Gene TIE1 (Mouse)

TIE1

Species: Mouse
Alias: TIE1, Tie1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Tie

Sequence

Name Sequence Type Origin Length Description Download
TIE1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
TIE1.NA RNA Sugen 4091 None Fasta, JSON
TIE1.AA Protein Sugen 1134 None Fasta, JSON

Protein domain

Protein domains of TIE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG TIE1.AA IG 129-211 19 0.000428 20.85 SMART 1-58 (58) Show / Hide 
Range on Protein: 129-211
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

KVTHTVNKGDTAVLSAHVHKEKQTDVIWKNNGSYFNTLDWQEADDGRFQLQLQNVQPPSS---GIYSATYLEASPLGSA--FFRLIVR
   .||. |.|..|.  |.      . |.                    |.. ||||  |   |.|  .    .  ...  ...|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
EGF TIE1.AA EGF 221-254 40 5e-06 27.38 SMART 1-32 (32) Show / Hide 
Range on Protein: 221-254
Range on HMM: 1-32/32
Sequence Identity: 40% (16 aa)

GCVKDCPGCLHG-----GVCHDHDGECVCP-PGFTGTRCE
 |     .| ||     |.|.    .| || ||.|| |||
ECA----PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE
EGF_CA TIE1.AA EGF_CA 225-254 40 0.000179 10.76 SMART 4-34 (34) Show / Hide 
Range on Protein: 225-254
Range on HMM: 4-34/34
Sequence Identity: 40% (14 aa)

DCPGCLHGG---VCHDHDG--ECVCPPGFTGTRCE
.|  | .||   .|.. .|  .| ||||.| ..||
EC-PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF TIE1.AA EGF 222-252 38 0.000383 16.91 Pfam 1-36 (36) Show / Hide 
Range on Protein: 222-252
Range on HMM: 1-36/36
Sequence Identity: 38% (14 aa)

CVKDCPGCLHGGVCHDH--DGECVCPPG---FTGTR
| ..  .|.|.| |.|   . .| ||||   .|| |
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_2 TIE1.AA EGF_2 222-253 35 0.005695 12.78 Pfam 1-29 (29) Show / Hide 
Range on Protein: 222-253
Range on HMM: 1-29/29
Sequence Identity: 35% (12 aa)

CVKDCPGCLHGGVCHDH-DGECVCPPG-FTGTRC
|   | |  |.|.| .  .| |.|..| ..|  |
C---CNG--HHGTCNNQGCGKCQCDDGWWQGDHC
EGF TIE1.AA EGF 265-301 20 0.224698 4.7 SMART 1-32 (32) Show / Hide 
Range on Protein: 265-301
Range on HMM: 1-32/32
Sequence Identity: 20% (9 aa)

SCQEQCPGT-----AGCRGLTFCLPDPYGCSCG-SGWRGSQCQ
 |.  |        . |.         | | |   |..| .|.
ECA-PCHHGGCEQHGTCI--------SYTC-CPGPGYTG-RCE
EGF_2 TIE1.AA EGF_2 270-300 30 32.223939 1.04 Pfam 1-29 (29) Show / Hide 
Range on Protein: 270-300
Range on HMM: 1-29/29
Sequence Identity: 30% (11 aa)

CPGTAGCRG-LTFCLPDPYG---CSCGSG-WRGSQC
|     | |   .|  .  |   |.| .| | | .|
C-----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC
EGF_2 TIE1.AA EGF_2 317-342 41 3e-09 32.4 Pfam 1-29 (29) Show / Hide 
Range on Protein: 317-342
Range on HMM: 1-29/29
Sequence Identity: 41% (13 aa)

CQCQN-GGTCDRFSG---CVCPSG-WHGVHC
| |.. .|||... |   |.|..| |.| ||
C-CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC
EGF TIE1.AA EGF 312-343 34 0.025736 14.94 SMART 1-32 (32) Show / Hide 
Range on Protein: 312-343
Range on HMM: 1-32/32
Sequence Identity: 34% (13 aa)

DCRLQCQCQNG-----GTCDRFSGCVCP-SGWHGVHCE
.|     |..|     |||     | ||  |..| .||
ECA---PCHHGGCEQHGTCI-SYTC-CPGPGYTG-RCE
EGF TIE1.AA EGF 313-341 27 1.4376 4.97 Pfam 1-36 (36) Show / Hide 
Range on Protein: 313-341
Range on HMM: 1-36/36
Sequence Identity: 27% (10 aa)

CRLQ-CQCQNGGTCDRFS---GCVCPSG---WHGVH
|  .   |...||| .      | || |   ..| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_2 TIE1.AA EGF_2 304-313 36 4.017313 3.87 Pfam 19-29 (29) Show / Hide 
Range on Protein: 304-313
Range on HMM: 19-29/29
Sequence Identity: 36% (4 aa)

CAPG-HFGADC
| .| ..|..|
CDDGWWQGDHC
IG TIE1.AA IG 355-442 10 0.005076 17.17 SMART 1-58 (58) Show / Hide 
Range on Protein: 355-442
Range on HMM: 1-58/58
Sequence Identity: 10% (10 aa)

ATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRKPDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDS---GFWECRVSTSGGQDSR--RFKVNVK
   |. . |   ...| ..        .....                      ... .... ||   |   |...  .||..    ... |.
PP-VTVKEGETVTLTC-VS--------QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
FN3 TIE1.AA FN3 445-528 18 0.000148 22.38 SMART 1-69 (69) Show / Hide 
Range on Protein: 445-528
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

PVPLTA---PRLLAKQSR------QLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSENVTLMNLKPK----TGYNVRVQLSRPGEGGEG
| | .    .|. .  |.      ....|              ...||                  .|. .|||     | |..||.    ...|||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 TIE1.AA FN3 544-627 14 0.015829 12.91 SMART 1-69 (69) Show / Hide 
Range on Protein: 544-627
Range on HMM: 1-69/69
Sequence Identity: 14% (14 aa)

LLQPWL---ESWHVEGPD------RLRVSWSLPSVPLSGDGFLLRLWDGARGQERRENISFPQARTALLTGLTPG----THYQLDVRLYHCTLLGPA
   |      ...  ...       ...||. |          .. .                   . .|||.||    | |.  || .  .  |. 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP---------IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 TIE1.AA FN3 640-722 20 3.6e-12 47.67 SMART 1-69 (69) Show / Hide 
Range on Protein: 640-722
Range on HMM: 1-69/69
Sequence Identity: 20% (20 aa)

PPAPRH---LHAQALSDS------EIQLMWQHPEAPSGPISKYIVEIQVAGGSGDPQWMDVDRPEETSIIVRGLNAS----TRYLFRVRASV---QGLG
|..|..   |.. . ...       ..| |..|      |  |.                         .|.|| .     |.| |||||     .| |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase TIE1.AA Tie 843-1103 86 3e-229 705.96 In-house 1-267 (267) Show / Hide 
Range on Protein: 843-1103
Range on HMM: 1-267/267
Sequence Identity: 86% (230 aa)

EGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHG
|||||||..||||||||||..||||.||||||.|||||.|||||.||.|||||||||.||||.|||||.|||||||||||||||||||.||||||||||.
EGNFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREHT

T------ASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFG
|      ||||||.|.|.||.|.|.||||||.||.|||||||||.||.||...||||||||||.||||||||||||||||||||||||||||||||||.|
TRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYG

VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
|||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||.||
VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
TyrKc TIE1.AA TyrKc 835-1103 41 1.6e-136 460.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-280/280
Sequence Identity: 41% (127 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLG-HHPNIINLLGACENR-------GYLYIAIEYAPYGNLLDFLR
||... .|||.||.| ... |     .. |.|||||.|    ..||  |....|||| |||||..|.|.|          . |.|  ||.|.|.|.|.||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVY--------VKKT----MGR--LP
|.|                 |. ..|| |. ..|.||.||..|..|||||||||.|||||.  ||.||||||  . .        ....     |.  ||
KHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCG-----MTCAELYEKLPQGYRMEQPRN--------CDDEVYELMRQCWRDRPYERPPFAQI
.||||.|..||...|||||||||||..||| ..|..|| |     |. .|..|.. |||||.|| |        | ||.|..|.|||.  | .|| |..|
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

ALQL
  ..
HECF
Pkinase_Tyr TIE1.AA Pkinase_Tyr 835-1103 46 3e-135 458.68 Pfam 1-270 (270) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-270/270
Sequence Identity: 46% (130 aa)

ITFEDLIGEGNFGQVIRAMIK--KDGLKMNAAIKMLKEYASEND--HRDFAGELEVLCKLGHHPNIINLLGACE-NRGY--LYIAIEYAPYGNLLDFLRK
|||   .|||.||.| ..  |  .|. |.  |.|||||.|.. .  ..||  |......|||||||..|.|.|   ..   .||  ||.|.|.|||.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

SRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVY-VKKTMGRLPVRWMAIESLNY
 |                 |.  .|| .. . |.||.||..|..|||||||||.||.||.  ||.||||.|     . | .|.. |.||..||| |..||
HR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY

SVYTTKSDVWSFGVLLWEIVSLGGTP-YCGMTCAELYEKL-PQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
...||||||||||||.|||...|..| | ||. .|.||..  .||||..|.|| ||.|.||.|||.  | .|| |..|  ||
GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TIE1.AA TK 835-1103 26 1.6e-117 395.73 In-house 1-486 (486) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-486/486
Sequence Identity: 26% (130 aa)

ITFEDLIGEGNFG---QVIRAMIK-----------------------KDGLKMNAAIKMLKEY--ASENDHRD--------------FAGELEVLCK-LG
||... .|||.||   .| ... .                       |.| |.  |.|||||   .|.....|              .| |....|  ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNIINLLGACENR------------GYLYIAIEYAPYGN----LLDFLRKSRVLETDPAFAREH----------------------------------
|||||..|.|.|               . ..|  ||.|.|.    |.|.|||.|  .....   ..                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------GTASTLSSRQLLR-------------------FASDAANGMQYLSEK------QFIHRDLAARNVLVGENLA-----------SKIADFGLSR-
         ..|. ..||.                   .. ..|.||.||..|      .|.||||||||.|||||.             ||||||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----------GEEVYVKKT------------------------MGRLPVRWMAIESLN---------YSVYTTKSDVWSFGVLLWEIVSLG-GTPYCGMT
           .. |..|.                         |.||.|||| |.||         | ..||||||||||||.|||...| ...| ||.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

---------CAELYEKLPQG--------------YRMEQPRNCD--------------DEVYELMRQCWRDRPYERPPFAQIALQL
         ..|..|.| .|              .||.|| .|               .|.|.||.|||.  | .|| |.|.  ||
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TIE1.AA TK-Unique 835-1103 41 3.6e-115 388.9 In-house 1-294 (294) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-294/294
Sequence Identity: 41% (123 aa)

ITFEDLIGEGNFGQVIRAMIKK----DGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRG-YLYIAIEYAPYGNLLDFLRKSR
....|.||||.||||.|.....    .. . ..|.||||..|.. |..||  |.... .|| ||||...||.|   .   .|..||.|.|||...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-V---------LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSE--KQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKK-TMGRLPV
 .         |  |.. ...    ...|...|..|| . |.||.||..  |...||||.|||||..|..  ||.|||..|    ..||... . ||.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAIESLN--YSVY-TTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNC-DDEVYELMRQCWRDRPYERPPFAQIALQL
|||| |||   . .| ||||||||||||.|||..||..|| ||  ... |....||||.|| .|  .|.|.||..||.. | ||| |.||. .|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TIE1.AA FGFR 835-1103 42 4.1e-111 375.46 In-house 1-293 (293) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-293/293
Sequence Identity: 42% (125 aa)

ITFEDLIGEGNFGQVIRAMIK---KD--GLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSR
 |    .||| ||||..|  |   .|    ..  |.||||. ... |  |   |.|..   | |.|||||||.|   | ||. .||.. ||| ||||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

VLETDPAFARE-------HGTAST--------LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRL
  . |  .  .       . .. .        |....| ..|   | ||.||  .  ||||||||||||...   ||.||||.|.    . | |.| |||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMT-CAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
|. ||| |.|   |||..|||||.|||||||  .||.|| .     |||. |  |.||| | ||  |.| .|.|||.  | .||.|.|.  .|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TIE1.AA Src 835-1103 39 6.3e-91 308.39 In-house 1-255 (255) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-255/255
Sequence Identity: 39% (107 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETD
|.... .|.|.|| |  .. ..   ... |.| ||.     .  .|  | ... ||  |.....|.  |      ||  ||   |.|||.|.|       
IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-------

PAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE----VYVKKTMGRLPVRWMAIESLNYSVYTTKS
       |. ..|. .||. .|   |.||.||.....|||||||||||||||.. |.||||| |  .    .|. ..  ..|..|.| | .|| ..|.||
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYE-LMRQCWRDRPYERPPFAQIALQL
||||||.||.|||. | .|| ||| .|  ... .|||| .|.|| ||.|| .|.|||. .| .|| |. .   |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TIE1.AA UTK 835-1103 33 7.4e-91 308.15 In-house 1-296 (296) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-296/296
Sequence Identity: 33% (102 aa)

ITFEDLIGEGNFGQVIRAMIKKDG---LKMNAAIKMLK-EYASENDHR---DFAGELE---VLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDF
. . ...|.|.||.| .|. ...    ..|  |.| .. . ... ...   ||  |     .. .. .|||...|.| | . . ..|..||.. |.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRKSRV-LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGEN-------LASKIADFG---LSRGEE------------
||..|  ..         .    |...|.| .|.| |.|||||....|.||||||||.||...       .  ||||||   .||.              
LRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESY

VYVKKTMGRLPVRWMAIESLNYS-VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQG--YRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQ
 | .   .|.|.|||| |.|..   .|||||||||||..|||.. | .|| ||. ... . .  |  |||..|. | ..||.||..||.  | ||| | .
YYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

IALQL
.  |.
LVQQM
Kinase TIE1.AA RTKB 835-1103 36 2.7e-84 284.08 In-house 1-264 (264) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-264/264
Sequence Identity: 36% (101 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLE
.      |.| ||.| .| ..  .       | | ||  ||. .. ||  |. |.  || |||.| ..| |     . . .|.. .||| |.||..|  .
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

TDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR-GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKS-
 .|          .|...||. |. . |.|| .|. .. |||||.||||||. .|. ||.|||..|  ..  ...|  |||..|||.||. .. ||||| 
HNPQ---------SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSG

DVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
|||||||  ||| |||||||     ... . |  |.|...||    .....|..||   . .|| |. ..  .
DVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase TIE1.AA Ret 962-1105 55 4e-72 245.65 In-house 147-293 (293) Show / Hide 
Range on Protein: 962-1105
Range on HMM: 147-293/293
Sequence Identity: 55% (81 aa)

GMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
||.||||   .||||||||||| | .  || ||||.|    .  |||.  .|.|| |||||||   ||||||||||||||.|||| .|. || | .   |
GMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERL

YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGR
.. |  ||||. | ||  |.| .|||||.. |  || |. |.  . .
WQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase TIE1.AA VEGFR 960-1103 50 1.1e-67 231.16 In-house 183-332 (332) Show / Hide 
Range on Protein: 960-1103
Range on HMM: 183-332/332
Sequence Identity: 50% (76 aa)

ANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG----EEVYVKKTM-GRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMT
|.|| .|...  |||||||||.|. ||   || ||||.|        ||.|.  |||| .|||.||.   ||||.|||||.||.|||| |||| || |  
ARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQ

-CAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
   |.. .|  ||||. |  |  |.|. | .||.  | ||| |.  .  |
IDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase TIE1.AA PDGFR 952-1103 50 5.1e-64 204.3 In-house 203-358 (358) Show / Hide 
Range on Protein: 952-1103
Range on HMM: 203-358/358
Sequence Identity: 50% (79 aa)

LLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGT
|| |..  |.|| .|  |  .||||||||||. .    || |||| |       || |   |||| ||| ||.  .||||.|||||.|.||||| ||||.
LLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLGGN

PYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
|| ||   .. | .  .||||.||    .|.|| |..||   |  ||.| |. . |
PYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase TIE1.AA Pkinase 835-1103 21 1.2e-38 137.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 835-1103
Range on HMM: 1-293/293
Sequence Identity: 21% (66 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAG-----ELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYG----NLLDFL
....  ||.|.||.| ... |..|     |.| .|    ....          |.... .| .||||. |....|.....|.  ||.. |     | |..
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLAS----KIADFGLSRG--EEVYVKKTMGRLPVRWMAIE
.            ..||. . .| ... ...   . |..|. .. .|||||   |.|. .|       ||.||||..   .  ..  |      ..|| |
ST-----------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE

SLN-YSVYTTKSDVWSFGVLLWEIVSLGGTPYCGM----TCAELYEKLPQGYRMEQPRNCD-----------------------DEVYELMRQCWRDRPY
 .. .. |..|.|.||.|..|.| .. | .|..|     . .. .... .  . . .....                       .|  .... |..  |.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

ERPPFAQIALQ--L
.|| ..||     .
KRPTAEQILQHPWF
Kinase TIE1.AA S_TKc 835-1106 23 1.3e-38 135.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 835-1106
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPY--GNLLDFLRKSRVLE
 .. ..||.| ||.| ..  ||   .   |||..|        ...  |...| |  |||||..|...... ..||.  ||..   |.|.|...| .   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTT-KSD
..          . ..  .  ...   .....|. ....|||||   |.|. |    ||.||||.|        |       .|| | |    |.. |.|
LR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCD

VWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL------QLGRM
.||.|..|.| .. | .|..  . .....|.            ..|. ...|.|..  | .||   ..        .   .
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TIE1.AA PDGFR 835-929 39 4.6e-22 67.31 In-house 1-98 (358) Show / Hide 
Range on Protein: 835-929
Range on HMM: 1-98/358
Sequence Identity: 39% (39 aa)

ITFEDLIGEGNFGQVIRAM---IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSR
  |    | | ||.|. |    . | .  |  |.||||. |          || ..  ||.| ||.||||||   |  ||  ||  || ||..|.. |
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR
Kinase TIE1.AA Ret 835-929 34 8.3e-21 67.76 In-house 1-100 (293) Show / Hide 
Range on Protein: 835-929
Range on HMM: 1-100/293
Sequence Identity: 34% (36 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNA-----AIKMLKEY-ASENDHRDFAGELEVLCKLGHHPNIINLLGACENRG--YLYIAIEYAPYGNLLDFLR
  ..|  ||| ||||..|   .  ..  .     |.||||.  |.    .|   |...| |.  ||..| |.|||   .   . . .||. || |  |||
LQLDDTLGEGHFGQVVKAQAFH--IRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLL-KQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

KSR
 ||
LSR
Kinase TIE1.AA VEGFR 841-929 39 3.3e-18 65.41 In-house 7-101 (332) Show / Hide 
Range on Protein: 841-929
Range on HMM: 7-101/332
Sequence Identity: 39% (38 aa)

IGEGNFGQVIRAM---IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACE----NRGYLYIAIEYAPYGNLLDFLRKSR
.|.| ||||. |    |.|       | ||||| |    ||    ||..|  .||| |  |.||.|     .. .. | .|| ..|||...||  |
LGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVI-VEYCCFGNLSNYLRTKR