Gene F19H6.1 (Nematode worm)

F19H6.1

Species: Nematode worm
Alias: aSWK228, F19H6.1, CE31484
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: No interpolated position., WormBase Physical Map location: X: 12395201-12393407,

Classification

Group: Other
Family: NEK
Subfamily: NEK6

Sequence

Name Sequence Type Origin Length Description Download
F19H6.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
F19H6.1.AA Protein Genbank 294 None Fasta, JSON

Protein domain

Protein domains of F19H6.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F19H6.1.AA NEK6 23-274 81 1.6e-209 696.12 In-house 1-252 (252) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-252/252
Sequence Identity: 81% (205 aa)

FIIEKKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRLI
|.|||||||||||||.||||.|.|.||||||.|.|||.|.||||||.|||||||||||.|||.||||||.||.||||||||.|||||||||||||..|||
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLI

PEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQ
||.|||||||||..||.||||||.|||||||||||||.|||||||||||||||||||||||||||||||||||||.|.|||||||.||.|||||||||||
PERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQ

SPFYGDKMNLYSLCKKIENCEYPPLPADIYSTQVSANLCFVQLSSATWYPVV
||||||||||||||||||.|.|||||||.||.|.....|........|.| .
SPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase F19H6.1.AA NEK 23-257 39 7.6e-129 434.35 In-house 1-260 (286) Show / Hide 
Range on Protein: 23-257
Range on HMM: 1-260/286
Sequence Identity: 39% (104 aa)

FIIEKKIGKGQFSEVFRAQCTWVDLH-----VALKKIQVFEMVDQKARQDCL-KEIDLLKQLNHVNVIRYYASFIDNN--QLNIVLELAE-AGDMSRM--
. | ||||.|.|..|.......   |     ...|||. ... ..| .|... .|. .||||.| |...|| |||...  .|.|| | .|  ||....  
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKIN-MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-IKHFKKGGRLIPEKTIWKYFVQLARALAHMHSK-----RIMHRDIKPANVFITGNGI----VKLGDLGLGRFFSSKTTAAHS-LVGTPYYMSPERIQES
 ||. |. | ...|..||..|.|.. || .||..     .|.||||||.|.|.| |..    ||.||.|. . ....|..|.. .|||||||||| .|. 
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

GYNFKSDLWSTGCLLYEMAALQS--PFYG-DKMNLYSLCKKIENC-EYPPLPADI-YSTQVS
.||.||| || ||.||||..|..  ||.. | ||..||..|| .. .|||.|  . ||.. .
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWD-MNMPSLYMKIMKGPQYPPIPSHRMYSQDLQ
Kinase F19H6.1.AA S_TKc 23-271 27 3.8e-74 253.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-271
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

FIIEKKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEA--GDMSRMIKHFKKGG-
. | .||||| |..|.... .  . .||.|.|           .. ..||..||. .| |....| .| | . | .|.|...   ||. ..||. ...| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-RLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNF-KSDLWSTGCLLYE
 . .|| ....|. |...||...||..|.|||.||.|....    .|..| || |..       ....|||.||.|| .   ||.. |.| || ||.|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MAALQSPFYGDKMNLYSLCKKIENCEYPPLPADIYSTQVS--ANLCFV---------QLSS-------ATWY
|.. . ||.    ... . |||             | ..    . |..         ..           | 
MLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase F19H6.1.AA NEK8 49-248 36 2.9e-73 208.5 In-house 29-244 (278) Show / Hide 
Range on Protein: 49-248
Range on HMM: 29-244/278
Sequence Identity: 36% (81 aa)

VALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEK----------------TIWKYFV
| .| | . .| . | ||. . ||..|. |.| |.| || .|...|.| |..| |. |   .|| |  ..  . .|.                .|  ||.
VIWKQINMHRM-SEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQH-QQNKLFEEERQLKQVNHCFNIYFNEQMILWYFF

QLARALAHMHSKRIMHRDIKPANVFITGN-GIVKLGDLGLGRFFSSKTTAAHS--LVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYGDK
|   |..|||.. | |||.|..|.| |   ..||.|| |.    ..|. .. .  .||||||||||  .   ||.||| |. || ||||. |   | .. 
QMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEAS-

MNLYSLCKKIENC-EYPPLP
 ||  |. ||  | .| |..
-NLPALVWKIMQCRAYEPIS
Kinase F19H6.1.AA NEK1 23-249 35 1.2e-68 234.42 In-house 1-243 (276) Show / Hide 
Range on Protein: 23-249
Range on HMM: 1-243/276
Sequence Identity: 35% (88 aa)

FIIEKKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQ--LNIVLELAEAGDMSRMIKHFKKGGR
... |.||.| |  .. .. .    | ..| |.| .|  .| |.. ..|  .|. . |.|...|. ||. | .  | || | ...||. . |.  |  | 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKM-QEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGK

LIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFIT--GNG---------------IVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYN
|..| .|  .|.|.  || |.|...|.|||||. |.| |   ||               .||||| |  |  .. .  |   .||||| ||| .|  .||
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

FKSDLWSTGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPA
 ||| || || |||  .|  || . ..    |  ||    |||.|.
NKSDIWSLGCVLYELCTLKHPFEANNWK--NLVLKICQGTYPPIPP
Kinase F19H6.1.AA Pkinase 23-228 33 6.5e-65 226.76 Pfam 1-215 (293) Show / Hide 
Range on Protein: 23-228
Range on HMM: 1-215/293
Sequence Identity: 33% (74 aa)

FIIEKKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCL-KEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAG----DMSRMIKHFKK
. |..|||.| |..|....       ||.|.| . .  ..| ... .  || ..| ||| |..|.| .| |.. . .|.|..| |    | ...|.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

GGRL-IPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIV----KLGDLGLGRFF-SSKTTAAHSLVGTPYYMSPERIQ-ESGYNFKSDLWS
.|..  .|... .|. |..|.|...||..|.|||.||.|..|  || .    |..| || ..|   . . .....|||.||.|| |.  ..|  |.| ||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

TGCLLYEMAALQSPFYGD
 ||.||||.  . ||.|.
CGCILYEMLCGRPPFPGH
Kinase F19H6.1.AA STE 23-248 25 3e-60 206.49 In-house 1-304 (359) Show / Hide 
Range on Protein: 23-248
Range on HMM: 1-304/359
Sequence Identity: 25% (78 aa)

FIIEKKIGKGQFSEVFRAQCT-WVDLH--------------VALKKIQVFEM--------------VDQKARQDCLKEIDLLKQLN--HVNVIRYYASFI
. . .||||| | .|..| .    ..|              .| |.. . .               .... .|. ||||...|..|  | |...|| ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DN-------NQLNIVLELAEAGDMSRMIK-HFKKGGRL---------IPEKTIWKYFVQLARA-LAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGR
..       ..|.|..|. ..|  . .||  ...|..|         .||. | .. .|. .. |.. ||..|.||||||||...     ||| | |.  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

FFSSK--------------TTA--AHSLVGTPYYMSPERIQE------SGYNFKSDLWSTGCLLYEMAALQSPFYG-DKM-NLYSLCKKIENC-------
 ....              |..    ..|||| .|.||.||       .||..|.| || ||.. |||  . |.     | ...   ...  .       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----EYPPLP
    . ||||
IVNGPPPPLP
Kinase F19H6.1.AA CAMK 28-248 20 1.4e-59 190.34 In-house 1-369 (425) Show / Hide 
Range on Protein: 28-248
Range on HMM: 1-369/425
Sequence Identity: 20% (75 aa)

KIGKGQFSEVFRAQCTWVD------------LHVALKKIQVFEMVD-------------------------QKARQDCLKEIDLLKQ-------LNHVNV
..|.|.|..|.... .                .|| | |    . |                         .| |.  ..||...|.       |.| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRYYASFID-------------------NNQLNIVL---ELAEAG----DMSRMIKHFKKGG-----------RLIPEKTIWKYFVQLARALAHMHSKRI
|. |  . |                   .... .|.   |... |    |.  .|.  ...|           . ..|.   .|| |.. |....||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

MHRDIKPANVFITGN-----------------GIVKLGDLGLGRFFSSK-----------------------TTAAHSLVGTPYYMS-PERIQ-------
.|||.|| |. .. |                 . .|. | |. ..| ..                       .   .  .|||.||. || ..       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------ESGYNFKSDLWSTGCLLYEMAALQSPFYGD-----------KMNLYSLCKKIENCEYP-PLP
       . .|..|.| || |..|| |    .|||||           .||.| |..|| ...|  | |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPP
Kinase F19H6.1.AA ULK 23-260 25 6.9e-59 201.96 In-house 1-297 (324) Show / Hide 
Range on Protein: 23-260
Range on HMM: 1-297/324
Sequence Identity: 25% (75 aa)

FIIEKKIGKGQFS-EVFRAQCTWV---DLHVALKKIQVFEMVDQKARQD------CLK-EIDLLKQLN---HVN--VIRYYASFIDN--NQLNIVLELAE
... ...|||.|   |... .      . .|| |.|. ..| ..| .|.       || || ..|.|.   |.|  ....|  | .   | . |..|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

AGDMSRMIKHFKK-----GGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGN------------GIVKLGDLGLGRFFS---SKTTAAHS
 || .  ||  ||      .. ..|. . ..| |.. .. ..|.. |.||||||.|  |. .            |..|..| |.....       .  ..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GTPYYMSPERIQ----ESGYN-FKSDLWSTGCLLYEMAALQSPFYGD--KMNLYSLCKKIEN-------CEYPPLPADI--YSTQVSANL
.|      |||.||.|. .|    .  |. .|.|.|| ||..|||   . ||...  . .||   | |.|        .. |.. ..  .. ..| ..
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC
Kinase F19H6.1.AA ULK 23-253 25 1.4e-56 194.29 In-house 1-299 (329) Show / Hide 
Range on Protein: 23-253
Range on HMM: 1-299/329
Sequence Identity: 25% (77 aa)

FIIEKKIGKGQFSEVFRAQC--TW--VDLHVALKKIQVFEMVDQKARQD------CLK-EIDLLKQLN--------HVNVIRYYASFIDN--NQLNIVLE
... ...|||.|  |... .  |   |.  || |.|. ..|  ..  |.      .|| ||...|.|.        | |....|  | .   | . |..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LAEAGDMSRMIKHFKK------GGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGN------------GIVKLGDLGLGRFFSSK---TT
. . || .  ||  ||       .. ..|. . ..| |.. .. ..|...|.||||||.|. |. .            |..|..| |.......      
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

AAHSLV------GTPYYMSPERIQESG----YN-FKSDLWSTGCLLYEMAALQSPFYGD--KMNLYSLCKKIEN------------CEYPPL-PADIYS
 ... |      |||.||.|. .|. |    |. .|.|.|| ||..|||   . |||.   . .|. . | |.|             ..|.  .... |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS
Kinase F19H6.1.AA Ciliate-E2 23-246 22 2.7e-55 188.24 In-house 1-309 (365) Show / Hide 
Range on Protein: 23-246
Range on HMM: 1-309/365
Sequence Identity: 22% (74 aa)

FIIEKKIGKGQFSEVFRAQCTWVDLHVALK-----------------KIQVFEMVDQKARQDCLKEIDLLK----------------QLNHVNVIRYYAS
... ||||.|.|. |....   |.  .|.|                 ||   ... ..  .  ..||....                |||| |.|..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FI--DNNQLNIVLELAEAGDMSRMIKHF-KKGGRLIP------EKTIWKYFVQLAR---------------ALAHMHSKR-IMHRDIKPANVFITGNGIV
|.  |.| . .|.|... ||.   ||.. || .  |.      || | ... |...               || ..|||  |.|||||| |...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDLGLGRFFSSKTT-------------------------------AAHSLVGTPYYMSPERIQESG---------YNFKSDLWSTGCLLYEMAALQSP
|. |.|| .... .                                  .....|||.||.|| ..  .         |..|.|.|| |..||||   . |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYGDKMNLYSLCKKIE-NCEYPP
|         . .... ....|.
F---------QQQIKQCKIDFPC
Kinase F19H6.1.AA NEK2 71-254 35 4.3e-54 180.48 In-house 48-290 (319) Show / Hide 
Range on Protein: 71-254
Range on HMM: 48-290/319
Sequence Identity: 35% (87 aa)

EIDLLKQLNHVNVIRYYASFID--NNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHS------------------KR---IM
|. .|.|| | |..|||   ||  |  | || |  | || | |||. .|  . ..|. ||. . || .||   |                   .    |.
ECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTIL

HRDIKPANVFITGNGI---------------------------------------VKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDL
||||||||.|   ..                                        ||||| || |     |  ||. |||||||||| ..   || ||| 
HRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDI

WSTGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPADIYST
|| |||.|||.||  || .   |   |  || . .. ..|. .||.
WSVGCLIYEMCALHPPFQA--TNQAQLQEKIKQGHFRRIPY-QYSR
Kinase F19H6.1.AA Pkinase_Tyr 23-218 26 1.6e-23 80.32 Pfam 1-207 (270) Show / Hide 
Range on Protein: 23-218
Range on HMM: 1-207/270
Sequence Identity: 26% (55 aa)

FIIEKKIGKGQFSEVFRAQCT----WVDLHVALKKIQVFEMVDQKA--RQDCLKEIDLLKQL-NHVNVIRYYASFI-DNNQ--LNIVLELAEAGDMSRMI
 .. ||.|.|.| ||... ..      ...|| |..   |  ....  |.| ..|. ..||| .| |..|.|.  . .  .  . ||.|... ||.    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFF--SSKT-TAAHSLVGTPYYMSPERIQESGYNFKSDLW
.  . ... .. |.. .. .| |..... .||.. |||.   |. .| |..|| .| || |     .   .....       |.|| |... .. ||| |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

STGCLLYEM
| | |..|.
SFGVLMWEI
Kinase F19H6.1.AA TyrKc 23-269 21 4.6e-18 67.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-269
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FIIEKKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQL--NHVNVIRYYASFIDN-------NQLNIVLELAEAGDMSRMI-
   .||.| |.| ||.... .   . || |...         |.| ..|. ....|  .| |..| |.  ..         .| ||.|... ||    . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSK--------TTAAHSLVGTP-----YYMSPERIQE
|| .|    .. |.  .. .| |.  .. |||.. |||.   |. .. |..|| .| || |.  ..        .  . .  |.        |.|| |..
KHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

SGYNFKSDLWSTGCLLYEMAALQSPFYGD----KMNLYSLCKKIENCEYPPLPADIY------STQVSANL-------------CFVQLSSAT
. ...||| || | ...|.  .  . | .    .|. . . ..... ...| |...|       ..   ..             .| .. .  
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF