Gene F14H12.4 (Nematode worm)

F14H12.4

Species: Nematode worm
Alias: F14H12.4, F14H12.4a, aSWK306, CE07064, F14H12.4A
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: X:-8.15, WormBase Physical Map location: X: 4308677-4312753,

Classification

Group: STE
Family: STE20
Subfamily: MST

Sequence

Name Sequence Type Origin Length Description Download
F14H12.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
F14H12.4.AA Protein Genbank 523 None Fasta, JSON

Protein domain

Protein domains of F14H12.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F14H12.4.AA MST 63-314 75 9.5e-227 727.89 In-house 1-254 (254) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-254/254
Sequence Identity: 75% (191 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYF--KHSDLWIVMEYCGAGSISDIMRARRKPLSEQEIS
||||.|||.||||||.||||...|...|||.|||..|||||||||||||||||||.||||||||  |....||||||||.||..|||......|.||.|.
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIA

AVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDI
..|.|||.||||||| |||||||||||||||..| .|||||||.|||||||||||||||||.|||||||.||.||.|||||||||||||||||.||||||
CILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDI

HPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
|||||.||||.|||||||.||.||.|||||...||.|.||.|.|| .|..|.||
HPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase F14H12.4.AA STE20 63-314 53 2.7e-168 565.38 In-house 1-288 (288) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-288/288
Sequence Identity: 53% (153 aa)

FDIVGKLGEGSYGSVHKAIHRESGHV----LAIKKVPVDTD------LQEIIKEISIMQQCKSKYVVKYYGSYFKH----SDLWIVMEYCGAGSISDIMR
.... |.|.||||.|.||.|...| .     ||||......      ...|.||||||.|||....|||||||.|.    ..|||||||||.||..|||.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ARRK-----PLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTD----TMA-KRNTVIGTPFWMAPEVIEE----
    . |     |..|..|....|..|.||.|||  ..|||||||.||||..|| .|||||||..|||.    ||. ||||..|||.|||||||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-IGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIP--TKPPPTFKK--PEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
  |||.|.|||||||||||||||.|||.|.|||||.||||  ..||||.|.  |. ||.||.||. .|| | ||.| ||  | .| ||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase F14H12.4.AA STE 63-314 38 5.1e-140 471.47 In-house 1-359 (359) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-359/359
Sequence Identity: 38% (139 aa)

FDIVGKLGEGSYGSVHKAIHR------ESGHV---------LAIKKVPVDTD-------------------LQEIIKEISIMQQCK--SKYVVKYYGSYF
.....|.|.|..|.|.||...      ..| |          |||.......                   .|.|.|||.||..|.  ....|||||.||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KH-------SDLWIVMEYCGAGSISDIMR---ARRKPLS----------EQEISAVLRDTLKG-LQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAG
|        ..|||.|||...||..||..    . |||.          |..|....|..||| |.|||....||||||..||||     .||.||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLTDTMA----------------KRNTVIGTPFWMAPEVIEE------IGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTK-----------
||||.||                ||||..||| |||||||.        |||||.||||||.|.||||.|.||..| |||||.||||..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPTFKK-----------------PEEWSSEFNDFIRSCLIKKPEERKTALRLCE--HTFI
    |||...                  |..||.||.|||. ||.| |..| ||  | .  | ||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase F14H12.4.AA YSK 63-314 51 8.20000000001e-139 420.76 In-house 1-257 (257) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-257/257
Sequence Identity: 51% (132 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEI---IKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRA-RRKPLSEQE
| .  . | ||.| | |.| .  . | ||| .  . .  ||    .|| .  ||.| |. |||||| | . |||.||||| ||..| |..    .. |. 
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

ISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEE--IGYDTKADIWSLGITAIEMAEGRPP
|. .||  |||| |||  .|||||||| |.||. .|  ||.|||||||.|||. |||| .|||.||||||| .   .||.|||||||||||.||| | ||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
|.| ||||. | || ..||. .. ...|  | .|.  || | ||.| .|  |  | ||
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase F14H12.4.AA PAKL 63-314 51 1.5e-130 440.01 In-house 1-256 (256) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-256/256
Sequence Identity: 51% (133 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPV-DT-DLQEIIKEISIMQQCKSKYVVKYYGSYFKH-SDLWIVMEYCGAGSISDIMRARRKPLSEQEI
| .  |||.|||||| ||||.... .||||  ..  . . ..| |||.|   ||. ..| |.||     . .|| |.|| .||| |.|    | | | .|
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

SAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMA-KRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYS
| .|. ||||| |||    ||||||| ||||| |.. |.|||||  || |.     |  ||||.|||||.|    |. |.|||||||||||||.|.|| .
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHY

DIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
|. ||||  ||| .|||||..|  || .||||.  |. | ||.|  .  |  | ||
DMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase F14H12.4.AA PAKA 63-314 42 3.7e-105 355.66 In-house 1-260 (260) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-260/260
Sequence Identity: 42% (110 aa)

FDIVGKLGEGSYGSVHKAIHRESGHV--LAIKKVPVDTDLQE--IIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRK----PL
.. . |.|.|. |.| .|. .. .     |||.  .... .   || ||..| .|| | .|.|. ||   ..||.|||| ..|.  |.  . ..    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

SEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGR
.|. |..|.| .|.||...|. . ||||||  ||||..||  |..||| . |||.   ||||. ||| |||||||    || | ||||||| ||||.|| 
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
||| .  | ||.. | |.  | .| |. ||.||.||   || . ...| .|  | .| |.
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase F14H12.4.AA S_TKc 63-314 32 6.5e-100 339.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-231/231
Sequence Identity: 32% (86 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGA--GSISDIMRARRKP-----LS
..|. |.|.|..|.|.|..|...|.. |||...     . |..||.|... . ...||.|...   ..|..|||||.   |.  |... |...     ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDT-KADIWSLGITAIEMAEGR
| ..  ... ....|.|.|... ||||.|  ||||..    |..|||.| ||       .|..|||..|||||.   ||.. |.|.||.|.. .||. |.
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

PPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCE-------HTFI
||..    | ..| .              |.|. |||| || | ||.| ||  . .       | ..
PPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F14H12.4.AA Ste20-DD1 63-314 47 1.2e-99 337.35 In-house 1-268 (268) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-268/268
Sequence Identity: 47% (128 aa)

FDIVGKLGEGSYGSVHKA-------IHRESGHVLAIKKVPVDT-DLQE---IIKEISIMQQC-KSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRAR
| ||   | ||.| |          .      | |.| | ..  |  |     ||| |.    .  |.||| | | | . | ||||||  ||| |||   
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC

RKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEE----IGYDTKADIWSLGIT
 | | | .| |..    ||| |||  . .||||||||.|.|  | .|||||||   .  .  | ||||| |.||.||.|       ||| ||||||||||
SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT

AIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
||||||  ||  .. | | || || ..||| | | .|| ||||||. || . |. |  |  |  | ||
AIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase F14H12.4.AA KHS 63-314 46 3.9e-99 334.11 In-house 1-258 (258) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-258/258
Sequence Identity: 46% (122 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIK--KVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEIS
.... ..| | || |.|| . .|... |.|  |.  . |.. | .|| .|..|.   .| |.|||...  |||.|||||.||. || ..   ||||  |.
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTG-PLSELQIA

AVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---EEIGYDTKADIWSLGITAIEMAEGRPPY
 | |.||.||.|||  .|.|||||  ||||. .|  |||||||..|.| |.|||   ||||.||||||     . ||.   |||..||||||.||  || 
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

SDIHPMRAIFMIPTKP---PPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
 |.|||||.|.. ||    ||. |  . ||. | .|.. .|.| |  | || .| .|.|.
FDLHPMRALFLM-TKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase F14H12.4.AA SLK 63-314 43 1.2e-91 309.45 In-house 1-259 (259) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-259/259
Sequence Identity: 43% (112 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDT--DLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEIS
..|.| ||.| .| |.|| |.| . . | | . ..   .|.. . || |. .||  ..|| |..|.   .||...|.|. | .  ||    .|| |. | 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

AVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----EEIGYDTKADIWSLGITAIEMAEGRP
 | . .. .|..||. | ||||.||||||.  ||  .||||||. ... || || | ||||.||||||.      .  || |||||||||| ||||.. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
|.... ||| .. |    ||| ..| .||.||.||.. || | |. | |. .| .| ..
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase F14H12.4.AA NinaC 63-314 44 1.7e-91 310.24 In-house 1-267 (267) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-267/267
Sequence Identity: 44% (119 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEII-KEISIMQQ-CKSKYVVKYYGSYFKHS-----DLWIVMEYCGAGSISDIMRA---RRK
. |.   | | || | |.  ...| . |.|    . |..| |  |  |... |    ||..|| |.|        ||.|||||  ||. |. .    . .
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCGR

PLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----EEIGYDTKADIWSLGITA
 ..|. |. .|.... ||| ||  . ||||.|  |||| |.|  || ||||  ||. |  .||| .|||.|||||||      .  ||  .|.|||||||
RMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITA

IEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
||.. | ||  |.|||||.| ||  ||||  .||.|. ||||||  ||.|  | | .   . || ||
IELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase F14H12.4.AA Pkinase 63-314 29 3.2e-87 300.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIK------EISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAG----SISDIMR-ARR
. |..|.|.||.|.| |..|. .|.. |.|.......  .  .      ||.||. ......|..|...  ......|||||. |    . .|...  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPL--SEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIA----KLADFGVAGQL-TDTMAKRNTVIGTPFWMAPEVIE-EIGYDTKADIWSL
...  ||.|.  ... .|.||.|.|. . ||||.|  |||.. .|      |..|||.| |. .      .|. |||..||||||    .|..|.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GITAIEMAEGRPPYSDI----HPMRAIFMIPTKPPPTFKKPEEWS---------------------SEFNDFIRSCLIKKPEERKTALRLCEHTFI
|.. .||. ||||...     . .. ..||  . .| .. ...|.                     .|. |||..|| |.|..| ||  ...| ..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase F14H12.4.AA Pkinase_Tyr 63-302 27 2.8e-39 133.64 Pfam 1-260 (270) Show / Hide 
Range on Protein: 63-302
Range on HMM: 1-260/270
Sequence Identity: 27% (71 aa)

FDIVGKLGEGSYGSVHKAIHR----ESGHVLAIKKVPVDTDLQE-----IIKEISIMQQC-KSKYVVKYYGSYF-KHSD--LWIVMEYCGAGSISDIMRA
  .  |||||..|.|.|.. .    . .   |.|... ... ..      ..|..|| |  . . .|..||    .     ..|||||.  |.  |  |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---RKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQL--TDTM-AKRNTVIGTPFWMAPEVIEEIGYDTKADIWSL
.   ..||. ...    ..  ||..||.. . ||||. | |.|.. ....| .||| |  .  .|.   ||       .|||||.| .  . || |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GITAIEMAE-GRPP-YSDIHPMRAIFMI-PTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEER
|..  |.   |. | | .. . . . .|         ..||  . |  | ...|  ..||.|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDR
Kinase F14H12.4.AA TyrKc 63-314 25 1.4e-25 92.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 63-314
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQC--KSKYVVKYYGSYFKH-------SDLWIVMEYCGAGSISDIMRARRKP
     ||||| .| |.|.. .      |.|..  |. ......|..|| .   . . .|. ||   ..         |.|||||.  |.  |  |..|. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT----MAKRNTVI----GTP-----FWMAPEVIEEIGYDTKADI
|. ..      .  .| .|||. . ||||. | |.|.. ....| .||| .  ..|      .|   .     |.       |||||.| .  . || |.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSLGITAIEMAE-GRPPYSD-----IHPMRAIFMIPTK----PPPT-----FKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI
|| |..  |.   | .||..     . . ..|  . .     .||      |    . ..|  . ...|   .||.| |   .  | ..
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Mst1_SARAH F14H12.4.AA Mst1_SARAH 471-519 57 1e-29 98.43 Pfam 1-49 (49) Show / Hide 
Range on Protein: 471-519
Range on HMM: 1-49/49
Sequence Identity: 57% (28 aa)

DFEFLRNITLDELIRRKESLDSEMEEEIRELQRRYKTKRQPILDVIEIK
|||||......||..|..|||..||.||.||..||..|||||||..|.|
DFEFLKSWSYEELQQRLASLDPMMEQEIEELRQRYQAKRQPILDAMEAK