Gene F23C8.8 (Nematode worm)

F23C8.8

Species: Nematode worm
Alias: F23C8.8=F23C8.d, aSWK043, F23C8.8, CE20717
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:-8.78, WormBase Physical Map location: I: 2432582-2429701,

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
F23C8.8.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 242 Kinase domain by global Sugen HMM Fasta, JSON
F23C8.8.AA Protein Genbank 301 None Fasta, JSON

Protein domain

Protein domains of F23C8.8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F23C8.8.AA MARK 27-268 31 6.7e-106 347.1 In-house 4-262 (262) Show / Hide 
Range on Protein: 27-268
Range on HMM: 4-262/262
Sequence Identity: 31% (82 aa)

PRPIATTAHSVVFKVDSQLYRREVIVKIVDRKSIPANVAEKFFPRELEITMKVRHPHIARCLAITR-PAPTK-FVIISDYYERGTLLEWILQK-KRLKEH
 . | . ....| .. .....|.| .||......  . . | . ||.|| .|. ||.| ... .   . ... ...| .|...| |...| .. ..  ..
LKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHE

PLAATLFRQLIEAINYLHKRGIVHRDVKLENILIDGNG--DIKLIDFGFARHIERRERSRSFCGTQPYTCPQITKYRPYEAYAADYYACGIVLFTMVTGK
..| ..|||...|.||.|...||||| |.|||||| ||  .||.|||||...|.  ..  .|||| || .|.|....||.....|....|.||..||.|.
EEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGY

WPNM--T-----ENPNIYPEGYP-----SRSCRKLVSSLLDGNEMSRAGYDECVNSEWM
.| .  |      . .|. . |.     |..||.|...||  | . |. ..|... .||
FPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase F23C8.8.AA CAMKL 47-268 28 1.2e-77 247.34 In-house 25-297 (297) Show / Hide 
Range on Protein: 47-268
Range on HMM: 25-297/297
Sequence Identity: 28% (78 aa)

RREVIVKIVDRKSIP-ANVAEKFFP-----------RELEITMKVR---HPHIARCLAITRPAPT-----KFVIISDYYERGT--LLEWILQK----KRL
...| .||.|.| |    ...| ..           || .| ....   ||.| . . .     .     |....  | . |   |...| ..    .|.
GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRM

KEHPLAATLFRQLIEAINYLHKRGIVHRDVKLENILIDGNGD--IKLIDFGFARHIER-----RERSRSFCGTQPYTCPQITKY--RPYEAYAADYYACG
.||  |  .|||...|.||.|..|||||| |.||||.| ||.  ||.|||||. ....      .  . |||. || .| | .   .||.....|  .||
PEH-EARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCG

IVLFTMVTGKWP-------------------NMTENPNIYPEGYPSRSCRKLVSSLLDGNEMSRAGYDECVNSEWM
..|..||.|..|                   .|.   .. .  ..| .|| | ...|  | . |.  .. .| .||
VILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase F23C8.8.AA CAMK 29-268 17 1.1e-67 216.93 In-house 1-425 (425) Show / Hide 
Range on Protein: 29-268
Range on HMM: 1-425/425
Sequence Identity: 17% (75 aa)

PIATTAHSVVFKVDSQLYR------------REVIVKIVDRKSIPANV-------------------------AEKFFPRELEITMK-------VRHPHI
 . . . ..|...   .              ..| .||.|.| .. ..                          .|...||.|| .|       ..||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ARCLAI--------------TRPA-----PTKFVIIS---DYYERG----TLLEWILQK---------------KRLKEHPLAATLFRQLIEAINYLHKR
 ... .              |        .......    .| . |     |...| ..               .|..|.  |...|||...|..|.|..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTER-EARRYFRQICSAVHYCHSH

GIVHRDVKLENILIDGN-----------------GDIKLIDFGFARHIER------------------------RERSRSFCGTQPYTC-PQITKY----
.||||| |.||||.| |                 ..||.||||||.....                         .  . |||| .| . | . ..    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------RPYEAYAADYYACGIVLFTMVTGKWPNMTE-----------------------NPNIY-PEGY-----------------------PSRSC
         .||  ...|  .||..|..|..|. |   .                       . . . |. |                        | .|
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

RKLVSSLLDGNEMSRAGYDECVNSEWM
. |....|  .   |.  ..| | .||
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase F23C8.8.AA TSSK 46-223 33 5.9e-50 162.13 In-house 23-228 (289) Show / Hide 
Range on Protein: 46-223
Range on HMM: 23-228/289
Sequence Identity: 33% (70 aa)

YRRE----------------VIVKIVDRKSIPANVAEKFFPRELEITMK-VRHPHIARCLAITRPAPTKFVIISDYYERGTLLEWILQK------KRLKE
....                | .||.|||  |. . .||.|||..|  | ..||.| ..... .  . |  ..  | |.|.|||.|  .      ..|.|
HKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAEHGDLLEYIQRRTQERCCGALHE

HPLAATLFRQLIEAINYLHKRGIVHRDVKLENILIDGNGDIKLIDFGFARHIERRERSRS------FCGTQPYTCPQITKYRPYEAYAADYYACGIVLFT
 ..| ..|||...|. |.| ...||||.|.|||| | .. |||.||||||  .| .. |.      |||   |..| | . .||   ..|  ..|..|..
-EQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEILRGIPYDPKWYDVWSMGVILYI

MVTGKWP
||.|. |
MVCGCMP
S_TKc F23C8.8.AA S_TKc 24-268 24 3e-46 160.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-268
Range on HMM: 1-231/231
Sequence Identity: 24% (64 aa)

TFSPRPIATTAHSVVFKVDSQLYRREVIVKIVDRKSIPANVAEKFFPRELEITMKVRHPHIARCLAITRPAPTKFVIISDYYER--GTLLEWILQKKR--
    |.|   | ..|.|.      |.| .||..          . . ||..| .| .||.| ... . .   ... .. .| .   |.|.. | ...|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LKEHPLAATLFRQLIEAINYLHKRGIVHRDVKLENILIDGNGDIKLIDFGFARHIERRERSRSFCGTQPYTCPQITKYRPYEAYAADYYACGIVLF
    . |   |. ...|...|..|.|..||.|||.| ||||.|    ||..|||.||..      ..||||  |  | .    .|   ..| ..||..|.
LRFPFPE--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

TMVTGKWPNMTENPNIYPEGYPSRSCRKLVSSLLDGNEMSRAGYDECVN-------SEWM
 |..|. |   .   ..     |.... ... .|. .   | .  |. .        .|.
EMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F23C8.8.AA Ciliate-E2 67-268 19 2.7e-43 146.45 In-house 78-365 (365) Show / Hide 
Range on Protein: 67-268
Range on HMM: 78-365/365
Sequence Identity: 19% (58 aa)

KFFPRELEITMKVRHPHIARCLAITRP-APTKFVIISDYYERGTLLEWIL--QKKRLKEHP--------LAATLFRQLIE---------------AINYL
|.   |..|  .. ||.| ..         ... .. .|.. |.|...|   .|||..| .         ......|...               |..||
KKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYL

HKRG-IVHRDVKLENILIDGNGDIKLIDFGFAR-----HIERR---------------------------ERSRSFCGTQPYTCPQITKYRPYEA-----
|... |.||| |.||||.     ||.||||...     ...|.                           .  ...||| .| .|.| .. .|.      
HSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK

---YAADYYACGIVLFTMVTGKWP--NMTENPNIYPE------------------GYPSRSCRKLVSS----LLDGNEMSRAG-YDECVNSEWM
   |..|....|..|. |..||.|  .  .. .|                      . | .|  | .     .|. ..  | . .... | .|.
GYDYKCDIWSLGVILYEMLFGKPPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase F23C8.8.AA Pkinase 36-223 27 5.7e-41 145.94 Pfam 13-211 (293) Show / Hide 
Range on Protein: 36-223
Range on HMM: 13-211/293
Sequence Identity: 27% (55 aa)

SVVFKVDSQLYRREVIVKIVDRKSIPANVAEKFFP-RELEITMKVRHPHIARCLAITRPAPTKFVIISDYYERG----TLLEWIL--QKKRL--KEHPLA
..|.|   . ....| |||......  .. .  .  .|..|  ...||.| |.. . .  ...  .. .| | |     | ..|   .....   |.  .
GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW-EC

ATLFRQLIEAINYLHKRGIVHRDVKLENILIDGNGDI----KLIDFGFARH--IERRERSRSFCGTQPYTCPQITKYRPYEAYAADYYACGIVLFTMVTG
   ..|......|.|..||.|||.|.|||||| ||.|    |..|||.|..  . . .   .|||| .|  | . . ..|  ...| ..||..|. |..|
KFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCG

KWP
. |
RPP
Kinase F23C8.8.AA Ciliate-E2-Unclassified 97-223 25 1.1e-35 121.21 In-house 95-269 (352) Show / Hide 
Range on Protein: 97-223
Range on HMM: 95-269/352
Sequence Identity: 25% (44 aa)

KFVIISDYYERGTLLEWILQ------------KKRLKEHPL----AA-----TLFRQLIEAINYLHKRG-IVHRDVKLENILIDGNG---DIKLIDFGFA
.. |. .| | |.|...| .            ..... . .    |.     ..|.|......|||. . |.||| |.||||.| ||    ||.||||..
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

RHIE----------------RRERSRSFCGTQPYT----CPQITKYRPYEA---YAADYYACGIVLFTMVTGKWP
....                ..... .||||  |      | . .   |.    |..|....|..|. |..|..|
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase F23C8.8.AA CAMK-Unique 57-223 20 4.7e-33 106.3 In-house 51-292 (363) Show / Hide 
Range on Protein: 57-223
Range on HMM: 51-292/363
Sequence Identity: 20% (50 aa)

RKSIPANVAEKFFPRELEITMKVRHPHIARCLAI------TRP------------APTKFVIISDYYERGTLLEWILQ--------------------KK
|..|     .  . ||..|  .| ||.| . . .      .|             |  ...|. .| . |.|..||..                    . 
RYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQG

RLKE-HPLAATLFRQLIEAINYLHKRGIVHRDVKLENILIDGNGD----------------IKLIDFGFARHIERRERSR---SFCGTQPYTCP------
.. |   ........| .|..|.|. .||||| |||||..  ...                |||.||| ..|..  . .    ..||| .|  |      
HFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCK

--------QITKYRPYEAYAA---DYYACGIVLFTMVTGKWP
        .. . ..|        |  ..| ....| .|. |
NYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPP
Kinase F23C8.8.AA TKL 46-223 17 7.2e-32 112.03 In-house 14-288 (364) Show / Hide 
Range on Protein: 46-223
Range on HMM: 14-288/364
Sequence Identity: 17% (50 aa)

YR-----------REVIVKIVDRKSIP---------------------ANVAEKFFPRELEITMK---VRHPHIARCLA--ITRPA----------PTKF
.|           ..| ||.  ...                       .. |..|. .| | .|     |||.| ....  .  |           ....
WRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQL

VIISDYYERGTLLEWILQKKRLKEHPLAATLFRQLIEAINYLHK--------RGIVHRDVKLENILIDGNGD--------------IKLIDFGFARHIER
 |. .|...|.||. ..       ...   . ..   ..||||         ..|.||| | .|||.| |.               .|. |||..| ...
CIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQ

RE--------------------RSRSFCGTQPYTCPQITKYRPYEAYAA---------------DYYACGIVLFTMVTGKWP
..                    .. . |||  .  | . .  ..   ..               | |. ||||. ..|...|
SGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase F23C8.8.AA QIK 49-223 28 1e-31 111.71 In-house 26-217 (272) Show / Hide 
Range on Protein: 49-223
Range on HMM: 26-217/272
Sequence Identity: 28% (56 aa)

EVIVKIVDRKSIPANVAEKFFPRELEITMKVRHPHIARCLAITRPAPTKFVIISDYYERGTLLEWILQKKR--------------------LKEHPLAAT
.| .||.|.  . .   .| . || .|    .|||| . . . .     . |...| . | . . . .. |                    ..|   |. 
KVAIKIIDKSQLDEENLQKCY-REVQIMKMLYHPHIIKLYQVMETDDMMY-IVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAEN-EARR

LFRQLIEAINYLHKRGIVHRDVKLENILIDGNGDIKLIDFGFARHIERRERSRSFCGTQPYTCPQITKYRPYEAYAADYYACGIVLFTMVTGKWP
 | |.. |. |.|||.|||||.| ||||.| | .||..||||  . .  .   ..||. ||  | . . . |.   .|    |.||. .|.|. |
WFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALP
Kinase F23C8.8.AA ULK 50-268 23 1.9e-30 105.28 In-house 31-324 (324) Show / Hide 
Range on Protein: 50-268
Range on HMM: 31-324/324
Sequence Identity: 23% (69 aa)

VIVKIVDRKSIPA-------NVAEKFFPRELEITMKVR---HPH--IARCLAITRPAP-TKFVIISDYYERGTLLEWILQKKRLKEHPL---------AA
| .|..|.|..         ... ... .| .|  |     ||.  | . . ... .  . . || .| . |.| . | ..|.|.|. .         | 
VACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPET-EEKKRLSEQEAI

TLFRQLIEAINYLHKRGIVHRDVKLENILIDGN------------GDIKLIDFGFARHIERRERSRSFC----------GTQPYTCPQITKYR----PYE
  |.|....  .|||..|.||| |..||||  .            | .|. |||||.|..  . .   |          ||  | .||| . .    || 
QFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYY

AYAADYYACGIVLFTMVTGKWP----NMTEN--------------------PNIYP---EGYP-SRSCRKLVSSLLDGNEMSRAGYDECVNSEWM
 | .| .  |.... |..|| |    .....                    |  .|   .... |  |. | . .|  .|  |   .|  | .|.
DYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
TyrKc F23C8.8.AA TyrKc 24-282 16 1.3e-07 -99.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-282
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

TFSPRPIATTAHSVVFKVDSQLYRREVIVKIVDRKSIPANVAEKFFPRELEITMKV--RHPHIARCLAITRPAP------TKFVIISDYYERGTLLEWIL
    . .   |  .|.|   ... ..| || .   .      .. | ||..| .|.  .||.| |.... .             |.  | . | |.. . 
ITLGKKLGEGAFGEVYK--GTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QKKRLKEHPLAATLFRQLIEAINYLHKRGIVHRDVKLENILIDGNGDIKLIDFGFARHIERR----ERSRSFCGTQPYTCP--QITKYRPYEAYAADY--
 ...   ..       |  .  .|||.....|||    |.|.. |. .|  ||| .| |.      |..     ..   .      .  . |.   ..  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF

------YACGIVLFTMVTGKWPNMTENPNIYPEGYPS-----RSCRKLVSSLLDGNEMSRAGYDE------CVNSEWMGVHPVWMF---------ANHAY
      .. |.... . |       . |      ||       | . ..  . .|. | .  .|.      |     .     |..         . | .
TTKSDVWSFGVCMWEIFT-----YGQQP------YPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

F
|
F
Kinase F23C8.8.AA TSSK 238-268 25 0.000287 9.89 In-house 259-289 (289) Show / Hide 
Range on Protein: 238-268
Range on HMM: 259-289/289
Sequence Identity: 25% (8 aa)

SRSCRKLVSSLLDGNEMSRAGYDECVNSEWM
| .|. |....|  .   |. ..|.....||
SQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase F23C8.8.AA Pkinase 236-268 15 0.024435 9.35 Pfam 261-293 (293) Show / Hide 
Range on Protein: 236-268
Range on HMM: 261-293/293
Sequence Identity: 15% (5 aa)

YPSRSCRKLVSSLLDGNEMSRAGYDECVNSEWM
. |..|.......|. .  .| . .......|.
NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF