Gene K08B12.5 (Nematode worm)

K08B12.5

Species: Nematode worm
Alias: CE30818, K08B12.5, aSWK003
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 6269785-6260009, WormBase Genetic Map location: V:-3.37,

Classification

Group: AGC
Family: DMPK
Subfamily: GEK

Sequence

Name Sequence Type Origin Length Description Download
K08B12.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
K08B12.5.AA Protein Genbank 1548 None Fasta, JSON

Protein domain

Protein domains of K08B12.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase K08B12.5.AA DMPK 83-351 67 5.1e-292 733.32 In-house 1-270 (270) Show / Hide 
Range on Protein: 83-351
Range on HMM: 1-270/270
Sequence Identity: 67% (184 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPES
||.|||||.|.||||.|||.. ....||||..|||||.||||||||.||||..|.|..||||.||||||||..||.||.|..|||.|||.|.. |.|||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDG-RGRYGKECDWWSLGICMYEM
||.||.|||||||.|.|..||||||.||||.|||..|||.|||||||... .|| | |.||||||||||||.|.||||. .||||.||||||.|.|||||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LYGTTPFYSERLVDTYGKIMSH-QDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFF
|||.|||| ..||.||||||.| ...|.||||.  |.|||||||||.||.|....|.||||. ||. ||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPK-WDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase K08B12.5.AA GEK 83-351 78 5.4e-206 690.63 In-house 1-269 (269) Show / Hide 
Range on Protein: 83-351
Range on HMM: 1-269/269
Sequence Identity: 78% (212 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPES
||.|||||.|||||||||.|......|||||||||||.||||||||||||||||.||||||||||||||||..||.|||||.|||.||||||| |..||.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEML
||.|||||||.||||.|.|.|||||.|||||||||.|||||||||||||. .||.|.||||||||||||||||.|||||.||||.||||||||.||||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

YGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFF
||.||||.|.||.||||||.|.|...||..|.||.|||||||||||||||...|.||||..||. ||||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase K08B12.5.AA AGC 83-351 30 1.3e-167 437.48 In-house 1-395 (395) Show / Hide 
Range on Protein: 83-351
Range on HMM: 1-395/395
Sequence Identity: 30% (124 aa)

FEVLKVIGKGAFGEVAVVRMR------GVGEIYAMKILNKWE--------MVKRAETAC-------FREERDVLVYGD----------RRWITN-LHYAF
||.|||||||.||.|  ||..      . |..||||.|.|..        ||... |..       ..|||..|.  .            .|.. |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEKN--LYFVMDY--------YIGGDMLTLLSKFVD----HIPESMAKFYIAE-------MVLAIDSLHR-LGYVHRD-VKPDNVLLDMQGHIRLADFG
||...  |||||.|        |.||.. ..|... .    . .|..|.||.||       .|||...||. .|..||| .||.|.||| .|||.|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SCLRILADG-------------------------------------------------SVASNVAVG--TPDYISPEILRAMEDGRGRYGKECDWWS--L
.| ..  ||                                                  .  .  .|  ||.|..||||         |||.|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GICMYEMLYGTTPFYSERLV----------DTYGKIMSHQ----DMLDFP-----DDEIDWVVSEEAKDLIRQLIC-SSDVRFGRN-------GLSDFQL
|..|||||.| .|||..  .          ... |||...    . . ||     . . |  .|.||||||..|.|   . | | .       | .. . 
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPFF
||.|
HPWF
Kinase K08B12.5.AA ROCK 83-351 52 3.8e-129 435.36 In-house 1-263 (263) Show / Hide 
Range on Protein: 83-351
Range on HMM: 1-263/263
Sequence Identity: 52% (141 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPES
|...||||.|||||| .|| .   ..||||.|.| ||.||.. | | ||||.. .    ||  |||||||.. || ||||  |||.  |.|..   .|| 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNY--DVPEK

MAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEML
 |.|| .|.|||.|..| .|..||||||||.||| .||..||||| |... ..| | .. |||||||||||.|..   . |.||.|||||| |. .||||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQG-QDGEYGRECDWWSVGVFIYEML

YGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFF
 | |||| . || ||.||| |.. | ||||     .|..|||||.. .   ..| ||||. | . |.||
VGDTPFYADSLVGTYSKIMDHKNSLKFPDDV---EISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase K08B12.5.AA CRIK 83-351 44 3.4e-118 378.49 In-house 1-272 (272) Show / Hide 
Range on Protein: 83-351
Range on HMM: 1-272/272
Sequence Identity: 44% (124 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPES
|||  .||.| ||.| ||| .  . |||||.. | ..  . . . | ||||..      |...| |||||. ||| .| |  ||| | |.. . |   |.
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

MAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMED---GRGRYGKECDWWSLGICMY
||.|| || ..|. |||  ||||||.||.|.|.|  ||| ||||||   .  .. | |   ||||||. ||.|  |     ..| || .|||||.||  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLYGTTPFYSERLVDTYGKIMS------HQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFF
|| .|.|||     . || .||.       | .| ||||     || .. |||..|.|    | .  .|     ||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDP---KVSPNYRDLIQSLLCNQSKRLKYEQL---CCHPFF
Kinase K08B12.5.AA S_TKc 83-351 32 2.9e-85 290.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 83-351
Range on HMM: 1-231/231
Sequence Identity: 32% (92 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIG--GDMLTLLSKFVDH--
.|.|..|||||||.|  .| .. |.|.|.||..            .| |...|   .  .| .|...||| ..||.||.|  |  ||..... |   |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGK-ECDWWSL
   .|| .|.||......|.. .|..| .|||.||.|.|||   || ..|||.. ..        .  .|||.|..||.|         ||| .|||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLIC-SSDVRFGRNGLSD----FQLHPFF
|...||||.| .||.   .  .. ||.                 |.||||.||.. .   . | .   .        .||.|
GCILYEMLCGYPPFP--QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase K08B12.5.AA NDR 83-238 51 1.6e-84 260.51 In-house 1-155 (350) Show / Hide 
Range on Protein: 83-238
Range on HMM: 1-155/350
Sequence Identity: 51% (83 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGD--RRWITNLHYAFQDEKNLYFVMDYYIGGDMLT---LLSKFVD
||..|.||||||||| .||..  |.||||||..| ||... ..|  | |||...  |   .|.. | |.|||...||.||.| .|||| |   ||.|. |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

HIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSV
  .|..|.|||||||.||.|.|..||.|||.|||| |.| .||| | |||     |..|..
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG-----LCTGGM
Kinase K08B12.5.AA RSK 86-351 37 2.5e-77 263.22 In-house 1-278 (278) Show / Hide 
Range on Protein: 86-351
Range on HMM: 1-278/278
Sequence Identity: 37% (106 aa)

LKVIGKGAFGEVAVVRMR---GVGEIYAMKILNKWEMVKRAE-TACFREERDVLVYGD-RRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDH--
||| |.|..|.| ..|       | |||||.|.| ..|.|.  |.  ..||..|        | .||||||.|. || .|.|  ||...| |.| .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

IPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDM---QGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLG
. |. |.||.|| |||.. || .| .||| ||.|.|.|    .|||.| ||| |    .| .   .  ..| .|. ||.|.  . ..| ..| |||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLG

ICMYEMLYGTTPFYS---ERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLIC-SSDVRFG--RNGLSDFQLHPFF
. ||||| | .||..   .   ..  .|.. .  |..| ..    .|.|||||||.. .     | |  ...... . ||.|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQ---YLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase K08B12.5.AA Akt 83-329 39 1.2e-71 228.28 In-house 1-239 (264) Show / Hide 
Range on Protein: 83-329
Range on HMM: 1-239/264
Sequence Identity: 39% (100 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIY-AMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPE
|..|||.|||.|| |  |.    ...| |||.| |   ... . .    || .|.  .   |.||||.||....|||||||  ||.  ..|..    ..|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR-KRRFSE

SMAKFYIAEMVLAIDSLHRLGYVHRD-VKPDNVLLDMQGHIRLADFGSCLRI-LADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWS-LGICM
. |.||.||..|||. ||  . . ||  || |.|.| .|||.|.||| | .. . |. ..  .  ||| |..||||    .| | ..| .|||. ||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTF-CGTPEYLAPEIL----NGNG-HTKAVDWWGSLGCVM

YEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQL
|||..|  |||..     . ||.. .  . |||     ..| |.||||..|
YEMMCGRPPFYNQDHHQMFKKIKNQP--VKFPDK---DWISPECKDLISGL
Kinase K08B12.5.AA MAST 83-227 41 6.9e-57 172.02 In-house 1-147 (337) Show / Hide 
Range on Protein: 83-227
Range on HMM: 1-147/337
Sequence Identity: 41% (61 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQD--EKNLYFVMDYYIGGDMLTLLSKFVDHIP
|| .|.|.|||.| |  |. .  ....|||..|.  . ..      . ||..|.. .  .. .. |.||   .| |..||.| .|||  .||. .    |
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFG
|.|||.|||| ||... ||  | ||||.||||.|.|  ||| |.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase K08B12.5.AA MAST 83-227 41 4.8e-56 179.01 In-house 1-144 (334) Show / Hide 
Range on Protein: 83-227
Range on HMM: 1-144/334
Sequence Identity: 41% (60 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPES
||  |.|.|||.| |  |. .  ....|||...| .| ..  .   . ||..| . .  .. .. |.|| ...|..||.| .|||  .||. .    .|.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

MAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFG
|||.||||.||... ||. | ||||.||||.|.|  ||| |.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase K08B12.5.AA Pkinase 83-331 28 7e-53 186.8 Pfam 1-275 (293) Show / Hide 
Range on Protein: 83-331
Range on HMM: 1-275/293
Sequence Identity: 28% (80 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFR-EERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGG----DMLTLLS-KFV
......||.|.||.|   . .| |.|.|.||..| .  .  . . .|  |  ..   .   |  |...|.|....|.||.|  ||    |  ...| .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DHI--PESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHI----RLADFGSCLRI-LADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKEC
  .  .|  .|||. ... ... .|. | .|||.||.|.|.| .|||    ...|||..  . .  .|   .. .|||.|..||..|    |.  ||...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR----GGQYYGPKV

DWWSLGICMYEMLYGTTPFYSE------RLVDTYGKIMSHQDMLDFPDD---------------EIDWVVSEEAKDLIRQLIC
|.||.|. .|||| | .||...      .    . .||. . . |.| .               .    .|||.||.|. ..|
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLC
Kinase K08B12.5.AA NDR 243-351 42 3.3e-44 133.83 In-house 241-350 (350) Show / Hide 
Range on Protein: 243-351
Range on HMM: 241-350/350
Sequence Identity: 42% (49 aa)

AVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFP--DDEIDWVVSEEAKDLIRQLIC-SSDVRFGR
.||||||. ||..   . |   |...|||||||  ||||| | .||.|.   .|. |||. . ..| |  ... .  .|.||.||||.|.|   | | |.
TVGTPDYMAPEVFQQ-KTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGS

NG--LSDFQLHPFF
.|    ... ||||
HGKGVDEIKSHPFF
Kinase K08B12.5.AA MAST 244-351 39 1.1e-32 96.73 In-house 229-337 (337) Show / Hide 
Range on Protein: 244-351
Range on HMM: 229-337/337
Sequence Identity: 39% (45 aa)

VGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVD-TYGKIMSHQDMLDFPDD---EIDWVVSEEAKDLIRQLICSS-DVRFG
.||||||.||..     |.| |||  ||||.|| ||| | |..||  .     . ..| .|.... .|..   . |. .|.||.|||..|      .| |
CGTPDYIAPEVIL----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

RNGLSDFQLHPFF
 ||  .   ||||
ANGADEIKQHPFF
Kinase K08B12.5.AA MAST 244-351 37 9.8e-28 86.22 In-house 225-334 (334) Show / Hide 
Range on Protein: 244-351
Range on HMM: 225-334/334
Sequence Identity: 37% (43 aa)

VGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQ-DMLDFPDD---EIDWVVSEEAKDLIRQLICS-SDVRFG
.||||||.||..     |.| .||  ||||.||.||| | |..||  .    ....| ..      .|..   . |.  |.||.|||..|      .| |
CGTPDYIAPEVIL----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

RN-GLSDFQLHPFF
 | |  . . ||||
ANNGADEVKQHPFF
Kinase K08B12.5.AA S_TK_X 352-416 28 6.8e-16 60.05 SMART 1-79 (79) Show / Hide 
Range on Protein: 352-416
Range on HMM: 1-79/79
Sequence Identity: 28% (23 aa)

EGIDWNTIR----DSNPPYVPEVS----SPEDTSNFD-VDVCEDDFTPCETQPPRVLAAFTGNH--------LPFVGFSYTH
 ||||....       ||..|...    ||.||||||     |..    .| ....| .  ..         .|| ||.| .
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM---LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase K08B12.5.AA Pkinase_C 369-418 36 3.4e-10 39.15 Pfam 1-46 (46) Show / Hide 
Range on Protein: 369-418
Range on HMM: 1-46/46
Sequence Identity: 36% (19 aa)

EVSSPEDTSNFD-VDVCEDDF-TPCETQPPRVLAAFTGNHLPFVGFSYTHGS
.|.||.||||||  . .|..  ||     |     . |...||.||.|.. .
QVKSPTDTSNFDPEFTDEPPMDTP-----PDWR-MSSGDQEPFRGFTYVNPD
Kinase K08B12.5.AA TyrKc 83-342 18 1.4e-09 -67.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 83-342
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYG--DRRWITNLHYAFQDE-------KNLYFVMDYYIGGDMLTLLS
 . .|..| ||||||   ...   .  | | |..         . |..|  ..     .   | .|. .  ..       . |. || |  .|| .  | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILAD---GSVASNVAV-----GTPD-----YISPEILRAMED
|  .... .    .        . ||. ...|||    |.|.. ..... .||| .  |  |   | ... . .     |. .       .|| .     
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECI-----

GRGRYGKECDWWSLGICMYEML-YGTTPFYS-----ERLVDTYGKIMSHQDMLDFPDDEIDWV----VSEEAKDLIRQLICS--------SDVRFGRNGL
  |..  . | || |.||.|.. || .| .          . . ....   |   |.|.   .     ..|  ....|            |..   .  .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
TMF_DNA_bd K08B12.5.AA TMF_DNA_bd 524-556 26 1.027802 5.58 Pfam 100-133 (75) Show / Hide 
Range on Protein: 524-556
Range on HMM: 100-133/75
Sequence Identity: 26% (9 aa)

VAESEKKLKELK-ERNKQLVMEKSEIQRELDNIN
..|.||...||| ..  .|..| .. ...|.. .
NKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd K08B12.5.AA TMF_DNA_bd 593-619 28 5.738966 2.91 Pfam 48-75 (75) Show / Hide 
Range on Protein: 593-619
Range on HMM: 48-75/75
Sequence Identity: 28% (8 aa)

SVKRLQ-DEAEKAKKQVADFEEKLKEIE
....|. .. ||. |.... |..||. |
QISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd K08B12.5.AA TMF_DNA_bd 646-697 30 0.119527 8.92 Pfam 24-75 (75) Show / Hide 
Range on Protein: 646-697
Range on HMM: 24-75/75
Sequence Identity: 30% (16 aa)

LSEEVVAAKNTIASLQATNEERETEIKKLK-QRMDEERASHTAQSEQEMKQLE
||    .  ||| .|...|.| |..|..|| .....  ... .. ||..|. |
LSKQELKHNNTIKKLRKKNKELEKQISELKHKKIEKLEKEI-ENLEQRLKRAE
DMPK_coil K08B12.5.AA DMPK_coil 664-684 42 5.113639 2.63 Pfam 41-61 (61) Show / Hide 
Range on Protein: 664-684
Range on HMM: 41-61/61
Sequence Identity: 42% (9 aa)

NEERETEIKKLKQRMDEERAS
| | | |...|| .| . || 
NRELEQEMEQLKKEMEMLRAR
DMPK_coil K08B12.5.AA DMPK_coil 810-861 32 0.001167 15.11 Pfam 1-52 (61) Show / Hide 
Range on Protein: 810-861
Range on HMM: 1-52/61
Sequence Identity: 32% (17 aa)

DLQRQLQAEIDAKLKLKAELKNSQEQYLTSAARLDDTEKRMASLMREVAMLK
.||  | ||| ||  .. ||.  ..  .    .| ..||.   |  |...||
ELQSALEAEIRAKQSIHEELNKVKAANIQFECKLQEAEKKNRELEQEMEQLK
C1 K08B12.5.AA C1 956-1005 29 5.4e-17 63.69 SMART 1-61 (61) Show / Hide 
Range on Protein: 956-1005
Range on HMM: 1-61/61
Sequence Identity: 29% (18 aa)

HNFERMKIKTPTKCGHCTSILIGLDRQ-----GLFCQSCQYACHVSCAERVSQ-------SC
|.... .. .||.| || . ..|...|     |..|. |.|.|| .|...|.|       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 K08B12.5.AA C1_1 956-1008 36 1.5e-14 57.12 Pfam 1-55 (55) Show / Hide 
Range on Protein: 956-1008
Range on HMM: 1-55/55
Sequence Identity: 36% (20 aa)

HNFERM-KIKTPTKCGHCTSILIG-LDRQGLFCQSCQYACHVSCAERVSQSCPVP
|....    | ||.| || ... | | .||. || |.| ||  |...|.  |.  
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
CNH K08B12.5.AA CNH 1138-1450 27 1e-123 418.22 SMART 1-375 (375) Show / Hide 
Range on Protein: 1138-1450
Range on HMM: 1-375/375
Sequence Identity: 27% (105 aa)

RVAQCCAIIDRS----KIVIGFSDHGLYCIEISRQLLIP--VGGEKENKQRCVETVEYDEAEQLLMMIVG----PAKDRHVRI----------------V
.....|..|...    |.......||.||..|..|....  ...|.....|||......|....||||.|    ......|..                .
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

PSAALDGRDLKW-IKVNDTKG-CHLLAVGTNNPGGRAGFFAVAFKKSVTIF-QIDRSEKRHKKWKD--------LAMPGTPQSIAIFNGRLYVGFSHSFR
....|..|...| .|..|||| ||...|..|.......|...|...||.|. |..........||.        ..|........||.....|.|.|...
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

--SWSLVGVDSSPVGSGDASGAVLQHI------------SLVNMEDTSLQFLNQQTSY-----EAKLIVNVPGSP----DEYLLVFNMIGLYVNEMG---
  .|...|.|. ||| |.......||.            |.|||.|.||.|.|||||.     ... ...|..|.    |.|||.....|..||..|   
ERPWICIGCDK-PVG-GMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEW

RRSRLPEVMFPTQAKYFAYHEPYLCVFSENEVDIFNVTLAEW-VQTINLRSAKPLSGDGILSTCLCNDSPIFVLLQN
||.| |.........|||||.||...|..|...|.... .|| .|.|. |..........|.||.|.|..||...|.
RRWRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH K08B12.5.AA CNH 1142-1432 19 7.6e-44 156.78 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1142-1432
Range on HMM: 1-336/336
Sequence Identity: 19% (70 aa)

CCAIIDRSKIVIGFSDHGLYCIEI--SRQLLIPVGGEKENKQRCVETVEYDEAEQLLMMIVGPAK-D--RHVRIVPSAALDGRDLKW-I-----------
.|..... .. .|  | ||| ..|  .|. . ... ..  ..  |  ..  |....|.||.   . |  .|..  |  .||.....| .           
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSR-RVTQIYVIEEFNILIMIS---GCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHR

-------------KVNDTKGCHLLAVGTNNPGGRAGFFAVAFKK-----SVTIFQIDRSEKRH-------------KKWKD-LAMP----GTPQSIAIF-
             |. |||.||. .. ..|.  .  . ..| |.     .. ......  |..             .| .. .. |     ...|.... 
IERIMPRKFAMWQKLPDTKHCHFFCW-IRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLP

--NGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTS--LQFLNQQTSYEAKLIVNVP-GSPDEYLLVFNMIGLYVNEMGR-RSR--L
    .| ||... |   .| |                |. .|....|.|  ..| ..  . ..  .. .. .   |.||... .. |||  |. |||   
QEKPKLCVGCQKGFHIVNLDGT--------------GQPWWLHDPADHSVQQDFMARRENCKPICMHRINDD-E-EFLLCYDECCVYVNKQGWPRSRKHD

PEVMFPTQAKYFAYHEPYLCVFSENEVDIFNVTLA-EW---VQTINLRSAKPLSGDG
 |.|..  ...||...||| .|..| ..|..|    ||   ||.|.......|  ..
WEIMWEGMPQSFACCYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
PBD K08B12.5.AA PBD 1500-1538 31 2.1e-10 41.8 SMART 1-38 (38) Show / Hide 
Range on Protein: 1500-1538
Range on HMM: 1-38/38
Sequence Identity: 31% (13 aa)

ISTPS-DFMHIVHMG-PAPVMELQQNFIDLQSNHSHTSSDK
||||. .|.||||.| . .    ...| .|.....|  . .
ISTPTGNFKHIVHVGPWDG---QTGEFTGLPHQWQHLLKHC