Gene C05C12.1 (Nematode worm)

C05C12.1

Species: Nematode worm
Alias: CE02965, aSWK088, C05C12.1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 11253962-11255680, WormBase Genetic Map location: IV:4.9,

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
C05C12.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
C05C12.1.AA Protein Genbank 405 None Fasta, JSON

Protein domain

Protein domains of C05C12.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C05C12.1.AA TTBKL 25-296 41 1.7e-137 463.08 In-house 1-288 (288) Show / Hide 
Range on Protein: 25-296
Range on HMM: 1-288/288
Sequence Identity: 41% (119 aa)

YQVVESIGEGAYGQVF--KVSKNAKK-YAMKVEPNRLDGGPASITKEIEVMMELNNRGAKFFPIFETGGREPKFHMVVMTLLGENLQVLRMKGCNPKACT
...|..||||..|||.  ...|..|. .|||.|.|||.||.. . .|..|.|.|...|...||..  .|........||||.|.|||.||.. .|.|...
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

PGTWSRIGIQCLFVVKQMHDCGILHHDLKPTNFVWGQSDE-ALTCRVFYLIDFGISRKFIRHVK---GTPINQQNGFEFRTEKK--KVHSLVGTPKYTSP
.|||||||||||...|||||||..|.|.||.|..|| .|. ...||..||||||..|..... .   | || ..|....|....  . ... ||..|.||
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNG-PI-HENKWMMRRPRNFRHKAPFRGTTRYCSP

KAHAMADLGRGDDLWSLMYMIAELVKPLPWEILEAKM-LENTKLKSKLKDHFGM--------DGFGKIETMLHACTFNSFPNYEMIYLAF
 .|.....|| |||||.||||.||...|||. .| || .| .|...|..| |.         . |.|....|........|.|||||  |
NMHDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase C05C12.1.AA CK1 25-292 27 2.7e-95 322.92 In-house 1-339 (339) Show / Hide 
Range on Protein: 25-292
Range on HMM: 1-339/339
Sequence Identity: 27% (93 aa)

YQVVESIGEGAYG-QVFKV------SKNA------KKYAMKVEPNRLDGGPASITKEIEVMMELN------------------NRGAKFFPIFETGGREP
..||. ||||..| |..||      ...       ..|||||||.   |.. .  .|......|.                  . | ....... .|.|.
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

KFH-MVVMTLLGENLQVLRMKGCNPK-ACTPGTWSRIGIQCLFVVKQMHDCGILHHDLKPTNFVWGQSDE----------ALTCRVFYLIDFGISR-KFI
... ..||||||.||. ||.......  .. .|| .|.||.|.....|||||..| |.||.||. | ..             ..|..|.||||..| |..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

RHVK-----GTPINQQNGFEFRTEKK--KVHSLVG-TPKYTSPKAHAMADLGRGDDLWSLMYMIAELVKP---LPWEILEAKM------LENTKLKSKLK
.  .     | |  ... .. |. ..  | ....| |..|.|. .|   ..|| |||||..||..|..|.   |||  ....|       |  | ... .
DKDGHNRWNG-P--RDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDE

DHFGM--------------DGFGKIETMLHACTFNSFPNYEMI
. . .              . | || ........ ..|.||||
KKMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase C05C12.1.AA Worm6 25-292 27 5.2e-42 145.88 In-house 1-279 (279) Show / Hide 
Range on Protein: 25-292
Range on HMM: 1-279/279
Sequence Identity: 27% (79 aa)

YQVVESIGEGAYGQVFKVSKNAKK----YAMKVEPNRLDGGPASITKEIEVMMELNNRGAKFFPIFETGGREPK--FHMVVMTLLGENLQVLRMKGCNPK
..|.. ||||..| |.||..  .|    .|||.|             |. |...........|. .|  |. ..  |. .||||.|.||. ||.     .
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP-DR

ACTPGTWSRIGIQCLFVVKQMHDCGILHHDLKPTNFVWGQS--DEALTCRVFYLIDFGISR--KFIRHVKGTPINQQNGFEFRTEKKKVHSLVGTPKYTS
. . ||  .|.||||  . ..| || .| |.|| ||  |.   .|    .  |..|||..|  |..           .| | || . ...  .||..| .
KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYC----------NKGNELRTPRWTACGFRGTVRYAP

PKAHAMADLGRGDDLWSLMYMIAELVKP-LPWEILEAKMLEN-TKLKS--KL-----KDHFG---MDGFGKIETMLHACTFNSFPNYEMI
  .|   ...| ||. | .||..|.... |||  ....  ..  | .   ..     .. ||   ...| .| ...    . . |.|. |
LACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase C05C12.1.AA TTBK 25-180 33 4.5e-20 67.65 In-house 1-152 (257) Show / Hide 
Range on Protein: 25-180
Range on HMM: 1-152/257
Sequence Identity: 33% (53 aa)

YQVVESIGEGAYGQVFKVSKNAKK---YAMKVEPNRLDGGPASITK-EIEVMMELNNRGAKFFPIFETGGREPKFHMVVMTLLGENLQVLRMKGCNPKAC
 .||  || |..| ..       .    |.|||  .    |  . | |. |.  |   | ..   | . ||. ||  .||.|.|.||  || |     . 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQ---PKQVLKMEVAVLKKL--QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPR-GCF

TPGTWSRIGIQCLFVVKQMHDCGILHHDLKPTNFVWGQSDEALTCRVFYLIDFGISRKFI
. .|  |.|.| |  ... |. | || | || ||  |.   . |||  |..|||  |...
SLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR--NPSTCRKCYMLDFGLARQYT
Kinase C05C12.1.AA CK1-Unique 25-240 22 1.9e-19 64.13 In-house 1-224 (337) Show / Hide 
Range on Protein: 25-240
Range on HMM: 1-224/337
Sequence Identity: 22% (54 aa)

YQVVESIGEGAYGQVFKVSKNAKK--------YAMKVEPNRLDGGPASITKEIEVMMELNNRG-----AKFFPIFETGGREPKFHMVVMTLLGENLQVLR
..| . || | || | .| . .          |.|| |  .     .  . |  || ...         . |.  .  .  .     |||..| ..  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

MKGCNPKACTPG------TWSRIGIQCLFVVKQMHDCGILHHDLKPTNFVWGQSD-EALTCRVFYLIDFGISRK--FIRHVKGTPINQQNGFEFRTEKKK
|.   . . |..      .  . | |||.|.  ||  | .| ..|| |.. .      .  ...| .|.||.|.  |.           |  . |   ..
MM-MKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQ--HCYYMLDYGICRRVFFV----------SNNHQIRQPRPI

VHSLVGTPKYTSPKAHAMADLGRGDDLWSLMYMIAELV
. .  |...| .   |   ..||.||. |. ||.  ||
T-PFRGCKDYCPCSCHQCREHGRRDDMESWFYMLYHLV
Kinase C05C12.1.AA CK1-Unclassified 25-107 27 3.8e-14 38.17 In-house 1-90 (244) Show / Hide 
Range on Protein: 25-107
Range on HMM: 1-90/244
Sequence Identity: 27% (25 aa)

YQVVESIGEGAYGQVFKV--SKNAKKYAMKVEPNRLDGGPASITKEIEVMMELNNRG-----AKFFPIFETGGRE--PKFHMVVMTLLGENL
|.|.| || |. |...|.  ... ...|.|.| .        ...|. .|..|.|.       | .|   . |.|    .  .||.|||..|
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase C05C12.1.AA S_TKc 25-335 15 2.1e-12 4.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-335
Range on HMM: 1-231/231
Sequence Identity: 15% (52 aa)

YQVVESIGEGAYGQVFKVSKNA--KKYAMKVEPNRLDGGPASITKEIEVMMELNNRG-AKFFPIFETGGREPKFHMVVMTLLGE---NLQVLRMKGCNPK
|.... ||.||.|.|.|. ..   ...|.|. .        .| .||..... .     |.. .|..     ..  .|| ...    .|  .  |   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

AC---TPGTWSRIGIQCLFVVKQMHDCGILHHDLKPTNFVWGQSDEALTCRVFYLIDFGISRKFIRHVKGTPINQQNGFEFRTEKKKVHSLVGTPKYTSP
 .   .. .  ..  | .  .. .|. ||.| |||| |    .        .  ..|||..|..                        ....||| | .|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL------------------------TTFCGTPWYMAP

KAHAMADLGR-GDDLWSLMYMIAELVK-PLPWEILEAKMLENTKLKSKLKDHFGMDGFGKIETMLHACTFNSFPNYEMIYLAFKEVFNKSGVSWLDPYDW
        |.   | ||.  ...|..    |..  ...|... .                                                      . 
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------------------------------------------------SP

EGK-------NMPSYKRWRQHAEKQ-------RPLF
|.|       ..   ||.      |        | |
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C05C12.1.AA CK1-A 25-250 27 3.9e-12 39.0 In-house 1-210 (261) Show / Hide 
Range on Protein: 25-250
Range on HMM: 1-210/261
Sequence Identity: 27% (62 aa)

YQVVESIGEGAYGQVFKV--SKNAKKYAMKVEPNRLDGGPASITKEIEVMMELNNRGAKFFPIFETGGREPKFHMVVMTLLGENLQVLRMKGCNPKACTP
|..|  || |..| ..     .| .  |.|.| |.       .  |  |   |  .|.  .|  .  |.|  . ..|| |||  |  |    |. .  | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARH--PQLIYEAKVYRIL--QGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCK-RRFTM

GTWSRIGIQCLFVVKQMHDCGILHHDLKPTNFVWGQSDEALTCRVFYLIDFGISRKFIRHVKGTPINQQNGFEFRTEKKKVHSLVGTPKYTSPKAHAMAD
 |   .  | .  .  .|  . .| |.|| ||. |       |   .|||||...|.        .. .   ..|..|.    |.|| .| | .||   .
KTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI---GRHCNKLFLIDFGLAKKYRD------SRTRQHIPYREDKN----LTGTARYASINAHLGIE

LGRGDDLWSLMYMIAEL-VKPLPWEILEA
  | ||. |. |..     . |||  ..|
QSRRDDMESMGYVMMYFNRGKLPWQGMKA
Kinase C05C12.1.AA CK1 25-107 23 1.9e-11 35.83 In-house 1-91 (271) Show / Hide 
Range on Protein: 25-107
Range on HMM: 1-91/271
Sequence Identity: 23% (22 aa)

YQVVESIGEGAYGQVFKVSKNAK---K--YAMKVEPNRLDGGPASITKEIEVMMELNN---RG-AKFFPIFETGGRE--PKFHMVVMTLLGENL
|.|.. ||.|. |.....    .   .  .|.|.|.|.    |  . .|. ....|..    . .. .|   . |.|   ..  .||.|||..|
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK-HP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL
Kinase C05C12.1.AA AGC 25-53 35 2.5e-10 21.41 In-house 1-37 (395) Show / Hide 
Range on Protein: 25-53
Range on HMM: 1-37/395
Sequence Identity: 35% (13 aa)

YQVVESIGEGAYGQVFKVSKNA--------KKYAMKV
....  ||.|..|.|. | |.         | |||||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKV
Kinase C05C12.1.AA CK1-Unclassified 128-234 30 2.9e-10 26.51 In-house 109-204 (244) Show / Hide 
Range on Protein: 128-234
Range on HMM: 109-204/244
Sequence Identity: 30% (33 aa)

IGIQCLFVVKQMHDCGILHHDLKPTNFVWG-QSDEALTCRVFYLIDFGISRKFIRHVKGTPINQQNGFEFRTEKKKVHSLVGTPKYTSPKAHAMADLGRG
|. | .  . ..| ....| |.|| ||. |    .. ..   |.||||.| ..|.       . ..  ..| .|    .|.||  |.|  ||     .| 
IADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQV---YIIDFGLSKRYIDM-----DKTGKHIPYRENK----NLTGTARYASINAHLGIEQSRR

DDLWSLMY
||| ||.|
DDLESLGY
Kinase C05C12.1.AA CK1 128-236 27 3.1e-09 28.17 In-house 110-206 (271) Show / Hide 
Range on Protein: 128-236
Range on HMM: 110-206/271
Sequence Identity: 27% (30 aa)

IGIQCLFVVKQMHDCGILHHDLKPTNFVWGQSDEALTCRVFYLIDFGISRKFIRHVKGTPINQQNGFEFRTEKKKVHSLVGTPKYTSPKAHAMADLGRGD
|. | .  .  .| ....| |.|| ||. |       | . |.||||.. ...       .. ..  ..|. |    .|.||  |.|  .|     .| |
IADQMIQRIEYVHNKNFIHRDIKPDNFLMGR--YGKHCHQVYIIDFGLAKRYR------DDKTHQHIPYRENK----NLTGTARYASINTHLGIEQSRRD

DLWSLMYMI
|. ||.|..
DMESLGYVL
Kinase C05C12.1.AA TTBK 208-245 53 3.9e-09 28.45 In-house 169-207 (257) Show / Hide 
Range on Protein: 208-245
Range on HMM: 169-207/257
Sequence Identity: 53% (21 aa)

GTPKYTSPKAHAMADLGRGDDLWSLMYMIAELVK-PLPW
||  | |  ||   ..|| |||||| ||  | |.  |||
GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPW
Kinase C05C12.1.AA Pkinase 25-76 27 1e-06 24.26 Pfam 1-58 (293) Show / Hide 
Range on Protein: 25-76
Range on HMM: 1-58/293
Sequence Identity: 27% (16 aa)

YQVVESIGEGAYGQVFKVSKNAKK--YAMKVEPNRLDGGPASITK----EIEVMMELN
|.... ||.|..|.|.|  .      .|.|. . | .     .|.    ||..| .||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN
Kinase C05C12.1.AA NDR 25-53 38 6e-06 13.68 In-house 1-31 (350) Show / Hide 
Range on Protein: 25-53
Range on HMM: 1-31/350
Sequence Identity: 38% (12 aa)

YQVVESIGEGAYGQVFKVSKN--AKKYAMKV
..... ||.||.|.|. | |.   . ||||.
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKI
Kinase C05C12.1.AA NDR 136-155 40 0.000368 8.01 In-house 117-136 (350) Show / Hide 
Range on Protein: 136-155
Range on HMM: 117-136/350
Sequence Identity: 40% (8 aa)

VKQMHDCGILHHDLKPTNFV
. ..|  |. |.|.|| ||.
IESVHKMGYIHRDIKPDNFL
Kinase C05C12.1.AA Pkinase 139-240 22 0.00068 14.85 Pfam 124-206 (293) Show / Hide 
Range on Protein: 139-240
Range on HMM: 124-206/293
Sequence Identity: 22% (23 aa)

MHDCGILHHDLKPTNFVWGQSDEALTCRVFYLIDFGISRKFIRHVKGTPINQQNGFEFRTEKKKVHSLVGTPKYTSPKAHA-MADLGRGDDLWSLMYMIA
.|..||.| |||| |.   . ..  .   . ..|||....|                    .   ....||| | .|  .    . |.  | ||.  ...
CHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD----------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY

ELV
|..
EML
Kinase C05C12.1.AA AGC 170-215 11 0.002314 2.96 In-house 196-276 (395) Show / Hide 
Range on Protein: 170-215
Range on HMM: 196-276/395
Sequence Identity: 11% (10 aa)

LIDFGISRKFI------------------------------RHVKGTPINQQNGFE------FRTEKKKVHSLVG--TPKYTSP
| ||| . ...                              .  . . ....| ..         .... ....|  || | .|
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNK-CNPNNWQRNN-MSQEDDTTR-KKRDRTWTFCGPCTPEYMAP
Kinase C05C12.1.AA NDR 194-215 31 0.007478 3.9 In-house 229-250 (350) Show / Hide 
Range on Protein: 194-215
Range on HMM: 229-250/350
Sequence Identity: 31% (7 aa)

FEFRTEKKKVHSLVGTPKYTSP
.. .. ... .|.|||| |. |
SWKQNRRCLAYSTVGTPDYMAP