|.|. |                ....   ..  ..| ...||.|  |.|||| .  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ETTTR-----HKVLIMEFCPCGSLYTVLEEPSNAYG-----------LPESEFLIVLRDVVGG-MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF
   .      .  ..||... |||  ....     .           .|||.  ...|... | ...| ...|.||||||.||.           ||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF

GAARELED-----------------DEQFVSLYGTEEYLHPDMYER---AVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF---RPF
| .  |.|                 ...  .. ||  .  | . ..   .       |.|.. .| ||.| |  . |||  |.    |.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM

Kinase TBK1.AA ULK 9-176 25 5.5e-38 132.39 In-house 1-210 (324) Show / Hide
Range on Protein: 9-176
Range on HMM: 1-210/324
Sequence Identity: 25% (53 aa)

WLLSDILGQGATA-NVFRGRHKKT---GDLYAVKVFN-----NISFLRP----VDVQMREFEVLKKLN---HKN--IVKLFAIEEETTTRHKVLIMEFCP
. |...||.|. .  |..||.|||   . ..|.|. .     ... ...     . ...| ...|||.   |.|  ||||. . |...  .  .|||.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

CGSLYTVLE------EPS-NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGE---------DGQSVYKLTDFGAARELEDD----EQF
.| | . ..      |   .   |.|.| ...... . |. .|....|.|||||| ||.   |            . |.|..||| |. ....     ..
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMC

VSLY------GT
 ..       ||
QTCVNEKRIKGT

Kinase TBK1.AA CAMKL 9-222 26 2e-36 113.63 In-house 1-237 (297) Show / Hide
Range on Protein: 9-222
Range on HMM: 1-237/297
Sequence Identity: 26% (65 aa)

WLLSDILGQGATANVFRGRH-KKTGDLYAVKVFN-NISFLRPVDVQM-------------REFEVLKKLN---HKNIVKLFAIEEETTT----RHKVLIM
. . . ||.|. . |  ..| . ||  .|.|. . .   ..|.  ..             || . .|.||   |.||.||. . |  ..     . .|.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCPCGS--LYTVLEEPSNAY-GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED-----DEQFVSLYGTEE
| |. |.  |.  ...  .    .||.|     | .| ..|.. ..||||||||| ||.  . |.| .. |..||| . . ..     .. .    |. .
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENIL--LDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFR
|  | .....     ... .|  || || ||. |   .| |||.
YMAPEIFQGN-----NKPYDGPKVDIWSCGVILYAMVCGYLPFD

Kinase TBK1.AA Ciliate-E2 9-242 20 2.9e-33 111.54 In-house 1-304 (365) Show / Hide
Range on Protein: 9-242
Range on HMM: 1-304/365
Sequence Identity: 20% (66 aa)

WLLSDILGQGATANVFRGRHKKTGD-----------------------LYAVKVF--NNISFLRPVDVQMREFE----------VLKKLNHKNIVKLFAI
  .  ..|||. . |......|..                        .||.|..  |.| ..  .. .||| .          .|..|||.||.|..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

EEETTTRHKVLIMEFCPCGSLYTVLE---EPSNAY-----GLPESEFL-IVLRDVVG--------------GMNHLRENG-IVHRDIKPGNIMRVIGEDG
 .|... .  |.||.|  |.|.  ..     .|        . | | . |    . |              ....| ... |.|||||| ||.       
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

QSVYKLTDFGAARELEDD--------------------------------EQFVSLYGTEEYLHPDMYE-RAVLRKDHQKKYGATVDLWSVGVTFYHAAT
    |..||| .... ||                                ..| ...|| .|. | ...         || |.  .|.||.||..|   .
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GSLPFRPFEGPRRNKEVMYKIITGKP
| .||             ...|  ..
GKPPF-------------QQQIKQCK

Kinase TBK1.AA CAMK-Unique 9-221 18 7.1e-30 95.65 In-house 1-293 (363) Show / Hide
Range on Protein: 9-221
Range on HMM: 1-293/363
Sequence Identity: 18% (55 aa)

WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ-------------------MREFEVLKKLNHKNIVKLFAI-----EEET-------
. .  |.|.|.   |...  ..||...|.|....    . . .|                   .|| ...|...| ||.||. .     . ..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--TTR---HKVLIMEFCPCGSLYTVLEEPSN-----------------AYGLPE--SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDG----
  | |   . ...||.|..| |. .. . .                     . |  .. . . . ..   ... ...|||||.|. |||    ..     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------QSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHP---------DMYERAVLRKDHQKKYGATV----DLWSVGVTFYHAATGSLPF
        ..  ||.||| .....  .      .  ||..|. |         .|   .|.    . .|.  .    |.|| ||. |  ..|..||
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN---MQCYDQQCSPASDIWSLGVIMYYMLCGCPPF

Kinase TBK1.AA TKL 15-222 16 7.2e-27 93.79 In-house 1-290 (364) Show / Hide
Range on Protein: 15-222
Range on HMM: 1-290/364
Sequence Identity: 16% (51 aa)

LGQGATANVFRGRHKK--------TGDLYAVKVFNNIS-FLRPV-----------------------DVQMREFEVLKKLN--HKNIVKLFAIEEETTTR
.|.|. . |..|...         ||   |||.|.  .  ..                           . .|.|.. ...  | |||.. ..  . . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------HKVLIMEFCPCGS-LYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG--------IVHRDIKPGNIMRVIGEDGQSV--------
           .  ..||.||.|| |....           . ..   .|.  |||.|  ..        |.|||.|. ||.  . |... |        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNIL--VDENWTNVSNYMYNPN

----YKLTDFGAARELEDDE--------------------QFVSLYGTEEYLHPDMYERAVLRKD--------HQKKYGATVDLWSVGVTFYHAATGSLP
     |..||| .|... ..                    .  .  ||  .. | . . .   ..        ....|   .| .| |. ..  .|. .|
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

FR
..
YY

Kinase TBK1.AA RSK 11-244 28 6.4e-26 91.92 In-house 1-236 (278) Show / Hide
Range on Protein: 11-244
Range on HMM: 1-236/278
Sequence Identity: 28% (71 aa)

LSDI--LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRP---VDVQMREFEVLKKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA
|..   .|.|.   . . .|..|| .||.|| .   . .    .   |.| ..|.  . |..||.|.  .   |  .  ||||.|. | |.| |..    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLH--YAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

YGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE--LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK-YGAT
  . |.|  .... .|  . || . ||.|||.|| ||.    . ..   |||||| ...  ... ..  .  .| ||. | |  ||    . |.. ... 
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRA----N-QQGGHDKA

VDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK--PSG
.|.|| ||  |   || .||.  ..    ||.| .| .||  ...
CDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTM

Kinase TBK1.AA TyrKc 9-326 17 1e-11 -33.35 SMART 1-280 (280) Show / Hide
Range on Protein: 9-326
Range on HMM: 1-280/280
Sequence Identity: 17% (63 aa)

WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKL--NHKNIVKLFAIEEET-----TTRHKVLIMEFCPCGSLYTVLEEP
  | ..|| ||   |..|. |      |||. .. .    .   ||| ....||  .|.|||.|...  .            ..||..| |.|   | ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-------EQFVSLY--GTE----------EYLHP
 .   |. ...|    ..  ||..| .....|||.   |..  .||..  . | .||| .|...||       .  ..    |.           | .  
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL--VGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

DMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGP----RRNKEVMYKIITG----KPSG----AISGVQKAENGPIDWSGDMPLSCSLS
             .|.    | || ||. .   |  .   | .|.      |.||. .. .|    .|      .                         
-----------NYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------

QGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSL-----QHMTAHKIYI
                           |  . .| ....              ... . ..
---------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase TBK1.AA Pkinase_Tyr 53-136 27 5e-10 34.58 Pfam 51-137 (270) Show / Hide
Range on Protein: 53-136
Range on HMM: 51-137/270
Sequence Identity: 27% (24 aa)

MREFEVLKKL-NHKNIVKLFAIEEETTTR-HKVLIMEFCPCGSLYTVLEEP-SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDI
||| ...|.| .|.|||.| ..  .     .  ..||..|.|.|.. | .. ..   |. .. |   ...  ||..| .....|||.
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase TBK1.AA ULK 193-222 36 1e-06 19.12 In-house 225-257 (329) Show / Hide
Range on Protein: 193-222
Range on HMM: 225-257/329
Sequence Identity: 36% (12 aa)

DH--QKKYG-ATVDLWSVGVTFYHAATGSLPFR
..  ||.|. ...|.||.|. ||   .|  ||.
GQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY

Kinase TBK1.AA ULK 193-222 36 2e-06 18.63 In-house 221-253 (324) Show / Hide
Range on Protein: 193-222
Range on HMM: 221-253/324
Sequence Identity: 36% (12 aa)

DH--QKKYG-ATVDLWSVGVTFYHAATGSLPFR
..  ||.|. . .|.||.|. ||   .|. ||.
GQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFF