Gene E02D9.1 (Nematode worm)

E02D9.1

Species: Nematode worm
Alias: E02D9.1a, CE27902, aSWK320, E02D9.1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 6810263-6812858, WormBase Genetic Map location: I:1.38,

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
E02D9.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 238 Kinase domain by global Sugen HMM Fasta, JSON
E02D9.1.AA Protein Genbank 427 None Fasta, JSON

Protein domain

Protein domains of E02D9.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase E02D9.1.AA STE7-Unclassified 162-394 30 7.6e-121 407.78 In-house 1-288 (301) Show / Hide 
Range on Protein: 162-394
Range on HMM: 1-288/301
Sequence Identity: 30% (88 aa)

LQRGKYVGNGMHATVRMALHEK---------TQKWYVIKTILSQNTDKTEYEKEILAYEECSQSDYVVGYHGCEVSSIK---KELVLEYMDKGDFR----
|.|.||.|.|||.||...||..         ...|.||.|....|........|. ....|....|.|.|.|.......   .....||||.|...    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

-----------PFGILPFSVHQSVALSLIRAIRHVWNSGPGYIHRDIKPENILVNSQGYVKICDFGAAKRIDNTYRIASSAAGTQMYQAPEQQMGQ----
           ..|..|..|....|...|........... .|||||||.||||||.|.|||||||......||...|....|.|||..||...||    
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHH-IIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHR

-DYSEKVDIWCFGLTLWEFAIGPNLEEY------------------LNGLSSYEEITVEPIDG------FPESLAVLISNCLRRQPSAR
 .||.|.|||..|||.||.|.|....||                  ...||......|.....      ........||.|.   |  |
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRER
Kinase E02D9.1.AA STE7 162-394 24 3.3e-91 309.31 In-house 1-275 (288) Show / Hide 
Range on Protein: 162-394
Range on HMM: 1-275/288
Sequence Identity: 24% (68 aa)

LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILSQNTD---KTEYEKEILAYEECSQSDYVVGYHGCEVSSIK--KELVLEYMDKGDFRPF---------
|......|.|.. .|....|....|.. .|.| ..|.|   .. . .|. .. .|....|.|...|. ..  .    ...||||.| .. |         
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GILPFSVHQSVALSLIRAIRHVWNSGPGYIHRDIKPENILVNSQGYVKICDFGAAKRIDNTYRIASSAAGTQMYQAPEQQMG--QDYSEKVDIWCF
    |..|..... .|...|..... ..   ..||||.||.||||||.|.||.|||| ..........|....|.|.|.|||...|  |.|. . |.|..
GIKKGRIPEQILGKIAVAVIKGLHYLHEK-HKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSL

GLTL-WEFAIG----------------------------PNLEEYLNGLSSYEEITVEPIDGFPESLAVLISNCLRRQPSAR
|.|.  |.|.|                             .|....|.. .. ..      .|....  ....||...|. |
GITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNEN-PPPRLP-----KFSPEFQDFVNKCLQKDPNER
Kinase E02D9.1.AA STE 162-406 17 4.6e-46 159.34 In-house 1-359 (359) Show / Hide 
Range on Protein: 162-406
Range on HMM: 1-359/359
Sequence Identity: 17% (65 aa)

LQRGKYVGNGMHATVRMALHEK---------------TQKWYVIKTILSQN------------------TDKTEYEKEILAYEECSQ-SDYVVGYHGCEV
... . .|.|   ||  |.. |               |.... || .  .|                  ... ...|||    .|.. ....| |.||..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SS-------IKKELVLEYMDKGDFRPFGI------------------LPFSVHQSVALSLIRA-IRHVWNSGPGYIHRDIKPENILVNSQGYVKICDFGA
          .  ...|||| | .. .                    .| |.   .. .....   .  . .  .||||||| |||.     ||.|||| 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

AKRIDNTYR----------------IASSAAGTQMYQAPEQQMG------QDYSEKVDIWCFGLTLWEFAIGPNLEEYLNGLSSYEEIT-----------
.........                   . .||. . |||  ..      ..|..|.|||..|.|..| | |      .. .. . .|.           
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-------VEPIDG--------------------FPESLAVLISNCLRRQPSARWNADQIEQ--SDYL
         |.                      . ...   |..||.. |. |..|.|  .     .
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase E02D9.1.AA Pkinase 162-406 22 1.3e-38 137.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 162-406
Range on HMM: 1-293/293
Sequence Identity: 22% (69 aa)

LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILSQNTDKTEYEK-----EILAYEECSQSDYVVGYHGCEVSSIKKELV--LEYMDKG----DFR-----
...|. .| |  ..|. . | .|.| ...|.|  ..... . .      ||    .. .....| ....  .  |...   .||...|    |       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-PFGIL--PFSVHQSVALSLIRAIRHVWNSGPGYIHRDIKPENILVNSQGYV----KICDFGAAKRI-DNTYRIASSAAGTQMYQAPEQQM-GQDYSEKV
   | .  .  . ..... ..|.. .  .   | ||||.||||||....|..    |||||| || .    .. ... .||  | |||  . ||.|. ||
WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWCFGLTLWEFAIG----PNL---EEYLNGLSSYEEITVEPIDGFP------------------------ESLAVLISNCLRRQPSARWNADQIEQSDY
|.| .|..|.|.. |    |.    .. .. .  ...|   |..                           |..  .|..||.. |. |..|.|| |...
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

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Kinase E02D9.1.AA S_TKc 162-406 22 8.4e-36 126.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 162-406
Range on HMM: 1-231/231
Sequence Identity: 22% (60 aa)

LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILSQNTDKTEYEKEILAYEECSQSDYVVGYHGCEVSSIKKELVLEYMDK--GDFRPFGI----------
 . .. .| |  ..|. . | ||.. . || |          ..||   ..  . ...| .... ..  .  .|.||.|   || . .            
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LPFSVHQSVALSLIRAIRHVWNSGPGYIHRDIKPENILVNSQGYVKICDFGAAKRIDNTYRIASSAAGTQMYQAPEQQMGQDYSE-KVDIWCFGLTLWEF
.|  . ....  ...|. .  .   | ||||.||||||...   .|||||| |...       ..  ||  | |||      |.  |.|.| .| .|.|.
FPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

AIGPNLEEYLNGLSSYEEITVEPIDGFPESLAVLISNCLRRQPSARWNADQIEQ-------SDYL
. |  . .  .    .. |        ....  .|..||.. |. |. | .. |         ..
LCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase E02D9.1.AA AGC 275-351 22 2.7e-28 68.93 In-house 174-301 (395) Show / Hide 
Range on Protein: 275-351
Range on HMM: 174-301/395
Sequence Identity: 22% (30 aa)

GYIHRD-IKPENILVNSQGYVKICDFGAAKRIDNTY--------------------------------------------------RIASSAAG--TQMY
|.|||| .|||||| ...|..|..||| .|.. | .                                                    ...  |  |  |
GIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEY

QAPEQQMGQDYSEKVDIWC--FGLTLWEFAIG
 |||      |.  .|.|.  .|  . |. .|
MAPEIL----YGKACDWWSFGLGCLMYEMLTG
Kinase E02D9.1.AA Ciliate-E2-Unclassified 165-351 20 1.6e-27 92.57 In-house 4-266 (352) Show / Hide 
Range on Protein: 165-351
Range on HMM: 4-266/352
Sequence Identity: 20% (54 aa)

GKYVGNGMHATVRMALHEKTQKWYVIKTIL--------SQNTDKTEYEKEILAYEEC------------------SQSDYVVGYHGCEVSSIKKELVLEY
.|  |.| ...|... |.|... |..|..         .... . |.  |... ..                   ... ..| .. |. .  .  .|.||
IKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEY

MDKG------DFRPF---------------GILPFSVHQ-----SVALSLIRAIRHVWNSGPGYIHRDIKPENILVNSQG---YVKICDFGAAKRIDNT-
.. |        |..                |..    .       .  .. .. .   .. . |||||||||||....|   |.||.||| .|....  
CEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

--------------YRIASSAAGTQMYQ----APEQQMGQDYS----EKVDIWCFGLTLWEFAIG
              . .... .|| .|.    |||  .|| |.    .|.|||..|  | |.  |
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG
Kinase E02D9.1.AA TKL 168-404 16 6.5e-26 90.3 In-house 1-364 (364) Show / Hide 
Range on Protein: 168-404
Range on HMM: 1-364/364
Sequence Identity: 16% (60 aa)

VGNGMHATVRMALHEKTQ--------KWYVIKTILSQN-------------------------TDKTEYEKEILAYEECSQ--SDYVVGYHGCEVSSIK-
.| |  ..|  . .  .         |. ..|.. |.|                         . . . ..|.     .|.   . .| . |.  .. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KELVLEYMDKGD-FRPFGILPFSVHQSVALSLIRAIRHVWNSG------PGYIHRDIKPENILVNSQGY--------------VKICD
              .| ||...|. .  .    ...  . ||.  |.. .  ...      |. ||||.|..||||.. .               .||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

FGAAKRID-------------------NTYRIASSAAGTQMYQAPEQQMGQ----------------DYSEKVDIWCFGLTLWEFAIG--PNLEEYLN--
|| .....                   |.    ..  ||  . |||  .||                .||||.|.. ||. ||| . .  |  ..  .  
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPM

----------GLSSYEEITVEPI------------DGFPESLAVLISNCLRRQPSARWNADQIEQSD
           . ...    ..             . .|.|.. |.  |    |..| ....| .  
IFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase E02D9.1.AA Ciliate-E2 275-406 22 1.6e-25 84.61 In-house 180-365 (365) Show / Hide 
Range on Protein: 275-406
Range on HMM: 180-365/365
Sequence Identity: 22% (45 aa)

G-YIHRDIKPENILVNSQGYVKICDFGAAKRIDNTYR-------------------------------IASSAAGTQMYQAPEQQMGQD---------YS
.  |||||||||||.     .||.||| .|..|. .                                .. . .|| .|.|||  .|..         |.
NNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD

EKVDIWCFGLTLWEFAIG--PNLEEYLNGLSSYEEITVEPIDGFPE---------------------SLAVLISN----CLRRQPSARWN-ADQIEQSDY
.|.|||..| .| |.  |  |           ...|   .|| ...                     .   ||..    .| ..|. | . ..|| .  .
YKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPW

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Kinase E02D9.1.AA Ciliate-E2b 277-394 35 6.2e-25 72.84 In-house 124-258 (272) Show / Hide 
Range on Protein: 277-394
Range on HMM: 124-258/272
Sequence Identity: 35% (48 aa)

IHRDIKPENILVNSQGYVKICDFGAAKRIDNTYR---IASSAAGTQMYQAPEQQM-----GQDYSEKVDIWCFGLTLWEFAIG--PNLEEYLNGLSSYEE
|.||||||||.| ..||.|. |.|.|| ..          .  ||  | |||        |. |. ||||| .| .|.||  |  |  |.  .    |.|
IYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQE

ITVE-PIDGFP----ESLA--VLISNCLRRQPSAR
|. .   ..||    . .|   |.. || ..|  |
IIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVR
Kinase E02D9.1.AA MEK5 162-351 30 4.4e-24 85.1 In-house 1-187 (254) Show / Hide 
Range on Protein: 162-351
Range on HMM: 1-187/254
Sequence Identity: 30% (58 aa)

LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILSQNTDKTEYEKEILAYEEC---SQSDYVVGYHGCEVSSIKKELVLEYMDKGDFRPFGILPFSVHQSV
..    .| |   ||  | |  . |   .| || . |   | .|.|..  |      | |..|. |      .  .  |.|| |    .  .| ..   .
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDIT--LELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRCIPEHILGRM

ALSLIRAIRHVWNSGPGYIHRDIKPENILVNSQGYVKICDFGAAKRIDNTYRIASSAAGTQMYQAPEQQMGQDYSEKVDIWCFGLTLWEFAIG
. .... .  .||     .|||.|| |.||| || .|.|||| .  . |   |.    ||  | |||  .|..|    |.|  |. . |.|.|
TVAIVKGLNYLWNL--KIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNS--ITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATG
Kinase E02D9.1.AA MEK1 205-351 35 2.3e-23 76.28 In-house 46-192 (297) Show / Hide 
Range on Protein: 205-351
Range on HMM: 46-192/297
Sequence Identity: 35% (54 aa)

KEILAYEECSQSDYVVGYHGCEVSSIKKELVLEYMDKGD----FRPFGILPFSVHQSVALSLIRAIRHVWNSGPGYIHRDIKPENILVNSQGYVKICDFG
.|.    ||  | |.||..|  .|     . .|||| |     ..  | .| ..   |..  .| .  . .     .|||.|| ||||||.| .|.||||
RELQVLHEC-NSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILGKVSVAVLRGLTYLRDKH-KIMHRDVKPSNILVNSRGEIKLCDFG

AAKRIDNTYRIASSAAGTQMYQAPEQQMGQDYSEKVDIWCFGLTLWEFAIG
 . ..     .| |  ||  | .||   |  |. . ||| .|| | |.|||
VSGQLIDS--MANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIG
Kinase E02D9.1.AA TyrKc 162-406 18 2.2e-10 -54.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 162-406
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILSQNTDKTEYEKEILAYEEC-SQSDYVVGYHGCEVSS-------IKKELVLEYMDKGDFRPFGILPFS
.. ||  |.|   .|. .          .|.. .    . .  .|.    .   . . .|  .|. ...           .|.|||..|| . .  |  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY--LRKH

VHQSVALSLIRAIRHVWN--------SGPGYIHRDIKPENILVNSQGYVKICDFGAAKRIDNT---------YRIASSAAGTQM----YQAPEQQMGQDY
 ..   |..   .   |         .  ..||||.   |.||.... |||.||| .. |..          || ...  |  |      |||  .   .
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SEKVDIWCFGLTLWEFA-------IG-----PNLEEYLNGLSSYEEITVEPID------GFPESLAVLISNCLRRQPSARWNADQIEQSDYL
..| |.| || ..||          |      . .| .. . . .     | |      . |. .  ... | ...|. | .  .|   ...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase E02D9.1.AA Pkinase_Tyr 275-347 37 1.8e-07 25.96 Pfam 131-206 (270) Show / Hide 
Range on Protein: 275-347
Range on HMM: 131-206/270
Sequence Identity: 37% (29 aa)

GYIHRDIKPENILVNSQGYVKICDFGAAKRI--DNTY-RIASSAAGTQMYQAPE--QQMGQDYSEKVDIWCFGLTLWE
..||||.   |.||.... ||||||| |. |  | .| | ....       |||  . .   ...| |.| || ..||
NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKSDVWSFGVLMWE
Kinase E02D9.1.AA MEK5 365-406 26 0.037319 3.53 In-house 213-254 (254) Show / Hide 
Range on Protein: 365-406
Range on HMM: 213-254/254
Sequence Identity: 26% (11 aa)

EEITVEPIDGFPESLAVLISNCLRRQPSARWNADQIEQSDYL
|.  . |.| | |     |  |...||  |   ... |  ..
EHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI