kin-25

Species: Nematode worm
Alias: YWR1_CAEEL, B0302.1, Cehd-20, CE03866, aSWK327, B0302.1a, kin-25, B0302.1A
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 17151022-17157607, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: Ack

Sequence

Name Sequence Type Origin Length Description Download
kin-25.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
kin-25.AA Protein Genbank 1223 None Fasta, JSON

Protein domain

Protein domains of kin-25.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SAM_Ack kin-25.AA SAM_Ack 8-72 35 2.9e-30 105.03 In-house 1-65 (65) Show / Hide
Range on Protein: 8-72
Range on HMM: 1-65/65
Sequence Identity: 35% (23 aa)

LVDDNVLEVLRKAQLDAFISQFVFLFNVRRFDHFSHVRDKDMLEIGMQQVQIRQLREQILKMSRE
 ......|.||.|||.....|... ..|.|.|||..|.|.|...|||.....|.|.|.. ||...
EECQWLYEFLREAQLEQYYNQIRDHLKVTRLDHFDYVKDEDLECIGMSRPEQRRLWEAYKKMCPH

Sam7 kin-25.AA sam7 8-70 20 1.6e-05 17.61 In-house 1-70 (70) Show / Hide
Range on Protein: 8-70
Range on HMM: 1-70/70
Sequence Identity: 20% (14 aa)

LVDDNVLEVLRKAQL---DAFISQFVFLFN---VRRFDHFSHVRDKDMLEIGMQQVQIRQ-LREQILKMS
  ...| | |.....   . ....|        |  .||. |. ..|..|.|.  .  |. . ..| .| 
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR

Kinase kin-25.AA Ack 107-363 55 8.4e-190 636.84 In-house 1-266 (266) Show / Hide
Range on Protein: 107-363
Range on HMM: 1-266/266
Sequence Identity: 55% (148 aa)

IKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDI---SPNIMDDLRVEASHLLKLQHPSLIRLYGIVR-QPA-MMVFELCEGGSLLDRLRDDKK-A
|.|.|..|.|.|.||.||.||...|.|..||||.||..   .||.|||...|......|.||.|.||||.|. ||. |||.||...|||||.||.... |
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

ILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQK--KVPFAWCPPEALRHRKFSHASDVWSYGVT
..|...|.|.|||||.....||.|.|.|||.|||||||..|.|.||||||||||||..||..|.|....  |||||||.||.||||.||||||||..|||
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT

IWEVFTFGEEPWVGCRAIDVLKNID-AGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDL
.||.|..|||||.||.....|..|| .||||..|..|.|.|||.|..||...||.|..|.|||..|
LWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL

Kinase kin-25.AA TyrKc 107-363 34 1.9e-122 414.04 SMART 1-280 (280) Show / Hide
Range on Protein: 107-363
Range on HMM: 1-280/280
Sequence Identity: 34% (101 aa)

IKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDISPNIMDDLRVEASHLLKL--QHPSLIRLYGIVR---------QPAMMVFELCEGGSLLDRLR
|.| . .||| | .| .|||.      ..|||| |.. .   . |.. ||. . ||  .|| ..||||...         .| |.|.|....|.|.|.||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DDKKAILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKEN------EQMYTMA--PQKK--VPFAWCPPEALRHRK
. ..  | .. |...| |||.  ..|.||.|.||| ||||.|....  ||||.||||.|....       ...|...   ..|  .|  |..||.....|
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FSHASDVWSYGVTIWEVFTFGEEPWVG-----CRAIDVLKNIDAGERLEKPKY--------CSERIYQIMKNCWKFNPAERCKFGAIREDL
|...|||||.||..||.||.|..|. |     . ...|......|.|...|..        |.. .||||| ||...|..|. | .|.|..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase kin-25.AA Pkinase_Tyr 107-363 38 3.1e-121 411.23 Pfam 1-270 (270) Show / Hide
Range on Protein: 107-363
Range on HMM: 1-270/270
Sequence Identity: 38% (106 aa)

IKLYELIGEGSFAVVKRGTWT-QSNGTHVNVAVKILRDISPNI---MDDLRVEASHLLKL-QHPSLIRLYGIVR---QP--AMMVFELCEGGSLLDRLRD
|.. . .|||.| .|..|||. .  .|.. ||||.|.. .      ..|.  ||. . .| .|| ..||||..    .|   ..|.|....|.||| ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D--KKAILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMY-TMAPQKKVPFAWCPPEALRHRKFSHASDVW
    |  | ...| ..|.||||....||||.|.|||.||||.|....  .||||||||.|.. .|.  | ...   |.|  |..||.....||...||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SYGVTIWEVFTFGEEP-WVGCRAIDVLKNI-DAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDL
|.||..||.||.||.| . |.   .|.. | . |.|...|..|.. ||..|| ||...|..|  | .|.|.|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase kin-25.AA TK 107-363 19 1.3e-100 338.05 In-house 1-486 (486) Show / Hide
Range on Protein: 107-363
Range on HMM: 1-486/486
Sequence Identity: 19% (97 aa)

IKLYELIGEGSFA---VVKRGTWTQ----------------------SNGTHVNVAVKILRDISPNIMDDLRV--------------EASHLLKLQ----
|.| . .||| |    .| .|.| .                      ..|... ||||.|.. ... ... .               ||. . ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPSLIRLYGIVRQP--------------AMMVFELCEGGS----LLDRLRDDK----------------------------------------------
 || ..||||.. |.               |.| |....|.    |.| ||. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------KAILLVSRLHDYCMQIAKALQFLESK------HCVHRDVAARNILLARDER----------TVKICDFG---
                            |..| . .|. .|.|||.....|.||      ..||||.||||.|.... .          ..||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LMRALKENEQMYTMA-----------------------PQKKVPFAWCPPEALR---------HRKFSHASDVWSYGVTIWEVFTFGEEPWVGCR
     | |.. ...  |..                        .. |.|. |..||.|.         ..||...|||||.||..||.||.|.||. |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

AI----------DVLKNIDAG--------------ERLEKPKYCS--------------ERIYQIMKNCWKFNPAERCKFGAIREDL
            .|.... .|               |...|..|.              | .|..|. ||...|..|  | ...| |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase kin-25.AA UTK 107-363 29 1.6e-89 303.74 In-house 1-296 (296) Show / Hide
Range on Protein: 107-363
Range on HMM: 1-296/296
Sequence Identity: 29% (86 aa)

IKLYELIGEGSFAVVKRGTWTQSN--GTHVNVAVKILR--DISPNIMD---DLRVEAS---HLLKLQ-HPSLIRLYGIVRQ--PAMMVFELCEGGSLLDR
..| ...|.| | .| ....|| .  .. . |||| ..  . ..  ..   |.. ||     . ... ||...||.|.. |  | |.| |..|.|.|.. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRDDKK------AILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDE------RTVKICDFG---LMRALKE--------NEQMYTMAPQKK
||. ..      ..|   .. .....|| ..|.|.|...||||.||||.|.....      ...||.|||   . |...         . ..|....|..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPFAWCPPEALRHR-KFSHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLKNIDAG--ERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDL
.|..|. |||| |. .|...|||||.||. ||..|.|  |. |  . .|.... .|   |...|. |....|..|. ||. .|.||. |  ... .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase kin-25.AA TK-Unique 107-363 30 4.3e-78 265.75 In-house 1-294 (294) Show / Hide
Range on Protein: 107-363
Range on HMM: 1-294/294
Sequence Identity: 30% (91 aa)

IKLYELIGEGSFAVVKRGTWTQSN---GTHVNVAVKILR-DISPNIMDDLRVEASHLLKLQ-HPSLIRLYGIVR---QPAMMVFELCEGGSLLDRLR---
... ..||||.|  | ||. .. .   . ...|||| |. . ..   .|.  |.... .|  || .....|.     .| |...| |..|.|.. ||   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------------DDKKAILLVSRLHDYCMQIAKALQFLES--KHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVP
                     .. .. .   .|  .. |||.....|.|  |..||||..|||.||..   ..||||||. | .  |..  .|  |...|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-DKVCKICDFGMARDVYTNGVYSMMCSQGRIP

FAWCPPEALR--HRKF-SHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLKNIDAGERLEKPKYC-SERIYQIMKNCWKFNPAERCKFGAIREDL
 .|..||.|.  |. . .  |||||.||..||.||.|. |  | .. |....| .| |...|..| |...|..||.||. .| ||  | .|.  |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase kin-25.AA Fer 107-364 31 2.5e-73 249.06 In-house 1-283 (283) Show / Hide
Range on Protein: 107-364
Range on HMM: 1-283/283
Sequence Identity: 31% (89 aa)

IKLYELIGEGSFAVVKRG--TWTQSNGTHVNV---AVKILRD---ISPNI-MDDLRVEASHLLK-LQHPSLIRLYGI--VRQPAMMVFELCEGGSLLDRL
..| . .||| |  |..|  | .  .|. ..|   |||  .     .    . ..  ||  ... ..||  ...||.   .|| | |.|.| ||||...|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RDDKKAILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVK--ICDFGLMRALKENEQMYTMA-PQKKVPFAWCPPEALRHRKFSHASD
.  |.  . .  ....|.|.|. ...|.||.|.|||.||||.|.  |.  .|  | |||. |......  |.|. ...|||  | .||... . .|...|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSYGVTIWEVFTFGEEPWVG--------CR-AIDVLKNIDAGERLEKPKYCSERIYQIMK-NCWKFNPAERCKFGAIREDLV
|||.||..||.|| |.||. |        .    .. . |..| ..  |. . ..|.|||. .||. .| .|...  |.. | 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase kin-25.AA Src 107-363 34 2.2e-66 224.55 In-house 1-255 (255) Show / Hide
Range on Protein: 107-363
Range on HMM: 1-255/255
Sequence Identity: 34% (90 aa)

IKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDISPNIMDDLRVEASHLLKLQHPSLIRLYGIV-RQ-PAMMVFELCEGGSLLDRLR-DDKKAILL
||| . .|.| |  |  |.| .    ...|||| |.  .    ...  ||  . ||.|. |..|| .. .  |   | |. . ||||| |. |..   | 
IKLCRKLGQGQFGEVWMGYWNG----NTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLH

VSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCPPEALRHRKFSHASDVWSYGVTIWEVF
. .| |   |.|.  ..|||.  .||| ||||.|   .   .|..|||| | .||..  |..    |.|  |  |||.....|.  |||||.|. ..|..
LPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN-VCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

TFGEEPWVGCRAIDVLKNIDAGERLEKPKYCSERIYQ-IMKNCWKFNPAERCKFGAIREDL
|.|  |  | .  .||.....| |. .|. | ...|. ||. ||.  | .|  |  ... |
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase kin-25.AA EGFR 107-364 36 1.7e-65 216.38 In-house 1-258 (258) Show / Hide
Range on Protein: 107-364
Range on HMM: 1-258/258
Sequence Identity: 36% (96 aa)

IKLYELIGEGSFAVVKRGTWTQSNGTHVN--VAVKILRDIS-PNIMDDLRVEASHLLKLQHPSLIRLYGI-VRQPAMMVFELCEGGSLLDRLRDDKKAIL
.|.    | | |  | .| |    |  |   ||.|.||. . |.  ...  ||  .  ..|| |.|| |. . .  ..|  .   |.||| .|  | .| 
LKKVKVLGSGAFGTVYKGIWIPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIG

LVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCPPEALRHRKFSHASDVWSYGVTIWEV
    |  .|.|||| .|.|| .. |||| ||||.|. .    ||| |||| . |. .|. |...   |.|  |   | ..||.. |.|||||||||.||.
SQHLLN-WCVQIAKGMQYLEEHRMVHRDLAARNVLV-KSPNHVKITDFGLAKLLEHDEKEYHAQ-GGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

FTFGEEPWVGCRAIDVLKNIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDLV
 |||..|. | .| ..   .. ||||. |. |.  .|..|  ||   .. | .|  . | . 
MTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK

Kinase kin-25.AA Syk 107-357 34 5e-64 219.02 In-house 1-257 (257) Show / Hide
Range on Protein: 107-357
Range on HMM: 1-257/257
Sequence Identity: 34% (89 aa)

IKLYELIGEGSFAVVKRGTWTQS----NGTHVNVAVKILR-DISP-NIMDDLRVEASHLLKLQHPSLIRLYGIVRQPAMM-VFELCEGGSLLDRLRDDKK
. . . || | |  |. |.  .     ..  . ||.|.|. | .  .  . .  ||.   .| ||  .|. ||   ..|| | |. |.|.... | ....
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

AILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCPPEALRHRKFSHASDVWSYGVTI
 |   . |     |.|     ||.|| |||| ||||.||  ..   || |||. .||  ..| |.     | |  |  ||    .||||.|||||.|||.
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLV-NRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WEVFTFGEEPWVGCRAIDVLKNIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFG
|| |  |  |  . .  .|.| |. |.|...|  | . .||.|. ||.  .  |  |.
WEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV

Kinase kin-25.AA RTKD 107-365 33 8.4e-62 208.65 In-house 1-262 (262) Show / Hide
Range on Protein: 107-365
Range on HMM: 1-262/262
Sequence Identity: 33% (89 aa)

IKLYELIGEGSFAVVKRGTWTQ--SNG-THVNVAVKILRDISPNIMDDLRVEASHLLKLQHPSLIRLYGIVR--QPAMMVFELCEGGSLLDRLRDDKKAI
||. | ||.|.. .|  .      . | .   |||||..  |.  .. .  ||  .  ..|.  .||.|.|   || .|| | || |||   ||.    .
IKCLEPIGKGNWGMVFKAMLEEHIMKGIPGFLVAVKIMKNQSQEQVMEMTREAAFMAQFNHDNIVRLHGVVTTNQPHIMVMEYCEHGSLQAYLRENGEDM

LLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCPPEALRHRKFSHASDVWSYGVTIWE
 . .|.    . .|..|  |  . |.|||.|||||||  . |  || |||| |   . .  |  .  . .|  ||.||.|.  |||.|||||| .|...|
DNQHRFR-MARDVAMGLAYLHFRGCCHRDIAARNILLDSNYRA-KIGDFGLTRQQANGDSEYYISHGQAIPVRWCAPEVLEEHKFSQASDVWSWAVFVYE

VFTFGEEPWVGCRAIDVLKNIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDLVA
..| .. |  .     |  .. .| ||..|  |.. |...|  ||   |.||  .  . . .  
IWTQAQLPYRDMHNQKVWHYVIQGYRLTRPMQCPRDIWALMMDCWAEDPKERPRMCQVVDQMTK

Kinase kin-25.AA Jak 107-365 27 6.9e-61 208.6 In-house 1-299 (299) Show / Hide
Range on Protein: 107-365
Range on HMM: 1-299/299
Sequence Identity: 27% (81 aa)

IKLYELIGEGSFAVVKRGTWTQSN------GTHVN----VAVKILRDISPNIMDDLRVEASHLLKLQHPSLIRLYGIV----RQPAMMVFELCEGGSLLD
.|  | .|||.|. | |..    .      .   .    |..|.. . .|....|.  |.| . ...|. .....|..    ... .|| |. . |.|.|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

RLR----DDKKAILL-VSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDER--TVKICDFGLMRALKEN-EQMYTMAPQKKVPFAWCPPEALRHR
 |.      |. . .  ....... ||......||.|...|.||.|||||..|...  .||| .|.|| ....  |  ..|..    .  |..||.|.  
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDR-DERIPWYAPECLTNC

KFSH--ASDVWSYG-VTIWEVF-TFGEEPW---------VGCRAID------VLKNIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDLVA
||.   |.|.||.| ||.||.. ....|.           ||  ..       |.    |.||  |. |  .||..|..|| ..| .| .| .| .|| .
KFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ





Kinase kin-25.AA S_TKc 107-368 23 1.3e-45 158.78 SMART 1-231 (231) Show / Hide
Range on Protein: 107-368
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

IKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDISPNIMDDLRVEASHLLKLQHPSLIRLYGIVR-QPAMMVFELCEG--GSLLDRLRDDKK----
 .. ..||.|.|..|......    |.  ||.||..       ...| | . | | .|| ...||.. . .   ||.|.|.|  |.|.|.... ..    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

AILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCPPEALRHRKFSH-ASDVWSYGVT
  .   .   |. ||..||... |.. .|||.   |||| .   ..||||||| | |              .   ...|| |   .... ..|.|| |..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IWEVFTFGEEPWVGCRAIDVLKNIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIRE----DLVAAMF
..| .. |. |.       ..|.|            |.   .....|....|..|     . .          |
LYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase kin-25.AA Pkinase 107-363 24 2.1e-38 136.86 Pfam 1-293 (293) Show / Hide
Range on Protein: 107-363
Range on HMM: 1-293/293
Sequence Identity: 24% (74 aa)

IKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDISPNIMDD--LRV--EASHLLKLQHPSLIRLYGIVR--QPAMMVFELCEGG----SLLDRLR-
... . ||.|||..|.....  ..     |||||..  . .   |  .|   |.. ...|.||  .|||....  .   ||.|.||||    .| |... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

DDKKAILLVSRLH--DYCMQIAKALQFLESKHCVHRDVAARNILLARDERT---VKICDFGLMRA--LKENEQMYTMAPQKKVPFAWCPPEALR-HRKFS
.......  |  .  .|. ||...|... |. ..|||.   |||. ..  .   |||||||| .   .  |. |.| .    .   ...|| .| ... .
WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC----GTPWYMAPEVIRGGQYYG

HASDVWSYGVTIWEVFTFGEEPWVGC----RAIDVLKNIDAGER----LEKPKYCS-------------------ERIYQIMKNCWKFNPAERCKFGAIR
...|.||.|....|... |. |. |.    . .| .. |.   .     . |. ||                   |   ...|.|....|..|. .  | 
PKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

ED--L
..  .
QHPWF

Kinase kin-25.AA SH3 369-425 24 1.7e-05 25.53 SMART 1-58 (58) Show / Hide
Range on Protein: 369-425
Range on HMM: 1-58/58
Sequence Identity: 24% (14 aa)

LDAVARETYNSIQPGALQLTKGDEVVVVENTGQDWFGQNKK-NQKFGTFPRSVVFAQT
  ..|   |.. .|. | ..||| . |.| ....|.   .. . . | || . |  ..
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID

Kinase kin-25.AA SH3_2 370-424 15 0.000504 16.98 Pfam 1-68 (68) Show / Hide
Range on Protein: 370-424
Range on HMM: 1-68/68
Sequence Identity: 15% (11 aa)

DAVARETYNS-IQPGA-----LQLTKGDEVVVV-----ENTGQDWFG-QNKKNQKF--GTFPRSVVFAQ
 ... ..|..   ..      |...||| ..|      .. .  |..  .... .   | ||.. |  .
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNW-WWCWETIWGGRRMRGWFPSQWVEEC

GTPase_binding kin-25.AA GTPase_binding 476-513 38 3e-06 24.03 Pfam 8-46 (71) Show / Hide
Range on Protein: 476-513
Range on HMM: 8-46/71
Sequence Identity: 38% (15 aa)

ISMPVAGSFIHTGHGDPLGGQS-WGNPATIADMYLKNPV
|. |   .|||.|||.    .  ||.|  . . || ||.
IRVPLKHGFIHNGHGMSNMRHCYWGFPDEFDNNYLNNPM