akt-1

Species: Nematode worm
Alias: C12D8.10b, akt-1, C12D8.10a, C12D8.10B, CE05274, aSWK001
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 10251493-10255483, WormBase Genetic Map location: V:2.42539,

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
akt-1.AA Protein Genbank 541 None Fasta, JSON
akt-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of akt-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH akt-1.AA PH 16-118 30 4.3e-21 78.69 Pfam 1-92 (92) Show / Hide
Range on Protein: 16-118
Range on HMM: 1-92/92
Sequence Identity: 30% (31 aa)

VVIEGWLHKKGEHIRNWRPRYFMIFNDGALLGFRAKPKEGQPFPEPLNDFMIKDAATMLFEKPRPNMFMVRCLQWTTVIERTFYAESAEVRQRWIHAIES
|..||||||||  ...|..|.|..|| . |. .. .. .   .  ||.|  .... .     .||..| .|. ..    . .|.|||.| ...|..||.|
VIKEGWLHKKG-KRKSWKKRWFVLFN-NCLYYYKDDK-YRPKGSIPLSDCQVTKVPDN----KRPHCFQIRT-DR---RTYYFQAESEEEMNDWMQAIQS

ISK
...
ACR

PH akt-1.AA PH 16-120 24 3.5e-17 64.31 SMART 1-82 (82) Show / Hide
Range on Protein: 16-120
Range on HMM: 1-82/82
Sequence Identity: 24% (26 aa)

VVIEGWLHKKGEHIRNWRPRYFMIFNDGALLGFRAKPKEGQPFPEPLNDFMIKDAATMLFEKPRPNMFMVRCLQWTTVIERTFYAESAEVRQRWIHAIES
|..||||.||.    .|..|.|..|| . |. .. |       . ||.|  ... .          .| ... ..    . .|..||.| .|.|..||..
VIKEGWLYKKS--K-RWKKRWFVLFN-DCLYYYKDK---KPKGSIPLSDCTVRE-P----------CFEIHH-DR----TYYFQCESEEEMQEWMQAIQK

ISKKY
 ....
AIHNN

Kinase akt-1.AA Akt 193-450 58 1.5e-202 653.42 In-house 1-264 (264) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-264/264
Sequence Identity: 58% (155 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLY-AIKILKKDVIIAREEVAHTLTENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEP
||||||||||.||||.|.|.| |||.| |.|.||||.||.. .|.||.||...||.|.|||.. |.|||| |..|.|||...||||||.| .....|||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RARFYGAEIVLALGYLHRCDIVYRD-MKLENLLLDKDGHIKIADFGLCKEE-ISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWG-VGVVMYEMMCGR
|||||.|||.||...|| ..|.||| .|.||.|.||||||...|||||||. |. .||| ||||||||||||.|........||||| .|.|||||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

LPFYSKDHNKLFELIMAGDLRFP--SKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFF
.|||..|| ..|..|. ....||  ...|.|...|..||| |||..||||||.|| ||.|  .|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF

Kinase akt-1.AA AGC 193-450 35 3.3e-190 497.28 In-house 1-395 (395) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-395/395
Sequence Identity: 35% (142 aa)

FDFLKVLGKGTFGKVILCKEK------RTQKLYAIKILKKDV-IIARE--EVAHTLTE------------NRVLQRCK----------HPFLTE-LKYSF
|.||||.|||.||||.|...|       |.|.||.|.|||.. |. ..  .|.||.||             ..|..|.          |||..  |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QEQHY--LCFVMQ----FAN-----GG-ELFTHVR---KCGTFSEPRARFYGAE-------IVLALGYLHR-CDIVYRD-MKLENLLLDKDGHIKIADFG
| . .  |.|||.    ..|     || |||.| .   |.|.|.|.||||| ||       ||||| |||.  .|..|| .|.||.|||.|||||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEEISFG--------------------------------------------------DKTSTFCG--TPEYLAPEVLDDHDYGRCVDWWG--VGVVMY
|||| .. |                                                  |.|.||||  ||||.|||.|    ||. .|||.  .|..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMCGRLPFYSK----------DHNKLFELIMAG------DLRFP----------SKLSQEARTLLTGLLVKDPTQRLGGGPED-----ALEICRADFF
||..|. |||..          .....|..|| |      ...||          ...|.||. |...||.|||..||| |..|     | || .  .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase akt-1.AA SGK 193-450 47 6.2e-148 460.22 In-house 1-283 (283) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-283/283
Sequence Identity: 47% (134 aa)

FDFLKVLGKGTFGKVILCKEKRT------------------QKLYAIKILKKDVII-------AREEVAHTLTEN-RVLQRCKHPFLTELKYSFQEQHYL
||||||.||| |||| . | | .                  .|.||.|.|.|. ||       ...|. |...|   .|.  ||||.  |.|.|| . .|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMQFANGGELFTHVRKCGTFSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDH
 ||| ..||||.| | .. . |.|.||||| ||||.||.|||  ||.||| | ||.||| .||... |||||||.|   |.|.||||||||||||||  .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

DYGRCVDWWGVGVVMYEMMCGRLPFYSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFF
 ..| ||||  | |.|||| |  ||||.... ... |. ..|..|   | .|. |..||| |||..|||   .|..|| .  ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF

Kinase akt-1.AA PKC 193-450 52 5.1e-131 427.01 In-house 1-262 (262) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-262/262
Sequence Identity: 52% (138 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRC-KHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEP
|.|||||||| ||||.| . |.|...||||.|||||||  . |  |.|| |||    ||||||.|  .|| . .| ||| . ||| |  |. ... |.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRLPF
.||||.|||..|| .||. .|.||| ||.| |||..|||||||||.|||..  ||.||||||||.|.|||.|   .||  ||||  || |||||.|. ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPED---ALEICRADFF
  .|   ||. ||  . ..|  ||.||  ...|.. |.|..||| .|..   . .| .  ||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF

Kinase akt-1.AA RSK 196-450 43 3.1e-117 395.78 In-house 1-278 (278) Show / Hide
Range on Protein: 196-450
Range on HMM: 1-278/278
Sequence Identity: 43% (121 aa)

LKVLGKGTFGKVILCKEK---RTQKLYAIKILKKDVIIAREE-VAHTLTENRVLQRCK-HPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGT---
|||||.| .||| ||...    |...|| |.||| .|..|.  ..||.|| ..|.||. |||. .|.|.||.. .|  .|.. .||||||| .| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDK---DGHIKIADFGLCKE-EISFGDKTSTFCGTPEYLAPEVLD----DHDYGRCVDWWGVGV
||| .|.|| ||||||. .||  .|..|| |.|| |.|    .||||. |||.||.  .... .| |||.| ||.|||.|     .  ... .|||  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VMYEMMCGRLPFYS---KDHNKLFELIMAGD--LRFP--SKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFF
.||||  |..||..   ........ |. |.  |..|  ..|||||. |....| .|| .|||.||.|| || .  .|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase akt-1.AA PKA 193-450 42 1.4e-113 383.61 In-house 1-263 (263) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-263/263
Sequence Identity: 42% (114 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRCKHPFLT-ELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEP
|.....||.|.||.| ||..| . . ||.|.|||. |. .  | |...|...|| .||||.  .....||   || .|| ...|||.|.. || | ||.|
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RARFYGA-EIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDH-DYGRCVDWWGVGVVMYEMMCGRL
 |.|| | .||||| ||| ..|.||| | ||.|.||.|||||.|||  |.  .    |.| ||||||||||..  .  .|. ||||  |.. |||. |  
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYSK--DHNKLFELIMAGDLRFPSKLSQEA---RTLLTGLLVKDPTQRLGGGPEDALEICRADFF
||| .  | ....| | .|...||. ... |   . |.  ||..|.|.|.|   ...  | .  .|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF

Kinase akt-1.AA AktR 193-450 44 1.1e-111 377.37 In-house 1-268 (268) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-268/268
Sequence Identity: 44% (120 aa)

FDFLKVLGKGTFGKVILCKEK-RTQKLYAIKILKKDVIIAREEVAHTLTENRVLQ-RCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSE
|...|.||||.||||.|...|  .||.||.|..||  || |.   ||.||  ...  |.|||.  |.|.|| . .| |.|..  |||||.| .|...|||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PRARFYGAEIVLALGYLHRC-DIVYRDMKLENLLLDKDGHIKIADFGLCK-EEIS-FGDKTSTFCGTPEYLAPEVLDD-HDYGRCVDWWGVGVVMYEMMC
 .|||| |.|.||| |||   .|.|||.| ||.|||.|||.||.|||| | . .    .|. .|||||||.|||..     ... |||| .|.. |||. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRLPFYSKDHNKLFELIMAGD---LRFPSKLSQEARTLLT-GLLVKDPTQRLGGGPEDALEICRADFF
|  |||.|..| .|..|   .     .||..|.... |.. .|| |.|..||| . ... || .  .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF

Kinase akt-1.AA Eta 193-450 50 1.6e-111 376.8 In-house 1-261 (261) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-261/261
Sequence Identity: 50% (131 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRC-KHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEP
|.|.|||||| ||||.| . | |. .||||.|||||||  ..|  |.|| |.|    ||||||.|  .|| .  | ||| . |||.|  .. .   | ||
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRLPF
||||| ||...|| .||. ...|||.||.|.|||..|| |.||||.||| |  |  |.||||||.|.|||.| . .||  |||| .||.|||||||. ||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

YSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGP--EDALEICRADFF
       ||| |.  |  .|  |..||  .| . . | |..|||      .  .| .  ||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF

Kinase akt-1.AA Alpha 193-450 49 2.1e-108 366.46 In-house 1-259 (259) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-259/259
Sequence Identity: 49% (129 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRCKHP-FLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEP
| ||.||||| ||||.|   | |. |||||||||||||    |  |..| |||     | ||. .   ||    | ||| . ||| |  |. . | | ||
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRLPF
 | || |||  .| .||. .|.|||.|| | .|| .|||||||||.|||..  .. | ||||||.|.|||.     ||. ||||  || .|||| |  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

YSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFF
   | . ||. ||     .|  .|.||  . .|.|.| | .||| ||..  .|    ||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF

Kinase akt-1.AA PKN 193-450 52 1.5e-107 363.63 In-house 1-260 (260) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-260/260
Sequence Identity: 52% (136 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQ---RCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFS
| .. |||.| ||||.| . | | ..||||.|||  |.||.||   ..| |...   | .|||| .|   || ..  |||| .| ||.|  |. .   ||
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

EPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRL
||||.|| | .|| | |||.  |.|||.||.|||||..|..|||||||||| . .||.|||||||||.|||||| |. | | |||||.||..|||. |  
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFYSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFF
||   |   .|. |.  | |.|  || ||  ..  || | | .||| |  || .|    ||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF

Kinase akt-1.AA S_TKc 193-450 36 4.4e-102 346.36 SMART 1-231 (231) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANG--GELFTHVRKCGT---
...|...|||.|||| .|..|.|....||||.|           |.. | ..|.. .||..  |...||. ..|..|| ...|  |.||.. .|.|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDHDYGR-CVDWWGVGVVMYE
   |.| .|||| ..|..|| |.|.  |..|| | ||.|||.  ||||.||||...        .||||||.|.|||||    ||.  .||| .|...||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MMCGRLPFYSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDA--LEICRADFF
|.||. ||.  .....|..|.          |.||. .. ..|.|||..|..     .  ..|    .|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase akt-1.AA Pkinase 193-450 31 5.4e-96 330.02 Pfam 1-293 (293) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTL-TENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANGG----ELFTHVR--KC
. .....|.|.||.| .|..| |.|..|.||.||. .   ....|.. .| ....|..||.  .|...|..  ....|| ...||    .||....  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GTF--SEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHI----KIADFGLCKEE-ISFGDKTSTFCGTPEYLAPEVLD-DHDYGRCVDWWGV
|.|  ||  ..||  .|. .| |.|.. |..||.|.||.|.|..|||    ||.||||.|   .  .  ..||||||.|.||||.  . .||. ||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVMYEMMCGRLPFYSK------DHNKLFELIMAGDLRFPSKLS---------------------QEARTLLTGLLVKDPTQRLGGGPEDALEICRADFF
|...|||.|||.||...      |.......|| ..|.|..  .                     .|.. .....| |||..|..     | .|.  ..|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF





Kinase akt-1.AA S_TK_X 451-520 33 1.8e-20 75.23 SMART 1-79 (79) Show / Hide
Range on Protein: 451-520
Range on HMM: 1-79/79
Sequence Identity: 33% (27 aa)

RTVDWEATYR--KEIEPPYKPNVQ----SETDTSYFDNEFTSQPVQLTPPSRSGALATVDEQEEMQSN-----FTQFSFHN
| .||.. |.  ||||||.||...    |.||||.|| |||....    |  ..........| |        | .|.. .
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF

Kinase akt-1.AA Pkinase_C 470-522 33 1.6e-14 54.34 Pfam 1-46 (46) Show / Hide
Range on Protein: 470-522
Range on HMM: 1-46/46
Sequence Identity: 33% (18 aa)

NVQSETDTSYFDNEFTSQPVQLTPPSRSGALATVDEQEEMQSNFTQFSFHNVM
.| |.||||.|| |||..|...||        .    ...|..| .|.. | .
QVKSPTDTSNFDPEFTDEPPMDTP------PDWR-MSSGDQEPFRGFTYVNPD

Kinase akt-1.AA TyrKc 193-450 21 4.3e-14 5.25 SMART 1-280 (280) Show / Hide
Range on Protein: 193-450
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRC--KHPFLTELKYSFQEQ-------HYLCFVMQFANGGELFTHVR
  ..|.|| | ||.| ... |      |.| ||.|    ||.    . | |.. .   .|| .  |     .|       . |. || .. .| |  . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KCGT-FSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISF-------GDKTSTF--CGTP----EYLAPEVLDDHDYG
|..  .. .    .   |     |||.  .. ||    | |.......||.||||...  .          ....   .|        .|||..... . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RCVDWWGVGVVMYEMM-CGRLPFYS-----KDHNKLFELIMAGDLRFPSKL---------SQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFF
   | |  ||.|.|..  |  | .      ..   ..|....|. . . .          ..|  .. .     || .|         ||   ..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF

Kinase akt-1.AA Pkinase_Tyr 193-339 24 1.1e-07 26.7 Pfam 1-159 (270) Show / Hide
Range on Protein: 193-339
Range on HMM: 1-159/270
Sequence Identity: 24% (39 aa)

FDFLKVLGKGTFGKVILCKEK----RTQKLYAIKILKKDVIIA---REEVAHTLTENRVLQRC-KHPFLTELKYSFQ-EQHY--LCFVMQFANGGELFTH
  |.|.||.| ||.| ... |     |.   |.|.|| .       ||.    . | ...    .|| .  |      ..    .. || .. .| | ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF---MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

VRKC----GTFSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCK
 ||     . .. ..   . ..|  .. ||..  .. ||    | |.......||.||||..
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR

Kinase akt-1.AA Pkinase_Tyr 378-406 28 0.179515 5.61 Pfam 201-232 (270) Show / Hide
Range on Protein: 378-406
Range on HMM: 201-232/270
Sequence Identity: 28% (9 aa)

GVVMYEMMC-GRLP-FYSKDHNKLFELI-MAG
||.|.|..  |. | ..  . . ..|.|   |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG