Gene C24A1.3 (Nematode worm)

C24A1.3

Species: Nematode worm
Alias: aSWK416, C24A1.3, CE27723
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 696450-692544, WormBase Genetic Map location: III:-26.47,

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
C24A1.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
C24A1.3.AA Protein Genbank 850 None Fasta, JSON

Protein domain

Protein domains of C24A1.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank C24A1.3.AA Ank 115-148 32 5e-06 26.08 Pfam 1-33 (33) Show / Hide 
Range on Protein: 115-148
Range on HMM: 1-33/33
Sequence Identity: 32% (11 aa)

NGFTPLHIAIYRGDVAILKALIATKLVDLDQSGR
.||||||.|...|.. ..| |.  .  |..   .
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank C24A1.3.AA Ank 149-181 33 4.2e-05 22.67 Pfam 1-33 (33) Show / Hide 
Range on Protein: 149-181
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

HLLPALHLAAMIGDSEMLTILLNSGANIHVTDF
.   .||||.. |. |... ||. ||.....| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank C24A1.3.AA Ank 182-214 30 0.000119 21.03 Pfam 1-33 (33) Show / Hide 
Range on Protein: 182-214
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

VHFTALHCATYFGQENAVRTLISASANLNLGGA
  ||.||.| . |... |. |... |..|.   
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank C24A1.3.AA Ank 219-247 44 6e-05 22.11 Pfam 5-33 (33) Show / Hide 
Range on Protein: 219-247
Range on HMM: 5-33/33
Sequence Identity: 44% (13 aa)

PIHLAAAKGLTSITKLLLEAKADPLLADD
| |||. .| |.. |.||.. ||. . ||
PLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank C24A1.3.AA Ank 248-271 29 0.006738 14.71 Pfam 1-24 (33) Show / Hide 
Range on Protein: 248-271
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

EGNQALHYAAKSGSLVILNMLIKQ
.|. .||.|...|.. .. ||...
DGFTPLHLACRCGHTEVVKMLLQH
Ank C24A1.3.AA Ank 285-316 33 0.000458 18.92 Pfam 1-33 (33) Show / Hide 
Range on Protein: 285-316
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

YGDTALHLSCYSGRLDIVKSILD-SSPTNIVNM
.|.|.||| |..|....||  |.     |... 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank C24A1.3.AA Ank 355-387 45 1.6e-09 38.62 Pfam 1-33 (33) Show / Hide 
Range on Protein: 355-387
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

DGHTALHSACYHGHLRIVQYLLENGADQSLASR
|| |.|| ||..||...|..||..|||  .  .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank C24A1.3.AA Ank 320-354 40 0.007368 14.57 Pfam 1-33 (33) Show / Hide 
Range on Protein: 320-354
Range on HMM: 1-33/33
Sequence Identity: 40% (14 aa)

FSETPLHAACTGGKSIELVSFLMKYPGVDPNYQGQ
  .|||| ||  | ..| |..|..  | |.| |  
DGFTPLHLACRCG-HTEVVKMLLQ-HGADVNAQDD
Ank C24A1.3.AA Ank 435-455 38 0.587976 7.71 Pfam 1-21 (33) Show / Hide 
Range on Protein: 435-455
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DQQTPVIWAYERGHDAIVALL
| .||  .| ..||  .| .|
DGFTPLHLACRCGHTEVVKML
Kinase C24A1.3.AA HH498 516-780 61 3.7e-222 711.75 In-house 1-284 (284) Show / Hide 
Range on Protein: 516-780
Range on HMM: 1-284/284
Sequence Identity: 61% (174 aa)

IEFQESIGSGSFGKVYKGTYRGKLVAVKRYRAMAFGCKSE-----TDMLCREVSILSRLAHPNVVAFVGTSLDDPSQFAIITEFVENGSLFRRE------
|||.|.||||||||||||..|.|.|||||||||||.|||.     .||.||||||..||.||.||.||....||||||||.|....|||||...      
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIG

--------NGERKNYRVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHADGRSVVADFGESRFVCQREDENLTKQPGNLRWMAPEVFSQS
        .....|||.||......||.|||.||.|||.|...|.|||||||||||||.||..||||||||||||...|.|.|||||||||||||||||.
GAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQC

GKYDRKVDVFSFALVIWEIHTAELPFSHLKPAAAAAEMTYKRGRPTLPNQPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALL
.||..||||||.|..|||.||.|.||.|.|||||||||.|...||..|..||||.|.|...||...|||....||||..||..|
QKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase C24A1.3.AA MLK 516-780 40 1.4e-130 440.15 In-house 1-291 (291) Show / Hide 
Range on Protein: 516-780
Range on HMM: 1-291/291
Sequence Identity: 40% (119 aa)

IEFQESIGSGSFGKVYKGTYRGKL-----VAVKRYRAMAFGCKSE-------TDMLCREVSILSRLA-HPNVVAFVGTSLDDPSQFAIITEFVENGSLFR
|.|.| |||||||||.||..|.|.     |||||.||..| .||.        .| ||...|||..  ||....|.|..|..|..|.|..|..|.|||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RENGERK----------NYRVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHA------DGRSVVADFGESRFVCQREDENLTKQPGNLR
  .|.|.          |.||.|... ....|..|||| |||. | ||.|||||.||||||..      .|  ...|||.||...|.. .| ....|...
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

WMAPEVF--SQSGKYDRKVDVFSFALVIWEIHTAELPFS-HLKPAAAAAEMTYKRGRPTLPNQPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALL
||||||.  ....||..|.||.|...|.||..| |.|.. |..|.|.|....|.. ||..|..    .|.|. .|. | |......||.| .||  |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase C24A1.3.AA TKL 522-780 25 5.8e-90 305.18 In-house 1-364 (364) Show / Hide 
Range on Protein: 522-780
Range on HMM: 1-364/364
Sequence Identity: 25% (97 aa)

IGSGSFGKVYKGTYRG----------KLVAVKRYRAMAFGCKSETD----------------------MLCREVSILSRLA--HPNVVAFVGTSLDDPS-
||||.||.||||..||          | ||||... .   ......                      . ..|. |.. .   |||.| |.| ... |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------QFAIITEFVENGSLFRRENGERKNYRVMDPAFRLRISLDVARGMRYLHESAA-----KPVIHRDLNSHNILIHADGR------------
           |..|..|....|||. . .          .  |.|..||.|||| ||| .       .|.|||||.|.|||.. ...            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--SVVADFGESRFVCQREDENLTK------------------QPGNLRWMAPEVFSQS---------------GKYDRKVDVFSFALVIWEIHTAELPFS
    ..||| |||..|... | |.                  | |..|||||||. ..               ..|. |.||.||..|.||| | ..|..
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

HLKPA---------AAAAEMTYKRGRPTLPN--------QPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALL
....          . ..   .|. ||..|.        .|  ..| .. .|. . |... ..|| | ||.  |
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase C24A1.3.AA TKL-Unique 518-780 29 6.8e-69 235.19 In-house 1-290 (290) Show / Hide 
Range on Protein: 518-780
Range on HMM: 1-290/290
Sequence Identity: 29% (89 aa)

FQESIGSGSFGKVYKGTYRGKLVAVKRYRAMAFGCKSETDMLCREVSILSRLA-HPNVVAFVGTSLD---DPSQFAIITEFVENGSLFRRENGER-----
| ..||.|..|.||||..||. ||.|.    .   ..... . .||.....|  |||.| ..|.. |   .|... |..|... |||  ...  .     
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSL--YDVLHQNNNNN

---KNYRVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHAD-----GRSVVADFGESRFVCQREDENLT--------KQPGNLRWMAPEV
   .|   .... |... .|.|.|| ||| . .. .||||| | |.|.  .      .  ..||| |.|  .. .....           |..|||||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

FSQS-GKYDRKVDVFSFALVIWEIHTAEL------PFSHLKPAAAAAEMTY--KRGRPTLPNQPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALL
....  .|..|.||.||. | ||| | ..      |.... . . ..  .|  .. ||..||      |  .  || | ||...| || | ||.  |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPN----HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase C24A1.3.AA CZAK 516-780 36 1.1e-53 184.67 In-house 1-279 (279) Show / Hide 
Range on Protein: 516-780
Range on HMM: 1-279/279
Sequence Identity: 36% (102 aa)

IEFQESIGSGSFGKVYKGTYRGKLVAVKRYRAMAFGCKSET---DMLCREVSILSRLAHPNVVAFVGT-SLDDPSQFAIITEFVENGSLFRRENGERKNY
 .|   || | ||.|||.  ||| ||.|      |  |.|.    |  .||||.| | |||.| |.|  |.| |    |..|. . ||| ||   .. .|
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSL-RRLLTDHYFY

RVMDPAFRLRISLDVARGMRYLHE-SAAKPVIHRDLNSHNILIHADGR-------------SVVADFGESRFVCQREDENLTKQPGNLRWMAPEVFSQSG
    |  .. . .|.|||| |||      |..|||| | |||                     ..||| ||       |  |   | | |||||.|    
HKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFE-MTQTMGCLCWMAPECF-KGE

KYDRKVDVFSFALVIWEIHTAELPFSHLKPAAAAAEMTYKRGRPTLPNQPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALL
 |  ||||.||....|.| | . |   ..|   |    |   || .| ||.      .  || . |    ..|| | .|.  |
NYTEKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMP-QPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase C24A1.3.AA Dicty5 516-784 33 6.1e-49 166.59 In-house 1-260 (260) Show / Hide 
Range on Protein: 516-784
Range on HMM: 1-260/260
Sequence Identity: 33% (92 aa)

IEFQESIGSGSFGKVYKGTYRGKLVAVKRYRAMA-FGCKSETDMLCREVSILSRLA--HPNVVAFVGTSLDDPSQFAIITEFVENGSLFRRENGERK-NY
. | . | ||. |.||.| |.|. ||.| |     ..   . .   ||| |.|     |||.. . |    .     ..||.. |||||   |  ||   
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCF--DWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTG

RVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHADGRSVVADFGESRFVCQREDENLTKQPGNLRWMAPEVFSQSGKYDRKVDVFSFALV
  .    .| . .|.|..||.||    . .||||| | |.||  .    . ||| ||||  |   . |   |   |||.|.| ..  |. |.||.||. |
QPIAYFQQLHMAIDIAQSMRHLH---SMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNR--YHMTMHVGTQCWMACELF-NGQPYHQKCDVYSFGIV

IWEIHTAELPFSHLKPAAAAAEMTYKRGRPTLPNQPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALLEPHV
 ||. |   |.  .      . |  | .|||.|    .  |  |  ||   |    . || | ||.. .|  .
LWEMFTRKEPYDNIN-NWNIPVMVMKGERPTIP----KDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase C24A1.3.AA TyrKc 516-780 26 4e-47 163.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 516-780
Range on HMM: 1-280/280
Sequence Identity: 26% (80 aa)

IEFQESIGSGSFGKVYKGTYRGKLVAVKRYRAMAFGCKSETDMLCREVSILSRL--AHPNVVAFVGTSLDDP------SQFAIITEFVENGSL--FRREN
|.. . .|.| ||.|||||..   ||||  .. |        ...|| .|...|   |||.|...|  ...        .  |..|....|.|  . |..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GERKNYRVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHADGRSVVADFGESRFVCQR------EDEN------LTKQPGNLRWMAPEVF
...       ..  | .....|.||.|||.    ..|||||   |.|......  ..||| ||..         .|         .| .  .||||||..
RPK-----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

SQSGKYDRKVDVFSFALVIWEIHT-AELPFSHL----KPAAAAAEMTYKRGRPTLPNQPTAQ-----FPAHILSLIPQAWHPESSSRPDFVEIVALL
 . ||.  | ||.||  ..||| |  . | .      .... . |   ...|.  |  .         |. . ... | || . ..|| | ||. ..
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase C24A1.3.AA TK 516-780 15 7.2e-45 147.89 In-house 1-486 (486) Show / Hide 
Range on Protein: 516-780
Range on HMM: 1-486/486
Sequence Identity: 15% (76 aa)

IEFQESIGSGSFG---KVYKGTYRGK---------------------------LVAVKRYRA-MAFGCKSETD-------------MLCREVSILS--RL
|.. . .|.| ||   .||||..||.                            ||||  ..  |   . . |             ....| ....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

AHPNVVAFVGTSLDDP-----------SQFAIITEFVENGS----LF---RRENGERKNYRV--------------------------------------
 |||.| ..| ....              . |..|....|.    |    |.  ......                                        
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MDPAFRLRISLDVARGMRYLHES----AAKPVIHRDLNSHNILIHADGRSV-----------VADFG--
                               .... .| .....|.||.|||.       . ..||||  .|.|.. ...             .||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------ESRFVCQREDENLTKQPGN-------------------------LRWMAPEVFSQ--------SGKYDRKVDVFSFALVIWEIHT-AELPFSHL
       .| . ...|   ....|                          .||||||..           ||.  | ||.||  ..||| | .. |.   
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

KPA--------AAAAEMTYKRGRPT-----------LPNQPTAQFPA-------------HILSL-IPQAWHPESSSRPDFVEIVALL
 .          .      .||. .           ..  . .. |               .. . . | ||.. . ||.| ...  |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase C24A1.3.AA Pkinase 516-780 22 3.7e-41 146.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 516-780
Range on HMM: 1-293/293
Sequence Identity: 22% (69 aa)

IEFQESIGSGSFGKVYKGTYRGK--LVAVKRYRAMAFGCKSETDMLCR-------EVSILSRLAHPNVVAFVGTSLDDPSQFAIITEFVENG----SLF-
... . |||||||.|||.. .|   .||||        .|..... ..       |..|. || |||.| . ..  | ..   ...|..|.|    .|| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK------IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFD

---RRENGERKNYRVM--DPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHADGRS----VVADFGESRFVCQREDENLTKQPGNLRWMAPEV
   .      ......  ..    .. . ..||. |.|.     .||||| . ||||. .|       ..||| ....    .. .|   | ...|||||
YIST------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

FSQSGKYDRKVDVFSFALVIWEIHTAELPFSHL---KPAAAAAEMTYKRGRPTLPNQPTAQFP-------------------AHILSLIPQAWHPESSSR
   . .|..|||..|. ....|  . ..||..    .. .   .| .....| |. .     .                      ...|   ...  ..|
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PDFVEIVAL--L
| . .|.    .
PTAEQILQHPWF
Kinase C24A1.3.AA LRRK 561-782 28 4.9e-40 139.33 In-house 106-351 (351) Show / Hide 
Range on Protein: 561-782
Range on HMM: 106-351/351
Sequence Identity: 28% (72 aa)

REVSILSRLAHPNVVAFVGTSLDDPSQFAIITEFVENGSLFRRENGERKNYR-----VMDPAFRLRISLDVARGMRYLHESAAK-PVIHRDLNSHNILIH
.||.|.|.| |||.|  .| .. .|  .....|.. .|.| ..   .... .     .... ..|.|.|..|.||.|||   .. |.||||| |.|||. 
HEVWIMSHLNHPNIVSLKGFCI-HP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSPNILLW

AD----------GRSV--VADFGESR--FVCQRE-DENLTKQPGNLRWMAPEVFSQS--GKYDRKVDVFSFALVIWEIHTAE-LPFSHLK-------PAA
               .  .|||| ||  .... .    .. .||   |||||.        |. |||..||....||. | . .|| ...          
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPG---WMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

AAAEMTYKRGRPTLP-N-QPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALLEP
   ... .. |||.| . .|  |..   ..|| . |. .  .|| | .||  |. 
IEDKIIEGL-RPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase C24A1.3.AA S_TKc 516-784 22 2.3e-37 131.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 516-784
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

IEFQESIGSGSFGKVYKGTYRG--KLVAVKRYRAMAFGCKSETDMLCREVSILSRLAHPNVVAFVGTSLDDPSQFAIITEFVEN--GSLFR--RENGERK
 |. . ||.|.||||||.. ..  ..||.|. .          ....||..||..  |||.| . ..  |  . . ...|....  |.||.  ...| ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

NYRVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHADGRSVVADFGESRFVCQREDENLTKQPGNLRWMAPEVFSQSGKYDR-KVDVFSF
.......    ..   ..... |.|.   . .|||||   |||.    .  ..||| .|..        | . | . .|||||.    .|.. |.|. |.
LRFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

ALVIWEIHTAELPFSHLKPAAAAAEMTYKRGRPTLPNQPTAQFPAHILSLIPQAWHPESSSRPDFVEIVA-----LLEPHV
  ...|  . . ||.         .|..|. .           .   ...| . .. . . ||   |. .      . | .
GCILYEMLCGYPPFP-------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C24A1.3.AA Dicty4 561-782 32 1.1e-35 116.61 In-house 47-277 (277) Show / Hide 
Range on Protein: 561-782
Range on HMM: 47-277/277
Sequence Identity: 32% (76 aa)

REVSILSRLAHPNVVAFVGTSL---DDPSQFAIITEFVENGSLFRRENG---ERKNYRVMDPAFRLR---ISLDVARGMRYLHESAAKPVIHRDLNSHNI
.||.|.. . |||.. | |...     |. . | ||..  |.|..  .    | .    .|   ..|   . .|.|||| .||..    .||||| |||.
KEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNL

LIHADGRSVVADFGESRFVCQREDENL--TKQPGNLRWMAPEVFSQSGKYDRKVDVFSFALVIWEIHTAELPFS--HLKPAAAAAEMTYKRGRPTLPNQP
|. .. |  |.||| |.     || .   . . |   ||||||  ..  |. |.||.||..| ||| | . |..  |  .  ...    |  || .|   
LVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM-MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIP---

TAQFPAHILSLIPQAWHPESSSRPDFVEIVAL--LEP
 ...|. . .||   |... ..|| | ||.    || 
-DWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase C24A1.3.AA LISK 619-708 29 2.6e-26 82.34 In-house 103-225 (296) Show / Hide 
Range on Protein: 619-708
Range on HMM: 103-225/296
Sequence Identity: 29% (38 aa)

RLRISLDVARGMRYLHESAAKPVIHRDLNSHNILIH----ADGRSVVADFGESRFVCQRED----------------------ENLTKQ-----P-----
|..|.||.|.||.|||   .. .|||||.|.|.|.      . | .|.|||  | . ....                      ... |      .     
RVKIALDIACGMSYLH---SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTI

-GNLRWMAPEVFSQSGKYDRKVDVFSF
 |.  |||||.  .. .||...|||||
CGTPYWMAPEMLLGQ-SYDESCDVFSF
Kinase C24A1.3.AA Pkinase_Tyr 516-600 32 9.2e-23 77.71 Pfam 1-94 (270) Show / Hide 
Range on Protein: 516-600
Range on HMM: 1-94/270
Sequence Identity: 32% (32 aa)

IEFQESIGSGSFGKVYKGTYR------GKLVAVKRYRAMAFGCKSE---TDMLCREVSILSRL-AHPNVVAFVGTSL--DDPSQFAIITEFVENGSL
|.| . .|.|.||.|||||..      .  ||||  .    |. .|    ... ||..|.. |  |||.| ..|  .  ..|.|  |..|....|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase C24A1.3.AA Pkinase_Tyr 620-780 30 2.1e-21 73.13 Pfam 114-270 (270) Show / Hide 
Range on Protein: 620-780
Range on HMM: 114-270/270
Sequence Identity: 30% (51 aa)

LRISLDVARGMRYLHESAAKPVIHRDLNSHNILIHADGRSVVADFGESRFVCQREDENL-TKQP---GNLRWMAPEVFSQSGKYDRKVDVFSFALVIWEI
| .....|.|| ||..   |. |||||   |.|.. ..   ..||| .| .   .|..  .|.       .|||||... .  .  | || ||  ..|||
LQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEI

HT-AELP-FSHLKPAAAAAEMTYKRGRPTLPNQPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALL
 |  | | .  . . .   |. |..|.   . . .   |. | .|. | ||.. . || | ||.  |
FTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENC---PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase C24A1.3.AA LISK 521-603 35 2.3e-19 59.38 In-house 1-87 (296) Show / Hide 
Range on Protein: 521-603
Range on HMM: 1-87/296
Sequence Identity: 35% (31 aa)

SIGSGSFGKVYKGTYR--GKLVAVKRYRA--MAFGCKSETDMLCREVSILSRLAHPNVVAFVGTSLDDPSQFAIITEFVENGSLFRR
.||.|.||||||||.|  |. .|.|        .  .. .  . ||| .. .| |||.| |.| .  . .|. |.||... | |...
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQY
Kinase C24A1.3.AA Dicty4 516-543 67 1.4e-13 41.87 In-house 1-28 (277) Show / Hide 
Range on Protein: 516-543
Range on HMM: 1-28/277
Sequence Identity: 67% (19 aa)

IEFQESIGSGSFGKVYKGTYRGKLVAVK
| ... ||.||||.||||| ||| ||||
INIEQRIGKGSFGEVYKGTWRGKEVAVK
Kinase C24A1.3.AA LRRK 516-543 22 4.2e-10 31.93 In-house 1-57 (351) Show / Hide 
Range on Protein: 516-543
Range on HMM: 1-57/351
Sequence Identity: 22% (13 aa)

IEFQESIGSGSFG-KVYKGTYRG----------------------------KLVAVK
....|.||.|.|| .||....||                            . ||.|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIK
Kinase C24A1.3.AA LISK 766-780 46 0.126257 0.82 In-house 282-296 (296) Show / Hide 
Range on Protein: 766-780
Range on HMM: 282-296/296
Sequence Identity: 46% (7 aa)

ESSSRPDFVEIVALL
. ..|| | |||  |
DPKNRPSFKEIVQWL