Gene kin-22 (Nematode worm)

kin-22

Species: Nematode worm
Alias: kin-22, aSWK405, Cehd-4, CE24991, F49B2.5
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 14330272-14336988, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: Src
Subfamily: Frk

Sequence

Name Sequence Type Origin Length Description Download
kin-22.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
kin-22.AA Protein Genbank 507 None Fasta, JSON

Protein domain

Protein domains of kin-22.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 kin-22.AA SH3 60-117 41 3.7e-23 84.19 SMART 1-58 (58) Show / Hide 
Range on Protein: 60-117
Range on HMM: 1-58/58
Sequence Identity: 41% (24 aa)

ANFVALFQYDARTDDDLSFKKDDILEILNDTQGDWWFARHKATGRTGYIPSNYVAREK
  ..||. |.|...|.|||||.||...|... ..|| .|.. ||..|..|||||.. .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 kin-22.AA SH3_1 63-110 44 1.7e-21 75.38 Pfam 1-49 (49) Show / Hide 
Range on Protein: 63-110
Range on HMM: 1-49/49
Sequence Identity: 44% (22 aa)

VALFQYDARTDDDLSFKKDDILEILNDTQG-DWWFARHKATGRTGYIPS
|||. |.|...|.||||| ||....... . |||..| . ||..|..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 kin-22.AA SH3_2 61-116 20 2e-12 46.37 Pfam 1-68 (68) Show / Hide 
Range on Protein: 61-116
Range on HMM: 1-68/68
Sequence Identity: 20% (14 aa)

NFVALFQYDA-RTDDD-----LSFKKDDILEIL---NDTQGDWWFA-RHKATGRT--GYIPSNYVARE
 ......|.. .  ..     |.|||.|.....   .  ...||.. . ...||.  |..||..|.  
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 kin-22.AA SH2 124-201 48 5.6e-40 119.19 Pfam 1-81 (81) Show / Hide 
Range on Protein: 124-201
Range on HMM: 1-81/81
Sequence Identity: 48% (39 aa)

WYFGKMRRIDAEKCLLHTLNEHGAFLVRDSESRQHDLSLSVREND---SVKHYRIRQLDHGGYFIARRRPFATLHDLIAHY
||.||. | .||. |. . |..|.||||.||| . | .|||| ..   .||||||...| |||.|. |. |..|..|. ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 kin-22.AA SH2 122-207 48 2.3e-36 128.06 SMART 1-87 (87) Show / Hide 
Range on Protein: 122-207
Range on HMM: 1-87/87
Sequence Identity: 48% (43 aa)

QPWYFGKMRRIDAEKCLLHTLNEHGAFLVRDSESRQHDLSLSVRENDSVKHYRIRQLDHGGYFIAR--RRPFATLHDLIAHYQREADG
||||.|.. | .||. |..  ...|.||||||||   |..|||| .. |||||||..|.|.|.|.   ||.| .| .|..|||. ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase kin-22.AA Src 240-489 66 7.6e-187 627.01 In-house 1-255 (255) Show / Hide 
Range on Protein: 240-489
Range on HMM: 1-255/255
Sequence Identity: 66% (169 aa)

VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQEN-LLTFLQ--RRGRQCQMPQLV
..|.|..|.|||||||.| || |..|||| ||.|| .|..||.||||||||||.||..|||||...|||.||||.|... ||..|.  ..||....|||.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

EISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMK--ENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRL
...||||.||||||.||.|||||||||.|..... .|.||||||| |.|  ..||.||.||.||||||||||.||.|||.||||||||||||||||.|| 
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYD-IMQQCWRSDPDKRPTFETLQWKL
|||||||.||||||..|||||||..||  ||. ||.|||..||..|||||.|||.|
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase kin-22.AA Frk 240-493 72 6.1e-186 624.02 In-house 1-260 (260) Show / Hide 
Range on Protein: 240-493
Range on HMM: 1-260/260
Sequence Identity: 72% (189 aa)

VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQEN-LLTFLQ---RRGRQCQMPQL
..|||..|.|||||||||.||...|||||.||.||.||.|||.|||||||||||||..||||||..|||.|.||||... |...||   ..||||||.||
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENE--YEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGR
|...|||||||||||..|.|||||||||.|.......|||||||||.|||.||  ||.|.|||||||||||||||||.||.||||||||||||||.|.||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

LPYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLEDLF
.||||||||||||.||.|||||.|..||..||.||..||.|||.|||||||||||||| |
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase kin-22.AA SFK-Src 240-493 61 1.3e-182 546.65 In-house 1-259 (259) Show / Hide 
Range on Protein: 240-493
Range on HMM: 1-259/259
Sequence Identity: 61% (159 aa)

VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-NLLTFLQR-RGRQCQMPQLVE
.|| .. |.||||.|| ||||    |||| || |.     ||.|||.|||||||.|  ||||||  ||| |.||||.   || .|.  .||  .||||| 
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

ISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENE-YEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPY
  ||||.||||||. ||.||||||||.|. ..  .|..|||..|.| ...| |.|..||.||||||||||.|.||| .||||||||||..||||.|| ||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMTNAEVLQQVDA--GYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLEDLF
|||||.|||||||   ||||||| .||  .| || .||.  || |||||.|.|..|| |
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase kin-22.AA Pkinase_Tyr 240-489 47 6.00000000001e-152 515.24 Pfam 1-270 (270) Show / Hide 
Range on Protein: 240-489
Range on HMM: 1-270/270
Sequence Identity: 47% (128 aa)

VRLIRQIGAGQFGEVWEGRWN-----VNVPVAVKKLKAGTADP----TDFLAEAQIMKKL-RHPKLLSLYAVCT-RDEP--ILIVTELMQE-NLLTFLQR
.......|.|.||||..|.|.      ..|||||.|| |. ..     ||..||.|||.| .||....||.||| ..||  |.||.|.|.  .||..|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---GRQCQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENEY-EARTGARFPIKWTAPEAANYNRFTTKSDVWSF
.   ...  |..|.....|.|.||.|||..|.|||||||||.|..... |||.|||||| .... .|  .|.|...||||.|||. ||..||||||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTEIVTFGRLP-YPGMTNAEVLQQV-DAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKL
|.|. ||.|.|. | ||||.|.||.... . ||||||| .||  .||.|.|||. ||..||||. ....|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase kin-22.AA SrcA 240-489 63 9.69999999999e-145 460.56 In-house 1-250 (250) Show / Hide 
Range on Protein: 240-489
Range on HMM: 1-250/250
Sequence Identity: 63% (161 aa)

VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-NLLTFL-QRRGRQCQMPQLVE
.||.|..| |.||||| | || .  ||.| || ||  |  || |||||||||| ||  ||||   .||| |||| | .  || || .. |.. ..||||.
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

ISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYP
..||||.||||.| ||.||||| | |||. . |  ||||||||| |...|||.|| ||.||||||||||| | ||| |||||||||||||.|| ||.|||
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP

GMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKL
|| | |||.||. ||.|||| .||  |...|.|||| ||. ||||| ||  |
GMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase kin-22.AA Src-Unclassified 240-485 49 2.4e-138 465.92 In-house 1-280 (284) Show / Hide 
Range on Protein: 240-485
Range on HMM: 1-280/284
Sequence Identity: 49% (139 aa)

VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAG---TADPTDFL--------AEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-NLLTFLQRRG
|.|.| .| ||||||| | |   | |||| ...|   |  |. ||        .|||||||.||..|  |||||...||..|.||.|    || .|.  |
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

-RQCQMPQL------------VEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLS-----VKIADFGLAR-ILMKENEYEARTGARFPIKWTAPEAAN
 .   .. .            | |.|||| || |||.   .||||||||.||    |     ||..||||||  || . .|..||||.||.||.|||.. 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDAGYRMPCP--AGCPVTLYD-IMQQCWRSDPDKRPTFETL
|  |..||||||.|||| || | |. ||||| | ||| .|  ||||| |   .||  .|. || .||  ||..||||.||
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTL
Kinase kin-22.AA TyrKc 240-489 41 2.3e-136 460.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 240-489
Range on HMM: 1-280/280
Sequence Identity: 41% (119 aa)

VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKL--RHPKLLSLYAVCTRD-------EPILIVTELMQE-NLLTFLQRRGRQ
..|....| |.||||..|.|.  ..||||.||...    ||. ||.||.||  .|| .. ||.||| .       ||..||.|.|   .|. .|......
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

CQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKE-------NEYEART--GAR--FPIKWTAPEAANYNRFTTKSDV
 .|..|.... |.|.||.||...|.|||||||||.|... . |||.||||.| .  .         | ...  |..  .||.|.|||. ||..|||||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGILLTEIVTFGRLPYPG-----MTNAEVLQQVDAGYRMPCPAG--------CPVTLYDIMQQCWRSDPDKRPTFETLQWKL
||||... || |.|  ||||     |.|.||...|..|||||.|.         ||  .|.||.|||. ||..||||...  ..
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase kin-22.AA SrcB 240-490 58 1e-126 427.3 In-house 1-251 (251) Show / Hide 
Range on Protein: 240-490
Range on HMM: 1-251/251
Sequence Identity: 58% (147 aa)

VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-NLLTFLQ-RRGRQCQMPQLVE
..|....||||||||| | .| .. |||| .| ||  |  ||||| .||.| | .|  |||| |.. || |.|| |..  || ||.   | . ..|.|..
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

ISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYP
.|||.| ||||.|.||.||||| | |||. ..|. |||||||||| . .||| || ||.|||||||||| |.  || |||||||||||.||||.||.|||
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARI-IEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

GMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLE
||||.||..... |||||.|  ||  ||.||..||.. |. ||||. ||  |.
GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase kin-22.AA TK 240-489 25 9.79999999999e-126 423.76 In-house 1-486 (486) Show / Hide 
Range on Protein: 240-489
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

VRLIRQIGAGQFG---EVWEGRWNVN--------------------------VPVAVKKLKAG-TADPTDFLA--------------EAQIMKKLR----
..|....|.||||   ||..|.|.                            .||||| ||.| ......|..              ||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKLLSLYAVCTRD------------EPILIVTELMQ-EN----LLTFLQRRGR---------------------------------------------
 || ...||.|||..            ||..||.|.|.  .    |...|... .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QCQMPQLVEISAQVAAGMAYLEEM------NFIHRDLAARNILINNSLS-----------VKIADFG---
                              |  |.||. ...|.|.||.||...      ||.||||||||.|.....            .||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARILMKENEYEART------------------------GARFPIKWTAPEAAN---------YNRFTTKSDVWSFGILLTEIVTFGRLPYPG-M
     ||| . .. .| ...                        |...||.|.|||. |         |..|||||||||||.|. ||.|.|. ||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------AEVLQQVDAG--------------YRMPCPAGCP--------------VTLYDIMQQCWRSDPDKRPTFETLQWKL
.|         .||.... .|              .|||.|..||                .||.|||||. ||..||||..|. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase kin-22.AA SRM 242-490 50 1e-118 398.78 In-house 3-253 (253) Show / Hide 
Range on Protein: 242-490
Range on HMM: 3-253/253
Sequence Identity: 50% (127 aa)

LIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGT-ADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-NLLTFLQRR-GRQCQMPQLVEI
| |  |.| ||||||| |   |.||.|  |       ... .| | |||||| ....|.|||.  .|. |.||||.  ||. .|    ..  ..|.|...
LCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLLDF

SAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPG
  ||| ||.|||| |.|||||||||.|. . .  |..|||||| |.|.  |    . . |.||||||||||  . .||||||||||| |. | | .||||
ACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLAR-LIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPG

MTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLE
||| | .||.|.|||||||| ||   .  | .||..||..||.| .|  || 
MTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase kin-22.AA Src-Echino1 240-489 56 1.6e-118 400.1 In-house 1-252 (252) Show / Hide 
Range on Protein: 240-489
Range on HMM: 1-252/252
Sequence Identity: 56% (143 aa)

VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-NLLTFLQR-RGRQCQMPQLVE
.|. ..|| |..||||.| || | ||||| || .|  | |||||| .|||.||  .. .||||   ||| ||||||.. ||...|.| .... .|..|..
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

ISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYP
. |..|.|| ||.. |..||||||||.|...   .||||||||| .|....| .. ||..|||||||||| | ||| ||||||||||.||.|||||.|||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLAR-MMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYP

GMTNAEVLQQVDAGYRMPCPAGCPVTLYDI-MQQCWRSDPDKRPTFETLQWKL
||.| |||.||| ||||| .  ||  ||.. | .||  || .||||| |   .
GMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase kin-22.AA UTK 240-489 40 3.7e-114 385.56 In-house 1-296 (296) Show / Hide 
Range on Protein: 240-489
Range on HMM: 1-296/296
Sequence Identity: 40% (119 aa)

VRLIRQIGAGQFGEVWEGRWN------VNVPVAVKKLK---AGTADPT---DFLAEAQ---IMKKLR-HPKLLSLYAVCTRDEPILIVTELMQ-ENLLTF
|.| ||.|.|.|||| ..|..        . ||||...   ... .|.   ||. ||.   .||... ||..| |..|||..||..||||.|.  .|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LQRRGRQCQ-------MPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNS-------LSVKIADFG---LARILM---------KENEYEARTGAR
|.| ....        . |... ....|.||.||....|.||||||||.|.. .       ...||||||   ..| .            ..| |.   |
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPIKWTAPEAANYN-RFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDAG--YRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKL
 ||.|.|||| ... ||||||||||||... ||.|.||||||||.|..|..|| .|  ||||||..|| ..|..|..||..||..||.||.|  ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase kin-22.AA S_TKc 240-493 27 1.3e-57 198.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 240-493
Range on HMM: 1-231/231
Sequence Identity: 27% (74 aa)

VRLIRQIGAGQFGEVWEGRWNV-NVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE---NLLTFLQRRGRQ-----C
 ...|.|| | ||.|. .|..  .  ||.|..|       ... | ||.|| .|| .  || |.   . . .|.|..     .|......|||.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENEYEARTGARFPIKWTAPEAANYNRFTT-KSDVWSFGILLTEIV
   .   . .|.. ...|. ....|||||   |||...   .||.||||||.|         |       . |||      ... |.|.||.|..| | .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TFGRLPYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQ----WKLEDLF
. |. |.|  . .......            .  . |....|.. ||.|||| | ||    .|.   |
C-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase kin-22.AA Pkinase 240-483 26 7.4e-47 166.75 Pfam 1-285 (293) Show / Hide 
Range on Protein: 240-483
Range on HMM: 1-285/293
Sequence Identity: 26% (77 aa)

VRLIRQIGAGQFGEVWEGRWNVNV-PVAVKKLKAGTADPTDF-----LAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-----NLLTFLQ-RRG
 ...|.||.| ||.|.....  .   ||||..|  ....        |.|.||||.|.||  . || .....  | .|.|...       | .... .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RQC--QMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSV----KIADFGLARILMKENEYEARTGARFPIKWTAPEAAN-YNRFTTKSDVWS
.    .. ..  .  |.. |..|. .|..|||||   ||||.|   .    ||.|||||. .  .  ..  |.    . . |||  . ..  ..|.|.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGILLTEIVTFGRLPYPGM----TNAEVLQQVDAGYRMPCPAGCP-----------------------VTLYDIMQQCWRSDPDKRPTFE
.|..| | .. ||.|.||     . .. .| ..   . | .  .|                        .. |..  |.. || ||||.|
CGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE