daf-2

Species: Nematode worm
Alias: Y55D5A.5, aSWK379, Y55D5A_392.a, daf-2, CE27499
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 3024336-2991292, WormBase Genetic Map location: III:-9.61094,

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
daf-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 275 Kinase domain by global Sugen HMM Fasta, JSON
daf-2.AA Protein Genbank 1843 None Fasta, JSON

Protein domain

Protein domains of daf-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain daf-2.AA Recep_L_domain 177-302 37 1.8e-42 144.53 Pfam 1-121 (121) Show / Hide
Range on Protein: 177-302
Range on HMM: 1-121/121
Sequence Identity: 37% (51 aa)

NCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQ--HYALIIYRNPD--L-EIGL
||||..|.|.|. . .|                .....  ||..||||| ||.. | ..  . . |||||.| ||.|..  .|||.|| ||.  | |...
NCTVIYGNLEITWRDEHNE--------------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWM

DKLSVIRN--GGVRIIDNR--KLCYTKT-IDWKHLI
 .|..|..  |||.| .|   ||||| | |.|....
WNLKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY

Furin-like daf-2.AA Furin-like 358-492 28 6.3e-24 79.07 Pfam 31-182 (182) Show / Hide
Range on Protein: 358-492
Range on HMM: 31-182/182
Sequence Identity: 28% (46 aa)

CWSNT--TCQ----KSCAYDRLLPTKEIGP-GCD--ANGDRCHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDA----------------HLYLLLQ
||. .   ||    | |.       .. .  .|   ..|. ||.|| |||   |..|.|.||...|| | | ..|                  . |    
CWGPNPQHCQTLTKKVCP-------EQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPPMMIYNPTTFQMEPNPDGTYQFEG

RRCVTREQCLQLNPVLSNKTVPIKATAGLCSDKCPDGYQINP-DDHRECRKCVGKCEIVCE
.||||...| .|..  ..  . |    | |   || ||..|  .. ..| .| |.|  ||.
WRCVTFKECPKLSHNPDCNYYVI--HNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY

FU daf-2.AA FU 380-429 24 0.000631 20.29 SMART 1-48 (48) Show / Hide
Range on Protein: 380-429
Range on HMM: 1-48/48
Sequence Identity: 24% (13 aa)

GPGCDANGDRCHDQCVGGCERVNDATACHACKNVYHK---GKCIEKCDAHLYL
.  |     .||..| .||   . ...| .|.. |..   |.|...| .  | 
DGVC----KPCHPECATGCWGPG-PDQCTSCPHGYYLHHNGTCVSQCPPGYYP

Recep_L_domain daf-2.AA Recep_L_domain 508-624 31 5.7e-36 122.65 Pfam 1-121 (121) Show / Hide
Range on Protein: 508-624
Range on HMM: 1-121/121
Sequence Identity: 31% (40 aa)

LCNIIDGNLTIEIRGKQDSGMASELKD---IFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKSLFRN-LYAITVFENPN--LKKLFDST-TDLTLDR
 |..|.|||.|..|....      |..    |.||..||||||....... .|..|.||| |. ..|| .  ||. ...|||  |..|..   ...| ..
NCTVIYGNLEITWRDEHNE-----LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKN

GTVSIANNK--MLCFKYIKQLMSKLN
|.| | ||.  .||. ..........
GGVYIHNNPHPKLCYTHTEIMWWMIY

FN3 daf-2.AA FN3 773-1049 5 1.3e-05 25.92 SMART 1-69 (69) Show / Hide
Range on Protein: 773-1049
Range on HMM: 1-69/69
Sequence Identity: 5% (17 aa)

PDPPT----LALAQVDSD------AIHITWEAPLQPNGDLTHYTIMWRENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLL
|.||.    | .  |.|.       ....|..|       ..|.                                                        
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------------------

TMMGHEDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHI
                                                                                                    
----------------------------------------------------------------------------------------------------

SKKKPSSSSTTSTPAPTIASMYALTRKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHY----TLYAISLSACQ-NMTVPG
                                                             |....|| .    | | ....|   |.  .|
-------------------------------------------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

FN3 daf-2.AA FN3 1070-1160 14 0.005415 16.95 SMART 1-69 (69) Show / Hide
Range on Protein: 1070-1160
Range on HMM: 1-69/69
Sequence Identity: 14% (15 aa)

IDKVLN-ETIEWRFMNNSQ-----QVNVTWDPPTEVNGGIFGYVVKLKSKVDGSIVMTRCVGAKRGYSTRNQGVLFQNLADG-----RYFVSVTATSV--
 . . | ......  ...      .|...|.||      | ||.                             . . .|  |     .| ..|.| .   
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-----------------------------YTVTGLKPGQYPWTEYEFRVRAVNGND

HGAG
.| |
AGEG

Kinase daf-2.AA InsR 1243-1519 55 2.1e-213 715.24 In-house 1-278 (278) Show / Hide
Range on Protein: 1243-1519
Range on HMM: 1-278/278
Sequence Identity: 55% (155 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKRE
.||...||.||||.||.|.....|.....|||.||||.........|....|.||..||.|.....|.|.||.|..||..||||||..|.|..||||.|.
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

DEVFNETDCN-FFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDS
.|.||...|| .......|..|..||.||||||||...||.|||||.||||.|.|.|||||||||.||...||||...||.|.|||||.|||||||.|..
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

KSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAA
.||||||||||.||||||.|||.||||..||.||||...|...||.|..||...|.|||.|.|..|||||...|.|  
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD

Kinase daf-2.AA TyrKc 1243-1517 36 3.2e-124 419.89 SMART 1-280 (280) Show / Hide
Range on Protein: 1243-1517
Range on HMM: 1-280/280
Sequence Identity: 36% (112 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNF--KTNFIVKLYGVISTV-------QPAMVVMEMMDLGNL
..||.. ||| ||.||.|| .           ..|.|   .|         . ||.||...  .   ||.||||...        .| |.||| |..|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

RDYLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYH-------DYYKP----SGKR
.||||..|..             .. ....... ||..||.||.| .. |||||||||..... ||||.|||..||.  .       |||..    .|| 
KDYLRKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

MMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIG-----LSNDEVLNYIGMARKVIKKPE-------CCENYWYKVMKMCWRYSPRDRPTF
|.|.|||.||....||| .|||||||||...|. |.|.||| |     .||.||..|.   .   . |.       ||    |..||.||.. | |||||
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

LQLVHLL
 ......
SEIHECF

Kinase daf-2.AA Pkinase_Tyr 1243-1517 39 3.9e-113 383.8 Pfam 1-270 (270) Show / Hide
Range on Protein: 1243-1517
Range on HMM: 1-270/270
Sequence Identity: 39% (112 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTE--NLNYLMEANIMKNF-KTNFIVKLYGVIS-TVQP--AMVVMEMMDLGNLRDY
...|.. |||.||.||.|| .    ....   |.|.|.  ..  . .      . ||.|||.. .   ||.||||..   .|   ..||| | .|.|.||
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYY-KPSGKRMMPVRWMSPESLK
||..|          .  . ..     ....||..||.|||| .. |||||||||..... .|||.|||.|||..  ||| . .|. ..|..||.||...
LRKHR----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

DGKFDSKSDVWSFGVVLYEMVTLGAQP-YIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLL
.||| .|||||||||...|..|.|.|| | |.|| ||..||.  .   ..|| |    |..||.||.| | ||||| .... |
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase daf-2.AA TK 1243-1517 23 6.1e-106 356.23 In-house 1-486 (486) Show / Hide
Range on Protein: 1243-1517
Range on HMM: 1-486/486
Sequence Identity: 23% (117 aa)

VVLGQQCGEGSFG---KVYLGTGNNVVSLMGDRF------------------GPCAIKINVDDPASTENL-------------NYLMEANIMKNFK----
..||.. ||| ||   .||.|. ..   . |.||                   |.|.|.  .. |....              ..|.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-TNFIVKLYGVISTV------------QPAMVVMEMMDLGN----LRDYLRSKREDEVF--------NETDCNFFDI-----------------------
    ||.||||.. .            .| |.|||.|..|.    ||||||..|...          ...... . .                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHCMKGDITYSHESNSPCPEEQD

--------------------------------IPRDKFHEWAAQICDGMAYLESL------KFCHRDLAARNCMINRDET-----------VKIGDFG--
                                ..    . ...||..||.||.|.      .| |||||||||..... .           .||.|||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------MARDLFY------------------------HDYYKPSGKRMMPVRWMSPESLK---------DGKFDSKSDVWSFGVVLYEMVTLGAQPYIG-
      .|||. .                        .|||. . ....|.|||.||.|.         .||| .|||||||||...|..|.|..|| | 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

LSN---------DEVLNYIGMA-------------RKVIKKPECCE--------------NYWYKVMKMCWRYSPRDRPTFLQLVHLL
.||         .||..|. .              |   ..|. |                 .| .|..||.| |.||||| ||.. |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase daf-2.AA UTK 1243-1517 32 1e-77 264.5 In-house 1-296 (296) Show / Hide
Range on Protein: 1243-1517
Range on HMM: 1-296/296
Sequence Identity: 32% (100 aa)

VVLGQQCGEGSFGKVYLGTGNNVV---SLMGDRFGPCAIKINVDDPASTENL---NYLMEAN---IMKNFK-TNFIVKLYGVISTVQPAMVVMEMMDLGN
| ||.| |.| || |.... ...     .|. .   |     ....| .|       ..||.   .||.|.    ...|.|| .  .| |.|.|.|  |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ----HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGD

LRDYLRSKREDEVFNETDCNFFDIIPRDKFH-----EWAAQICDGMAYLESLKFCHRDLAARNCMINRD-------ETVKIGDFG---MARDLF------
||.|||. |..             .... .      ..|..| .||.||.| .| ||||||||| ....       ...||.|||   |.|..       
LRSYLRRHRPTPP-----------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN

---YHDYYKPSGKRMMPVRWMSPESLKDG-KFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMA-RKVIKKPECCENYWYKVMKMCWRYSPRD
   . .||.... ...|.|||.||.| .. .| .||||||||||..|..| |..|| |.||..|.  ..   |   ..|. |    |..|. ||.|.|..
RYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQE

RPTFLQLVHLL
||.| .||  .
RPDFEDLVQQM

Kinase daf-2.AA TK-Unique 1243-1517 33 3.3e-75 256.17 In-house 1-294 (294) Show / Hide
Range on Protein: 1243-1517
Range on HMM: 1-294/294
Sequence Identity: 33% (103 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGP--CAIKINVDDPASTENLNYLMEANIMKNFK-TNFIVKLYGV-ISTVQPAMVVMEMMDLGNLRDYLR
...|.. |||.|| |. |.   |........ .   |.| . |.   |.  ..| |...||. .    ||...|. ... .| | .|| .  |||..|||
LEVGDVIGEGAFGQVWRGE---VWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

SKRED-----------------EVFNETD-CNFFDIIPRDKFHEWAAQICDGMAYLES--LKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKP
..| .                 . ...|.  . .| .       .| ||. ||.||.|   |. ||||.|||.....| ..||.|||||||.  .  |  
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSM

SGK-RMMPVRWMSPESLK--DGKF-DSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECC-ENYWYKVMKMCWRYSPRDRPTFLQL
...  ..|.|||.|||||  .| .  .|||||||||...|..||||.|| |........ |  . .  ..|| |  .  |..|| ||...| .||.| |.
MCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQI

VHLL
.| |
KHRL

Kinase daf-2.AA Trk 1243-1517 36 3.6e-72 243.96 In-house 1-275 (275) Show / Hide
Range on Protein: 1243-1517
Range on HMM: 1-275/275
Sequence Identity: 36% (101 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKRE
.|| .  ||| ||||.|.   | .   .  .   |.|    |..      .  || .. | . . |||.|||    .| . | | |  | |. |||..  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMM--VAVKT-LKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGP

D-EVFNETDC-NFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFY-HDYYKPSGKRMMPVRWMSPESLKDGKF
| ... . .          |.    | ||  || |. |. | |||.|.|||..  .  |||||||| ||..   |||.  .. |.|.||| |||    ||
DAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKF

DSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLL
   |||||||||. |  | | ||. .||| || ..|   |   ..|. |    |..|  ||.  |  | .  .. ...
TYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII

Kinase daf-2.AA Src 1243-1517 35 4.9e-70 237.12 In-house 1-255 (255) Show / Hide
Range on Protein: 1243-1517
Range on HMM: 1-255/255
Sequence Identity: 35% (98 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKRE
. | .. |.| || |. |. |. .        . |.|    .  |.| .  | ||.|||... . .|.|| | |.  |   | | |  |.| |||.    
IKLCRKLGQGQFGEVWMGYWNGNT--------KVAVKTLKPGTMSPEAF--LQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK---

DEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFY--HDYYKPSGKRMMPVRWMSPESLKDGKFD
     ....    .    .  . |||. .||||||| .. ||||||||  .. .  .|..||| || |.    | | ..   ..|..|. || .  |.| 
-----DGEGRHLHLP---QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFT

SKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYK-VMKMCWRYSPRDRPTFLQLVHLL
 ||||||||. |.|.|| |  || | .| |||  . ..     .|. |  . |. .|..||. .|..||||  | . |
IKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQV-ERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase daf-2.AA Fer 1243-1518 30 2.5e-66 224.87 In-house 1-283 (283) Show / Hide
Range on Protein: 1243-1518
Range on HMM: 1-283/283
Sequence Identity: 30% (91 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGD-RFGP--CAIKINVDDPA-STEN--LNYLMEANIMKN-FKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRD
|.|| . ||| ||.||.|.   .. .. . .. .  .|.| .  . . .|.      . ||.||.| ..   .||.|||..  || |.|||... |.|..
VTLGKKLGEGAFGEVYKGR-R-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDS

YLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVK---IGDFGMARD--LFYHDYYKPSGKRMMPVRWMS
||. . ..             .. .. .. ..|...||.||.| .  |||.||||| .  |...|   | ||||.|.     .||...   ...|.||..
YLKKNKNK------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLA

PESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIG----LSNDEV----LNYIGMARKVIKKPECCENYWYKVMK-MCWRYSPRDRPTFLQLVHLLA
||....| . .|.|||||||...|  | ||.|| |    . . .|       |  ...  . |. .    ...|. .|| . | ||||. .... | 
PETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase daf-2.AA ALK 1243-1519 34 1e-59 204.71 In-house 1-273 (273) Show / Hide
Range on Protein: 1243-1519
Range on HMM: 1-273/273
Sequence Identity: 34% (98 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFG-PCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKR
. |.   | | || || |    .  . ||    . |.|    |.   . . ..||| || .|.   .|.. |.    || |.| | |  | .. .||  |
ITLVRALGHGAFGEVYMG---QYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECR

EDEV-FNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDET---VKIGDFGMARDL-FYHDYYKPSGKRMMPVRWMSPESLKD
  .. .. .     | .        .  .  |  |||. .| ||| |||||     .    .||.|||||||  .  |||   |. |||| || || . |
PHPESLQPSQLTMKDLL------QCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMD

GKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAA
| | ||.||||||| . |   ||  || | .| ||.  .      .  |  |    |..|  ||.  | |||.| ...  . .
GIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGR-MDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY

Kinase daf-2.AA Ack 1363-1517 39 4e-57 191.22 In-house 108-266 (266) Show / Hide
Range on Protein: 1363-1517
Range on HMM: 108-266/266
Sequence Identity: 39% (63 aa)

HEWAAQICDGMAYLESLKFCHRDLAARNCMINRDE-TVKIGDFGMARDLFY-HDYYKPSGKR--MMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTL
.... ||..||.|||.  . ||||||||    .|. .|||.|||  | |    |||. ...|    |  |. ||.|. ..| ..||||.||| | || . 
CDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSY

GAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLL
| .|..|..  ..|  |. ..    .|.||    |..|. ||   | ||||| ... .|
GEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL

Kinase daf-2.AA CTKB 1366-1519 41 9.5e-55 188.2 In-house 115-269 (269) Show / Hide
Range on Protein: 1366-1519
Range on HMM: 115-269/269
Sequence Identity: 41% (64 aa)

AAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIG
|| . |||||. |..  |||||||||..  .  | |||||. || .   ||| ..   .|.|||||||. || . . |||||.|.|..|..| .  || .
AADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWSYGIVIWEIMTFAKMPYPE

-LSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAA
 ..| ||   |        .|. |    |  |  ||   | ||. |  |   .  
YETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISFKELHEKTLL

Kinase daf-2.AA S_TKc 1243-1525 25 1.7e-41 145.13 SMART 1-231 (231) Show / Hide
Range on Protein: 1243-1525
Range on HMM: 1-231/231
Sequence Identity: 25% (73 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDL--GNLRDYLRSK
  .... |.|.|||||... ..           .||||           . . | .|.|. .  .|||||.|. . .   .|||..|   |.|.||....
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

RE---DEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDG
.    . .|.| .. |.           ..|||....|. |....||||   | ....  ..||.|||.|| |                 .|.|| |   
GRHGLRFPFPE-HARFY-----------MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

KFDS-KSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVH-LLAAEASPEF
...  |.|.||.|..||||.. |  |.         ..  | .|.       .  .   .. |... |..|||  .. .  ... . | |
GYGKCKCDWWSCGCILYEMLC-GYPPFP--------QMQMMFKKIG-----SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase daf-2.AA Pkinase 1243-1517 22 1.4e-32 116.33 Pfam 1-293 (293) Show / Hide
Range on Protein: 1243-1517
Range on HMM: 1-293/293
Sequence Identity: 22% (70 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYL---MEANIMKNFKTNFIVKLYGVISTVQPAMV-VMEMMDLG----NLR
 ..|.. |.||||.||...  .            |.||   . .. . . ..   .|. |||...  .||.||..  .  . .  ||| .. |     | 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLF

DYLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETV----KIGDFGMARDLFYHDYYKPSGKRMMPV---R
||..         . ...|    . .    .. ||. |..|. | ...||||   |..|... ..    ||.||| |. .     | ...  . ..   .
DYIST--------WRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPW

WMSPESLK-DGKFDSKSDVWSFGVVLYEMVTLGAQPYIGL------SNDEVLNYIGMARKVIKKPECCE-------------------NYWYKVMKMCWR
.|.|| .. . . ..|.|.||.|..||||.. |  |. |       . ..... |....     |. |.                       ...| |..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

YSPRDRPTFLQLVHL--L
. | .|||. |...   .
KDPKKRPTAEQILQHPWF

Kinase daf-2.AA CTKB 1243-1341 37 1.7e-08 26.37 In-house 1-97 (269) Show / Hide
Range on Protein: 1243-1341
Range on HMM: 1-97/269
Sequence Identity: 37% (38 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDR-FGPCAIKINVDDPASTENLNYLM-EANIMKNFKTNF-IVKLYGVISTVQPAMVVMEMMDLGNLRDYLRS
.|| |. ||| || || |    .   | |    | |||.  |  .| |  |  | |  ||.       ||.| |.     | ..|.|.|  | |.  || 
IVLKQKLGEGHFGVVYAGEAKKI---MPDQAVTPVAIKMLQD--SSSEATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRN

KR
 |
SR

Kinase daf-2.AA Ack 1243-1338 31 1.9e-05 14.36 In-house 1-94 (266) Show / Hide
Range on Protein: 1243-1338
Range on HMM: 1-94/266
Sequence Identity: 31% (31 aa)

VVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDD--PASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPA-MVVMEMMDLGNLRDYLR
. |. . |.|.|| |  |.  |  .  |..  . |.|.  .|  .. ..    | |..|| .     .|.||||  . ||. | |.|.  .| | | ||
ITLCEKLGDGCFGVVWRGEWTN-PG--GKHI-QVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLD-QPMLMMVTELAPCGSLLDCLR