Gene K04C1.5 (Nematode worm)
K04C1.5
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| K04C1.5.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 292 | Kinase domain by global Sugen HMM | Fasta, JSON |
| K04C1.5.AA | Protein | Genbank | 255 | None | Fasta, JSON |
Protein domains of K04C1.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | K04C1.5.AA | Worm9 | 1-255 | 74 | 9.69999999999e-227 | 759.54 | In-house | 37-291 (291) | Show / Hide |
Range on Protein: 1-255 Range on HMM: 37-291/291 Sequence Identity: 74% (191 aa) MLVGERLENEPNFYQEIDFLKHLAGINGVPVVHKHFQYEQKRVLVMDKYLENLEQFRKRKEDEKLSPRVVIKLAFRLVSILEHIHRKGVVHQDIKLDNVV |.|||..||.|.||||.|||.||.||||||..|.|||||||||..||||||||||||||..|...|.|..||.|||||.||||||.|||.|||||.|||. MVVGEQFENDPQFYQEFDFLNHLRGINGVPNIHQHFQYEQKRVMMMDKYLENLEQFRKRCDDRRISDRNIIKIAFRLVNILEHIHQKGVIHQDIKTDNVM FGAKVGNKLDIVLIDYGIAAFTKPKPPRDLVDGALHCTTDFSSSVYASPGLVQGLKGDPVDDLQMLSFMLLWASKYNPFGEDSLESLRKKKEFIAKPSIF |...|.||..||||||||..|.||||||||||.|.||...|.|.|..||.||||||.|||||||||||||.|.|||.|||.||.||.|||||||..|... FRSRVQNKVNIVLIDYGISTFNKPKPPRDLVDDAKHCEIMFRSHVHVSPALVQGLKADPVDDLQMLSFMLIWCSKYHPFGPDSQESSRKKKEFITNPVKY TQGDYKFLRPVISKIMEQKRSKRPDYKAISKKCANKDNYFNPDTAVHLGNAYEFF .||||||||||..|||||||||||.|.|||.|||||||||||||||||||||||| VQGDYKFLRPVMTKIMEQKRSKRPNYQAISDKCANKDNYFNPDTAVHLGNAYEFF |
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| Kinase | K04C1.5.AA | CK1 | 6-229 | 18 | 2e-37 | 128.13 | In-house | 53-339 (339) | Show / Hide |
Range on Protein: 6-229 Range on HMM: 53-339/339 Sequence Identity: 18% (55 aa) RLENEPNFYQEIDFL---------------KHLAGINGVPVVHKHFQYEQKRVLVMDKYLENLEQFRK--RKEDEKLSPRVVIKLAFRLVSILEHIHRKG .|. | ..|.. .. ||.. ..... .... . ...||. . .|||..|| | . |.| . ....| .... ||..|..| QLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCG VVHQDIKLDNVVFGAK------------VGNKLDIVLIDYGIAAFTKPKPPRDLV--------DGALHCTTD---------FSSSVYASPGLVQGLKGDP .| ||| ||...|.. ... ...||.|.| . | ..... . .. . . . |.|. .| . FIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARR-KYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGC-TARYCSINCHLGKEQGR VDDLQMLSFMLLWASKYN---PFGEDSLESL-------RKKKEFIAKPSIFTQGD----------YKFLRPVISKIMEQKRSKRPDYKAI .||| .. .||.. | . | .. |. ..|.|||... |... . . ... |...|...||||..| RDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | K04C1.5.AA | Ciliate-E2a | 81-128 | 29 | 5.4e-11 | 28.62 | In-house | 115-165 (275) | Show / Hide |
Range on Protein: 81-128 Range on HMM: 115-165/275 Sequence Identity: 29% (15 aa) LEHIHRKGVVHQDIKLDNVVFGAKVGNK---LDIVLIDYGIAAFTKPKPPR |...| ....| |.|..|. | . |. .||..|| | | | ... .. LHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKK |
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| Kinase | K04C1.5.AA | S_TKc | 1-240 | 12 | 1e-10 | -19.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-240
Range on HMM: 1-231/231
Sequence Identity: 12% (36 aa)
MLVGERL------------ENE-----------PNFYQEIDFLKHLAGINGVPVVHKHFQYEQKRVLVMDKYLE---NLEQFRKRKEDEK----LSPRVV
... . ... ....||. ||. . . . .|| .. .||. .| .. |.. .. ... ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA
IKLAFRLVSILEHIHRKGVVHQDIKLDNVVFGAKVGNKLDIVLIDYGIAAFTKPKPPRDLVDGALHCTTDFSSSVYASPGLVQGLKGDPVDD--------
... ... ||..|..|..| |.| .|. . | ..| |.|.. || . | .| .. . .
RFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------------TTFCGTPWYMAPEVL------GYGKCKCDWWSC
----LQMLSFMLLWASKYNPFGEDSLESLRKKKEFIAKPSIFTQGDYKFLRPVISKIMEQKRSKRPDYKAISKKC--ANKDNYF
||. .. .. . || . .. |.|... .||| . . . .... .|
GCILYEMLCGYPPFP---------QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | K04C1.5.AA | VRK | 42-119 | 32 | 2.5e-10 | 29.71 | In-house | 104-180 (284) | Show / Hide |
Range on Protein: 42-119 Range on HMM: 104-180/284 Sequence Identity: 32% (25 aa) RVLVMDKYLENLEQFRKRKEDEKLSPRVVIKLAFRLVSILEHIHRKGVVHQDIKLDNVVFGAKVGNKLDIVLIDYGIA | .||... . |. ... ..|.. | || |. .|| .| .. || ||| |. | .|. .|.||| | RFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFE-KNPDQVYLVDYGLA |
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| Kinase | K04C1.5.AA | Ciliate-E2 | 33-119 | 19 | 4.5e-10 | 30.74 | In-house | 98-203 (365) | Show / Hide |
Range on Protein: 33-119
Range on HMM: 98-203/365
Sequence Identity: 19% (22 aa)
HKHFQ--YEQKRVLVMDKYLE-NLEQ---FRKRKEDEK------LSPRVVIKLAFRLVS---------------ILEHIHRKG-VVHQDIKLDNVVFGAK
. .|| ... |||. . .|.. .| |.... .. . .... ... ||..| |. ..| |||..|..|
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---
VGNKLDIVLIDYGIA
| .|| |..
------IKIIDFGLS
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| Kinase | K04C1.5.AA | Worm8 | 20-119 | 31 | 3e-09 | 22.85 | In-house | 51-149 (261) | Show / Hide |
Range on Protein: 20-119 Range on HMM: 51-149/261 Sequence Identity: 31% (31 aa) LKHLAGINGVPVVHKHFQYEQKRVLVMDKYLENLEQFRKRKEDEKLSPRVVIKLAFRLVSILEHIHRKGVVHQDIKLDNVVFGAKVGNKLDIVLIDYGIA | ||..|||| . ||.. . |. | | . | . || || || .|.|| ||| || . . ||.|.|.. LTALADVNGVPRMFDYGSTDYHNWIVMEQLSDDLINIICRNENKMFSKPTGYQIMWQLVKILQDIHSFGIVHGDIKADNLMVSHSN-RMFMLVLVDFGCS |
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| Kinase | K04C1.5.AA | CAMK-Unique | 70-120 | 20 | 4.2e-09 | 25.97 | In-house | 159-221 (363) | Show / Hide |
Range on Protein: 70-120 Range on HMM: 159-221/363 Sequence Identity: 20% (13 aa) VIKLAFRLVSILEHIHRKGVVHQDIKLDNVVFGAKVG------------NKLDIVLIDYGIAA .. . ..|.| ... | ...|| |.||.|... . . ..|.|.|.|... TCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCC |
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| Kinase | K04C1.5.AA | Worm7 | 13-119 | 32 | 5.5e-09 | 26.13 | In-house | 47-152 (263) | Show / Hide |
Range on Protein: 13-119 Range on HMM: 47-152/263 Sequence Identity: 32% (35 aa) FYQEIDFLKHLAGINGVPVVHKHFQYEQKRVLVMDKYLENLEQFRKRKEDEKLSPRVVIKLAFRLVSILEHIHRKGVVHQDIKLDNVVFGAKVGNKLD-I . .|| | | . ..| || ..|| || || .| || |... | | || |. .| |.. .|| | ||. . YDREIEFFKYCHHVPNIPKLFHHFTHVGWNCIVMSEEGQNLRDVVKRNNNKPFSTNNVIRIAWQIGSTLCFIHNKSFIHRDVHSQNVLVTLK--NKVCKM VLIDYGIA ||||.| | VLIDFGNA |
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| Kinase | K04C1.5.AA | Ciliate-E2-Unclassified | 33-119 | 21 | 2.3e-08 | 25.16 | In-house | 87-194 (352) | Show / Hide |
Range on Protein: 33-119 Range on HMM: 87-194/352 Sequence Identity: 21% (23 aa) HKHFQYEQKRVLVMDK--------YLENLEQ--------FRKRKEDEKLSPRVVI-----KLAFRLVSILEHIHRKG-VVHQDIKLDNVVFGAKVGNKLD . .|| .|. .||.. |... .. |...|...... . .. ... ... ||..|.|. ..| |||..|..| . . .. FYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYY IVLIDYGIA | .||.||. IKIIDFGIS |
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| Kinase | K04C1.5.AA | CK1-A | 11-119 | 32 | 2.5e-08 | 25.37 | In-house | 39-145 (261) | Show / Hide |
Range on Protein: 11-119 Range on HMM: 39-145/261 Sequence Identity: 32% (37 aa) PNFYQEIDFLKHLAGINGVPVVHKHFQYEQKRVLVMDKY---LENLEQFRKRKEDEKLSPRVVIKLAFRLVSILEHIHRKGVVHQDIKLDNVVFG-AKVG | | . |.| |.| .. . . . |.||| ||.| | || . . . |. || ... .| .| |. .| ||| || . | . PQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKR----RFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHC NKLDIVLIDYGIA ||| |||.|.| NKL--FLIDFGLA |
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| Kinase | K04C1.5.AA | Pkinase | 64-129 | 17 | 3e-06 | 23.39 | Pfam | 102-169 (293) | Show / Hide |
Range on Protein: 64-129 Range on HMM: 102-169/293 Sequence Identity: 17% (12 aa) KL--SPRVVIKLAFRLVSILEHIHRKGVVHQDIKLDNVVFGAKVGNKLDIVLIDYGIAAF--TKPKPPRD .. |...... . ... ||..|..|..| |.|..|. . . .. .. ..| |.|.. . ... . CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT |
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| Kinase | K04C1.5.AA | Worm8 | 188-229 | 38 | 0.00024 | 8.4 | In-house | 217-257 (261) | Show / Hide |
Range on Protein: 188-229 Range on HMM: 217-257/261 Sequence Identity: 38% (16 aa) RKKKEFIAKPSIFTQGDYKFLRPVISKIMEQKRSKRPDYKAI ..|. | .| | |. |.|.| . || | ||||.| KMKMKFAKNPKKFL-GEHQDLKPIIKMLAKQKHYKEPDYKEI |
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