Gene frk-1 (Nematode worm)

frk-1

Species: Nematode worm
Alias: frk-1, T04B2.2, CE03609, aSWK358
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 10043947-10045626, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
frk-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 256 Kinase domain by global Sugen HMM Fasta, JSON
frk-1.AA Protein Genbank 390 None Fasta, JSON

Protein domain

Protein domains of frk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 frk-1.AA SH2 21-106 27 2.8e-25 91.22 SMART 1-87 (87) Show / Hide 
Range on Protein: 21-106
Range on HMM: 1-87/87
Sequence Identity: 27% (25 aa)

AEYYHGMVPRQDAEGFLKRE----GDFLVRKTEQMPGKVVLAMSVRVTDELCRHFMLNMDPTSNKFYFEH--THQESTISELINWHMTTKTP
 ..|||...|..||  ||..    ||||||  |..||. || . ..   . ..|. .. ... .|.|..    .. ... ||.|...... .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK---GKVKHYRIRRNDD-GKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 frk-1.AA SH2 23-100 25 1.3e-11 35.96 Pfam 1-81 (81) Show / Hide 
Range on Protein: 23-100
Range on HMM: 1-81/81
Sequence Identity: 25% (21 aa)

YYHGMVPRQDAEGFLKR----EGDFLVRKTEQMPGKVVLAMSVRVTDELCRHFMLNMDPTSNKFYFE-HTHQESTISELINWH
.||| ..||.||  |.     .|.||||. |  ||  .|      . .  .|.  . ... . .... |.   ....||.. .
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK--FCSLQELVEHY
Kinase frk-1.AA Fer 131-383 45 2.1e-147 496.02 In-house 1-283 (283) Show / Hide 
Range on Protein: 131-383
Range on HMM: 1-283/283
Sequence Identity: 45% (130 aa)

IVANKKLGEGAFGDVFIAE-----LDQGGKQ----EVAVKTMRAE-ATREARLRFMKEARLMRK-YQHKHVVKLIGVAIHEHPLMIVMEYCPNGSLLSHL
.. .|||||||||.|. ..     ..... .    .|.||....| ||.| . .||.|||.||. |.|..|||..||. .|.|.|||||.|..|||.|.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KKNK---VSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSA-KNELK--ISDFGMSDN----KDEIKDE-TLEKVPIKWLAPETMQEKVYTHKTD
||||   ||. ||.|.. .||.|..||.  .||||||||||||... |...|  |||||||..    .   |.  ...||||.||||||.| ..|..|||
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

IWTFGVLVWEIYSDGAEPYPG------LTKI--QTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKLR
.|.|||. |||...|||||||      .| .  |.|..|....|.|.||....|... .....||||.||.| ||..|..||.
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase frk-1.AA TyrKc 131-382 34 1e-117 398.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-280/280
Sequence Identity: 34% (99 aa)

IVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKY--QHKHVVKLIGVAIHE-------HPLMIVMEYCPNGSLLSHLKK
|. .||||||||| |. ....    ..||||.....|    |  ||.|||.|.|.  .|...|.|.||....       .||||||||.|.|.|...|.|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NK--VSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNKDEI------KDET------LEK--VPIKWLAPETMQEKVYTH
..  ... ..| | . .|.| .||.. .|||||.||||||.....  ||||||.| . ..       ||         .|  .||.|.|||.......|.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KTDIWTFGVLVWEIYSDGAEPYPG-----LTKIQTRAKIVVNDYRMKMPDG-------THPTVADVVTGTCWQKNPEKRSTMDSIHKKL
|.|.| |||. |||...|..||||     .. .. ....   ......|..        .. . . .  .||. .||.| |.  ||...
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase frk-1.AA Pkinase_Tyr 131-382 37 2.6e-112 380.98 Pfam 1-270 (270) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-270/270
Sequence Identity: 37% (103 aa)

IVANKKLGEGAFGDVFIAELD---QGGKQEVAVKTMRAEATREA--RLRFMKEARLMRKY-QHKHVVKLIGVAI-HEHP--LMIVMEYCPNGSLLSHLKK
|. .|||||||||.|. ....   ...|..||||...  |. |.  |  ||.||..|... .|...|.|.|| . .. |  ..|||||.|.|.||..|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N-----KVSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNK-----DEIKDETLEKVPIKWLAPETMQEKVYTHKTDIWT
.     .... ..| . .. |.| .|||. .|||||.||||||.. .|  ||.|||..          ..  .  |.||||.||| ......|.|.|.| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVLVWEIYSDGAEP-YPGLTKIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKL
|||| |||.. |..| |||..  .  ..|  . |||..|..... . |.    ||...||.| |.  || .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDL-MKQCWHYDPEDRPTFSEIHEQL
Kinase frk-1.AA TK 131-382 20 1.5e-99 334.45 In-house 1-486 (486) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-486/486
Sequence Identity: 20% (99 aa)

IVANKKLGEGAFG---DVFIAELDQ------------------------GGKQEVAVKTMRAEATREARLRFM-------------KEARLMRKYQ----
|.  ||||||.||   .|. .|. .                        |||..||||....... ... .|.             .||. | . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKHVVKLIGVAIHE------------HPLMIVMEYCPNGS----LLSHLKKNK----------------------------------------------
 |...|.|.||  ..            .|.||||||.|.|.    |...|.|..                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VSLIEKLRFTTEAADGIAYLERSKC------IHRDIAARNCLLSAKNE-----------LKISDFGMS-
                               ... ..| .   .|.| .||.. .|      .|||.||||||.. .|             ||.|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----------DNKDEIKDE-----------------------TLEKVPIKWLAPETMQEKV---------YTHKTDIWTFGVLVWEIYSDGAEPYPG-L
           ...|  ...                       .  |.||.|.|||.....|         .|.|.|.| ||||.|||.. |.|||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TK---------IQTRAKIVVN-----------DYRMKMP--DGTHP-------------TVADVVTGTCWQKNPEKRSTMDSIHKKL
.           .   ...              ||| ||  .. ..             .. . .   ||...||.| |.. .|..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase frk-1.AA UTK 131-382 30 3.1e-76 259.59 In-house 1-296 (296) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-296/296
Sequence Identity: 30% (90 aa)

IVANKKLGEGAFGDVFIAELDQ----GGKQEVAVKTMRAEAT-REARL---RFMKEAR---LMRKYQ-HKHVVKLIGVAIHEHPLMIVMEYCPNGSLLS-
.   ..||.||||.|. |...|    .... ||||. ...|. . ..    .||.|||   .| . . | .|..|.||   | |.|||.||..||.|.| 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

----HLKKN----KVSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAK-------NELKISDFG---MSDNKD---------EIKDETLEK---
    . . .     ..| ..| .    |.| .||.. ...|||.||||||. .        .  ||.|||   || .           |   ..      
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPIKWLAPETMQEK-VYTHKTDIWTFGVLVWEIYSDGAEPYPGLTKIQTRAKIVVND-YRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKL
.||.| ||| . .   .|.|.|.| |||..|||.. |. ||||..  |. . ..  . |||. |..   .| ....  ||...|..| ... . ...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMH-RCWHYDPQERPDFEDLVQQM
Kinase frk-1.AA TK-Unique 131-382 30 1.4e-71 244.08 In-house 1-294 (294) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-294/294
Sequence Identity: 30% (90 aa)

IVANKKLGEGAFGDVFIAELDQGG-----KQEVAVKTMRAEATREARLRFMKEARLMRKYQ-HKHVVKLIGVAIHEH-PLMIVMEYCPNGSLLSHLKKNK
.. ....|||||| |. .|. ..      .. ||||. ...|| . .  |.||...|..   |...|...|. .    | ||.|||||.|.|...|....
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------------------VSLIEKLRFTTEAADGIAYLER--SKCIHRDIAARNCLLSAKNELKISDFGMSD----NKDEIKDETLEKVPI
                           .|.   ..|  . | | .||..   |..|||..|||.||. ....||.||||..    |.. .. .. ...||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWLAPETMQ--EKVY-THKTDIWTFGVLVWEIYSDGAEPYPGLTKIQTRAKIVVNDYRMKMPDGT-HPTVADVVTGTCWQKNPEKRSTMDSIHKKL
.|.||| ..  ...| | |.|.| |||| ||| . || ||||. . . . . . . |||. |..   ...  .    |||..||.|.. ..| ..|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKS-CWQWEPEERPSFRQIKHRL
Kinase frk-1.AA SFK-Src 131-386 34 1.2e-64 190.31 In-house 1-259 (259) Show / Hide 
Range on Protein: 131-386
Range on HMM: 1-259/259
Sequence Identity: 34% (92 aa)

IVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNGSLLSHLKK---NKVSLI
|.  ||||.| ||||.       .. ||||||..  |. .    |..|| .|.| .|   ..|  |     |. |. | . .||||  |.        . 
IRLEKKLGSGQFGDVWKGRWN--NTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMP

EKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMS---DNKDE-IKDETLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSDG
     . . | | ||||    .||| |||| |    |  |. |||||    ..||    ... | |||| ||| |.   .  | |.| ||.|  ||   |
QLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYG

AEPYPGLTKIQTRAKIVV-NDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKLREFY
  ||||.|      .. . . |||  | .. |    ..   |||..|. | | .|   .. .|.
RIPYPGMTNMEVLQQVDRPEGYRMPCPPNC-PDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase frk-1.AA Src 131-382 36 4.9e-64 216.44 In-house 1-255 (255) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-255/255
Sequence Identity: 36% (95 aa)

IVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNGSLLSHLKK----NKVSL
|   .|||.| ||.|. .  .  |. .|||||...     .   | .|| .| | .|...|.|  |   | |  || ||  .||||  |||     ...|
IKLCRKLGQGQFGEVWMGYWN--GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHL

IEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFG----MSDNKDEIKDETLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSD
 . . ...  |.| ||||. . |||| |||| | . .|  |. |||    . ...||   ..  |.|||| |||  .. ..| |.| | ||.| .|| . 
PQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTY

GAEPYPGLTKIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKL
|  |||| |. ..  . | . ||| .|..  . . . .   ||.| ||.| | . ....|
GRVPYPGMTNHEV-LQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase frk-1.AA Abl 131-382 34 8.7e-63 208.1 In-house 1-252 (252) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-252/252
Sequence Identity: 34% (88 aa)

IVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNGSLLSHLKKNKVSLIEK-
|.  .||| | .|.|. .   . ..  |||||.. .. .     |.||| .|.. .|. .|.|.||  .| |  |. |. ..| || .|.... ....  
IMMKHKLGGGQYGEVYEGVWKRHDCT-VAVKTLKEDTMEVH--EFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAV

--LRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSD--NKDEIKDETLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSDGAE
  |   |  | |. |||. . ||||.||||||.. .. .|. |||..   ..|    .   | |||| ||| .  . .  | |.| ||||.|||   |  
VLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMS

PYPGLTKIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKL
||||.  ..   . . ..|||  |.|  | | ...   ||| ..  | .  .||...
PYPGI-DLSHVYHKLEKGYRMERPEGCPPKVYELMR-QCWQWSHTDRPSFKEIHHAM
Kinase frk-1.AA HMTK 131-381 30 1.5e-56 194.2 In-house 1-291 (291) Show / Hide 
Range on Protein: 131-381
Range on HMM: 1-291/291
Sequence Identity: 30% (89 aa)

IVANKKLGEGAFG-----------------DVFIAELD-------QGGKQE--VAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLM
. | | .| | ||                 .| .||.         ...|   .|||..|..|. | |  |. || .|   .| ..|.|.||.    | .
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQRPWL

IVMEYCPNGSLLS-----HLKKNKVSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNKDEIKD----ETLE-KVPIKWLA
.| ||.. | | .     . |. .... | | | .  |.| ||.  . ..|.|.||||||.. .| .|| ||| .  .|. .|    ..   | ||||.|
CVLEYMQYGDLRNVLKTCREKNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMA

PETMQ--EKVYTHKTDIWTFGVLVWEIYSDGAEPYP--GLTKIQTRAKIVVNDYRMKMP-DG-THPTVADVVTGTCWQKNPEKRSTMDSIHKK
||.|.  .|.   |.|.| |||..||| . |. ||.  ..  .. ....     |  .| .. . . . |. . |||.| |..| | .   |.
PEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGR-RLTQPPPDDCPDDFWDLMC-TCWHKDPHQRPTFAQLQKM
Kinase frk-1.AA Csk 131-382 38 2.5e-56 190.7 In-house 1-251 (251) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-251/251
Sequence Identity: 38% (100 aa)

IVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAE--ATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEH-PLMIVMEYCPNGSLLSHLKKNKVSLI
.   .. |.| |||| . |. |. |  |||| .. .  .. .|   |. ||  | . .|.  |.|||| .|.   | |||||  .|.|.  |     ..|
LHLGECIGHGEFGDVMQGEY-QNRK--VAVKCIKCDGNGMAQA---FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVI

EK---LRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNKDEIKD-ETLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSDG
..   | |    . | .|||  | .||| |||| |.|  .  |.|||| .       |  |  | |||| ||| . .| .. | |.| ||.| ||||| |
TRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFG

AEPYPGLTKIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKL
  ||| .  ..   | |   |||  |.|  | |  |    ||. || || |   . ..|
RVPYPRIP-LKDVVKHVEKGYRMEAPEGCPPHVYKVMK-QCWHLNPAKRPTFRQVREQL
Kinase frk-1.AA Frk 131-386 32 1.4e-54 187.55 In-house 1-260 (260) Show / Hide 
Range on Protein: 131-386
Range on HMM: 1-260/260
Sequence Identity: 32% (86 aa)

IVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNGSLLSHLK-----KNKVS
|   ..|| | ||.|.    ..  .  |||||... .       |..||..|.| .|  ...|  |   | |..|. |   .|||. .|.      ... 
IQLIRRLGSGQFGEVWEGLWNN--TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQ

LIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSD--NKDEI---KDETLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIY
. . .  .   | |.||||    ||||.|||| |.  .| .|| |||.     ||..      .  ..|||| ||| .. . .| | |.| ||.|. || 
MQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEII

SDGAEPYPGLTKIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKLREFY
  |  ||||.|  .   ..| ..|||  | .  ... ...   ||...|.|| | . .. || ...
TYGRMPYPGMTNAEV-LQMVDHGYRMPQPPNCPQQLYEIML-ECWHSDPMKRPTFETLQWKLEDYF
Kinase frk-1.AA S_TKc 131-386 24 1.1e-47 165.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 131-386
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

IVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPN--GSLLSHLKKNK-----
    .|.|.|||| |. .      ...||.| ..         ....| ....| .|...|||..|  . . | .|||||..  |.|....||..     
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNKDEIKDETLEKVPIKWLAPETMQEKVYTH-KTDIWTFGVLVWEIY
   .  .  ... . .....|. . . ||||.   | ||.   ..||.|||..         |   .   ..||| .    |.. | |.| .|....| .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SDGAEPYPGLTKIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHK-----KLREFY
. |  |.|    .|.  |...            | . |     |.||.|||| |   . .     |. .. 
C-GYPPFP---QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase frk-1.AA Pkinase 131-382 21 2.5e-37 133.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 131-382
Range on HMM: 1-293/293
Sequence Identity: 21% (64 aa)

IVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATRE-----ARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNG----SLLSHLK-
..  .|.|.|.|| |...     || .||||... . ...     .|..   |...|.. .|...|.|...   .  . .|||||..|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--KNKV--SLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNEL----KISDFGMSDN--KDEIKDETLEKVPIKWLAPETMQ-EKVYTHKTDI
  ....  |  |  .. .. . |..|. . ..||||.   |.|.. ....    ||.||| .           |   . . ..|||  .  . |..| |.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WTFGVLVWEIYSDGAEPYPGL-TKIQTRAKIVVNDYRMKMPDGTH-------------------------PTVADVVTGTCWQKNPEKRSTMDSIHKK--
| .|....| .. |  |.||  . .  . .... . .|. |   .                         ..  |.... |..|.|.|| | . | .   
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW-CLCKDPKKRPTAEQILQHPW

L
.
F