Gene atm-1 (Nematode worm)

atm-1

Species: Nematode worm
Alias: aSWK444, Y48G1BL.2, atm-1, CE30018, Y48G1C_55.a
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 203037-208356, WormBase Genetic Map location: n/a,

Classification

Group: Atypical
Family: PIKK
Subfamily: ATM

Sequence

Name Sequence Type Origin Length Description Download
atm-1.AA Protein Genbank 649 None Fasta, JSON

Protein domain

Protein domains of atm-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase atm-1.AA ATM 342-577 38 2.2e-53 168.74 In-house 2-241 (304) Show / Hide 
Range on Protein: 342-577
Range on HMM: 2-241/304
Sequence Identity: 38% (94 aa)

KTVWKKDDVRQDVLVEQMFDVTNNMLE--------KAMLRTYNVVPLDTECGVIEFCGGTVSLKEVMCGVTREGGLHREFNSEEVSASKVSSMMRQVQTE
. |  .||.|||  . |.| . | .|         |  . || ||||    ||.|.| ||.   . .  .  | | |. .   . || .    |  ||  
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFL--INNEDGAHKRYRPNDFSAFQCQKKMMEVQKK

STETRRQVFVEICQQYSPVFRHFFYTNFSTAQIWRQKIINYRQSLATWSIVCYIVGLGDRHASNILFDQKLCTFVHIDLGMILEYSKRTLPVPEQVPFRI
| | .  ||...|| . |||| |    |    ||  | . |  | || ||| ||.||||||  |||   .    ||||||.  |  |  || || ||||.
SFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGK-ILPTPETVPFRL

TRDVLDPILIEGIENGQLAEECTQIMEKLKENGKVILGVASALL
|||. | . | |.| |     | . || ..     .| .   ||
TRDIVDGMGITGVE-GVFRRCCEKTMEVMRNSQETLLTIVEVLL
Kinase atm-1.AA PIKK 333-576 30 1.3e-47 164.48 In-house 23-290 (290) Show / Hide 
Range on Protein: 333-576
Range on HMM: 23-290/290
Sequence Identity: 30% (81 aa)

IEGSDGKWYKTVWK-KDDVRQDVLVEQMFDVTNNMLEKA--------MLRTYNVVPLDTECGVIEFCGGTVSLKEVMCGVTR-EGGLHREFNSE------
| |.||| |    | ..| |||  |.| | . |..|.|          .|||.|.|. ..||.|| . ..|.|||        ....|.   .       
IRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIRHEQEAQMNYQTCM

------EVS--ASKVSSMMRQVQTESTETRRQVFVEICQQ-YSPVFRHFFYTNFSTAQIWRQKIINYRQSLATWSIVCYIVGLGDRHASNILFDQKLCTF
        |  . .. .... .| .. . . .|| |..|    ..|. .|   |....||  .  ||  |.|....| || |||||| .||..|.     
YRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEI

VHIDLGMILEYSKRTLPVPEQVPFRITRDVLDPILIEGIENGQLAEECTQIMEKLKENGKVILGVASAL
||||.| . |  ...||||| |||| ||.  .   . |.| | .   | ..|. ....   ...|  ..
VHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVE-GVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase atm-1.AA ATR 311-576 28 1.1e-33 111.9 In-house 2-267 (267) Show / Hide 
Range on Protein: 311-576
Range on HMM: 2-267/267
Sequence Identity: 28% (79 aa)

TWKRWKDVFTIADGISTPKIWEIEGSDGKWYKTVWK-KDDVRQDVLVEQMFDVTNNMLEKAM--------LRTYNVVPLDTECGVIEFCGGTVSLKEVMC
    . |.  |   .  ||   . |||||.|  . | |||.|.|    .. .. | .. | .        .||| |.||  .|..||.   |..|. .. 
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

GVTREGGLHREFNSEEVSASKVSSMMRQVQTESTETRRQVF-VEICQQYSPVFRHFFYTNFSTAQIWRQKIINYRQSLATWSIVCYIVGLGDRHASNILF
 . .| . . .|      . | |    . |        .||   .  .. |.|. .|   |  .| |     ||  | | |..| ||.||||||. |||.
KLWKEKKQYMQFYQLRQCMDKKSREEWEKQ--------KVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILI

DQKLCTFVHIDLGMILEYSKRTLPVPEQVPFRITRDVLDPILIEGIENGQLAEECTQIMEKLKENGKVILGVASAL
|.     ||.|  .|   | ... ||| ||||.|. .   .   . . |     |  ||  ....   |..|  . 
DKINGECVHVDYNCIFN-SGEQFEVPEIVPFRLTHNMVFGMGPMKTY-GLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase atm-1.AA PI3_PI4_kinase 340-586 17 7.4e-33 120.28 Pfam 1-300 (300) Show / Hide 
Range on Protein: 340-586
Range on HMM: 1-300/300
Sequence Identity: 17% (55 aa)

WYKTVWK-KDDVR--QDVLVEQMF-----------------------DVTNNML--EKAMLR------TYNVVPLDTECGVIEFCGGTVSLKEVMCGVTR
||. . | .|| |  || ...||.                        . |...  ... .|      .| ..|. ..||.||.   .....|. .    
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

EGG------------------LHREFNSEEVSASKVSSMMRQVQTESTETRRQVFVEICQQYSPVFRHFFYTNFSTA-QIWRQKIINYRQSLATWSIVCY
...                  .| .                      .... . . .|.... |.....|. .. .|  .| . . |.  |.| ...| |
KCKHKHFNKEHKMWMKMWPDWWHLM---------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDY

IVGLGDRHASNILF--DQKLCTFVHIDLGMILE-YSKRTLPVPEQVPFRITR------DVLDPI-----LIEGIENGQLAEECTQIMEKLKENGKVILGV
| |.||||..||..  | .    .||| |.... .   ....|| |||| |.      .  . .     | .  . | . ..| .... | ... ... .
ILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNL

A-------SALLRETMTNFRE
        .....  . ..|.
LKKAVMRGECMVHDGLPMWRS
Kinase atm-1.AA PI3Kc 342-638 19 3.3e-31 110.92 SMART 1-336 (336) Show / Hide 
Range on Protein: 342-638
Range on HMM: 1-336/336
Sequence Identity: 19% (66 aa)

KTVWKK-DDVRQDVLVEQMFDVTNNMLEKA--------MLRTYNVVPLDTECGVIEFCGGTVSLKEVMCGVTREGGL------HREFNSEEV--------
    |. || ||| .. ||| . |... |          .|.|...|.  .||.||..  ...| ....  . . ..       . |. . |        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

----SASKVSSMMRQVQTESTETRRQVFVEICQQYSPVFRHFFYTNFSTAQ-IWRQKIINYRQSLATWSIVCYIVGLGDRHASNILFDQKLCTFVHIDLG
    ...  . ||.  .. ..|.    . ..|..  ||....|. .| ..  .|.. . |. .|.| ...|.|| |.|||| .||..| |    .|||.|
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

MILEYSKRTLPVP-----EQVPFRITRDVLDPIL---IEGIENGQLAEECTQIMEKLKENGKVILGVASALLRETM-TNFREA--EQAAGRPSYISE-MA
.|.. . ...|..     | |||| |.| .. .    ..  . |.  . | .... ....  .|. . .....  .  ..|      .  | .   . . 
HIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLS

IGRLREKLRGTDDGVTAQSS-NLQIRRLLREATSADNL
    ...   |...   ..| . .. |.  ..    ..
DEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase atm-1.AA FRAP 466-586 36 2.4e-20 71.56 In-house 132-251 (251) Show / Hide 
Range on Protein: 466-586
Range on HMM: 132-251/251
Sequence Identity: 36% (44 aa)

IWRQKIINYRQSLATWSIVCYIVGLGDRHASNILFDQKLCTFVHIDLGMILEYSKRTLPVPEQVPFRITRDVLDPILIEGIENGQLAEECTQIMEKLKEN
|| ..  ||  |||| |.. || |||||| |||. .      |||| |   |   |    || .|||.||     . . ||| |.    |  .|. ..|.
IWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIE-GNYRNTCELVMKVIREH

GKVILGVASALLRETMTNFRE
   .. |  |     . . | 
KESVMAVLEAFVYDPLFYWRL
Kinase atm-1.AA FATC 617-649 39 3.8e-13 45.14 Pfam 1-33 (33) Show / Hide 
Range on Protein: 617-649
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

TAQSSNLQIRRLLREATSADNLSRMFCGWMPFL
.  | . |..|| .|||. .||..|..||.|..
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase atm-1.AA SMG1 474-527 48 4.5e-10 29.4 In-house 190-242 (242) Show / Hide 
Range on Protein: 474-527
Range on HMM: 190-242/242
Sequence Identity: 48% (26 aa)

YRQSLATWSIVCYIVGLGDRHASNILFDQKLCTFVHIDLGMILEYSKRTLPVPE
|  | |  |.| ||.||||||  |.| |      ||||     |  |  | |||
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE
Kinase atm-1.AA DNAPK 349-400 40 2.4e-07 22.58 In-house 42-101 (301) Show / Hide 
Range on Protein: 349-400
Range on HMM: 42-101/301
Sequence Identity: 40% (24 aa)

DVRQDVLVEQMFDVTNNMLE-------KAM-LRTYNVVPLDTECGVIEFCGGTVSLKEVM
| |||  .||.| | || .|       ... |||||..|.    | ||    || ||...
DLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL
Kinase atm-1.AA DNAPK 479-535 35 1e-06 19.74 In-house 192-251 (301) Show / Hide 
Range on Protein: 479-535
Range on HMM: 192-251/301
Sequence Identity: 35% (21 aa)

ATWSIVCY---IVGLGDRHASNILFDQKLCTFVHIDLGMILEYSKRTLPVPEQVPFRITR
... ..|    | | ||||  | .        . || |         |||||  ||| ||
RNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTR