Gene kin-13 (Nematode worm)

kin-13

Species: Nematode worm
Alias: kin-13, PKC1, F57F5.5, KPC2_CAEEL, CE29092, aSWK016
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 12026758-12017706, WormBase Genetic Map location: n/a,

Classification

Group: AGC
Family: PKC
Subfamily: PKCh

Sequence

Name Sequence Type Origin Length Description Download
kin-13.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
kin-13.AA Protein Genbank 707 None Fasta, JSON

Protein domain

Protein domains of kin-13.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD kin-13.AA C2_PKD 4-166 29 1.3e-32 111.43 In-house 1-183 (183) Show / Hide 
Range on Protein: 4-166
Range on HMM: 1-183/183
Sequence Identity: 29% (55 aa)

TGTVRVRVLEARQLRPTEWSRR----FRQDEAATAAIDSYVNVDWDEYH----IGKTQVRPKTNEPRWNEEFTASGVHQGKAIGFSVFHSCVMPPDDFVA
.|  |||...|  |.|.   ..    | .  |   ||| |. |. || |    ||.| ...||  | ||..| .  |  |  | . ..|   |||...||
MGFCRVRLCRADGLKPKMFQHWHNLTFGK-PADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHH-VYEGRHIQIVCMHNAIMPPNKMVA

NTRIAFDQLKI-----GSANDIWVDLEPHGQLHVVVEMHGTNVEDVHSH--NKTR----VFKERTNAFNDRQ-RRG-AMR-RKIH
.. . .. .       ..  .||..|||.|..|| ..    .... | .   ..     . ||. ...  .. ||| ||| .|||
ECTMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C2 kin-13.AA C2 7-98 28 8.8e-16 56.29 Pfam 1-90 (90) Show / Hide 
Range on Protein: 7-98
Range on HMM: 1-90/90
Sequence Identity: 28% (28 aa)

VRVRVLEARQLRPTEWSRRFRQDEAATAAIDSYVNVDWDEYHI----GKTQVRPKTNEPRWNEEFTAS-GVHQGKA-IGFSVFHSCVMPPDDFVANTR
.||.|.|||.|.|. |         ..  .| || |  .  ..     || | ..|  |.|||.|| .  ....   . |.|.... .  |||.  ..
LRVHVIEARNLPPMDW--------DKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC
C2 kin-13.AA C2 6-113 20 1.4e-15 59.0 SMART 1-92 (92) Show / Hide 
Range on Protein: 6-113
Range on HMM: 1-92/92
Sequence Identity: 20% (26 aa)

TVRVRVLEARQLRPTEWSRRFRQDEAATAAIDSYVNVDWDEYHIGKTQVRPKTN---EPRWNE---EFTASGVHQGKAIGFSVFHSCVMPPDDFVANTRI
|..|...|||.|.                  | || |        || | ..|.    |.|||   .|. . ..  . . |.|...      ||.  ..|
TLTVHIIEARNLP------------------DPYVKVY-------KTKVVKNTLSGFNPVWNEWMETFYFDVHP--Q-LRFEVWDH------DFIGHCCI

A--------------FDQLKIGSANDIW
               ..... |     |
PPNNPHWHQWDGCIHLSDIL-GYRH-WW
C1_1 kin-13.AA C1_1 171-223 45 2.8e-22 85.14 Pfam 1-55 (55) Show / Hide 
Range on Protein: 171-223
Range on HMM: 1-55/55
Sequence Identity: 45% (25 aa)

HKFMAL-FLRQPTFCAHCKEFIWG-IGKQGYQCQICTVVVHKRCHEDVVWKCPGN
|....  ...|||||.||.||.|| .|.||..|| | ...|.|||. |...|..|
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 kin-13.AA C1 171-220 35 2.2e-15 58.34 SMART 1-61 (61) Show / Hide 
Range on Protein: 171-220
Range on HMM: 1-61/61
Sequence Identity: 35% (22 aa)

HKFMALFLRQPTFCAHCKEFIWGIGKQ-----GYQCQICTVVVHKRCHEDVV-------WKC
|....    .||.|.||...|||. ||     ||.|. | ...||.||. |        | |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 kin-13.AA C1_3 194-213 28 0.076336 6.19 Pfam 10-30 (30) Show / Hide 
Range on Protein: 194-213
Range on HMM: 10-30/30
Sequence Identity: 28% (6 aa)

IGK-QGYQCQICTVVVHKRCH
|.   .| | .|  ..|..| 
IYRDPFYHCMQCDFMLHEDCA
C1_1 kin-13.AA C1_1 249-301 43 7.9e-25 93.6 Pfam 1-55 (55) Show / Hide 
Range on Protein: 249-301
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HRFSVH-SYKRPTFCDHCGSMLYG-LINQGLQCSTCKLNVHKRCQRNVANNCGIN
|.. .| ..|.||||.|||....| |. ||..|..|..|.|.||...|...|| |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 kin-13.AA C1 249-298 30 4.1e-19 70.74 SMART 1-61 (61) Show / Hide 
Range on Protein: 249-298
Range on HMM: 1-61/61
Sequence Identity: 30% (19 aa)

HRFSVHSYKRPTFCDHCGSMLYGLINQ-----GLQCSTCKLNVHKRCQRNVAN-------NC
|... ... .||.|.||..|..|.  |     |..|| ||...||.|...|..       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 kin-13.AA C1_3 260-291 25 0.00051 11.72 Pfam 1-30 (30) Show / Hide 
Range on Protein: 260-291
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCDHCGSMLYGLINQGLQCSTCKLNVHKRCQ
 .|. ||  .|.  . .  |..|  ..|..| 
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
Kinase kin-13.AA PKC 378-638 73 3.7e-219 717.29 In-house 1-262 (262) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-262/262
Sequence Identity: 73% (193 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDES
|.|.|||||||||||||||||||||.||||.||||||.|||||||||.|||.|.||.||||||.||..||| |||||||||||||||||.||..|.|.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPF
.|||||||..|||||||....|||||||||.|||.|||...||||||||...... |||||||||||||||||..||| ||||||.|||||||||||.||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

EADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQ-GGEDAIRAHPFF
....||.||..|..|...||.|||||||.|.|.||||| .|||||  .| .||..||.||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase kin-13.AA Eta 378-638 85 7.1e-216 723.46 In-house 1-261 (261) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-261/261
Sequence Identity: 85% (224 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDES
|.|.||||||||||||||||||||||||||.||||||.|||||||||.||||||||.||||||.||..|||.|||||||||||||||||||||||||||.
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPF
|||||||||||||.|||...||||||||||||||.||||.|||||||||||.....|.||||||||||||||||||||.||||||.||||||||.|||||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

EADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFF
||||||||||.||.|||||||||.||||.|||||||||. |||||...||||.|||.||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase kin-13.AA AGC 378-638 34 4.5e-195 510.14 In-house 1-395 (395) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-395/395
Sequence Identity: 34% (139 aa)

FTFMKVLGKGSFGKVMLAERK------GTDEVYAIKILKKDV-IVQDD--DVECTMCE------------KRILSLAAK---------HPFLTA-LHSSF
| | ||.||||||||.|...|      .|...||.|.|||.. ||...  .||.|| |            ..||... .         |||..  ||.||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTSDR--LFFVME----YVN-----GG-DLMFQIQ---RARKFDESRARFYAAE-------VTCALQFLHR-NDVIYRD-LKLDNILLDAEGHCRLADFG
|. |.  |.||||    |||     || .|....|   . ..|||.||||||||       ...||..||. ...|.|| ||..|||||..||..|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGINKD--------------------------------------------------NLTSTFCG--TPDYIAPEILQEMEYGVSVDWWA--LGVLMY
.||||.|..                                                  ..|.||||  ||.|.|||||    || ..|||.  ||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMAGQPPFEADN----------EDDLFEAIL------NDDVLYP----------VWLSKEAVNILKAFMTKNAGKRLGCVVSQG---GEDAIRAHPFF
||..|.||| .||          ....|. |.      |..| .|          .|.|.||....| ...|.  |||||  . .   | . |..||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase kin-13.AA Alpha 378-638 67 1.3e-174 586.43 In-house 1-259 (259) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-259/259
Sequence Identity: 67% (177 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDES
| |..|||||||||||||||||||| |||||||||||.||||||||| |||.| |  | |||...|| ||| |||.||||||||||||..||.  || |.
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPF
 | |||||.  .| |||. ..|||||||||..|||||| ..||||||||... |. | |||||||||||||     || |||||| |||.||||||||||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

EADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFF
. . ||.||.|| .  | ||  .|||||.| |.|.||. .|||||  .  ||  ||.||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPD--GEQDIREHPFF
Kinase kin-13.AA Delta 378-638 60 2.3e-147 495.84 In-house 1-259 (259) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-259/259
Sequence Identity: 60% (158 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDES
|.| ||||||||||||||| ||... |||| |||||...|||||||| |.|.|.||..||||. |  .||| . |||||||.||||||. ||  ..|||.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPF
||||||.|. |.|||||....|||||||||.||| .|| ..|||||||| ..... .||||||||||||||..   |  |||||. |||||||. || ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

EADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFF
. ..||.||..|.||   ||.|..||| ..||. . ..  ||||   .  |.  ||.|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGD--IRQHCFF
Kinase kin-13.AA Akt 378-638 48 3.4e-139 447.65 In-house 1-264 (264) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-264/264
Sequence Identity: 48% (130 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVY-AIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDE
|.| |||||||||||.|.. | |...| |.|.||||.|.| . || |. |..||     |||.. || ||||.|.|.|||.|.|||.| . .||.|.|.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

SRARFYAAEVTCALQFLHRNDVIYRD-LKLDNILLDAEGHCRLADFGMCKEG-INKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWA-LGVLMYEMMAG
.|||||.||. .|...|| ...|||| ||. |||.|..|| .|.|||.|||. |  .  | |||||| |.|||||.   .. .||||. ||..||||| |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QPPFEADNEDDLFEAILNDDVLYP--VWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFF
.||| ... . .|. |.| .| .|   |.|.|. ....   .|.  ||||     .. . |..||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGG--GPNDAQEIKRHPWF
Kinase kin-13.AA SGK 378-638 43 6.2e-135 419.36 In-house 1-283 (283) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-283/283
Sequence Identity: 43% (125 aa)

FTFMKVLGKGSFGKVMLAERKGT------------------DEVYAIKILKKDVIV-------QDDDVECTMCEK-RILSLAAKHPFLTALHSSFQTSDR
| |.||.||||||||.....|..                  | .||.|.|.|. |.       .   .  .| |.  ||..  ||||.  || .||| . 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKN-MKHPFIVNLHYAFQTKWK

LFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQE
|.|||.|||||.. . .||...| |.||||||||. |||  ||  |.|||||| .|||||..|||.| ||| ||||| . . |.|||||| | |||.|. 
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

MEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFF
 ... .|||| || ..|||| | |||.  |   ... |.| .   |   | .|  ...   .|.  ||||   .  .   |. ||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG---TKRDFMEIKNHPFF
Kinase kin-13.AA Iota 378-638 52 6.6e-123 411.37 In-house 1-271 (271) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-271/271
Sequence Identity: 52% (143 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDES
|  ..|.|.||. ||...| | |. .||.|..||... .|.|..    || .   |. ||||  ||| |||  |||||.|.|||||||| .|| ||  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

RARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPF
 ||||.||.  ||.|||   .|||||||||.|||.||| .| |.|||||||    .|||||||| |||||||   .|| |||||||||||.|||||  ||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

---------EADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQ-GGEDAIRAHPFF
         .   || ||  ||   .  |  ||  | ..||.|. |.   ||||      |   |. ||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase kin-13.AA PKN 378-638 51 1.2e-111 377.17 In-house 1-260 (260) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-260/260
Sequence Identity: 51% (136 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLA--AKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFD
| .. |||.| ||||.|.. |.|.|.||||.|||  ||  |.||  ||||||.  .  ..||||  |.. |||..  .|||||. ||||| .|     |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDV-FS

ESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQP
| ||.|||| |   ||.||.. .|||||||||.|||.||. ..||||.||||.     ||||||||...|||.| .  |   |||| ||||.|||. | .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFF
||  |.|...|..|.|||| || .|| ||..|..  . ||  .|||   ..   . |. .|||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLG--AGERDAEDIKMQPFF
Kinase kin-13.AA AktR 378-638 40 8.70000000001e-110 371.03 In-house 1-268 (268) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-268/268
Sequence Identity: 40% (109 aa)

FTFMKVLGKGSFGKVMLAERK-GTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDE
|.. |.|||| ||||.|...|  ....||.|..||  |..    . |  |. |.   ..|||.  || .||| . |||.|||. ||.| . ... .||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SRARFYAAEVTCALQFLHRN-DVIYRDLKLDNILLDAEGHCRLADFGMCK-EGIN-KDNLTSTFCGTPDYIAPEILQE-MEYGVSVDWWALGVLMYEMMA
..||||.|..  ||..|| . ..|||||| .||||| .|| ...|||. | .... .| .. .||||| |.|||....   .. ||||||.|.. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQPPFEADNEDDLFEAILNDD---VLYPVWLSKEAVNILK-AFMTKNAGKRLGCVVSQGGEDAIRAHPFF
|.|||...|  ..|. |.. .   . ||. .|... ....   . ||  ||||   . | |. |. ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGY-YCNGWEE-IKSHPWF
Kinase kin-13.AA S_TKc 378-638 35 2.1e-101 344.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-231/231
Sequence Identity: 35% (95 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNG--GDLMFQIQRARK--
.......|||.||||...  |.|....||||.|          | .. | .||.   .||..  |. .||. |.|..||||..|  |||.  |.. ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGV-SVDWWALGVLMY
    |.| .||||.... |||...|.. .|.|||| .|||||   |  ..|||....        .||||||.|.|||.|    ||  ..|||..|...|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMAGQPPFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFF
||..|.|||.  ... .|. |.          |.|| ....  ..|.  ||...     .| .|..||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase kin-13.AA Pkinase 378-638 28 1e-77 269.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 378-638
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTM-CEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGG----DLMFQIQ--R
... ...|.||||.| .. .||| ...|.||.||. .  . |.. .   | .|.    .||.   |. .|...|.. .||||..||    ||.  |.  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

ARKF--DESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHC----RLADFGMCKEG-INKDNLTSTFCGTPDYIAPEILQ-EMEYGVSVDWWA
 ..|  .|  ..||. .. ..|...|.. .|.||||..|||.| .||.    ...||| .|   . ..  ..||||||.|.|||...   .|| .||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLMYEMMAGQPPFEAD------NEDDLFEAILNDDVLYPVWLS---------------------KEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAH
.|...|||. |.|||  .      ... ... |.  .. .. . .                     .|.  ..|   .|.  ||..        . |  |
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-------AEQILQH

PFF
|.|
PWF
Kinase kin-13.AA S_TK_X 639-702 43 1.5e-30 108.76 SMART 1-79 (79) Show / Hide 
Range on Protein: 639-702
Range on HMM: 1-79/79
Sequence Identity: 43% (34 aa)

REIDWDALES--RQVKPPFKPKIK----SKRDANNFDSDFTKEEPVLTPSDPAVVRAINQDE---------FRGFSFIN
|.||||.|..  ....||||||||    | .|..||| .||.|.|.||| ||.......|.|         ||||....
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase kin-13.AA Pkinase_C 658-704 42 1.2e-18 68.79 Pfam 1-46 (46) Show / Hide 
Range on Protein: 658-704
Range on HMM: 1-46/46
Sequence Identity: 42% (20 aa)

KIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQDEFRGFSFINPH
..||..|. ||| .||.| |..||.|.   ....|..||||.. || 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase kin-13.AA TyrKc 378-632 20 5.5e-16 35.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 378-632
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLA-AKHPFLTALHSSFQTS-------DRLFFVMEYVNGGDLMFQIQ
 |. |.|| | ||.|.... |   .  |.| ||.|       .|  | | ||..    .|| . .|.    ..       . |. ||||. .|||   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RARK-FDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINK-------DNLTSTFCGTPD------YIAPEILQEMEYG
. |. .  .    ..  . |  ..||.. .| |||   |.|........ .|||..... ..       |  ...  .  .        ||| ... .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VSVDWWALGVLMYEMMA-GQPPFEA-----DNEDDLFEAILNDDVLYPVWL---------SKEAVNILKAFMTKNAGKRLGCVVSQGGEDAI
   | |. ||.|.|..  ||.| .       . ....| . . . . .            ..|  .| |     .. .|          . .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase kin-13.AA Pkinase_Tyr 449-578 21 2.5e-11 39.02 Pfam 80-217 (270) Show / Hide 
Range on Protein: 449-578
Range on HMM: 80-217/270
Sequence Identity: 21% (31 aa)

SDRLFFVMEYVNGGDLMFQIQR----ARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNL-TSTF------
. ... ||||. .|||    ..     .... ..   ..... .....|...  | |||   |.|.. ..... .|||...   |.|.  ...       
N-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPI

--CGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMA-GQPP-FE
  .      ||| ...... .  | |. ||||.|..  |. | ..
KWM------APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYP
Kinase kin-13.AA Pkinase_Tyr 378-412 38 6e-06 20.82 Pfam 1-39 (270) Show / Hide 
Range on Protein: 378-412
Range on HMM: 1-39/270
Sequence Identity: 38% (15 aa)

FTFMKVLGKGSFGKVMLAERK----GTDEVYAIKILKKD
 ||.|.||.|.||.|.... |    .|.   |.|.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG