Gene old-2 (Nematode worm)

old-2

Species: Nematode worm
Alias: aSWK392, tkr-2, CE03838, ZK938.5, old-2
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 9849501-9847387, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: KIN16

Sequence

Name Sequence Type Origin Length Description Download
old-2.AA Protein Genbank 498 None Fasta, JSON
old-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 287 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of old-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase old-2.AA KIN16 171-457 52 9.20000000001e-231 684.51 In-house 1-332 (332) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-332/332
Sequence Identity: 52% (173 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKN-KETESRLEVAVKSPLNEYNHIQQELIYDELKVMCAVGKHPNILALVGGITIGEK------RMIISELVENGD
.....|||||.||..|||.|..||.|| ||...|||||||||.|.....||..||||||||||.|||||.|||||..|....       ||..|.||.||
LEFEEPLGSGHFGVVRKGLLHMKNPKNEKEHKNRLEVAVKSPANPHDICQQKMIYDELKVMCAIGKHPNVLALVGAVTKNMRQGGRHMLMIVTEYVECGD

LLSFLRKNRRNFTIDQLAFEPEKP-------------------------------SLGLVDLVSFAFQIAKGMEYLIHVPC-VHRDLALRNVLIKGNMVI
|..|||..|.||. .|.  . |.                                || ..||.|||.|||.|||.|.|||| ||||||.|||.|| |..|
LRKFLRQHRNNFQNHQVCWDNERQSGYNINNKERKHYVFKNFCENEQLVIKDIFDSLCTSDLLSFAYQIANGMEWLAHVPCCVHRDLACRNVFIKRNKII

RIADFGLARRHKNKDYYKTQS-VDTPLPIHWMAPESIDK-----LLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQP
|||||||||.|.|||||...| .|||||..|||||...      . ||.|||||||||||||.||||..||.|......||.|..||..||..|.||.||
RIADFGLARWHENKDYYRMKSSMDTPLPMRWMAPECFEEEQERKMKFTEKSDVWSYGVCLYEIFSLGETPYPNCPNNNCRDDYFQYVMEYLRKGNRLPQP

AHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
.|...|||..||.||..|...|.|| .|.|||
EHCHPEIYDFMKMCWNFDPEKRPTFSECVEFF
Kinase old-2.AA TyrKc 171-457 36 1.3e-125 424.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-280/280
Sequence Identity: 36% (113 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQQELIYDELKVMCAVG-KHPNILALVGGITIG-------EKRMIISELVENG
|..|. ||.|.||...|| ..            ..||||.  ..     .| ...|...|| .| .||||..|.| .| .       |  ||. |....|
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLLSFLRKNRRNFTIDQLAFEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRHKNK-------DYYKTQ---S
||...|||.|..              | . ||.||..|||.||||| . .|.||||| ||.|.. | ...|.||||.| ....       |||...   .
DLKDYLRKHRPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

VDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAH--------ADAEIYNVMKLCWDLDM
 .|.||| |||||.|..  || ||||||.|||..|.|..|..|| ..|.    .   . |..|. .|.|. ||..        . .|.|..|| ||. | 
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

NSRTTFLDCIEFF
..| || ...|.|
EDRPTFSEIHECF
Kinase old-2.AA Pkinase_Tyr 171-457 39 1.9e-119 405.19 Pfam 1-270 (270) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-270/270
Sequence Identity: 39% (115 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQ--QELIYDELKVMCAVGKHPNILALVGGIT-IGEK--RMIISELVENGDLL
|..|. ||.|.|| ..|| ..      .. . ...||||.  . . | |  .|    |.|.|.  |.||||. |.| .|  ||    .|. |....||||
ITFGKKLGEGAFGEVYKGTWKG-----DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

SFLRKNRRNFTIDQLAFEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPE
..|||.|           ..|..| . ||.....|||||||||   .|.||||| ||.|.. |.|..|.|||||| . |.||| ... ...||| |||||
DYLRKHR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPE

SIDKLLFTQKSDVWSYGVCLYELFSLGKSP-YKNVIKYDERDSYCKYVLAYL-NEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
.|    || ||||||.||...|.|..|..| |...  ..        |..|.  .| |...| .. .|||..||.||. | . | || ...|..
CINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE--------VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase old-2.AA TK 171-457 25 7.8e-99 331.98 In-house 1-486 (486) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

ISKGRPLGSGEFG---IIRKGFLRSKNSKNK----------------ETESRLEVAVKSPLNEYNHIQQELIY----------------DELKVMCA-VG
|  |. ||.|.||    ..|| .|..| .|                 ... . .||||    . .. |.| .                  |.|.||. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNILALVGGITIG------------EKRMIISELVENGD----LLSFLRKNRRNFTIDQLAFE-----------------------------------
.||||. |.| .| |            |  ||. |....||    |...|||.|..|.  |   .                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------PEKPSLGLVDLVS-------------------FAFQIAKGMEYLIHVPC------VHRDLALRNVLIKGNMV-----------IRIADFG----
      .. |.|.. ||..                   ...|||.|||||   .|      |||||| ||.|.  |.|           ..|||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARRHKN-KDYYKTQSVDT----------------------PLPIHWMAPESID---------KLLFTQKSDVWSYGVCLYELFSLG-KSPYKNVI
    |||.. . .|||...| .|                       ||| |||||...         .  || ||||||.||...|.|..| . .| .. 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

KYDERDS-YCKYVLAYLNEG--------------KRLAQPAHAD--------------AEIYNVMKLCWDLDMNSRTTFLDCIEFF
  |   . ... |. || .|               |..||.|.               .|.| .|. ||..| . | || .. |..
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase old-2.AA TK-Unique 171-457 33 1.8e-70 240.45 In-house 1-294 (294) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-294/294
Sequence Identity: 33% (101 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQ-QELIYDELKVMCAVGKHPNILALVGGIT-IGEKRMIISELVENGDLLSFL
.  |. .|.|.|| . .| .....   |. . .  ||||  |..... . .    .|...| ..|.||||. ..|  |  .|  ||| | ...|.|...|
LEVGDVIGEGAFGQVWRGEVWGIW---KHWDKQKCVAVKM-LKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL

RKNRRN-FTI-------DQLAFEPEKPS---LGLVDLVSFAFQIAKGMEYLIH--VPCVHRDLALRNVLIKGNMVIRIADFGLARRHKNKDYYKTQSVDT
|..|.. ..          .. .|.||.   . . ||..||.|||.|||||      .|||||. ||||. .. |. |.|||.||.  .   | ..    
RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

PLPIHWMAPESID--KLLF-TQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAHA-DAEIYNVMKLCWDLDMNSRTTFL
..|| ||||||.   .  . | ||||||.|| ..|.|.||. || .. . |        ..  . .|.|. ||.|    |.||.|| || ..  .| .| 
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD--------IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFR

DCIEFF
...  .
QIKHRL
Kinase old-2.AA UTK 171-457 29 8.7e-63 213.62 In-house 1-296 (296) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-296/296
Sequence Identity: 29% (97 aa)

ISKGRPLGSGEFGIIRKGFLR---------------SKNSKNKETESR-----LEVAVKSPLNEYNHIQQELIYDELKVMCAVGKHPNILALVGGITIGE
.  ||.||.|.||...|. ..                ........|..     .| |                  || .| ..  |||.| |||  | .|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEAR-----------------ELQMMKQFHWHPNVLRLVGVCTQEE

KRMIISELVENGDLLSFLRKNRRNFTIDQLAFEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGN-------MVIRIADFG---LAR
  ||..|. |||||.|.||..|...        ..  .| | .....| .|| ||.||    .|||||| ||.|.  .       ||..|||||   ..|
PWMIVTEYMENGDLRSYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSR

RHKN--------KDYYKTQSVDTPLPIHWMAPESIDKL-LFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEG--KRLAQPAHAD
| ..         .|| ........|| |||||....   ||.||||||.|| ..|... |. ||..    .        |.. . .|   |...|..  
RVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQ--------VWHQVCNGGRYRMPCPWDCP

AEIYNVMKLCWDLDMNSRTTFLDCIEFF
...|..|. ||  |   | .| |  ...
HPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase old-2.AA FGFR 171-457 35 3.2e-61 207.38 In-house 1-293 (293) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-293/293
Sequence Identity: 35% (109 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQQELIY--DELKVMCAVGKHPNILALVGGITIGEKRMIISELVENGDLLSFL
 . | .|| | || . ..    |  ... .|    ||||  | . ||  ..|.    |. .|  .|||.||. | |  | .    .| |. . | |  ||
LTLGKMLGEGCFGQVWMA--EAKGIDCDRPEKEITVAVKM-LKM-NHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFL

RKNR---RNFTIDQL-------AFEPEK------PSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRHKNKDYYKTQS
|..|   .    |             ..      | |.  ||||.|.|.|.|||||    |.||||| ||||.  . |. |.||||||  .. |||.  .
RARRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTT

VDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLD
 .  ||| |||||. .   .| .|||||||| | | . .| .||  .    |         .|| ||.|.  |..   ||| .|  ||      | ||  
-NGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEE-------LYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQ

CIEFF
 .| .
LVEYL
Kinase old-2.AA Src 171-457 32 4.1e-56 189.13 In-house 1-255 (255) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-255/255
Sequence Identity: 32% (94 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQQELIYDELKVMCAVGKHPNILALVGGITIGEKRMIISELVENGDLLSFLRK
|   | ||.| ||   .|  . .           .||||. | . .  ..|    | ..|  . .|.....|    . .|   |. |. ..| || .|.|
IKLCRKLGQGQFGEVWMGYWNGN----------TKVAVKT-LKPGT-MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK

NRRNFTIDQLAFEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRHK-NKDYYKTQSVDTPLPIHWMAPESIDK
            ..|  .| | .|...| |.|.||.||     .||||| ||||.  | |  .|||||||  | ..| |  .. .  .|| |.||| |. 
------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH-GAKFPIKWTAPEAINY

LLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAHADAEIYN-VMKLCWDLDMNSRTTFLDCIEFF
  ||.||||||.|. |.|... |. ||.   . .        ||  .  | |. .|..  .|.|. .|. ||. |   | ||    .|.
GRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHE--------VLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase old-2.AA EGFR 171-458 32 1.3e-53 176.27 In-house 1-258 (258) Show / Hide 
Range on Protein: 171-458
Range on HMM: 1-258/258
Sequence Identity: 32% (95 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQQELIYDELKVMCAVGKHPNILALVGGITIGEKRMIISELVENGDLLSFLRK
. |.. |||| || . ||    .  .|     .  ||.|   .. .  ..| . || .||  | .||... |. |. .... ...  .   | || ..|.
LKKVKVLGSGAFGTVYKGIWIPE-GEN----VKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLL-GVCMHSQMQLVTQYMPYGCLLDYVRQ

NRRNFTIDQLAFEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLAR-RHKNKDYYKTQSVDTPLPIHWMAPESIDK
.. |              .|  .|. ...||||||.||     |||||| ||||.|    ..|.|||||.  ..... |. |.  .  || ||| |.| .
HKDN--------------IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKM--PIKWMALECIHH

LLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFFE
  .| .|||||||| . ||   |..||...   .        .   | .|.||.||      .| ||  || .| ..| ||   .| |.
RCYTHQSDVWSYGVTCWELMTFGQKPYDGIPARE--------IPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase old-2.AA Met 293-451 36 3.7e-47 152.5 In-house 105-271 (271) Show / Hide 
Range on Protein: 293-451
Range on HMM: 105-271/271
Sequence Identity: 36% (63 aa)

DLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRH-KNKDYYKTQSVDT--PLPIHWMAPESID--------KLL-FTQKSDVWS
||..|..|.||||.|.     |||||| || ..   ... .|||||.|     | ||  ..      ||. |||||.          .   || ||||||
DLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWS

YGVCLYELFSLGKSPYKNVIK-YDERDSYCKYVLAYLNEG--KRLAQPAHADAEIY-NVMKLCWDLDMNSRTTFL
 || . ||.  | .|| .|    |        .. .| .|  .|| || .    .|  ||  ||  .   | .| 
FGVVMWELMTRGAPPYPHVDNWFD--------ITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase old-2.AA VEGFR 289-396 53 1.2e-45 157.97 In-house 170-278 (332) Show / Hide 
Range on Protein: 289-396
Range on HMM: 170-278/332
Sequence Identity: 53% (59 aa)

LGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARR--HKNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLY
| ..||....||.|.|||.|    |.||||| ||.|.  | |. | ||||||    |. | |...   . ||| |||||||    .| .|||||||| | 
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPD-YVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLW

ELFSLGKSPY
| ||||.|||
EIFSLGGSPY
Kinase old-2.AA PDGFR 276-396 47 1.2e-42 134.49 In-house 185-304 (358) Show / Hide 
Range on Protein: 276-396
Range on HMM: 185-304/358
Sequence Identity: 47% (58 aa)

TIDQLAFEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQK
.....  | . . | . ||..|..|.|||||.|    ||||||| ||||.    |. | ||||||  .|   |      . ||. |||||||   ..| .
DVKNELMEDDSNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKG-NARLPVKWMAPESIFDCVYTTQ

SDVWSYGVCLYELFSLGKSPY
|||||||. | |.|||| .||
SDVWSYGILLWEIFSLGGNPY
Kinase old-2.AA Pkinase 171-457 21 4.7e-31 110.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-293/293
Sequence Identity: 21% (71 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQQE-----LIYDELKVMCAVGKHPNILALVGGITIGEKRMIISELVENG---
. .||..||| ||  .|.  .. .          .||||    . .. ...     |   |...|  . .||||. | .  . . .  .. |..|.|   
YHIGRKIGSGSFGCVYKCHHKGTGK---------IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYV

-DLLSFLRKNRRNFTIDQLAFEPEKPSL--GLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVI----RIADFGLARR--HKNKDYYKTQSV
 || ....               .. ..     .. ... ||..|.||.    ..|||| . |.||. |..|    .|.|||||.   . |.  ..|  .
MDLFDYIST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG

DTPLPIHWMAPESID-KLLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAHAD---------------------AE
     ...|||| |      ..|.|.||.|. |||... |. |... .  .. . ...... ... |..|  .   .                      |
T----PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHC--WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

IYNVMKLCWDLDMNSRTTFLDCIEF--F
   ..| |...|...| |. .. .   |
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase old-2.AA S_TKc 171-457 21 1.5e-29 105.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 171-457
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

ISKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQQELIYDELKVMCAVGKHPNILALVGGITIGEKRMIISELVEN--GDLLSFL
  ..|..|.| ||  .|.  ..         .  .||.|           | |. |....    .||||  | . .   ..  .. |....  |||....
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

RKNRRN-----FTIDQLAFEPEKPSLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMA
.|..|.     |.  . .|              .. ||....||.     .||||   |.|.    .| |.||||||.                  ..||
KKRGRHGLRFPFPE-HARF--------------YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMA

PESIDKLLFTQ-KSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIE-------
|| .    ..  |.|.|| |..|||... |. |.       . .   | ..               . |  . .. |.. | . | |  .. .       
PEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP------QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

--FF
  .|
HPWF
Kinase old-2.AA PDGFR 418-457 50 3.6e-13 38.28 In-house 319-358 (358) Show / Hide 
Range on Protein: 418-457
Range on HMM: 319-358/358
Sequence Identity: 50% (20 aa)

EGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
|| | |||.|| .||| .|. |||.|   | ||    .| 
EGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase old-2.AA PDGFR 226-275 44 1.2e-07 20.2 In-house 52-101 (358) Show / Hide 
Range on Protein: 226-275
Range on HMM: 52-101/358
Sequence Identity: 44% (22 aa)

ELKVMCAVGKHPNILALVGGITIGEKRMIISELVENGDLLSFLRKNRRNF
|||.|   |.| ||  | |  |.|    || |    |||| .|...|  |
ELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHSF
Kinase old-2.AA Met 172-280 23 3.1e-07 19.44 In-house 1-106 (271) Show / Hide 
Range on Protein: 172-280
Range on HMM: 1-106/271
Sequence Identity: 23% (27 aa)

SKGRPLGSGEFGIIRKGFLRSKNSKNKETESRLEVAVKSPLN-----EYNHIQQELIYDELKVMCAVGKHPNILALVGGITIGEKR---MIISELVENGD
 .....| | || . .| .. . ..      .  .|.|| |.     . .||  .  . |  .|    .|||.|.|. || .       ... .  ..||
HFDDVIGQGHFGCVYHGMYHDNDGN------EHHCACKS-LHGERITDIQHI--SQFLREGIMMKHF-DHPNVLSLI-GICLDPEGHMPWVVLPYMKHGD

LLSFLRKNRRNFTIDQL
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LKTFIRNPQNNPCVRDL
Kinase old-2.AA VEGFR 226-275 32 8.1e-07 21.95 In-house 52-104 (332) Show / Hide 
Range on Protein: 226-275
Range on HMM: 52-104/332
Sequence Identity: 32% (17 aa)

ELKVMCAVGKHPNILALVGGITI---GEKRMIISELVENGDLLSFLRKNRRNF
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ELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTKRMYF
Kinase old-2.AA VEGFR 416-457 30 0.000151 13.3 In-house 291-332 (332) Show / Hide 
Range on Protein: 416-457
Range on HMM: 291-332/332
Sequence Identity: 30% (13 aa)

LNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFF
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LKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL