Gene K12C11.4 (Nematode worm)

K12C11.4

Species: Nematode worm
Alias: K12C11.4, aSWK050, CE18058
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 1305583-1328152, WormBase Genetic Map location: I:-17.27,

Classification

Group: CAMK
Family: DAPK
Subfamily: DAPK

Sequence

Name Sequence Type Origin Length Description Download
K12C11.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
K12C11.4.AA Protein Genbank 1435 None Fasta, JSON

Protein domain

Protein domains of K12C11.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase K12C11.4.AA DAPK 73-332 62 3e-253 738.95 In-house 1-264 (264) Show / Hide 
Range on Protein: 73-332
Range on HMM: 1-264/264
Sequence Identity: 62% (165 aa)

RKQRQRIG--QFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCAKECL
......||  |||||...|...||..|||||||||||..|||||.|..|||||..|..|||..|...||.|||...||...|||||||||||..|.||||
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECL

DEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQ--IKIIDFGLSREIEPGAVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVVTYILL
.|.||..||||||..|.|.||.||.|.|.||||.||..|....  ||||||||...||||...|...|||||||||.||||.|...||||..||.|||||
NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILL

SGGSPFLGDNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWI
||.||||||...||..|||.|.|||...||||||.||||||.||.|.|...|.|..||||||||
SGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase K12C11.4.AA DAPK 75-332 60 6.4e-237 660.49 In-house 1-264 (264) Show / Hide 
Range on Protein: 75-332
Range on HMM: 1-264/264
Sequence Identity: 60% (159 aa)

QRQRIG--QFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCA--KECL
.....|  ||||||..|...||..||||||||||...|||||.|..||.|...|...||..||..||.||||..|||..||.||||||||..|.  .|||
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

DEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQ--IKIIDFGLSREIEPGAVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVVTYILL
.|..|..|.|||| .|..|||..|.|||.||.|.||..|...|  ||||||||||.|..|....|..||||.||||.||||.||.|||||..||.|||.|
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML

SGGSPFLGDNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWI
||.||||||...|||.||..|.|.||..||..||.||||||.||.|.|...|.|.|||||||||
SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase K12C11.4.AA MLCK 80-332 45 7.89999999999e-135 357.74 In-house 10-257 (257) Show / Hide 
Range on Protein: 80-332
Range on HMM: 10-257/257
Sequence Identity: 45% (116 aa)

GQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCAKE-CLDEVEAAAF
| | .|.|.....|| ..||||||       |... ..|...|. .. . .   |.. .|. .|| .... ..|..||||||. . . .  | | | . .
GKFGIVHRCIEKSTGKTWAAKFIKC------RKPKDKENVKNEIEIMNQLHHP-NLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVIHY

IKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQIKIIDFGLSREIEPGAV-VKDMVGTPEFVAPEVVNYEALSPATDMWAVGVVTYILLSGGSPFLGD
..||. .|.|.|. .|||||.||||.|.  |  .||||||||| |...|.   || | |||||||||||||. ....||||.|||..|.|||| |||.||
MRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFMGD

NRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWI
|  ||..|.| ... | |  |.. |  ||||| ||.|.| . | |..|||||||.
NDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase K12C11.4.AA CAMK 78-332 25 1.3e-117 380.73 In-house 1-425 (425) Show / Hide 
Range on Protein: 78-332
Range on HMM: 1-425/425
Sequence Identity: 25% (107 aa)

RIGQ--FAVVRRVRDRKTG------------EKYAAKFIKKRRYATS----------------------RRGVTRQNIEREVRVLQKIRG------NSNV
 .|.  |..|.......|.            .|.|.|.|.|..   .                      ||...|.|..||.....|..|        |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VELHAVYE------------TASD--------VIIVL---ELVSGGEL----FDHVCAKEC---------------LDEVEAAAFIKQILLAVRHLHSLH
. |. |||            | |.        ...|.   |..|||||    ||......|               ..| ||. ...||. ||...||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHLDIKPENVMLKQRGD---------------SQIKIIDFGLSREIEP------------------------GAVVKDMVGTPEFVA-PEVVNY-----
|||.|.||||..| ...|                .|||||||......|                        |   |...||||..| |||.|.     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EALSPATDMWAVGVVTYILLSGGSPFLGD-------------NRDETFSNITRVRYHFSDRYFKNTS--------------------KHAK
         .  .|..|||..||..||.|.| .|| ||             |  |.| .|.. .|.| . ||...|                    . .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFIYRLFVRDVDQRATVEECLQHPWI
|.| .. ..| ..|.|.|.||.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase K12C11.4.AA DRAK 72-332 43 2.4e-116 363.23 In-house 1-259 (259) Show / Hide 
Range on Protein: 72-332
Range on HMM: 1-259/259
Sequence Identity: 43% (116 aa)

ARKQRQRIGQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFD--HVCAKEC
. |.| | |.|||||.   . ||. .||||.|||| . .     |..| .|..||   ... .|. ||.||||.|..| |||. .|||.|.       ||
TAKERGR-GKFAVVRKCIHKNTGQHFAAKFMKKRRRGQD----CRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEEC

LDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLK-QRGDSQIKIIDFGLSREIEPGAVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVVTYILL
. | ..   ..||| .|. ||.  ||||| || |..|   .  . |||.|||.|| |. |  | .. |||..||||. ||. .. ||||| .||.||..|
FCEKDVQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVML

SGGSPFLGDNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWI
.. |||.|| . ||| ||  .   .|.  |   |. | ||| .| | . ..|.| ||||.|||.
THISPFVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase K12C11.4.AA Trio 70-332 37 1.1e-105 271.83 In-house 1-258 (258) Show / Hide 
Range on Protein: 70-332
Range on HMM: 1-258/258
Sequence Identity: 37% (101 aa)

FIARKQRQRIGQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCAKEC
.    . .| | |.||||.. . ||   |||||       . |  ..    .| ..||  .    |. ||. |||    |..||| ..||| . .  .. 
YTFQEEIGR-GRFSVVRRCWHKATGRTCAAKFI-------PYRMMDKEQVYHEYEMLQHLQHP-CVCSLHDTYETPRHYILILELCDDGELLCCLMRWGS

LDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGD--SQIKIIDFGLSREIEPG--AVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVVTY
. | | .... |.| ||. ||. || ||||||||.|. ..     ||||.|||   .. |.         |.|||.|||... .  |..|| |..||.||
YCESEVKTYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTY

ILLSGGSPFLGDNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWI
..||| |||....  ||  || |... |.. ||...|  ||.||  . ..|   | . .||||||| 
VMLSGISPFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase K12C11.4.AA CAMK1 82-332 37 6.9e-102 296.97 In-house 12-276 (276) Show / Hide 
Range on Protein: 82-332
Range on HMM: 12-276/276
Sequence Identity: 37% (100 aa)

FAVVRRVRDRKT---GEKYAAKFIK-KRRYATSRRGVTRQNIEREVRVLQKI--RGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCAKECLDEVEA
|..|... ...|   |..|| | |. |.  .....   ....|.|. ...|       |.. .. .||. ... .|.|||.|||||| .  |..  | .|
FSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQK-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYTEKDA

AAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQR-GDSQIK--IIDFGLSREIEPGA-VVKDMVGTPEFVAPEVVNY---EALSPATDMWAVGVVTYILL
.  .|||| || ..||. ||| |.||||  ..    ||.||  |.|||||. ....  . |...|||..|||||...   .. . | ||| .||.|||||
RHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILL

SGGSPFLGDN-RDETFSNITRVRYHFSDRYFKNTSKH-AKDFIYRLFVRDVDQRATVEECLQHPWI
 | .|| ..|  .| |. |..  | |   .. | |.. |||||  . . |  .| |.|.||.||||
CGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase K12C11.4.AA S_TKc 74-332 29 9.5e-89 302.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 74-332
Range on HMM: 1-231/231
Sequence Identity: 29% (83 aa)

KQRQRI---GQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSG--GELFDHVCAKE
 .  |.   | |..|...|..|||...| | ||             ..|.||...|.|  .  |.| |. |... ... .|.|...|  |.|||. . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

C------LDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQIKIIDFGLSREIEPGAVVKDMVGTPEFVAPEVVNYEALSP-ATDMWAVG
.      ..| .|. ...||..|. ..||..|.| |.||||..| .    .|||.||||.|..      . ..|||...||||.     .. . |.|..|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VVTYILLSGGSPFLGDNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQ-------HPWI
.. |..|.|  ||   . ...| .|               |. ||||| .....| ..| |. |.||       |||.
CILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase K12C11.4.AA CAMKL 80-332 28 6.3e-83 264.46 In-house 10-297 (297) Show / Hide 
Range on Protein: 80-332
Range on HMM: 10-297/297
Sequence Identity: 28% (84 aa)

GQFAVVRRVRD-RKTGEKYAAKFIKKRRYATSRRGVTRQN-----------IEREVRVLQKIR--GNSNVVELHAVY-------ETASDVIIVLELVSGG
| |..|.  .. | ||||.| |.|.|..  .. . ....|           |.||.. .....  .  |.. |. |.       || ... .|.|..|||
GSFGKVKLATHIRTTGEKVAIKIIDKKK--IWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGG

E--LFDHVCAKEC----LDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQIKIIDFGLSREIEP-----GAVVKDMVGTPEFVAPEVVN
|  |||.......    ..| ||  . .||. || ..||..||| ||||||..| ..|...|||||||.| ...|     |   |   |.|.. |||...
EMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQ

Y--E-ALSPATDMWAVGVVTYILLSGGSPFLGDNR------DETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWI
   .    |..|.|. ||. | .. |  || .|.       .         .  . .. ..  |  ..|.| .. ... ..|.|... ..||| 
GNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase K12C11.4.AA Pkinase 80-332 28 2.7e-78 271.21 Pfam 10-293 (293) Show / Hide 
Range on Protein: 80-332
Range on HMM: 10-293/293
Sequence Identity: 28% (82 aa)

GQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGG----ELFDHVC--AKECL--D
| |..|.. ....||...| | ||||  . |   .|. .. .|....... .  |.|.|. ..|. ... .|.|.. ||    .|||..   .. |.  .
GSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

EVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDS--QIKIIDFGLSRE--IEPGAVVKDMVGTPEFVAPEVVN-YEALSPATDMWAVGVVTYI
| |.  ...||| .. ..||  |.| |.||||......|.    .||.||||..   . ..   .. .|||...||||.. ..  .|. |||..|.. |.
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYE

LLSGGSPFLGD------NRDETFSNITRVRYHFSDRYFKNTS-----------------KHAKDFIYRLFVRDVDQRATVEECLQHPWI
.|.|  || |.      . .. . .| . ..||.  .  . |                 . .||||.... .|  .| | |..|||||.
MLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase K12C11.4.AA RSK 80-332 28 1.3e-75 257.53 In-house 10-278 (278) Show / Hide 
Range on Protein: 80-332
Range on HMM: 10-278/278
Sequence Identity: 28% (78 aa)

GQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCAKEC---LDEVEAA
| . ..|......||  || | .||.  ... . . .    .|...|. ...  ..|.|| ...| . . ...|...|||||.| . ...   ..| ||.
GKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTM--TERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEAC

AFIKQILLAVRHLHSLHIVHLDIKPENVMLKQ-RGD-SQIKIIDFGLSRE--IEPGAVVKDMVGTPEFVAPEVVN----YEALSPATDMWAVGVVTYILL
. . .| |||.|||...|.| |.||||... . . .   ||..|||....  .. .   .  ..| |..|||...     .. . | | |  ||. | .|
FYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEML

SGGSPFLG---DNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRAT-----VEECLQHPWI
.| .|| |   .||.|.. .| . .. ..    .. |. |||.| ... ||  .| .     .|| .||||.
TGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase K12C11.4.AA MSK 80-332 28 1.9e-71 240.79 In-house 10-277 (277) Show / Hide 
Range on Protein: 80-332
Range on HMM: 10-277/277
Sequence Identity: 28% (77 aa)

GQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCAKECLDEVEAAAFI
| | ..|......||  ||.| ..| .  ..|.  |  .  .|...|. .... |.|.|| .. . .   .|.|...||||| | . .|  || |..  .
GKFFICRKCVHHDTGKLYAMKILSKATVVQKRK--TAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESECRMIM

KQILLAVRHLHSLHIVHLDIKPENVMLKQRGD-SQIKIIDFGLSREIEPGAVVKDMV--GTPEFVAPEVVN----YEA-LSPATDMWAVGVVTYILLSGG
 .. .||.|.|...|.| |.||||...  . |  ..|.||||..|.  ..   ..    .| .. |||...     .   ..| |.| .||..| .|.| 
RELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQ

SPFL--GDNRD---ETFSNITR--VRYHFSDR--YFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWI
.||   .| |.   .. . | .   .  || .    .| |. |||.| .|  .|   | .... ..| |.
VPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase K12C11.4.AA TyrKc 71-332 21 6.9e-13 -14.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-332
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

IARKQRQRIGQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKI-RGNSNVVELHAVYETA-------SDVIIVLELVSGGELFD
|  ..    |.| .|.. . .   .. | | .|.           |. . || |.. |.   . |.| |..|  .          . ||.|....| | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HVCAKEC-LDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQIKIIDFGLSREIEPG-------AVVKDMV--GTPEFV-----APEVVN
.  ...  |   .   |  ||    ..||| ...| |.   |.... ..  ..|| ||||||.|. .        . . .   |.   .     |||. |
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

YEALSPATDMWAVGVVTY-ILLSGGSPFLGDNRDETFSNITRVRYHFSDRYFKNTSKH--------AKDFIYRL----FVRDVDQRATVEECLQHPWI
|   ....| |. ||. . |.  |..|  |.     . . ..|. .  ..|     ..        . | .|..      .| ..| | .|.  |  .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase K12C11.4.AA Pkinase_Tyr 116-225 25 0.000937 13.34 Pfam 47-161 (270) Show / Hide 
Range on Protein: 116-225
Range on HMM: 47-161/270
Sequence Identity: 25% (30 aa)

RQNIEREVRVLQKIRGNSNVVELHAVYE-TASD--VIIVLELVSGGELFDHVCA----KECLDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQ
|.   ||.... ..  . |.| |..|         ..||.|.. .| | |.  .    |. |.  .   .  ||  .  .|.| ...| |.   |.... 
REDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE

RGDSQIKIIDFGLSREI
  . ..|| ||||.| |
--NNVVKICDFGLARDI
Ank K12C11.4.AA Ank 633-665 39 1.6e-08 34.95 Pfam 1-33 (33) Show / Hide 
Range on Protein: 633-665
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

NKKTALHLAAHYGHVDIIRVLLLARADVTLRGD
.  |.||||...||..... || . ||| .. |
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank K12C11.4.AA Ank 567-599 33 5.7e-08 33.01 Pfam 1-33 (33) Show / Hide 
Range on Protein: 567-599
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

DGKTALIIALENGNVDIASILITNGCDINHADH
|| |.| .| ..|...... |. .|.|.|. | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank K12C11.4.AA Ank 435-467 36 2.1e-07 30.95 Pfam 1-33 (33) Show / Hide 
Range on Protein: 435-467
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

NGATAMHCAAKYGHAEVFNYFHMKGGNICARDD
.| |. |.|...||.||  ..  .| ...|.||
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank K12C11.4.AA Ank 534-566 33 2.7e-07 30.59 Pfam 1-33 (33) Show / Hide 
Range on Protein: 534-566
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

REETPLHVAAARGHVDCVQALLDANSPIDAVEQ
  .||||.|. .||...|. ||...  ..|.  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank K12C11.4.AA Ank 501-533 33 7e-06 25.52 Pfam 1-33 (33) Show / Hide 
Range on Protein: 501-533
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

TGETALHCAVESADTRVVRLLLQLRPRLDLPNA
 |.|.||.|... .|.||..|||    ... . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank K12C11.4.AA Ank 600-632 27 5.8e-05 22.15 Pfam 1-33 (33) Show / Hide 
Range on Protein: 600-632
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

HGDTALHIASKHGLLQAVQTLCHCAVTVDSVNA
.|.|.||.|...| .. |. |  .   |. .. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank K12C11.4.AA Ank 468-500 33 0.007904 14.46 Pfam 1-33 (33) Show / Hide 
Range on Protein: 468-500
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

NGDTPLHVACRFAQHTVAGYVANEKIDVDSINK
.|.||||.|||  .. |. .  .   ||.  ..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
ROC K12C11.4.AA ROC 709-952 17 9.2e-19 59.9 In-house 1-215 (215) Show / Hide 
Range on Protein: 709-952
Range on HMM: 1-215/215
Sequence Identity: 17% (48 aa)

LRRIKLKLLGHSQSGKTRLVQTLHSSRGISSFLESVTRRISDHYSPSSSMKDDGIHSTNGSFVSESNNNSSFDLAAAAGSKYAPPHSQYTRGID-VQTVN
....|| |.|.  .||| |...| .             . ....|..|                                  . .. . | ||. .|.. 
CNEMKLMLCGQGGVGKTSLCKQLMH-------------DKFSDCSCYSC---------------------------------DKGNHPTTHGIEPIQQWV

INGC----------GEFSVWEFGGYEPMHTCYDHFVGNADCIHLILYRTSD---PTEVQ----YKQ--ILYWMNFLKGRVTP-----FEPIGHCGFSSRR
...           . |.||.||| | .| ....|  |  ...|. .  ..   . . .      .  . ||..|.| |.       . |          
LDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQP----------

SKVIIVGTHATSSLFPQMNQEGEYVSSDIEAMLNTVRLRFETHF------DMDHRLILLDATNPSCIGMKTLKME
|.|||||||.  .   . .    |...... |   .| .|.  .         .  .  |..   | |.. |.. 
SPVIIVGTHWDKVPRQDNKV---YQHKQCCRMWQKLRNKFPNICHSWMQIEHYQGFFHVDCETG-CKGIDKLRHH
COR K12C11.4.AA COR 953-1099 14 3.5e-11 32.19 In-house 1-185 (434) Show / Hide 
Range on Protein: 953-1099
Range on HMM: 1-185/434
Sequence Identity: 14% (27 aa)

LAKCRTNILAK------LLKPLAILDTVVNHLNLVRKKHA------NFPVITWPDFIQLVRNEINP--------LTGDAHCRQIVQQLQLIGELVYLR--
..|....|. |      . .|..     ..  . ......      ..|...| .|.|..... .|        .. ..  ......|.  |....    
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCK--QKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIW

-NDLCDADYVVLNAEWFGTHILGQLLSAEFLSKA---SPNGS-YHTSSLAKIFPE--------------IPEQSDLMTILEVLQLCAP
 .|    |.|||. .|| . ......... . .     ..|  .... |.||...                .. .|  ..| ..|| |
DHDPMLKDFVVLDPQWFCQ-MMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYP
COR K12C11.4.AA COR 1154-1310 13 0.193913 0.05 In-house 253-434 (434) Show / Hide 
Range on Protein: 1154-1310
Range on HMM: 253-434/434
Sequence Identity: 13% (26 aa)

FPRIQVALRRSINDYQ-----PAKDTQLHQWSECSKLVSQDR---EAVIRMV--GDAVEIRARGPSES----ATSMFYFMEDLINLVEHAAAEV--GPGI
.|| ||.| . | |..      .  ..  .|    .|. ..    ||.. ..  . .  |. ||. .     .. ... ....|   .|  ..   .|| 
WPRFQVRLHHFIHDMFKCFYERSC-CEWMYWRNGMVLKWEGHNKNEALVKCDNHDNKIYITVRGCQDCWIDMCCQLWQIIRQHI---QHIHNSWWPWPGL

S-------LERHFISPKHLKEHRE-HPA--LFPPESMMEMQQRESLSVKGTQDE--EELFTDVVCFGSRDVARHLTLGIDV-GVAD
        .. ....| ....| .  .    .  .. .. .... .|.. .  .  .. | .  |..  ..  |  .| ..  . |
QYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
Death K12C11.4.AA Death 1317-1399 30 1.8e-20 71.0 Pfam 1-87 (87) Show / Hide 
Range on Protein: 1317-1399
Range on HMM: 1-87/87
Sequence Identity: 30% (27 aa)

CELACLLDPPHAMGRDWSILAVKLQL-TDQVPDVDSTGQSL----SRTDQLLNEWAIHHPEQASVGNLCRILVELGRCDARDALYRTV
..|  ||||.| .|.||  || || .  ...  . .. |.     |.| |.|. | ..| ..|.|..|...| ..||.|..... . .
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL