Gene C04H5.4 (Nematode worm)

C04H5.4

Species: Nematode worm
Alias: aSWK286, C04H5.4, C04H5.4a, CE23518, C04H5.4A
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 14543695-14543696, WormBase Genetic Map location: II:22.44,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
C04H5.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 228 Kinase domain by global Sugen HMM Fasta, JSON
C04H5.4.AA Protein Genbank 1034 None Fasta, JSON

Protein domain

Protein domains of C04H5.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor C04H5.4.AA ANF_receptor 42-255 18 8.9e-26 91.98 Pfam 1-228 (364) Show / Hide 
Range on Protein: 42-255
Range on HMM: 1-228/364
Sequence Identity: 18% (44 aa)

MLESILEMAKKKMTEQGV-LGEKLDIQIITVEGC--GASFEGVAAAAELYHVQKVDAYFGPYCSKELSPVATMASYWNIPIFAYTATSAEFAN--TKVYK
...  ..|| .     .  |. .......  . |    .  .||||....| ..|.| .||.|| . .||| .|..||||.. . .|. .. .   . |.
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

TLLRTSFQSLNSISEATAAFMAH-HNITKAAIVANIGTD--SFEK---IQSLEKALRSRGITVARR-VMFEEAASAQDLVDNGYMNEL--RDNARVILPI
...||   ... ...| .... |  . .. |.... ..   . .    .. ....||..|... .. .  .  .. .|  |         ...||||. .
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIV-M

FSSTRDL----STVFRNATWLANMASPEFIYI
...  |.      ....| . ..| | .. .|
CCYPDDMGLLQRQIMQQA-HELGMMSGGYVWI
Kinase C04H5.4.AA RGC 502-769 32 7e-116 391.29 In-house 1-300 (300) Show / Hide 
Range on Protein: 502-769
Range on HMM: 1-300/300
Sequence Identity: 32% (99 aa)

VNTHAVYDLYEQR---QNIRFTREDLILLTKMKQAVHDNINPFIGVSFNEKSE-----LLLLWKFCSRGTLQDVIYCEKFAMDEKFQGAFVRDITMGLEY
 ......  ..||   ... |||... .| .|.|..|||.|.||| ......|     ....|..||||.|||..... . ||..|...|.|||. |..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSPIGYHGGLACWSVLIDKNWMLKLTDYAVCDPLKRWEKHGRIN--CKVDNEAEKQWQKMASLYVPPEIRTANEKNRLKRMDQKWQ--GQTILKRQQS
||.|||.||| | .|. ..| .|..|.||. ...||..|.|||.||  || ..... |.|.. . | ...  || | .|  ||...|.  .||....|. 
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKG

DIYAFGVIIYEILFRSLPYDEKVD-------LTELAQKAAE--------GDKIQKPSIQRNKK-----LNPDLIALLQDCWSDQPDMRPT-IRRVRLATE
|.|.||.|.|||..|. |.|....        ....... |        | |   |||.....     .||.|..|..|||. .|..||. ....|.. .
DVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLK

I
 
T
Kinase C04H5.4.AA RGC 502-769 32 7e-116 391.29 In-house 1-300 (300) Show / Hide 
Range on Protein: 502-769
Range on HMM: 1-300/300
Sequence Identity: 32% (99 aa)

VNTHAVYDLYEQR---QNIRFTREDLILLTKMKQAVHDNINPFIGVSFNEKSE-----LLLLWKFCSRGTLQDVIYCEKFAMDEKFQGAFVRDITMGLEY
 ......  ..||   ... |||... .| .|.|..|||.|.||| ......|     ....|..||||.|||..... . ||..|...|.|||. |..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSPIGYHGGLACWSVLIDKNWMLKLTDYAVCDPLKRWEKHGRIN--CKVDNEAEKQWQKMASLYVPPEIRTANEKNRLKRMDQKWQ--GQTILKRQQS
||.|||.||| | .|. ..| .|..|.||. ...||..|.|||.||  || ..... |.|.. . | ...  || | .|  ||...|.  .||....|. 
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKG

DIYAFGVIIYEILFRSLPYDEKVD-------LTELAQKAAE--------GDKIQKPSIQRNKK-----LNPDLIALLQDCWSDQPDMRPT-IRRVRLATE
|.|.||.|.|||..|. |.|....        ....... |        | |   |||.....     .||.|..|..|||. .|..||. ....|.. .
DVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLK

I
 
T
Kinase C04H5.4.AA TKL 687-767 23 9.5e-14 45.89 In-house 268-364 (364) Show / Hide 
Range on Protein: 687-767
Range on HMM: 268-364/364
Sequence Identity: 23% (23 aa)

QQSDIYAFGVIIYEILFRSLPYDEKVDLTEL------AQKAAEGDKIQKPSIQ----------RNKKLNPDLIALLQDCWSDQPDMRPTIRRVRLAT
...|.|.||....||| | .||..    ...      .  .  .|| ..| |            ..   |... |.||||.  |. ||.  ..    
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase C04H5.4.AA RAF 687-769 25 3.2e-13 38.91 In-house 200-282 (282) Show / Hide 
Range on Protein: 687-769
Range on HMM: 200-282/282
Sequence Identity: 25% (21 aa)

QQSDIYAFGVIIYEILFRSLPY-DEKVDLTELAQKAAEGDKIQKPSIQRNKKLNPDLIALLQDCWSDQPDMRPTIRRVRLATEI
.|||.|.||...||.. |..||  .  .    .     |   .  | .| ..    .  |..|||. |.. ||  . .  . ..
FQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVR-QDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase C04H5.4.AA LRRK 687-759 29 1.4e-12 40.84 In-house 261-341 (351) Show / Hide 
Range on Protein: 687-759
Range on HMM: 261-341/351
Sequence Identity: 29% (25 aa)

QQSDIYAFGVIIYEILFRS-LPYDE-K-VD----LTELAQKAAEGDKIQKPSIQRNKKLNP-----DLIALLQDCWSDQPDMRPT
...|.|.||.|..|.| |. .|.|| . .|     ... .|  ||   ..|.|  .   .|     .. .|.|.||. .|. ||.
EKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEG---LRPTIPQH-YCPPCQPWHMYQDLIQHCWQHDPKKRPH
Kinase C04H5.4.AA RAF 687-767 27 3.1e-11 34.75 In-house 196-275 (275) Show / Hide 
Range on Protein: 687-767
Range on HMM: 196-275/275
Sequence Identity: 27% (22 aa)

QQSDIYAFGVIIYEILFRSLPYDEKVDLTELAQKAAEGDKIQKPSIQRNKKLNPDLIALLQDCWSDQPDMRPTIRRVRLAT
.||| ||||.. ||.. ...||  .     .  .   |    ..|   ....  ..  ||..||| ||. ||. ...    
FQSDVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKA-RVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase C04H5.4.AA TKL-Unique 687-767 22 4.5e-11 35.46 In-house 207-290 (290) Show / Hide 
Range on Protein: 687-767
Range on HMM: 207-290/290
Sequence Identity: 22% (20 aa)

QQSDIYAFGVIIYEILFRSL------PYDEKVDLTELAQKAAEGDKIQKPSIQRNKKLNPDLIALLQDCWSDQPDMRPTIRRVRLAT
..||.|.||.. .||. | .      || ...| .........  . . | |  .  .....  |.|.|| ..|. ||.   ..   
EKSDVYSFGIVLWEIATRKITKTYKKPY-QGMDQEQWCEMVHYMEENYRPPIPNH--CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase C04H5.4.AA TK 688-767 15 1.1e-09 27.8 In-house 374-486 (486) Show / Hide 
Range on Protein: 688-767
Range on HMM: 374-486/486
Sequence Identity: 15% (18 aa)

QSDIYAFGVIIYEILF--RSLPYDEKVD--------LTELAQKAAEGD--------KIQKPSIQRNKKLNP--------------DLIAL-LQDCWSDQP
.||...||| ..||.   .  .| .  .        ..|. ..  .|         ..     .   .. |              ..... .|.||. .|
KSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDP

DMRPTIRRVRLAT
. ||| . .. . 
EDRPTFSQLHEQL
S_TKc C04H5.4.AA S_TKc 465-770 16 2.7e-09 -40.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 465-770
Range on HMM: 1-231/231
Sequence Identity: 16% (53 aa)

VQILDEE------QVKSVVSLNSASTKMSQVETKLIKNHAIVGVNTHAVYDLYEQRQNIRFTREDLILLTKMKQAVHDNINPFIGVSFNEKSELLLLWKF
 .||..       .|. ..  .       .|  | ||                     ... ||  ||        |.||  ...|  .  ..| .   .
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK---------------------EHIRREIQILKK-----HHPNIVKLYDVFQD--DHLYMVMEY

CSR--GTLQDVIYCEKFA-----MDEKFQGAFVRDITMGLEYLHSSPIGYHGGLACWSVLIDKNWMLKLTDYAVCDPLKRWEKHGRINCKVDNEAEKQWQ
|.   |.| |.|   .       ..|     ... |  .|||.||  |  |  |    .|.|.   .|..|  ..  |                     .
CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL-------------------TTF

KMASLYVPPEIRTANEKNRLKRMDQKWQGQTILKRQ-QSDIYAFGVIIYEILFRSLPYDEKVDLTELAQKAAEGDKIQKPSIQRNKKLNPDLIALLQDCW
     |..||.                           .|....|.|.|| | .  |..   .. .. .|                   |... ... |.
CGTPWYMAPEVL--------------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------SPEAKDFIRKCL

SDQPDMRPTIRRVRL------ATEIA
   |. |||.  .        . .  
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C04H5.4.AA MLK 689-759 26 2.3e-08 25.29 In-house 217-283 (291) Show / Hide 
Range on Protein: 689-759
Range on HMM: 217-283/291
Sequence Identity: 26% (19 aa)

SDIYAFGVIIYEILFRSLPYDEKVD-LTELAQKAAEGDKIQKPSIQRNKKLNPDLIALLQDCWSDQPDMRPT
.|.. .||...|.| | .||.. .| .. ... |..|     ||       .. .  |...||.. |  ||.
CDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST-----CPEHWKKLMKQCWNQDPHKRPS
TyrKc C04H5.4.AA TyrKc 431-767 13 3.6e-07 -106.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 431-767
Range on HMM: 1-280/280
Sequence Identity: 13% (55 aa)

VVCIIL-------TVFLGIWLRRACETSALDKMPWRVFRDDVQILDEEQVKSVVSLNSASTKMSQVETKLIKNHAIVGVNTHAVYDLYEQRQNIRFTRED
.. .         .|..|.|                                            ||  | .|..|                      |||
ITLGKKLGEGAFGEVYKGTWK------------------------------------------IQVAVKMLKEDA----------------------RED

LIL-LTKMKQA--VHDNINPFIGVSFNEK------SELLLLWKFCSRGTLQDVI-YCEK-FAMDEKFQGAFVRDITMGLEYLHSSPIGYHGGLACWSVLI
..  .  |..    |.||  ..||   ..        |...  ... | |.| . .... . |... .  |  .|  | |||||                
FMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLS--FCWQIACGMEYLHSK---------------

DKNWMLKLTDYAVCDPLKRWEKHGRI--------NCKVDNEAEKQWQKMASLYVPPEI--------RTANEK------NRLKRMDQKWQGQ---------
                        ..        || |...                .        |   ..         .|. .. .|          
------------------------NCIHRDLAARNCLVGENH--------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

--TILKR---QQSDIYAFGVIIYEIL-FRSLPYDE----KVDLTELAQKAAEGDKIQKPSIQRNKKL-----NPDLIALLQDCWSDQPDMRPTIRRVRLA
  .| ..    .||...||| ..||. .   || .    ... .|. ..  .|.   .|       .      ...  . ..||  .|..||| . ..  
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

T
 
F
Kinase C04H5.4.AA TKL-Unique 535-622 22 9e-06 16.59 In-house 55-160 (290) Show / Hide 
Range on Protein: 535-622
Range on HMM: 55-160/290
Sequence Identity: 22% (24 aa)

HDNINPFIGVSFN---EKSELLLLWKFCSRGTLQDVIY---------CEKFAMDEKFQGAFVRDITMGLEYLHSSP--IGYHGGLACWSVLIDKN-----
|.||  ..|...      ... .   .|..|.| ||.           ..  .. . .  ...||  |..|||..   | .|. |   ..|.| |     
HPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAE

WMLKLTD
|  |. |
WNIKICD
Kinase C04H5.4.AA UTK 518-623 20 1e-05 15.62 In-house 44-169 (296) Show / Hide 
Range on Protein: 518-623
Range on HMM: 44-169/296
Sequence Identity: 20% (26 aa)

RFTRE---DLILLTK----MKQAV-HDNINPFIGVSFNEKSELLLLWKFCSRGTLQD-VIYCEK--FAMDEKFQGA----FVRDITMGLEYLHSSPIGYH
....|   |......    |||   | |.  ..|| ..|.  ..... ....| |.. . .. .  .| .. .       ...||  |..||||  .  |
QQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF-VH

GGLACWSVLIDKN-------WMLKLTDY
. ||.  .|....       .  |. |.
RDLAARNCLVHMHRMMWHCMMVCKIADF
Kinase C04H5.4.AA TK 530-623 12 1.6e-05 13.67 In-house 92-295 (486) Show / Hide 
Range on Protein: 530-623
Range on HMM: 92-295/486
Sequence Identity: 12% (26 aa)

MKQAV-----HDNINPFIGVSFNEK-----------SELLLLWKFCSRGT----LQDVIY-CEKFAMDEKFQGA--------------------------
||.       |.||  ..||.. ..             ....  ... |     |.|    | . ...|   ..                          
MKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESN

-----------------------------------------------FVRDITMGLEYLHSSPI-----GYHGGLACWSVLIDKNWM-----------LK
                                               . ..|  |.||||| ..       |. ||.  .|...|              |
SPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

LTDY
..|.
IADF
Kinase C04H5.4.AA Pkinase 689-761 13 3.1e-05 19.57 Pfam 193-285 (293) Show / Hide 
Range on Protein: 689-761
Range on HMM: 193-285/293
Sequence Identity: 13% (13 aa)

SDIYAFGVIIYEILFRSLPYDEK------VDLTELAQKAAEGDKIQKPSI---------------QRNKKLNPDLIALLQDCWSDQPDMRPTIR
.|....|.|.|| |.. .|....       ..  ....     . . |                  . ........ .. .|.   |  |||..
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAE
Kinase C04H5.4.AA UTK 745-767 26 0.000173 11.27 In-house 274-296 (296) Show / Hide 
Range on Protein: 745-767
Range on HMM: 274-296/296
Sequence Identity: 26% (6 aa)

LLQDCWSDQPDMRPTIRRVRLAT
|...||   |..||...... . 
LMHRCWHYDPQERPDFEDLVQQM
Kinase C04H5.4.AA TKL 535-599 21 0.000321 11.11 In-house 84-161 (364) Show / Hide 
Range on Protein: 535-599
Range on HMM: 84-161/364
Sequence Identity: 21% (18 aa)

HDNINPFIGVSFNEKS------------ELLLLWKFCSRGTLQDVIYCEKFAMDEKFQGAFVRDITMGLEYLHS--------SPI
|.|| .|.|.......            .| .   .|..|.| ...              ...||  |..||||         ||
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPI
Kinase C04H5.4.AA UTK 687-702 43 0.00469 6.3 In-house 219-234 (296) Show / Hide 
Range on Protein: 687-702
Range on HMM: 219-234/296
Sequence Identity: 43% (7 aa)

QQSDIYAFGVIIYEIL
..||...|||  .||.
TKSDVWSFGVVCWEIW
Kinase C04H5.4.AA MLK 535-596 20 0.010541 5.36 In-house 64-142 (291) Show / Hide 
Range on Protein: 535-596
Range on HMM: 64-142/291
Sequence Identity: 20% (16 aa)

HDN----INPFIGVSFNEKSELLLLWKFCSRGTLQDVIYCEK-------------FAMDEKFQGAFVRDITMGLEYLHS
| |    | .| ||. .. ......  .|. | | .|.. ..             . .|  .   .  ..  |..||||
HPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHS
CYCc C04H5.4.AA CYCc 805-1000 39 1.3e-94 321.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 805-1000
Range on HMM: 1-231/231
Sequence Identity: 39% (92 aa)

EANLRAERLLFQLLPKHVAIELKAGR-TVAPKMYDSATVMFSDIVGFTKLCSASTPIEVVNLLNKLYSEFDTVISKHD-----CYKVETIGDAYMVVSGI
... ...||| |.||.||| .||.|| .|.|. ||..|..|.||||||.|||..||..|||.|| .|. ||..|..|.     ||||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PIENG-------------------QRHVANISAVTLGIMDLLKVFEVPHR----RDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGETVNIAAVMESSGE
| .|.                   ..|  .|. . |.... .| |.|.|.    ... | .| |. .| | . |||. .||||.||.|||.|. |||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

GGRVQITETSKILL------ENEYPEFIIEI
.|.....|. . .|      ... . | .| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc C04H5.4.AA Guanylate_cyc 832-1019 33 2.3e-65 228.25 Pfam 1-214 (214) Show / Hide 
Range on Protein: 832-1019
Range on HMM: 1-214/214
Sequence Identity: 33% (72 aa)

VAPKMYDSATVMFSDIVGFTKLCSAST----PIEVVNLLNKLYSEFDTVISKH--DCYKVETIGDAYMVVSGIPIE-----NGQRHVANISAVTLGIMDL
| .. ||. |.||.||||||..||...    |...|..||..|. ||.....|  .||||.||||.||.|||.| .     ..  | . .   .|..|..
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

LKVFEVPHRRDYR-----LTIRLGFASGQVSAAVVG--LSSPRYCLFGETVNIAAVMESSGEGG--RVQITETSKILLENEY---PEFIIEIRGI--NKD
.. . |.|    .     ...| |  .| | | |.|  .. ||||..| ||| |  ||| |..|  .....|. . .|....   .|. ...||.   |.
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

VKQ-DDFVTYWLTG
 .. .  .||.|.|
KGKMGEMETYFLHG