Gene pdk-1 (Nematode worm)

pdk-1

Species: Nematode worm
Alias: H42K12.1A, H42K12.1, pdk-1, CE28739, H42K12.1H33H01.a, aSWK010, H42K12.1a
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 1325155-1331789, WormBase Genetic Map location: X:-18.1753,

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
pdk-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
pdk-1.AA Protein Genbank 632 None Fasta, JSON

Protein domain

Protein domains of pdk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase pdk-1.AA PDK1 69-362 40 6.9e-189 584.33 In-house 1-307 (307) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-307/307
Sequence Identity: 40% (129 aa)

FMFLQSMGEGAYSQVFRCREVAT----DAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLC
| |    |||.|| |...||..|    ..|.|.|...|.|..|..|.....|||.|...|..||.|||....||..|.|....|||.....||||.....
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

H--FGSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSA---QAFG-GLQLSQEGFTDANQASSRSSDSGSPPPTRFYSDEE
.  ||||||....|.|.||...|..||.|.|.|||.||.|.|..||.||.|||||.|   ...  ..   |. |    | .....|             |
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMD-----------KPE

EENTARRTTFVGTALYVSPEMLADGDVGPQTDIWGLGCILFQCLAGQPPFRAV-----NQYHLLKRIQELDFSFPEG--FPEEASEIIAKILVRDPSTRI
|  ..|...|||||.|||||.|.|....|..|||.||||..|..|||||||..     |.||....|......||..  ||..|.....|.|||||..|.
EDKQTRCKSFVGTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRL

TS-------QELMAHKFF
||       |...||.||
TSCDECGGYQQIKAHPFF
Kinase pdk-1.AA AGC 69-362 21 4.90000000001e-119 308.99 In-house 1-395 (395) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-395/395
Sequence Identity: 21% (93 aa)

FMFLQSMGEGAYSQVFRCREV------ATDAMFAVKVLQKSY---LNRHQKMDAIIRE------------KNILTYLSQECGG------HPFVTQ-LYTH
| ||   |.|....|. .|..      .|. ..|.|||.|..   ........ ...|            .|||. ..... .      |||... |.  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTH-NHPIKSHHPFIVKILHYS

FHDQAR--IYFVIGLVE---------NG-DLGESLC---HFGSFDMLTSKFFASE-------ILTGLQFLHD-NKIVHRD-MKPDNVLIQKDGHILITDF
|.|. .  .|||  ...          | .|  .|.   . |.||  ...|.|.|       |. .|..||. ..|.||| .||.|.|. .|||| .|||
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

GSAQAFGGLQ---------------------------------LSQEGFTDANQASSRSSDSGSPPPTRFYSDEEEENTARRT------TFVG--TALYV
|..  . . .                                 . ...  .                     . |   |.|        ||.|  |. |.
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNN-MS---------------------Q-E-DDTTR-KKRDRTWTFCGPCTPEYM

SPEMLADGDVGPQTDIWG--LGCILFQCLAGQPPFRAVN----------QYHLLKRIQ------ELDFSFP----------EGFPEEASEIIAKILVRDP
.||.|     |.. |.|.  |||.... |.|.|||.. |          .. . ..|.      . .  ||          . | .||  .| | |..||
APEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDP

STRIT----------SQELMAHKFF
. |..           .|...|..|
EKRLGCGGNDFGDKGAEEIKNHPWF
Kinase pdk-1.AA S_TKc 69-362 26 5.8e-83 282.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

FMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVEN--GDLGESLCHF
. .|.  |.||...|..||.. |.  .|.|..           . |.|| .||        .||.. .|| .|.|  ..|.|  ....  ||| . ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

GS------FDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAQAFGGLQLSQEGFTDANQASSRSSDSGSPPPTRFYSDEEEE
|.      |.  . .|.. .|. .|...|...|.||| ||.|.|. .  || |.|||.|  .                                      
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------------

NTARRTTFVGTALYVSPEMLADGDVGP-QTDIWGLGCILFQCLAGQPPFRAVNQYHLLKRIQELDFSFPEGFPEEASEIIAKILVRDPSTRITSQELMA-
     |||.||  |..||.|     |.   |.| .||||. .|.|.|||.  ... ..|.|           ..|| ..| |.|..||. |.|  |... 
-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------HKFF
      | .|
EWDIKCHPWF
Kinase pdk-1.AA Pkinase 69-362 26 1.9e-67 235.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-293/293
Sequence Identity: 26% (90 aa)

FMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIR--EKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENG----DLG--
. ...  |.|....|..|... |  ..|||.. |.  ....|  . .|  |  |.  |.     ||.. .||  |.|  .||.|  ..|.|    ||   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

---ESLCHFGSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHI----LITDFGSAQAFGGLQLSQEGFTDANQASSRSSDSGSPPPTRF
   .. . |  |.. . ||.. .|| ||...|...|.|||.||.|.|| ..|||     |.|||.|  |                               
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------------------------

YSDEEEENTARRTTFVGTALYVSPEMLA-DGDVGPQTDIWGLGCILFQCLAGQPPFRAV------NQYHLLKRIQELDFSFPEGFP--------------
     . |    |||.||  |..|| .  . . ||  |.|..||||.. | |.|||.        .|.....|| . ...|..  .              
-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFH

-------EEASEIIAKILVRDPSTRITSQELMAHKFF
       ||. ..| ..| .||. |.| .... |..|
WTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase pdk-1.AA CAMK 74-362 17 2.4e-67 215.8 In-house 1-425 (425) Show / Hide 
Range on Protein: 74-362
Range on HMM: 1-425/425
Sequence Identity: 17% (81 aa)

SMGEGAYSQVFRCREVATD------------AMFAVKVLQKSYLN-------------------------RHQKMDAIIREKNILTYLSQECG--GHPFV
  |.|....|..|..  |               .|.|.. |. |                          | .... . || .|.  |..  .   || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

TQLYTHFHD-------------------QARIYFVI---GLVENGDL-----------GESLCHF--------GSFDMLTSKFFASEILTGLQFLHDNKI
 .|| .. |                   . ..|.|     ....|.|           |   . |        | |.    ...   |. .....|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDMKPDNVLIQKD-----------------GHILITDFGSAQAFGGLQLSQ--------EGFTDANQASSRSSDSGSPPPTRFYSDEEEENTA-----
|||| ||.|.|....                 . | |.||| |. | . . .         | . .                            .     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN---------------------------QWTTPT

---RRTTFVGTALYVS-PEMLAD--------------GDVGPQTDIWGLGCILFQCLAGQPPFRAV-------------NQYHLLKRIQELDFSFPEG--
     .||.||  |.. ||.|                  .||..|.| .|.||. .| | |||..              |.| |...|.. ...||.   
EGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYF

----------------------FPEEASEIIAKILVRDPSTRITSQELMAHKFF
                      . .|.   | |.|..||. |.| .. ..|...
SPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase pdk-1.AA RSK 72-362 28 1.7e-64 220.56 In-house 1-278 (278) Show / Hide 
Range on Protein: 72-362
Range on HMM: 1-278/278
Sequence Identity: 28% (91 aa)

LQSMGEGAYSQVFRCREV---ATDAMFAVKVLQKSYLNRHQK-MDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLC---
|.  |.|.|  || ||..   .|.  .|.|||.|. . ..||      .| |||    ..|..|||. .|.  |...  .| .  ... |.|.. |.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNIL----ERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEK

HFGSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQK---DGHILITDFGSAQAFGGLQLSQEGFTDANQASSRSSDSGSPPPTRFYSDEEEEN
||| |.  . .| ..||   ...||. .|.||| ||.|.|      .||| .|||| .  |                                     ..
HFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-----------------------------------RCDH

TARRTTFVGTALYVSPEMLA----DGDVGPQTDIWGLGCILFQCLAGQPPFRA---VNQYHLLKRIQELD--FSFP--EGFPEEASEIIAKILVRDPSTR
. .  ||..|. |. ||||.    .|  . . |.| ||....  |.|.|||..    |.  ..||||. .  ...|  .   .|| ..| | | |||. |
NQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKR

IT-----SQELMAHKFF
..      .|. .|..|
LGCGPQDAEEIKQHPWF
Kinase pdk-1.AA Ciliate-E2 69-362 20 2.7e-58 198.71 In-house 1-365 (365) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-365/365
Sequence Identity: 20% (82 aa)

FMFLQSMGEGAYSQVFRCREVATDAMFA-----------------------VKVLQKSYLNRHQKMDAII----------REKNILTYLSQECGGHPFVT
. |..  |.|....|..|.   .. .||                       .|...|. ..   ... |.           |||||  |.     ||.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-----HPNII

QLYTHFH--DQARIYFVIGLVENGDLGE---SLCHF--------GSFDMLTSKFFASEILT---------------GLQFLHDNK-IVHRDMKPDNVLIQ
..| .|   |.  ||.|  ... ||| .   . ...        ..|..   |..  .||                .|..|| .. |.||| ||.|.|. 
KMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

KDGHILITDFGSAQ--------AFGGLQLSQEGFTDANQASSRSSDSGSPPPTRFYSDEEEENTARRTTF----------VGTALYVSPEMLADGDVG--
    | |.||| ..         .. .|....     |. |  .....                     .          .||. |..||.|  .. .  
----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD---------------------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQ

-------PQTDIWGLGCILFQCLAGQPPFRAVNQYHLLKRIQELDFSFP------------------EGFPEEASEIIAK----ILVRDPSTRIT-SQEL
        . ||| ||.||...| |.|||        .. |.. ...||                  .  ..|.  .| |    .|..||. |||  ...
QKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI

MAHKFF
. |..|
LNHPWF
Kinase pdk-1.AA CAMKL 69-362 20 9.5e-56 176.32 In-house 1-297 (297) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-297/297
Sequence Identity: 20% (70 aa)

FMFLQSMGEGAYSQVFRCRE-VATDAMFAVKVLQKSYLNRHQKMDA------------IIREKNILTYLSQECGGHPFVTQLYTHFHDQAR------IYF
. ...  |.|....|  ..    |  . |.|.. |. ..  ..|..            | || .|.  |.   |.|| . .|| .. ..        || 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN--IGKHPNIIKLYEVIETPEHDIETKKIYL

VIGLVENGD--LGESLCHF----GSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDG--HILITDFGSA-----QAFGGLQLSQEGFTDAN
|  ....|.  | . ..      |...    ...   |. .....|...||||| ||.|.|. ..|   | |.||| .     .                
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC----------------

QASSRSSDSGSPPPTRFYSDEEEENTARR--TTFVGTALYVSPEMLAD---GDVGPQTDIWGLGCILFQCLAGQPPFRAV--------NQYHLLKRIQEL
                        ..  .  .|| |.  | .||....      ||..||| .| ||.  . |. ||..         |.  |...| ..
-----------------------IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG

DFSFP--EGFPEEASEIIAKILVRDPSTRITSQELMAHKFF
 . .|     . ..  .| |.|...|. |.| ...| |...
-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase pdk-1.AA Ciliate-E2-Unclassified 69-362 20 2.3e-54 186.92 In-house 1-352 (352) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-352/352
Sequence Identity: 20% (78 aa)

FMFLQSMGEGAYSQVFRCREVATDAMF-----AVKVLQKSYLNRHQKMDAIIREKNILTYLS---------------QECGGHPFVTQLYTHFHDQARIY
. ...  |.|....|..|..  ..  .     . |. ... ..  .|   |..|....  ..               . .  |||.  .. .| |.  ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNH-PHPFIVKMFYCFQDKQNIY

FVIGLVENGDLGESLCHFGS-----------------FDMLTSK-----FFASEILTGLQFLHDNK-IVHRDMKPDNVLIQKDG---HILITDFGSAQAF
.|  ..|.||| . ......                 |.   .|     |.. .|| ||..|| .. |.||| ||.|.|....|   .| |.|||..   
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

GGLQLSQEGFTDANQASSRSSDSGSPPPTRFYSDEEEENTARR-----TTFVGTALYV----SPEMLADGDVGPQ----TDIWGLGCILFQCLAGQPPFR
.  . .. ..                            ....      .||.||  |     .||.|     . .     |||.||.||...| |..|| 
QQNNNCD-TNQ-------------------------QQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY

AVNQYH----------------LLKRIQELDFSFPE--------GFPEEASEIIA----KILVRDPSTRITSQELMAHKFF
. |..                 |.. |.. ...||.        . ..|| ..|     |.|. .|. ||| .... | .|
DNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase pdk-1.AA AktR 69-362 23 1.7e-53 184.03 In-house 1-268 (268) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-268/268
Sequence Identity: 23% (73 aa)

FMFLQSMGEGAYSQVFRCREV-ATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHFG
| ...  |.||...|. ...   .. ..| |.. |. . . ..|...|.|.||.    ..|  |||  .|.  | ..  ..|..  ...|.|   | . .
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIM----EMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKK

SFDMLTSKFFASEILTGLQFLHDN-KIVHRDMKPDNVLIQKDGHILITDFGSAQAFGGLQLSQEGFTDANQASSRSSDSGSPPPTRFYSDEEEENTARRT
 |.  ...|....|| .|..||.. .|. ||.||.| |. .|||. ||||| .                                       .... . .
KFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK----------------------------------LQFMMHYDEKAY

TFVGTALYVSPEMLAD-GDVGPQTDIWGLGCILFQCLAGQPPFRAVNQYHLLKRIQELD---FSFPEGFPEEASEIIA-KILVRDPSTRIT-----SQEL
.|.||  |..|||.      . . |.| .|. ..  ..|.||| . ||  ....|.. .   | .|. | ... ..|  |.| ..|  |..      .|.
SFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEI

MAHKFF
  |..|
KSHPWF
Kinase pdk-1.AA MSK 70-362 23 1.7e-50 168.94 In-house 1-277 (277) Show / Hide 
Range on Protein: 70-362
Range on HMM: 1-277/277
Sequence Identity: 23% (76 aa)

MFLQ-SMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAI-IREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHFG
. .   .|.|... . .|. . |.. .|.|.|.|  .   .|. .   .|  .|    . | .||.. .|.  |.||.  | |  ..  | | ..... .
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCL----EMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKRE

SFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKD---GHILITDFGSAQAFGGLQL-SQEGFTDANQASSRSSDSGSPPPTRFYSDEEEENTA
 ||     .   |.   ....|. .|.|||.|| |.|   .   ||. ..|||.|  |  .|  ..  ..                              
HFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLF--PQDEEWRMKS------------------------------

RRTTFVGTALYVSPEMLAD---GDV--GPQTDIWGLGCILFQCLAGQPPFR------A---VNQYHLLKRIQELDFSFP----EGFPEEASEIIAKILVR
    . .|  | .||||..   .|.  ... |.|.|| ||.  | || ||.            .  . |||.. .||||    ... ..| . | . | .
----PCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTK

DPSTRITSQELMAHKFF
||. | . ..| ||   
DPKKRLGMNDLRAHEWK
Kinase pdk-1.AA PKC 69-217 36 5.1e-36 114.11 In-house 1-145 (262) Show / Hide 
Range on Protein: 69-217
Range on HMM: 1-145/262
Sequence Identity: 36% (54 aa)

FMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHFGS
|.||. .| | .  |.  .   || ..|.||| |   .    ..    || .|   ..    ||| |.|.  |  . |..||.  |. |||      .. 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWK----HPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRR

FDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFG
|.    .| | ||. .|||||.. |. || | ||||. ..||| |.|||
FKEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFG
Kinase pdk-1.AA PKC 266-362 27 2.9e-19 58.94 In-house 158-262 (262) Show / Hide 
Range on Protein: 266-362
Range on HMM: 158-262/262
Sequence Identity: 27% (29 aa)

TTFVGTALYVSPEMLADGDVGPQTDIWGLGCILFQCLAGQPPFRAVNQYHLLKRIQELDFSFPEGFPEEASEIIAKILVRDPSTRITS--------QELM
.|| ||  |..|| |.  . |.  | | .|  ... .|||.|| ...   | . | . . ..|  . .||..|. . . ..|..|. .        |. .
STFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIR

AHKFF
.| ||
EHPFF
Kinase pdk-1.AA TyrKc 69-362 19 1.1e-11 -33.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 69-362
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

FMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECG-GHPFVTQLYTHFHDQ-------ARIYFVIGLVENGDLG
  ...  ||||. .|....      . |||.|...       . ...|| .|.. |    |  || . .||    .|         .. |  ....||| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKL----GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

ESL----CHFGSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAQAFGGLQLSQEGFTD-ANQASSRSSDSGSPPPTRFYS
. |     .   . | .   |.  |  | ..||.....|||    |.|. ..... |.|||         || ..  | ..                   
DYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG---------LSRDIYDDDQQG------------------

DEEEENTAR---RTTFVGTALYVSPEMLADGDVGPQTDIWGLGCILFQCLA-GQPPFRA-----VNQYHLLKRIQELDF-SFPEG--------FPEEASE
 ...  ...    . ..      .|| . .|   ...|.|  |  ..  .  ||.|        .. ......... .    |.          |.|  .
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ

IIAKILVRDPSTRITSQELMAHKFF
|. .   .||. | | .|.  |..|
IMKQCWHEDPEDRPTFSEI--HECF
PDK1_PH pdk-1.AA PDK1_PH 465-564 44 2e-58 200.43 In-house 1-112 (112) Show / Hide 
Range on Protein: 465-564
Range on HMM: 1-112/112
Sequence Identity: 44% (50 aa)

NPFHIFT--NNSLILKQGYLEKKRGLFA----RRRMFLLTEGPHLLYIDVPNLVLKGEVPWT-PCMQVELK-----NSGTFFIHTPNRVYYLFDLEKKAD
.|.| |   .. .|||.|...|..||||    .||...||.||.|.|.|. ..|.|||.||. ....||.|     |...||||||||.||..|....|.
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN

EWCKAINDVRKR
.||.||..|.||
KWCEAIEKVCKR
PH pdk-1.AA PH 476-565 28 4e-06 27.53 SMART 1-82 (82) Show / Hide 
Range on Protein: 476-565
Range on HMM: 1-82/82
Sequence Identity: 28% (26 aa)

ILKQGYLEKKRGLFARRRMFLLTEGPHLLYIDVPNLVLKGEVPWTPCMQVELKNSGTFFIHTPNRVYYLFDL-EKKADEWCKAINDVRKRY
..|.|.| || .   ..| | |..   |.| . .   .||..| . | .|.     .| ||. .|.||..   |. ..|| .||... ...
VIKEGWLYKKSK-RWKKRWFVLFN-DCLYYYKDK--KPKGSIPLSDC-TVRE-P--CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN