Gene flr-4 (Nematode worm)

flr-4

Species: Nematode worm
Alias: F09B12, aSWK251, F09B12.6, flr-4, CE26710
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 15093120-15097309, WormBase Genetic Map location: X:20.6,

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
flr-4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 234 Kinase domain by global Sugen HMM Fasta, JSON
flr-4.AA Protein Genbank 570 None Fasta, JSON

Protein domain

Protein domains of flr-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc flr-4.AA S_TKc 40-331 21 3.7e-39 137.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-331
Range on HMM: 1-231/231
Sequence Identity: 21% (67 aa)

YKYIQDLGKGRFGTVCKFSNGN--TFETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPR--GSVKD
|. .. .||| ||.|.|  . .      .|...                  .... | . |.|   .   ||...... | . .|.  ||..   |...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFD

LLVKET-------LGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSS
...|         . | .| .|. ....||.|.|..   .||||.| .|.|...   ||.. ||| | |                |  |. |.|||||  
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--

ALGPGNRNAYEL-PADIWALGCTFIEMLLKRPPHFEYFGHIDEIPKVLLGYAKSEDGKVLPYTSEVLVPSSSNCVQKIVDLVFIKSPEHRPNTHKLRI--
         |   ..|.|..||...|||  .||      ..... |...                     |. . . ...  . | ||.||   ..    
--------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDE

---QIKKIL
    .   .
WDIKCHPWF
Pkinase flr-4.AA Pkinase 40-260 25 2.2e-38 136.82 Pfam 1-211 (293) Show / Hide 
Range on Protein: 40-260
Range on HMM: 1-211/293
Sequence Identity: 25% (61 aa)

YKYIQDLGKGRFGTVCKFSNGNTFE--TVKKVDLTIFNHWTQ------SETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRG
|. .. .|.| ||.|.|  . .| .   ||....   ..| .      || .. .||.         |.       || ..... |.. .|.  ||.. |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---------HPN------IVRLYDWFEDKDHIYMVMEYCEGG

----SVKDLLV---KETL--GEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSI----KLANFGLVRDLAVDGFGIAIASEITLDFRATL
    . .|..    . ..   |.....|. .....|.|.|.    .||||.| .|.|| .|. |    |.. ||| . .          .. . .|  |.
LYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTP

LYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPP
 |.||||.        .. |  ..|.|..||...|||..|||
WYMAPEVIR------GGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase flr-4.AA STE 40-323 20 1e-37 130.76 In-house 1-351 (359) Show / Hide 
Range on Protein: 40-323
Range on HMM: 1-351/359
Sequence Identity: 20% (76 aa)

YKYIQDLGKGRFGTVCKF---------SNGNT--------FETVKKVDLTIFN-----HWTQSETKVSNRLDTFLYEFRHLHKVTNDNN----RIVNFLG
.. |. .||| ||||.|          ..|..        .  .|...|   |       .  .  ..|. .. . .. .  |. .. |     ||...|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQ-EN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG

IYADS-------NQMYIMSEYLPRGSVKDLLV-K-ETLG-------------EDTAIKYLMETVEA-LDYLHNLSPPVIHRDIKAANLLITSNDSIKLAN
 | .        .. .|  ||.. ||. |..  | ....             |.  .... ..... |.|||..   .||||||.|| |.     .||..
CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCD

FGLVRDLAVDGFGI--AIASEI----TLDFRA-----TLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEYFGHIDEIPKVLLGYA
||.   |. .. .|  .. . |    | . .      |  . ||||..   .. ... |   .||| |||| |||.  .||....  .    ..   ...
FGVCGQLTDSMANIQSNN-I-IDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

KS---------EDGKVLPY---------------TSEVLVPSSSNCVQKIVDLVFIKSPEHRPNTHKL
 .         ..   ||                |   .  . | . .  ... ..| |..||....|
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTT---YPHKWSPEFKDFINKCLQKDPNKRPTASQL
Kinase flr-4.AA Ciliate-E2 40-260 19 1e-25 85.22 In-house 1-295 (365) Show / Hide 
Range on Protein: 40-260
Range on HMM: 1-295/365
Sequence Identity: 19% (59 aa)

YKYIQDLGKGRFGTVCKF---SNGNTF-----------------ETVKKVDLTIFNHW----TQSETKVSNRLDTFLYEFRHLHKV-----TNDNNRIVN
|| |. .|.| ||.|.|    .... |                  ..|.. . |...     . .| .. ....   |  . . .      ..... |..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FY--KKI-NEKNILEQLNHPNIIK

FLGIYA--DSNQMYIMSEYLPRGSVKDLLVKE-TLG-----------EDTAIKYLMETVE---------------ALDYLHNLSPPVIHRDIKAANLLIT
.   .   | | .|.  ||.  |. .|.. .  .             |  ....  . ..               || |||.  . .||||||  |.|. 
MYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-

SNDSIKLANFGLVRDLAVD---GFGIAIASEITLDFRA-----------------------TLLYVAPEVLSS-----ALGPGNRNAYELPADIWALGCT
    ||.. ||| ...  |   ...    ... .. .                        |. |.|||.|..          ... |   .|||.||..
----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVI

FIEMLLKRPP
. ||| ..||
LYEMLFGKPP
Kinase flr-4.AA TKL 108-260 20 4.7e-25 87.17 In-house 87-288 (364) Show / Hide 
Range on Protein: 108-260
Range on HMM: 87-288/364
Sequence Identity: 20% (43 aa)

IVNFLGIYADSNQ-------------MYIMSEYLPRGS-VKDLLVKETLGEDTAIKYLMETVEALDYLHNLS------PPVIHRDIKAANLLITSNDS--
|| |.|.  ....             ..|  || |.||   .|.       .  ..  ...  ...|||.        ||.||||.| .|.|. .|    
IVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV

------------IKLANFGLVRDLAVDGFGIAIASE------------ITLDFRATLLYVAPEVLSSALGPGNRN---------AYELPADIWALGCTFI
            .|.. ||| |..  .|   ....              |   . |. . |||||  ..   . .          |   .|... |  . 
SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW

EMLLKRPP
|.|  ..|
EILTRCRP
Kinase flr-4.AA STE-Unique 119-260 22 3.2e-24 82.52 In-house 367-552 (616) Show / Hide 
Range on Protein: 119-260
Range on HMM: 367-552/616
Sequence Identity: 22% (43 aa)

NQMYIMSEYLPRGSVKDLLVKETLG----------EDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSND-----SIKLANFGLVRDLAVDGFG
|. .|  ||.. |......     .          |. .|.|. . .|.|.|||    |.||||.|..| .... .     ..|...||.   .. |.|.
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE

I-------------------------------AIASEITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPP
                                 |   .  . . |  | .|||.. . . .| | | . .||| |||....|.   ||
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQ-IN-NPYDTKVDIWSLGCMCFHMCCGCPP
Kinase flr-4.AA ASK 92-263 36 1.2e-22 71.96 In-house 38-199 (254) Show / Hide 
Range on Protein: 92-263
Range on HMM: 38-199/254
Sequence Identity: 36% (65 aa)

LYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRGSVKDLLVKE--TLG--EDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLI-TSNDSI
|.|   |||     | || .||  .. . . |  |  | ||. .||      .   |.|   |    .| | |||.    ..|||||  | |. |    .
LHEEIALHKQLRHRN-IVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYTKQILEGLKYLHENQ--IVHRDIKGDNVLVNTYSGVV

KLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFE
|.. ||  . ||    ||  ..|    |. || |.||||.      | |  |  |||||..||| .||   .|| .|
KISDFGTCKRLA----GINPCTET---FTGTLQYMAPEVIDQ----GQR-GYGKPADIWSFGCTMVEMATGKPPFHE
Kinase flr-4.AA ULK 108-260 28 7.4e-22 73.14 In-house 80-255 (329) Show / Hide 
Range on Protein: 108-260
Range on HMM: 80-255/329
Sequence Identity: 28% (51 aa)

IVNFLGIYADS--NQMYIMSEYLPRGSVKDLLVKE-TLGEDT----------AIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSND----------
|| .. .. .|  |  ||. || . |  .... |  .|.|||          ||....  .... .||     .|||||| .| ||. ..          
IVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHP

--SIKLANFGLVRDLAVDGFGIAIASEIT---LDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPP
   .|.| ||. . .  |.. ....   .   . .. | || ||..|.. .  .. . |.  .||| ||| | |||  .||
NGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKR-LCGTPLYMAPQILQGQG--EQKPYYDYKCDIWSLGCIFYEMLYGKPP
Kinase flr-4.AA MEKK15 40-260 30 8.5e-21 72.13 In-house 1-206 (264) Show / Hide 
Range on Protein: 40-260
Range on HMM: 1-206/264
Sequence Identity: 30% (67 aa)

YKYIQDLGKGRFGTV-CKFSNGNTFETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRGSVKDLLV
.|  . |||| .||| |   |      ||.|.|       ... . ...    | |   | |     | || .||.  . | . |  ...| ||.  .. 
WKKGNILGKGAYGTVYCGLTNTGQLIAVKQVEL------DEIDKEKAKQQYRKLQEEVDLLKTLKHKN-IVAYLGVCLEDNVVNIFMQFVPGGSISSIIN

K-ETLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSSALGPGNRNA
.   | |    ||    ..   |||.    |.||||| .|... .   |||  ||  . |.. |   .  |..    | |  ..||||.       .   
RFGPLDEMVFCKYTKQILQGVQYLHENC--VVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRT-HSDMLKSMRGTPYWMAPEVI-------METG

YELPADIWALGCTFIEMLLKRPP
|   .|||..|||  ||  ..||
YGRKSDIWSIGCTVFEMATRKPP
Kinase flr-4.AA ULK 105-260 26 1.6e-20 69.58 In-house 75-251 (324) Show / Hide 
Range on Protein: 105-260
Range on HMM: 75-251/324
Sequence Identity: 26% (49 aa)

NNRIVNFLGIYADS--NQMYIMSEYLPRGSVKDLLVKE-TLGEDT----------AIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSND-------
.  || .. .. .|  |  ||. || . |  .... |  .|.| |          ||....  .... .||.    .|||||| .|.||. ..       
H-HIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKK

-----SIKLANFGLVRDLAVDGFGIAIA----SEITLDFR---ATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPP
      .|.| ||. . .  ...   .      |          | || ||..|.. .  .. . |.  .||| ||| | |||  ..|
VHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNE-----KRIKGTPLYMAPQILQGQG--EQKPYYDYKCDIWSLGCIFYEMLYGKYP
Kinase flr-4.AA STE20 108-264 31 9.6e-20 69.06 In-house 66-230 (288) Show / Hide 
Range on Protein: 108-264
Range on HMM: 66-230/288
Sequence Identity: 31% (55 aa)

IVNFLGIYADS----NQMYIMSEYLPRGSVKDLLV-----KE-----TLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGL
||...| |  .    .. .|  ||.  ||. |..      .      .. |.     . |....|||||.    .|||||||.| |.|.. ..||| ||.
IVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNH--IIHRDIKADNILLTEDGEVKLADFGV

VRDLAVDGFGIAIASE-ITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEY
  .|   | .   .       |  |  . ||||..   ||  .. |   .|||.|| | |||.  .||.|..
CAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEVIQCMEGP--DKGYDYKCDIWSLGITAIEMAEGEPPYFDM
Kinase flr-4.AA STE11 106-260 31 1.1e-19 68.0 In-house 70-237 (303) Show / Hide 
Range on Protein: 106-260
Range on HMM: 70-237/303
Sequence Identity: 31% (55 aa)

NRIVNFLGIYA---DSNQMYIMSEYLPRGSVKDLLV-K-ET--LGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITS-NDSIKLANFGLVRDL
..|| ..|.     . . ..|  || | ||....|  |  .  . | .  ||     |.| |||     .||||||.||.|. | . ..||| ||  . |
KNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRL

AVDGFGIAIASEITLD---FRATLL--------YVAPEVLSSAL-GPGNRNAYELPADIWALGCTFIEMLLKRPP
| ..   .  ... ..   .. |.         . ||||..    .      |  .||||.|||| |||.  .||
AWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRD-----GYGRKADIWSLGCTVIEMATGKPP
Kinase flr-4.AA TyrKc 40-327 19 8.7e-12 -32.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-280/280
Sequence Identity: 19% (63 aa)

YKYIQDLGKGRFGTVCKFSNGNTFETV--KKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKV--TNDNNRIVNFLGIYADS-------NQMYIMSEYL
 . .. || | ||.|.|       ..|  |..                  .  |. | | ..|.   ..|  ||...|.  ..        ...|  || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPN--IVRLYGVCTQQGRNFMYIEPLMIVMEYM

PRGSVKDLLVKET--LGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVD---GFGIAIASEITL----DFR--AT
| |. || | |    |  .. ...     .  .|||    ..||||. | | |...|  .| . ||| ||.  |   |   .  . ..     . .    
PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLP

LLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEYFGHIDE----IPKVLLGYAKSEDGKVLPYTSEVLVP-----SSSNCVQKIVDL
.   |||..       | . .    |.|. | .  |..      .    . ..    ..   . ... ..|. .|   ... |      ..   | |   
IRWMAPECI-------NYGKFTTKSDVWSFGVCMWEIF-----TYGQQPYPGMIQQMMSNQEV-IEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQ-IMKQ

VFIKSPEHRPNTHKLRIQI
     || ||.   .. ..
CWHEDPEDRPTFSEIHECF
Kinase flr-4.AA Pkinase_Tyr 104-197 29 1.3e-08 29.83 Pfam 62-161 (270) Show / Hide 
Range on Protein: 104-197
Range on HMM: 62-161/270
Sequence Identity: 29% (30 aa)

DNNRIVNFLGIYA-DSNQ--MYIMSEYLPRGSVKDLLVKE-----TLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVR
..  ||...|.   .. .  .||  || | |. .| | |       |   . ... ..  ....||..     ||||. | | |.|.|  .| . ||| |
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR

DL
|.
DI
Kinase flr-4.AA TKL 46-56 54 0.005418 6.63 In-house 1-11 (364) Show / Hide 
Range on Protein: 46-56
Range on HMM: 1-11/364
Sequence Identity: 54% (6 aa)

LGKGRFGTVCK
.|.|.||.|.|
IGSGGFGEVYK
Kinase flr-4.AA STE20 40-56 35 0.013942 5.61 In-house 1-17 (288) Show / Hide 
Range on Protein: 40-56
Range on HMM: 1-17/288
Sequence Identity: 35% (6 aa)

YKYIQDLGKGRFGTVCK
|. .. .|.| .|.|.|
YELLEKIGQGSYGKVYK
Kinase flr-4.AA ULK 40-56 50 0.07728 2.38 In-house 1-18 (324) Show / Hide 
Range on Protein: 40-56
Range on HMM: 1-18/324
Sequence Identity: 50% (9 aa)

YKYIQDLGKGRFG-TVCK
|  .. |||| || .|.|
YCLNHCLGKGSFGVKVYK
Kinase flr-4.AA ULK 40-56 52 0.083266 2.19 In-house 1-17 (329) Show / Hide 
Range on Protein: 40-56
Range on HMM: 1-17/329
Sequence Identity: 52% (9 aa)

YKYIQDLGKGRFGTVCK
|  .. |||| ||.|.|
YCLNHCLGKGSFGKVYK
Kinase flr-4.AA Pkinase_Tyr 40-56 41 0.137705 6.0 Pfam 1-17 (270) Show / Hide 
Range on Protein: 40-56
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

YKYIQDLGKGRFGTVCK
 . .. ||.| ||.|.|
ITFGKKLGEGAFGEVYK