let-502

Species: Nematode worm
Alias: let-502, CE08098, aSWK004, C10H11.9
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 4744310-4738251, WormBase Genetic Map location: I:-0.614415,

Classification

Group: AGC
Family: DMPK
Subfamily: ROCK

Sequence

Name Sequence Type Origin Length Description Download
let-502.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
let-502.AA Protein Genbank 1173 None Fasta, JSON

Protein domain

Protein domains of let-502.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase let-502.AA DMPK 68-330 61 6.9e-277 695.06 In-house 1-270 (270) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-270/270
Sequence Identity: 61% (166 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYE--VSEK
|..|||||||.||||..|||..||.||||||.||..|.|||..|.||||||||.|.||.||..|.|||||...|||||||||||||..||..||  ..|.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

WTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQD--AEFGKEVDWWSVGVFIYEM
..|||.||.| |. ..|.|||.|||.||||||....|||||||||.|.|||..|.||...|||||||||||||.....|  ...|.|.|||||||..|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LVGETPFYAEALVSTYTNIMNH-KTSLKFPDEPL--ISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFF
|.|||||||..||.||..|||| |..|.|||.|   .|..|||.|...|... .|||||...|...|.||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF

Kinase let-502.AA ROCK 68-330 74 7.4e-207 693.49 In-house 1-263 (263) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-263/263
Sequence Identity: 74% (197 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEVSEKWT
|...|||||||||||.||||.....|||||||.|..||||.|||||||||||||||||||||.|.|||||.|.|||||.|||||||||||..|.|.|||.
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEKWA

RFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWSVGVFIYEMLVGE
||||.|.|.||.|.||||.|||||||||||....||.||||||||.|||.||.|||.||||||||||||||..||||.|.|.|.|||||||||||||||.
RFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGD

TPFYAEALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFF
|||||..||.||..||.||.||||||.. ||.||||.|.|||.....|||||.||||..||||
TPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF

Kinase let-502.AA AGC 68-330 30 8.49999999999e-167 435.34 In-house 1-395 (395) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-395/395
Sequence Identity: 30% (123 aa)

FRQLKVIGRGAFGEVHLVRHT------RTNTVYAMKMLNKDD--------MIKRADSAF-------FWEERDIMAHAN----------SEWIVR-LQYAF
|. |||||.|.||.|.|||.        |. .||||.|.|..        |.... ...       .||||.|....|          . .||. | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDPRH--LYMVMEYMP--------GGDLVNLMTSY------EVSEKWTRFYTAE-------IVEALAALHS-MGYIHRD-VKPDNMLISISGHIKLADFG
||..|  ||.||||||        ||..  ..  .        .|...|||.||       || ||  ||| ||.|||| .||.|.|.   |||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TCVKMNANG-------------------------------------------------VVRCSTAVG--TPDYISPEVLRNQGQDAEFGKEVDWWS--VG
 | ... .|                                                  .|..| .|  ||.|..||.|         ||..||||  .|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWWSFGLG

VFIYEMLVGETPFYAEALV----------STYTNIMNH----KTSLKFP--------DEPLISTQAKDIIKKFLS-AAPDRLGRNS-------VDDIRNH
...||||.| .|||..  .           .. .|||.    .  .|||        ... .| .|||.|||.|     .||| .        ...|.||
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

KFF
..|
PWF

Kinase let-502.AA GEK 68-330 52 4.6e-123 415.15 In-house 1-269 (269) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-269/269
Sequence Identity: 52% (141 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYE--VSEK
|  ||||||||||||  |.   |. |||||.||| .|.|||. | | ||||.. .  . || .| ||||| ..||.||.|  ||||. |.  .|  . |.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

WTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLR--NQGQDAEFGKEVDWWSVGVFIYEM
  ||| ||.| |. ..| ..|.|||.||||.|.   |||.||||| |..||..|.|. . |||||||||||.|.  ..|   ..|.| ||||.||..|||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDG-KGRYGPECDWWSLGVCMYEM

LVGETPFYAEALVSTYTNIMNHKTSLKFPDEPL---ISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFF
| |||||||| || ||  |||||  ..||..     .| .|||.|.. .  .  ||||| ..| ..| ||
LYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF

Kinase let-502.AA CRIK 68-330 44 1.1e-116 373.6 In-house 1-272 (272) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-272/272
Sequence Identity: 44% (123 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYE--VSEK
|    .||.| ||.|..||   || .|||| . |  .  . . .|| ||||||. .||.|. .|||||||  .|| .|||.|||||  ||  ..    | 
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

WTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQD----AEFGKEVDWWSVGVFIY
  ||| || . |.  || |||.|||.||.| ||   |||||||||   ||| |. |     ||||||. ||||     .    . .| . ||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLVGETPFYAEALVSTYTNIMN------HKTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFF
|| .| |||     . || ||||       .  |.||| | .| .. | |.  |     ||   .   . .| ||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF

Kinase let-502.AA S_TKc 68-330 33 8.8e-96 325.43 SMART 1-231 (231) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPG--GDLVNLMTSYE----
.. |..||.||||.|...||..|. ..|.|...            .. |..|. . . ..||.| ..|||  ||||||||..|  |||  .. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGK-EVDWWSVG
    .| ..|||...|..||. .||.| ||||.||.| |..   |||..||| . ..        .| .|||.|..||||        .|| ..||||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

VFIYEMLVGETPFYAEALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPD-RLGRNSVDD----IRNHKFF
. .||||.|..||.   .  .. .|.              | .|||.|.| |   |. |..   .      |..| .|
CILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase let-502.AA RSK 71-330 37 3e-85 289.52 In-house 1-278 (278) Show / Hide
Range on Protein: 71-330
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

LKVIGRGAFGEVHLVRHT---RTNTVYAMKMLNKDDMIKRA-DSAFFWEERDIMAHAN-SEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEV---
||| |.|..|.| |.| .    |...|||| |.|  ...|. | .  ..||.|... . .  ||.| ||||.. .||..|||..||.|       .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

-SEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISI---SGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLR-NQGQDAEFGKEVDWWSVG
 ||.  .|| |||| |.  ||. | |||| ||.|.|      .||||| ||| | .....   .  | ..| .|. ||.|.  . |.   .| .|||| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLG

VFIYEMLVGETPFYA---EALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAP-DRLG--RNSVDDIRNHKFF
| .||||.| .||..   .    . ..|.. | ||..|  . .|. |||.|.| |   | .|||  .. ...|..|..|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase let-502.AA Akt 68-330 40 3.3e-84 269.08 In-house 1-264 (264) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-264/264
Sequence Identity: 40% (110 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVY-AMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEV-SEK
|. |||.|.|.|| | ||.   |. .| |||.| ||  |..   .    || |  | |.  || | |.||.. .||.||.|..||.| ...   .. ||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

WTRFYTAEIVEALAALHSMGYIHRD-VKPDNMLISISGHIKLADFGTCVKMN-ANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWS-VGVFIYE
 .||| |||. |. .|||.. | ||  || | |..  |||.|.||| | |.|      .. |  ||| |..||.| ..|    ..| ||||. .|...||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC-KENIIKDHDKTKTFCGTPEYLAPEILNGNG----HTKAVDWWGSLGCVMYE

MLVGETPFYAEALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPD-RLG--RNSVDDIRNHKFF
|. |  |||..     . .|.| .  .|||| . || ..||.|.. |.  |. |||   | ...|..| .|
MMCGRPPFYNQDHHQMFKKIKNQP--VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF

Kinase let-502.AA NDR 68-210 51 1.9e-79 244.55 In-house 1-149 (350) Show / Hide
Range on Protein: 68-210
Range on HMM: 1-149/350
Sequence Identity: 51% (77 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHAN--SEWIVRLQYAFQDPRHLYMVMEYMPGGDLVN---LMTSYEV
|  .|.||.|||||| |||.  |. .|||| ..| .|...   |    |||||| |.  ..|.|.| |.|||. .|| ||||.||||.     |   ...
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

-SEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFG
 .| |.||| ||.|.|. ..|.|||||||.|||| ||   ||||| |||
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG

Kinase let-502.AA Pkinase 68-330 32 5.4e-70 243.65 Pfam 1-293 (293) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFW-EERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGG----DLVNLMT---S
.. ...||.|.||.| . .|  |. ..|.| ..|..  .  | . ..  |  ||.. |.. |||| ..|.|..|.||||||..||    ||  ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

YEV--SEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHI----KLADFGTCVKM-NANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVD
  .  ||.  .||  .|...|. .|||| ||||.||.| ||.  |||    |..||| . .. . |..  ..| .|||.|..|||.|    . . |..||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR---GGQYYGPKVD

WWSVGVFIYEMLVGETPFYAE------ALVSTYTNIMNHKTSLKFPDEPLIS-----------------TQAKDIIKKFLSAAPDRLGRNSVDDIRNHKF
.||.|. .|||| |..||. .           . .||  ...  .| .  ||                   .||.||. |   | .  | . ..| .|..
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK--RPTAEQILQHPW

F
|
F

Kinase let-502.AA MAST 68-210 44 2.5e-62 188.96 In-house 1-147 (337) Show / Hide
Range on Protein: 68-210
Range on HMM: 1-147/337
Sequence Identity: 44% (67 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKR--ADSAFFWEERDIMAHANSEWIVRLQYAFQD--PRHLYMVMEYMPGGDLVNLMTSYE--
|  .|.|..||.| | ||.| .||  .||| .|..|.|..   |..|   ||.| . .  ...| . |.||    ..|.|||||| |||   |. .|   
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFV--ERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNC

VSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFG
  |  ...|.||.| .|  |||.| .|||.|||||||   |||||.|||
MPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG

Kinase let-502.AA MAST 68-210 46 9.7e-61 194.39 In-house 1-144 (334) Show / Hide
Range on Protein: 68-210
Range on HMM: 1-144/334
Sequence Identity: 46% (68 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKR--ADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSY-EVSE
|   |.|..||.| | ||.| .||  .||| ..|.|||..   |. .   ||.| | . ....| . |.||  ..|.|||||| |||.  |. .|    |
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQV--ERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDE

KWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFG
  ...|.||.| .|  |||.| .|||.|||||||. .|||||.|||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG

Kinase let-502.AA NDR 226-330 38 2.3e-44 134.35 In-house 241-350 (350) Show / Hide
Range on Protein: 226-330
Range on HMM: 241-350/350
Sequence Identity: 38% (44 aa)

AVGTPDYISPEVLRN-QGQDAEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYTNIMNHKTSL-----KFPDEPLISTQAKDIIKKFLS-AAPDRLGR
.||||||. |||. . .|..    ...||||.|.  |||||| .||...    |. .||| |. .      || |  .| .|.| |....   .  |||.
TVGTPDYMAPEVFQQKTGYN----QTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGS

NS--VDDIRNHKFF
.   ||.|..| ||
HGKGVDEIKSHPFF

Kinase let-502.AA MAST 227-330 43 1.4e-37 111.92 In-house 229-337 (337) Show / Hide
Range on Protein: 227-330
Range on HMM: 229-337/337
Sequence Identity: 43% (49 aa)

VGTPDYISPEVLRNQG-QDAEFGKEVDWWSVGVFIYEMLVGETPFYAEALVS-TYTNIMNHKTSLKFPDE------PLISTQAKDIIKKFLSAAP-DRLG
.||||||.|||.  || .    || |||||.|. .|| |||..|| ..     .  || ||.  . .|.|        .|  |.|.|||.|   | .|||
CGTPDYIAPEVILGQGTY----GKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

RNSVDDIRNHKFF
 | .|.| .|.||
ANGADEIKQHPFF

Kinase let-502.AA MAST 227-330 39 2.6e-34 107.76 In-house 225-334 (334) Show / Hide
Range on Protein: 227-330
Range on HMM: 225-334/334
Sequence Identity: 39% (45 aa)

VGTPDYISPEVLRNQG-QDAEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYTNIMNHK---TSLKFP----DEPLISTQAKDIIKKFLSAAP-DRLG
.||||||.|||. .|| .    || |||||.|. .|| ||| .||  .    .. || |..   ... ..    |.  .|  |.|.|.|.|   | .|||
CGTPDYIAPEVILGQGTH----GKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

RN-SVDDIRNHKFF
 |  .|.. .|.||
ANNGADEVKQHPFF

Kinase let-502.AA Pkinase_Tyr 68-210 30 4e-16 55.24 Pfam 1-156 (270) Show / Hide
Range on Protein: 68-210
Range on HMM: 1-156/270
Sequence Identity: 30% (48 aa)

FRQLKVIGRGAFGEVHLVRHT----RTNTVYAMKMLNKDDMIK---RADSAFFWEERDIMAHA-NSEWIVRLQYAFQ-DPRH--LYMVMEYMPGGDLVNL
 . .|..|.||||||.. . .     |..  | |||. . | .   |.|   | .|  || .  . . ||||  .   . ..  .|.||||||.||| . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCRED---FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

MTSY-----EVSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFG
  .       .. |.   . ..| .... |.|...||||.   | |.. ....| .|||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG

Kinase let-502.AA TyrKc 68-330 22 3.7e-14 6.24 SMART 1-280 (280) Show / Hide
Range on Protein: 68-330
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHA--NSEWIVRLQYAFQDP-------RHLYMVMEYMPGGDLVNLMT
 . .|..|.||||||.. . .   .  | |||..|        . | .|  || .   . . ||||  .  ..         |..||||||.||| .   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SYE--VSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNAN-------GVVRCSTAVGTPD-----YISPEVLRNQGQD
...  .. |    .   | .  . |||...||||    | |..  ...| .||| . .            . | ..  |. .       .||..    ..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

AEFGKEVDWWSVGVFIYEMLVGETPFYAE-----ALVSTYTNIMNHKTSLKFPDEPL------ISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFF
 .|  . | || || ..|..    . | .        .   .   .   .. |....       ..   .|.|.   . |.   | .  .|  |..|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED--RPTFSEI--HECF

Pkinase_C let-502.AA Pkinase_C 350-396 31 2.2e-09 36.34 Pfam 1-46 (46) Show / Hide
Range on Protein: 350-396
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

SLKSDDDTTHFEEIETRDRDNAGDFQLPKTFNGNQLPFIGFTYSNEY
 .||..|| .|.. .|. ...      .  ..|.|.||.||||.|..
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD

S_TK_X let-502.AA S_TK_X 333-394 22 1.4e-07 32.45 SMART 1-79 (79) Show / Hide
Range on Protein: 333-394
Range on HMM: 1-79/79
Sequence Identity: 22% (18 aa)

DEWTFATLR----EASPPVIPSLK----SDDDTTHFEEIETRDRDNAGDFQLPKTFNGNQLP----------FIGFTYSN
... . .|.    |  || .| .|    |. ||  |.. .|.  .   . . |  .|... .          |.||||..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF

C1 let-502.AA C1 1060-1112 19 1.2e-12 49.28 SMART 1-61 (61) Show / Hide
Range on Protein: 1060-1112
Range on HMM: 1-61/61
Sequence Identity: 19% (12 aa)

HDFQELSYHIRTFCDVCNKKLSDIIRPTP---AFECKNCHFKTHKDHVAQGSLP------MC
|.... ..  .|.|..|.|... . ....   ...| .|..| ||..... ...      ||
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC

C1_1 let-502.AA C1_1 1060-1102 19 2.8e-05 23.04 Pfam 1-43 (55) Show / Hide
Range on Protein: 1060-1102
Range on HMM: 1-43/55
Sequence Identity: 19% (9 aa)

HDFQEL-SYHIRTFCDVCNKKLSDIIRP---TPAFECKNCHFKTHKD
|....  ..   |||..|.. .    ..    ... | .||.. |..
HHWVHHWNFKQPTFCCHCGEFC----WGWLGHQGWKCQWCHYNCHHR

PH let-502.AA PH 951-1146 8 8.5e-05 23.19 SMART 1-82 (82) Show / Hide
Range on Protein: 951-1146
Range on HMM: 1-82/82
Sequence Identity: 8% (16 aa)

IQMEGWLSLRDNTKKSRKPKWTNCFVALNEYSFTIYVDEKAVSVILLIEAGAMAHVRHVTAADLRNVDDSQLPKIFHIMYDDASCNSSRHASNSDLSMIE
...||||. .       | .|. ... | . ....| |.|   .| | ..     .                                            
VIKEGWLYKKS------K-RWKKRWFVLFNDCLYYYKDKKPKGSIPLSDCTVRE-P--------------------------------------------

SFREESWKRHDFQELSYHIRTFCDVCNKKLSDIIRPTPAFECKNCHFKTHKDHVAQGSLPMCRYNTGLSRELVLMAPQTDNCNKWVSQLRRFIESS
                                      .|| .. .                        .... ..  . ...|.. ... |...
--------------------------------------CFEIHH-DR-----------------------TYYFQCESEEEMQEWMQAIQKAIHNN