Gene gcy-1 (Nematode worm)

gcy-1

Species: Nematode worm
Alias: gcy-1, CE01450, AH6.1, aSWK293
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 9516840-9512394, WormBase Genetic Map location: n/a,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
gcy-1.AA Protein Genbank 1137 None Fasta, JSON

Protein domain

Protein domains of gcy-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor gcy-1.AA ANF_receptor 53-432 19 1e-69 242.69 Pfam 1-364 (364) Show / Hide 
Range on Protein: 53-432
Range on HMM: 1-364/364
Sequence Identity: 19% (78 aa)

VCGGAVPLAIERLKEMGFVKDFDFEYIVDYTEC----DLGSVVRAGMEFIKTHKVDVIIGPPCAQALRLMSFLAENYKKPVLGWGFVSDTDLSD--VIRF
 |..|...|||...  . . ...... .....|    |    | |...... ..|..|||| | .. . .. .|. ...|...|| .... |.|   .|.
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWG-CTCPCLTDKAKNRY

PHLTTVIPNSLML-GYAASKMLTT-FHWNRVALLYYFSDVKYCSGV---MNDIEATFNDPSTPNVNI--VIKAEIYLNDNETTDNVFQT-VKSRARIILW
|... ..|..... |.|..... . | |..||..|. .| .|. |.   |.... .....  ..|..  | . . . .| .. . . .  .|..||.|..
PYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVM

CTQTSVE---KRDYLIKIATHDMIGDEYVHIMLSMRNVAFGTQTSLGKPTFSQSGLTPIWESFTEGTDGFEKMAKQAATRMFVLDVNSEVADKKYLEYMQ
|..       .| ...... . | ...||.|. .. . ... | .                      |  .... ..|  ... .    . .... |.||
CCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W-------------------WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQ

KNIIKAVQSPPMNCSTVECMTANTTIMGGYARHLFDVVYLYGIALTHTNSTDPAVYGDV---------DVLVHQFV-TSFQGMTGHVVISPNLTRMPIFQ
..                    ..| | .|| ...| ||||. || .....||... .          ..| .    ..|.|.||.|..  |  |.| ..
RWKK------------------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYM

LYGLNSD
.. .| |
YWIMNWD
Kinase gcy-1.AA RGC 586-825 33 4.7e-123 415.12 In-house 1-300 (300) Show / Hide 
Range on Protein: 586-825
Range on HMM: 1-300/300
Sequence Identity: 33% (100 aa)

EKEMVLTAKYQYT----HLTK--ADKERFVKMRKLDHENINRFIGLSIDSA------HFISVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEY
|...|.. |....    |..   ...  . .||.|.|.|.|.|||..||.       ....|...||||||||||......|| .|... |||..||..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMD----------------------NLV-EEQTPPKKRLLWVAPEVLRGSLSVSQME---------PSAD
||. ..| ||||.|..|.|...|.||.. .|.                       ..  ....| .|..|| |||.||.... .|..         ...|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFAIIASEILTKKEAWDIL-----------DRKEDCEEIVYNVKKGGLFPIRPEIITDIH----DVNPALIALVKDCWAEVPEDRPT-AENICSQMKG
.|||.||..||.|.|..||.            ...|. ||..| .|||| .|.||.|..|      ..||.|..|..||||| ||.||. ...|..|.|.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-1.AA RGC 586-825 33 4.7e-123 415.12 In-house 1-300 (300) Show / Hide 
Range on Protein: 586-825
Range on HMM: 1-300/300
Sequence Identity: 33% (100 aa)

EKEMVLTAKYQYT----HLTK--ADKERFVKMRKLDHENINRFIGLSIDSA------HFISVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEY
|...|.. |....    |..   ...  . .||.|.|.|.|.|||..||.       ....|...||||||||||......|| .|... |||..||..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMD----------------------NLV-EEQTPPKKRLLWVAPEVLRGSLSVSQME---------PSAD
||. ..| ||||.|..|.|...|.||.. .|.                       ..  ....| .|..|| |||.||.... .|..         ...|
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFAIIASEILTKKEAWDIL-----------DRKEDCEEIVYNVKKGGLFPIRPEIITDIH----DVNPALIALVKDCWAEVPEDRPT-AENICSQMKG
.|||.||..||.|.|..||.            ...|. ||..| .|||| .|.||.|..|      ..||.|..|..||||| ||.||. ...|..|.|.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-1.AA TKL 605-823 21 8.6e-33 115.27 In-house 72-364 (364) Show / Hide 
Range on Protein: 605-823
Range on HMM: 72-364/364
Sequence Identity: 21% (63 aa)

KERFV-KMRKLDHENINRFIGLSIDSAH-------------FISVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLHKTFL-------RLHG
.|. .  |..|.|.|| .|.| .... .             .  |. .|..||| ..|           .. ...|.|.|..|||            .| 
EEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHR

NLRSATCLVNDSWQ--------------VKLAEYGMDNLVEEQTP-----------------------PKKRLLWVAPEVLRGSLSVSQME---------
.| |. .||.. |.              .|.. .|    ... .                        .   . | |||||||..  ..           
DLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGF

---PSADIYSFAIIASEILTKKEAWD-ILDRKEDCE----EIVYNVKKGGLFPIRPEIITD------IHDVNPALIALVKDCWAEVPEDRPTAENICSQM
   ...|.|||.|.  |||| .. .. .  . ...     |. . | . || | .|.|  .       .|. | .. | .|||.. ||.||... | ...
EYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase gcy-1.AA TKL-Unique 611-823 23 2.4e-22 75.75 In-house 49-290 (290) Show / Hide 
Range on Protein: 611-823
Range on HMM: 49-290/290
Sequence Identity: 23% (60 aa)

MRKLD-HENINRFIGLSI----DSAHFISVTKLCSRGSLQDILS---------RGNFSMDYFFMFCIIRDVAKGLEYLHKTFL-RLHGNLRSATCLVNDS
| ||. |.|| ...| ..    . .... |.  |..||| | |.         . |  ...  .  ...|.|.|..||| .    .|..|.|   ||.  
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN

-----WQVKLAEYGMDNLVE-EQTPPKKRL------------LWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKE------AWDILDRKEDCEEI
     |..|..  |   .   . . .....            .|.||||||..   .|   ..|.|||.|.  ||.| |         . .|....|| .
SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMV

VYNVKKGGLFPIRPEIITDIHDVNPALIALVKDCWAEVPEDRPTAENICSQM
 |  ...     ||.| ...   .. .  | ..||.  |..||. ..| .  
HYM-EEN----YRPPIPNHC---PKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase gcy-1.AA TK 610-823 14 9e-16 48.61 In-house 93-486 (486) Show / Hide 
Range on Protein: 610-823
Range on HMM: 93-486/486
Sequence Identity: 14% (57 aa)

KMRK---LDHENINRFIGLSIDS------------AHFISVTKLCSRGS----LQDILS--RGNFS----------------------------------
|| .   ..|.|| |..| . ..             ... |. ... |.    |.| |   |..|.                                  
KMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNS

---------------------------------------MDYFFMFCIIRDVAKGLEYLHKTFLR-----LHGNLRSATCLVNDSWQ-----------VK
                                       ..   .  . ...|.|.||||.   .      |..|    |||... .           .|
PCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

LAEYG----------MDNLVEEQTPPKK----------------------------RLLWVAPEVLRGSLSVSQ-----MEPSADIYSFAIIASEILT--
.| .|           |   ..    |.                             . | |||.|..    ..       .  |..|| .   ||.|  
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYG

-KKEAWDILDRK----EDCEEIVYNVKKG-----------GLFPIRP--EIITD----IHDVNP-----ALIAL-VKDCWAEVPEDRPTAENICSQM
 .  .... ...    .|..|.. ....|           |    .|  .  .|     .   |     .....  ..||.. |||||| . . .|.
QEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase gcy-1.AA DRK 611-754 33 4.7e-13 40.58 In-house 51-197 (258) Show / Hide 
Range on Protein: 611-754
Range on HMM: 51-197/258
Sequence Identity: 33% (51 aa)

MRKLDHENINRFIGLSIDSAHFISVTKLCSRGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLH-KTFLRLHGNLRSATCLVNDSWQVKLAEYGMDN--
| .| | ||  |.|    .     ..   .||||  ||     .||   |  .  |.|||. |||  .   .|  | |   || ..|||| | .|     
MCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRF

-LVEEQTPPKKRL---LWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILT
  .....  .       |.||||||   .    |  ||.|||||.  |..|
KKHKQHKFAMTMCGTPCWTAPEVLR---NQRYTE-KADVYSFAIVLWECVT
Kinase gcy-1.AA RAF 611-825 24 1.3e-12 36.95 In-house 52-282 (282) Show / Hide 
Range on Protein: 611-825
Range on HMM: 52-282/282
Sequence Identity: 24% (58 aa)

MRKLDHENINRFIGLSIDSA--HFISVTKLCSRGSLQDILSRGNF--SMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMD
..|  | ||  | | . .     .  ||. |   ||   .   .    .| . .. | | |..|..|||.    .|  |.|   .  .  .||   .|. 
YKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKFDMHWLIDISRQVCQGMDYLHAKNI-IHRDLKSNNIFLHEDMTVKIGDFGLM

NLVEEQT--------PPKKRLLWVAPEVLR-------GSLSVSQMEP---SADIYSFAIIASEILTKKEAW--DILDRKEDCEEIVYNVKKGGLFPIRPE
 .    .         |    || |||| |       | .      |     |.||| |.  |..|..     .| .|.     |.. . .| | | . .
TVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRD----QIIFMCGRGYLRPDLSK

IITDIHDVNPALIALVKDCWAEVPEDRPTAENICSQMKG
.  |.     |.  |..|||.  .|.||  ..| .... 
VRQDCPK---AMHRLMEDCWKFQREERPLFQQILKRITV
Kinase gcy-1.AA LRRK 720-825 25 9.5e-12 37.83 In-house 244-351 (351) Show / Hide 
Range on Protein: 720-825
Range on HMM: 244-351/351
Sequence Identity: 25% (30 aa)

LWVAPEVLR--GSLSVSQMEPSADIYSFAIIASEILTKK-EAWDILD-RKED--CEEIVYNVKKGGLFPIRPEIITDIHDVNP-----ALIALVKDCWAE
.|.|||..|  |  . ..    .|.|||..|  |.|| .  . | .| ..     |.|  ....|    .|| |  .    .|      . .| ..||..
GWMAPEIMRYNGEEEYTEK---VDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEG----LRPTIPQH-Y-CPPCQPWHMYQDLIQHCWQH

VPEDRPTAENICSQMKG
 |..||... | .... 
DPKKRPHFSQIVKRLSQ
Kinase gcy-1.AA Pkinase 721-823 20 2.8e-11 40.95 Pfam 177-293 (293) Show / Hide 
Range on Protein: 721-823
Range on HMM: 177-293/293
Sequence Identity: 20% (25 aa)

WVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKEAWDIL---DRKEDCEEIVYNVKKGGLFPIRPEIIT--------------DIHDVNPALIALVK
..||||.|   . .   |..|..|. .|  | |...  ..     |.  |  ......... |   .|. ..                | ...... ..|
YMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIK

DCWAEVPEDRPTAENICSQ--M
.|..  |..||||| |.    .
WCLCKDPKKRPTAEQILQHPWF
S_TKc gcy-1.AA S_TKc 557-824 15 5.9e-11 -16.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 557-824
Range on HMM: 1-231/231
Sequence Identity: 15% (43 aa)

LQSAPSISTGHSGVTTVSDFCENYTMMMYEKEMVLTAKYQYTHLTKADKERFVKMRKLDHENINRFIGLSIDSAHFISVTKLCSR--GSLQDILSRGNFS
 .    |  |  |.       .           .   |       .. .|. . ..  .|.|| ....   |  |.  |. .|.   |.| |.. . .  
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----MDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQTPPKKRLLWVAPEVLRGSLSVSQMEP-SADIYSFAII
     ..     .... ....|||.|.    .|  |  .  |...  ..|..  |.  ..   |     . ..|||||       .  . ..|..|. .|
GLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

ASEILTKKEAWDILDRKEDCEEIVYNVKKGGLFPIRPEIITDIHDVNPALIALVKDCWAEVPEDRPTAENICS--------QMK
  | |. .  ..        .. .... .                  | .. ... |.   ||.||||  .          .  
LYEMLCGYPPFP-------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc gcy-1.AA TyrKc 582-823 21 1.5e-09 -68.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 582-823
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

MMMYE---------------------KEMVLTAKYQYTHLTKADKERFVK----MRKL--DHENINRFIGLSIDS-------AHFISVTKLCSRGSLQDI
  . .                     | .   |           .| | .    |.||  .|.|| |..|  ...            |. ... |.|.| 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

L--SRGNFSMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGM--DNLVE-------EQTPP----KKR----LLWVAPEVLR
|  .|....|. .  ||.  ..|.| ||||.  .  |  |    |||..  .|| .  |.  |   .       .   .     ..    . | |||...
LRKHRPKLCMKDLLSFCW--QIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GSLSVSQMEPSADIYSFAIIASEILT---KKEAWDILDRKEDCEEIVYNVKKGGLFPIRPEIITDIHD-----VNPALIALVKDCWAEVPEDRPTAENIC
 .   ..     |..|| .   ||.|   .    .|.  . . .|.. .||.|.  |. |..             ...  . |.||.| |||||| ..|.
YGKFTTK----SDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY----PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

SQM
...
ECF
Kinase gcy-1.AA Dicty5 740-827 32 1.2e-08 25.83 In-house 184-260 (260) Show / Hide 
Range on Protein: 740-827
Range on HMM: 184-260/260
Sequence Identity: 32% (29 aa)

ADIYSFAIIASEILTKKEAWDILDRKEDCEEIVYNVKKGGLFPIRPEIITDIHDVNPALIA-LVKDCWAEVPEDRPTAENICSQMKGLV
.|.|||.|.  |..|.||. | . .     .|   | ||.    ||.|  |.    |  |. |.| || . |  ||.   ||  .. ..
CDVYSFGIVLWEMFTRKEPYDNINNW----NIPVMVMKGE----RPTIPKDC----PTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase gcy-1.AA MLK 721-823 20 3.1e-08 24.82 In-house 199-291 (291) Show / Hide 
Range on Protein: 721-823
Range on HMM: 199-291/291
Sequence Identity: 20% (22 aa)

WVAPEVL-RGSLSVSQMEPSADIYSFAIIASEILTKKEAWD-ILDRKEDCEEIVYNVKKGGLFPIRPEIITDIHDVNPALIALVKDCWAEVPEDRPTAEN
| ||||. .  .  ..   ..|..|....  |.||...  . ..|     . . ... .|   ||...        .. .  | |.|| . |..||.   
WMAPEVIQQ--FRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDP---MAIAWWVAYNGLRPPIPST-------CPEHWKKLMKQCWNQDPHKRPSFRQ

ICSQM
| .. 
IVQHL
Kinase gcy-1.AA MLK 612-676 25 8.2e-07 19.81 In-house 60-142 (291) Show / Hide 
Range on Protein: 612-676
Range on HMM: 60-142/291
Sequence Identity: 25% (21 aa)

RKLDHEN----INRFIGLSIDS-AHFISVTKLCSRGSLQDILSRGN-------------FSMDYFFMFCIIRDVAKGLEYLHK
|.|.|.|    | .| | ....  ||  |.  |. ||| ..|  ..             . .|  ... .  ..|.|..|||.
RILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHS
Kinase gcy-1.AA Pkinase 611-676 28 8.5e-07 25.12 Pfam 54-126 (293) Show / Hide 
Range on Protein: 611-676
Range on HMM: 54-126/293
Sequence Identity: 28% (21 aa)

MRKLDHENINRFIGLSIDSAHFISVTKLCSRG----SLQDILS---RGNFSMDYFFMFCIIRDVAKGLEYLHK
|..|.|.|| |...   |. |   |. .|  |    .| |..|   .|.|....    .... ...||||.|.
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS
Kinase gcy-1.AA Dicty5 615-704 26 1.4e-05 15.21 In-house 56-149 (260) Show / Hide 
Range on Protein: 615-704
Range on HMM: 56-149/260
Sequence Identity: 26% (25 aa)

DHENINRFIGLSIDSAHF-ISVTKLCSRGSLQDILSRGNF----SMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYG
|| |. |. |           || .|..||| . |          . ||    .  |.|.....||      |  | |   |..  |..|.  .|
DHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNI-IHRDLKSMNFLITENWKIKIIDFG
Kinase gcy-1.AA DRK 794-825 31 0.000112 11.81 In-house 227-258 (258) Show / Hide 
Range on Protein: 794-825
Range on HMM: 227-258/258
Sequence Identity: 31% (10 aa)

VNPALIALVKDCWAEVPEDRPTAENICSQMKG
. |  |.| .||| | |  ||. . .   .  
CPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase gcy-1.AA Pkinase_Tyr 803-823 52 0.000165 15.89 Pfam 250-270 (270) Show / Hide 
Range on Protein: 803-823
Range on HMM: 250-270/270
Sequence Identity: 52% (11 aa)

KDCWAEVPEDRPTAENICSQM
|.||.. |||||| . | .|.
KQCWHYDPEDRPTFSEIHEQL
Kinase gcy-1.AA Pkinase_Tyr 611-675 25 0.000172 15.83 Pfam 57-128 (270) Show / Hide 
Range on Protein: 611-675
Range on HMM: 57-128/270
Sequence Identity: 25% (18 aa)

MRKL-DHENINRFIGLSI-DSAH--FISVTKLCSRGSLQDILSRG---NFSMDYFFMFCIIRDVAKGLEYLH
|..| .|.|| |..|  . .. .   . |. ..  |.| | | .    . . .   . .. ...|||.|||.
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase gcy-1.AA LRRK 666-676 63 0.099748 1.87 In-house 172-182 (351) Show / Hide 
Range on Protein: 666-676
Range on HMM: 172-182/351
Sequence Identity: 63% (7 aa)

DVAKGLEYLHK
..|||.||||.
QIAKGMEYLHS
Guanylate_cyc gcy-1.AA Guanylate_cyc 889-1077 44 1.1e-102 352.26 Pfam 1-214 (214) Show / Hide 
Range on Protein: 889-1077
Range on HMM: 1-214/214
Sequence Identity: 44% (95 aa)

VEPEGFDSVTVFFSDVVKFTILASKCS----PFQTVNLLNDLYSNFDTIIEQH--GVYKVESIGDGYLCVSGLPTR-----NGYAHIKQIVDMSLKFMEY
|... .|.||..|.|.| || ..|.||    |.| |..|||.|..||....||  |.|||. ||| |.|||||| .     ....|. ...||.|..|||
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

CKSFNIPHLPREN-----VELRIGVNSGPCVAGVVG--LSMPRYCLFGDTVNTASRMESNGKPS--LIHLTNDAHSLLTTHYPNQYET--SSRGEVIIKG
|...|..|..||.     ...|||...||.||||.|  ..|||||..|||||.||||||.|.|.   ||... ....|..|.. |.|.  ..|||. .||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGV---METFWVHG
||    |||...||
KGKMGEMETYFLHG
CYCc gcy-1.AA CYCc 862-1058 42 1.7e-102 347.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 862-1058
Range on HMM: 1-231/231
Sequence Identity: 42% (99 aa)

LEKKKADILLSRMLPKQVAERLKAGQ-TVEPEGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSNFDTIIEQHG-----VYKVESIGDGYLCVSGL
 ||.|.| || .|||. ||..||.|. .|.|. .|.||. |.|.| || |.|.|.|.|.||.|||.|..||.||..||     .|||| |||.| .|||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PTRNG-------------------YAHIKQIVDMSLKFMEYCKSFNIPHL----PRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGK
||||.                   ..|...|.|..|. .| .|.|...|     | ... .|||...||.|.||||. |||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PSLIHLTNDAHSLL-----TTHYPNQYETSS
|  ||.. .....|      .. ..|.|.. 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
HNOBA gcy-1.AA HNOBA 849-883 51 5e-07 26.97 Pfam 200-234 (234) Show / Hide 
Range on Protein: 849-883
Range on HMM: 200-234/234
Sequence Identity: 51% (18 aa)

LEEEIEERTKELTLEKKKADILLSRMLPKQVAERL
| ...|. ..||  |||| | ||  |.||.||.||
LKDKLEQMHRELEEEKKKTDDLLYSMFPKSVANRL