Gene kin-4 (Nematode worm)

kin-4

Species: Nematode worm
Alias: CE20493, aSWK007, kin-4, C10C6.1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 11439408-11447027, WormBase Genetic Map location: n/a,

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
kin-4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON
kin-4.AA Protein Genbank 1370 None Fasta, JSON

Protein domain

Protein domains of kin-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF1908 kin-4.AA DUF1908 74-123 52 1.2e-11 42.65 Pfam 184-233 (369) Show / Hide 
Range on Protein: 74-123
Range on HMM: 184-233/369
Sequence Identity: 52% (26 aa)

RPRSRSLTSPMKFLNEYNIEMVNRTSVYKERFPRAKLQMEERLNAFVAEN
||||||| || .    .  | |    |||||||.|  ||||||  |....
RPRSRSLSSPSRSCITFDNEIVMMNHVYKERFPKATQQMEERLQHFIHHF
DUF1908 kin-4.AA DUF1908 189-319 52 9e-58 203.04 Pfam 243-369 (369) Show / Hide 
Range on Protein: 189-319
Range on HMM: 243-369/369
Sequence Identity: 52% (69 aa)

IGDGATRFLHHQIVEIALDCLGKSKDDLITCSYFCEMSQRLEETLNEAQMKTSPESLEYLSKLVKKLLMIVSRPARLLECLEFDPDEFYHLLEEAEGVVR
. |.  || |||.||.| ||| ||.. |||  || ||. .||  | ||. .  .|    .....||||.|.||||||||||||||.||||||| |||. .
LADPVVRFIHHQVVEMARDCLHKSHAKLITSRYFYEMQEKLERLLHEAHERSESEEVPFITHVIKKLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAK

EQLGSGTARVPDLPQYIIGKLGLDRDPLIDS
.. |  |    |.|.||| .||| |||. . 
VMQGIKT----DIPRYIIHQLGLNRDPIEEM
Kinase kin-4.AA MAST 358-633 49 4.5e-214 661.28 In-house 1-337 (337) Show / Hide 
Range on Protein: 358-633
Range on HMM: 1-337/337
Sequence Identity: 49% (167 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVVSFYGSFET--RQYLCMLMEYVEGGDCAALLKSAG-TLP
|..|...|.|||||||||.|..|..|||.|..|.|.....|||||||.||.||||..|||||... ||.|  ..|||| |||.|||||| ||.. | ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGY--------------DAVVETQQFQ------------
......|.|||.|..|||||||||||||||||.||...||||||||||||.|.|..|| ..|||              ..  ..||||            
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

------------------------DKQLCGTPEYIAPEVILRRG-YGKPVDWWALGIILYEFLVGIVPFFGETPEA-LFSKVIS--EDVEYPEE-----D
                        .|| ||||.||||||||..| ||||||||..|||.||||||..||.|.|||  .|...|.  ...|.|||     |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

EALPPEAADLCRRLLEKNPAERLGTLNGAAQLMAHEFF
....||| ||...||..|| .|||.  ||.. . |.||
DCMSPEAQDLIKKLLQPNPKKRLGAN-GADEIKQHPFF
Kinase kin-4.AA MAST 358-633 46 1.2e-195 636.64 In-house 1-334 (334) Show / Hide 
Range on Protein: 358-633
Range on HMM: 1-334/334
Sequence Identity: 46% (154 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLKSAGTLPVEL
|..|...|.||||.||||.|..|..|||.|...|. ....|.||||..||.||.|..|||||... ||.|..|||| |||.|||||| ||.. |......
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

VRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGY--------------DAVVETQQFQ---------------
...|.|||.|..|||||.|||||||||||.||...||||||||||||.|.|.... . |||              .   ...||.               
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

--------------------DKQLCGTPEYIAPEVILRRG-YGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVISED---VEYPEE-----DEALP
                    .||.||||.||||||||..| .|||||||..|||.||||||..||...||| .|.......   .|.||.     |||..
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

PEAADLCRRLLEKNPAERLGTLNGAAQLMAHEFF
||| ||...||. .| .|||. |||.. . |.||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase kin-4.AA AGC 358-633 28 2.5e-166 434.09 In-house 1-395 (395) Show / Hide 
Range on Protein: 358-633
Range on HMM: 1-395/395
Sequence Identity: 28% (113 aa)

FDTIRLVSNGAYGAVYLVRHR------ETRQRFALKKMNKQT--------LMLRNQVDQ-------VFAERDILTMAD----------NPFVVS-FYGSF
|. ..... |..| |||||..       | . .|.|...|..         . .... .       |..||.||....          .||.|.  . ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETRQY--LCMLMEYVE--------GGDCAALLKSAG-----TLPVELVRLYVAE-------TILAIEYLHS-YGIVHRD-LKPDNLLITAMGHIKLTDFG
.. ..  |...|||..        ||.|  .|   |     ... | .| | ||       ..||.|||||  ||.||| |||.|.|... |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKIGLMNRTTLVAEGY------------------------------------DAVVETQQFQDKQLCG--TPEYIAPEVILRRGYGKPVDWWA--LGII
|.|.| ....  .. ..                                    |     .... . .||  ||||.|||..    |||..|||.  ||..
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCL

LYEFLVGIVPFFGETPE----------ALFSKVI------SEDVEYP-------EEDEALPPEAADLCRRLLEKNPAERLGTLN------GAAQLMAHEF
.||.|.|. ||.|..|.           .| |..      ...|..|       .||. . ||| ||...||.|.|..|||...      || ....|..
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase kin-4.AA S_TKc 358-633 31 1.1e-98 335.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 358-633
Range on HMM: 1-231/231
Sequence Identity: 31% (91 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEG--GDCAALLKSAGT---
.. .|..  ||.| ||..||..| ...|.|...          ...  |..|| . . |..| .|..|.. ..|.| |||..|  ||   ..|. |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGYDAVVETQQFQDKQLCGTPEYIAPEVILRRGY
   .|   .| |......|.||.|| ||.||||||.|.|..   |||..||||...                        . .||||.|.||||.   ||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL---GY

GK-PVDWWALGIILYEFLVGIVPFFGETPEALFSKVISEDVEYPEEDEALPPEAADLCRRLLEKNPAERLGTLNGAA---QLMAHEFF
|| ..|||..|.||||.|.|  ||   .....| |.              .||| |. |..|.|.|..|..     .     ..|..|
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase kin-4.AA RSK-Unclassified 358-633 37 1.3e-96 304.01 In-house 1-283 (283) Show / Hide 
Range on Protein: 358-633
Range on HMM: 1-283/283
Sequence Identity: 37% (107 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLK--SAGTLPV
|  .||.  |  | ||||| ..| | .|.| ..|. .. .| .  |  |..|. . . ||.|  | || |. || . |||  |||    |       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

ELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIG------LMN---RTTLVAEGYDAVVETQQFQDKQLCGTPEYIAPEVILR
..|| |..|...| ||||  ... ||||||| .    ||..||||.||. .       |      |.|    |  .    |  .  ||| ||.|||.| |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYV----DTKICDHGFRTNSFCGTEEYLAPEMIRR

RGYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVISEDVEYPEEDEALPPEAADLCRRLLEKNPAERLGTLNG-AAQLMAHEFF
 | .| |||| |||..|| |.|. |. |.  . .|. .  ..|  |.. . .  .. || ..||..||| |||   | |.   .| ||
CGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSY-ISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase kin-4.AA Pkinase 358-633 27 9.3e-85 292.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 358-633
Range on HMM: 1-293/293
Sequence Identity: 27% (86 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFA--ERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGG----DCAALLK--S
. ..| .  |..| ||. .|. |....|.|...|.     ..  . .   |  |. . . |..| .|..||......| |||.|||    | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

AGTL--PVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHI----KLTDFGLSKIGLMNRTTLVAEGYDAVVETQQFQDKQLCGTPEYIAPEV
 |..  . . .. |. ... ..||.|| ||.||||||.|.||   |||    |..||||.|                    ..   . .||||.|.||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------------Y-NNS--MTTFCGTPWYMAPEV

IL-RRGYGKPVDWWALGIILYEFLVGIVPFFGE------TPEALFSKVISEDVEYPEEDE------------------ALPPEAADLCRRLLEKNPAERL
|. ...||..||.|..|.||||.| |  || |.      .. ... .. . ....... .                  ....|. |.....|.|.|..|.
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

GTLNGAAQLMAHEFF
.    |.|.. |..|
T----AEQILQHPWF
Kinase kin-4.AA AktR 358-633 34 1.3e-84 287.41 In-house 1-268 (268) Show / Hide 
Range on Protein: 358-633
Range on HMM: 1-268/268
Sequence Identity: 34% (99 aa)

FDTIRLVSNGAYGAVYLVRHR-ETRQRFALKKMNKQTLMLRNQVDQVFAERDILT-MADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLKSAGTLPV
|. ...  .||.| ||||... .. . .|.|   |...  ||| ...  ||.|.  ....|| | .. .|.|. .|  .|||..||.    ||. ...  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ELVRLYVAETILAIEYLHSY-GIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGYDAVVETQQFQDKQ------LCGTPEYIAPEVILR-R
| .| | |. .||.||||.   |. |||||.|.|.   ||.|.|||||||                     ||..        .||||||.|||.|..  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKK

GYGKPVDWWALGIILYEFLVGIVPFFG-ETPEALFSKVISEDVEYPEEDEALPPEAADLCR-RLLEKNPAERLG-TLNGAAQLMAHEFF
|..|.|||||.|| .|| ..|. ||.   . . .... |..   .... . . ... ||.  .|| ||| .|||   ||. ..  | .|
GHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase kin-4.AA RSK 361-633 31 1.5e-81 277.27 In-house 1-278 (278) Show / Hide 
Range on Protein: 361-633
Range on HMM: 1-278/278
Sequence Identity: 31% (92 aa)

IRLVSNGAYGAVYLVRHR---ETRQRFALKKMNKQTLMLRNQ-VDQVFAERDILTMAD-NPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLKSAGT---
...   |.||.|.|.|      |.| .| |  .| ... |.  .  ...||.|| .    ||.|. . .|.| ..| . |||..||.    |.  ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITA---MGHIKLTDFGLSKIGLMNRTTLVAEGYDAVVETQ-QFQDKQLCGTPEYIAPEVIL---
.  . .. | || .||.|.||. ||.||||||.| | .     |||||||||..|..                  .  .. .  |.| ||.|||..    
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF----------------RCDHNQWTMTFCYTIEYMAPEMLKRAN

-RRGYGKPVDWWALGIILYEFLVGIVPFFG---ETPEALFSKVISED--VEYPEEDEALPPEAADLCRRLLEKNPAERLG-TLNGAAQLMAHEFF
 ..|..| .||| ||...|| |.| .|| |   .... .. .. . .  .. | ... | .|| || |..|...|. |||   ..|... .|..|
QQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMP-NWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase kin-4.AA NDR 358-504 47 5.2e-77 236.9 In-house 1-152 (350) Show / Hide 
Range on Protein: 358-504
Range on HMM: 1-152/350
Sequence Identity: 47% (72 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMAD--NPFVVSFYGSFETRQYLCMLMEYVEGGDCAA---LLKSAGT
|. |.... ||.| |.|||...|.. .|.|.|.|.. | .|||..| |||||.. ||  ||.||. | ||   |||.  |||. |||      ||.  ..
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSK
.. .. | | ||...|||..|..|..|||.||||.|| . ||||||||||..
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCT
Kinase kin-4.AA PKA 358-504 40 1.2e-51 177.9 In-house 1-149 (263) Show / Hide 
Range on Protein: 358-504
Range on HMM: 1-149/263
Sequence Identity: 40% (61 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVV-SFYGSFETRQYLCMLMEYVEGGDCAALLKSAGTLPVE
|..|... .| .| |.|.||... . .|.| ..||.   ..||. |  |. ||.  ..||.| . |..| ...|| |.||||.||.    |   | ..  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

LVRLYVA-ETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSK
  ..|.| . .||.|||||  |..||||| |.||   ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase kin-4.AA Akt 358-504 40 1.7e-51 162.81 In-house 1-149 (264) Show / Hide 
Range on Protein: 358-504
Range on HMM: 1-149/264
Sequence Identity: 40% (60 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRF-ALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLKSAGTLPVE
|| ...   |..| |.||.   | . . |.|   |. .  .||| ....|| || . ..||.|. . || | ..|.. |.|. ||.   .|. ... . .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

LVRLYVAETILAIEYLHSYGIVHRD-LKPDNLLITAMGHIKLTDFGLSK
  | |.|| |||||.||| .|. || ||| |.|. . |||.||||||.|
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK
Kinase kin-4.AA SGK 358-504 32 1.6e-50 153.99 In-house 1-173 (283) Show / Hide 
Range on Protein: 358-504
Range on HMM: 1-173/283
Sequence Identity: 32% (57 aa)

FDTIRLVSNGAYGAVYLVRHRET------------------RQRFALKKMNKQTLM-------LRNQVDQVFAER-DILTMADNPFVVSFYGSFETRQYL
|| . ..  | .| ||.|.| ..                   . .|.|  .||.          ....  . ||| .||     || |.   .| | ..|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CMLMEYVEGGDCAALLKSAGTLPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSK
 . |.||.||.    |. .. .|   .| |.|| ..|.|||||  |..|||||.|.|  ..||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase kin-4.AA Akt 532-633 39 1.6e-47 149.97 In-house 162-264 (264) Show / Hide 
Range on Protein: 532-633
Range on HMM: 162-264/264
Sequence Identity: 39% (41 aa)

LCGTPEYIAPEVILRRGYGKPVDWWA-LGIILYEFLVGIVPFFGETPEALFSKVISEDVEYPEEDEALPPEAADLCRRLLEKNPAERLG-TLNGAAQLMA
.||||||.|||...  |..|.||||. ||...||.. |  ||. .  . .| |  ...|..|.  ... ||. || ..||.|.| .||| . |.| ....
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKR

HEFF
|..|
HPWF
Kinase kin-4.AA PKA 532-633 37 1.5e-39 137.76 In-house 158-263 (263) Show / Hide 
Range on Protein: 532-633
Range on HMM: 158-263/263
Sequence Identity: 37% (41 aa)

LCGTPEYIAPEVILRR-GYGKPVDWWALGIILYEFLVGIVPFFGE--TPEALFSKVISEDVEYPEEDEALPPEA---ADLCRRLLEKNPAERLGTLN-GA
|||||||.|||.|... |.||.||||||||. ||.|.|. ||. .  .| ... | .. ....|...    . |    || ..||.... .|.|..  |.
LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFD---SDANYFKDLIKKLLQVDLTKRYGNMKNGV

AQLMAHEFF
 .   |..|
NDIKNHKWF
Kinase kin-4.AA SGK 533-633 37 3.3e-39 118.41 In-house 186-283 (283) Show / Hide 
Range on Protein: 533-633
Range on HMM: 186-283/283
Sequence Identity: 37% (38 aa)

CGTPEYIAPEVILRRGYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVISEDVEYPEEDEALPPEAADLCRRLLEKNPAERLGTLNGAAQLMAHEF
|||||| ||||.. ..... |||| ||..|||...|. ||.    . .. . |...   |       ..| ||   ||.|.| .|||| .....   | |
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase kin-4.AA NDR 534-633 41 2.1e-37 112.46 In-house 243-350 (350) Show / Hide 
Range on Protein: 534-633
Range on HMM: 243-350/350
Sequence Identity: 41% (45 aa)

GTPEYIAPEVILR-RGYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVISEDVEY-----PEEDEA-LPPEAADLCRRLLEKNPAERLGTLN-GAA
|||.|.||||... .||.. .||| || |.||.|||. ||...||.  . |...            . || | |||.|| |||.  .| .|||  . |. 
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

QLMAHEFF
.  .| ||
EIKSHPFF
Kinase kin-4.AA TyrKc 358-627 18 4.2e-13 -10.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 358-627
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

FDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMA--DNPFVVSFYGSFETR-------QYLCMLMEYVEGGDCAALLK
   ..   .||.| ||. . .   .  | |.... .      .     |  |...   ..| .| .||   .        . |...|||...||.   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SAGT-LPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMN-RTTLVAEGYDAVVETQQFQDKQ--LCGTPE---YIAP
. .  |...    .        ||||| ...||||   | |... ...| .|||||. .    ..          ....    |.   . |.      ||
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---------ESKDYYRKKEHKGGKTMLPIRWMAP

EVILRRGYGKPVDWWALGIILYEFL-VGIVPFFG-----ETPEALFSKVISEDVEYPEED--EAL-----PPEAADLCRRLLEKNPAERLGTLNGAAQL
|.|  . .    | |. |. ..| .  |  |  |      ... .. .| . .   . ..  . .     |.|  .. ..  . .|..|    .   ..
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase kin-4.AA Pkinase_Tyr 358-504 24 1.1e-09 33.48 Pfam 1-159 (270) Show / Hide 
Range on Protein: 358-504
Range on HMM: 1-159/270
Sequence Identity: 24% (39 aa)

FDTIRLVSNGAYGAVYLVRHR----ETRQRFALKKMNKQTLMLRN-QVDQVFAERDILTMA-DNPFVVSFYGSFE-TRQY--LCMLMEYVEGGDCAALLK
   ..    ||.| ||. . .    .|..  | |.. |.. | ..   .  ..|  |..   ..| .|..||     ..   ... |||...||    |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

S----AGTLPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSK
.     . |...    . ..   . |||.| ...||||   | |.|  ...| .||||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase kin-4.AA APH 360-474 17 0.005051 11.19 Pfam 1-112 (248) Show / Hide 
Range on Protein: 360-474
Range on HMM: 1-112/248
Sequence Identity: 17% (21 aa)

TIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQ----TLMLRNQVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLKSAGT-LP
..| .| |. ...|.... . |.|. |.  ...    .|    .. ...|...|   .  | |. .    |   ..  |||...| | ..      . |.
WWRPISGGWSNRTYYRTTDD-RPRYVLRRYPPPWWAEELHREHRWLRHLAAHGIP--VPVPRVLWGCTDDEFHGWPWYLMEWLPGEDLWRW-----HALH

VELVRLYVAETILAIEYLHS
 . .. .... . ..  ||.
CAQRPALLEALARFLARLHQ
Kinase kin-4.AA APH 476-506 17 0.227504 5.55 Pfam 171-205 (248) Show / Hide 
Range on Protein: 476-506
Range on HMM: 171-205/248
Sequence Identity: 17% (6 aa)

GIVHRDLKPDNLLIT-AMGHIK---LTDFGLSKIG
...|.|..|.|.... . .  .   . |.. . .|
CWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDACWG
PDZ kin-4.AA PDZ 982-1063 25 2.4e-12 48.27 SMART 1-80 (80) Show / Hide 
Range on Protein: 982-1063
Range on HMM: 1-80/80
Sequence Identity: 25% (24 aa)

FGFGFTLKSVRVYLGEHSEYYTIEHIVTAVVEGSPAFHAN------LQAEDMITHVNG-HPVHNLTHPQLMHRLLANGN-----ELILRLVPLA
 |.||....               .... ||.|.|| .|       |.. |.|. |||  || |.|| | . .| . |.     .. | ...  
GGLGFSIVG--------------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ kin-4.AA PDZ 974-1060 20 1.5e-07 28.4 Pfam 1-86 (86) Show / Hide 
Range on Protein: 974-1060
Range on HMM: 1-86/86
Sequence Identity: 20% (19 aa)

TITIRK--GPFGFGFTLKSVRVYLGEHSEYYTIEHIVTAVVEGSPAFHAN--LQAEDMITHVNGHPVHNLTHPQLMHRLLANGN-ELILRLV
..|. |  .. |.||..|..    .        . ... |..||.| ..   ... |.|. .|| .. |.|| . .  .   .. |. | . 
QVTLEKQDKRGGLGFSIKGGNDQRH------DQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ