Gene sek-1 (Nematode worm)

sek-1

Species: Nematode worm
Alias: aSWK319, R03G5.2, sek-1, CE31210
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: X: 7785800-7790123,

Classification

Group: STE
Family: STE7
Subfamily: MEK3

Sequence

Name Sequence Type Origin Length Description Download
sek-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
sek-1.AA Protein Genbank 343 None Fasta, JSON

Protein domain

Protein domains of sek-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase sek-1.AA MEK3 50-311 67 1.2e-227 762.62 In-house 1-264 (264) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-264/264
Sequence Identity: 67% (179 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYK-IGKHIP
.||..|||.|.||||.||.|||||.|||||||....|.|.||.||...|.|.||..||..|.||||||||||||||||||||.|||||||.|| .|.|||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

EPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKS-AYDVRADVWSLGITIIEIA
|...||.|.|....|..|.|||..|||||||||.|.|.|||||.|||||||.|..|||||..|||||||.|||||.|... .|||..||||||||.||.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

VGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFM
.|..||.||.|||.||||||.||||.||||.|||.|||.|...||.|.|.|||.||||...|||
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase sek-1.AA STE7 50-311 52 1.5e-174 586.19 In-house 1-288 (288) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-288/288
Sequence Identity: 52% (152 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSIND-QSQKQMLNELDACRRSDCCPQMVRFYGAMFREGD--VWICMEVMD-TSLDKFYRHAYKIG-
|....|||.| ||.|.||.|..||.|||||||....|| ..|||.| |||.......|| .|.||||...|||  .|||||.|| ..|||||....|.. 
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----KHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSM-AKTVQAGCKPYMPPERIDGETKSAYDVRADVWSL
    ..|||...||.|..|| ||....|... |||||||||||.|..||||.|||||.|.|..|| |.|...||.||| |||||| .|. ||||.|||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG-NKQHYDVRSDVWSL

GITI-IEIAVGTHPYANWKT-----------------PFEQLKQVVKE-PPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLA-MPFM
|||. ||.|.|..||.||.|                 .||||...|.| |||.||   .|| ..| ||..|| ||.||||||..|.. .||.
GITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP---KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase sek-1.AA MEK4 50-311 49 6.00000000001e-142 466.19 In-house 1-275 (275) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-275/275
Sequence Identity: 49% (136 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIK-SSIN-----DQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKI
|  |.|.|.| .| | ||.|..|| |||||||. . .      . .||..| |.|.  .|  ||  |.||||.|.||| ||||| ||.|.||||. .|..
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

GK-HIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDG-ETKSAYDVRADVWSLGI
 | .|||  .|. .. ... ||. ||... ||||||||||||.||| || |||||.| | .|.|||. |||.||| |||||  . .  ||.| |||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TIIEIAVGTHPYANWK--TPFEQLKQVVKEPPPKLPMESG---FSVDCQYFVKRCLEKDYNERPKYPELLAMPFM
|..|.| |  ||  |.    |.|...|||  ||.|  ..    .| .   |.  || || |.|||| .|. .|| 
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase sek-1.AA MEK7 50-311 43 1.3e-109 370.44 In-house 1-269 (269) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-269/269
Sequence Identity: 43% (118 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKI-GKHIP
|  ....| |  | | || |..|| |||||  . . |    |  |  ||    .  ||  |. .|.  .. |||||||.| | .||  .  ..     ||
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

EPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDG--ETKSAYDVRADVWSLGITIIEI
|  ||||  ..|  |.. ||    .|||||||||||   |..| ||||||| .. |.|.| .||| .|| |||||   .... ||.||||||||||..| 
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

AVGTHPYANWKTPFEQLKQVVKE--PPPKLPMESG--FSVDCQYFVKRCLEKDYNERPKYPELLAMPFM
| |  ||.. .. || .  .  .  .|| || . .  || | . ||. || ||  .||||..|.. ||.
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase sek-1.AA STE 50-311 29 1.3e-104 353.87 In-house 1-359 (359) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-359/359
Sequence Identity: 29% (107 aa)

LVVLEELGKGGYG-IVEKMQHRQS--------------GIIMAVKRIK----------------SSINDQSQKQMLNELDACRRSDC-CPQMVRFYGAMF
.  .|..|||..|  . .| | ..              | |||.|...                ...|.. ..| |.|.. ...... .|  |..||. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

REG-------DVWICMEVMD-TSLDKFYRHAYKIGK----------HIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISG
.||       ..||||| ||  |||....| |..||          ..||. |.... ....||   ..... ||||.||.||||     ||.||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

HLTNSMA----------------KT-VQAGCKPYMPPERIDGET---KSAYDVRADVWSLGITIIEIAVGTHPYANWKTP---------------FEQLK
 ||.|||                |.   .|.  .| ||.|....   .. ||...|.||||.|||| | | .|... . .               |||| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

QVVKEPPPKLPM-----------------ESGFSVDCQYFVKRCLEKDYNERPKYPELLA--MPFM
..|..|||.||                   . .| ... |...||.||.|.||.. .||    || 
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase sek-1.AA STE7-Unclassified 50-311 38 3.2e-89 302.71 In-house 1-301 (301) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-301/301
Sequence Identity: 38% (116 aa)

LVVLEELGKGGYGIVEKMQHRQ------SGIIMAVKRIKSSIN-DQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGD---VWICMEVMDT-SLD---K
|..|..||.| .| |.|  |        .|.||| | |.  .|    .|| | || . .    .|  |..||| . |.    . |||| ||  |||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

FYRHAYK----IGKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSM--AKTVQAGCKPYMPPERIDGE--TK
 |  .|.    .|. |||| .||.|..|| || . .|....||||.||.|||.|  |||||||||..| | |..  |||  .||  || |||| |.   .
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

SAYDVRADVWSLGITIIEIAVGTHPY-------ANWKTP-------FEQLKQVVKEPPPKLPMES---GFSVDCQYFVKRCLEKDYNERPKYPELLA-MP
 .| |. |.||||.||.| | |..||          ...       .| |  .|..| | || .     .| . . |...|. |. .||| . .||   |
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FM
. 
WI
Kinase sek-1.AA S_TKc 50-311 25 2e-74 254.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDT---SLDKFYRHAYKIGKH
  .|...|||..| | | .|. .| |.|.|.||        .....|.. ...   .|  |..|...   ......|| .|.   .| .. ..  . |..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDV-RADVWSLGITI
  .||  . ...  ....|... .. . ||||.||.||||..  ..||||||.. .|      | . |   ||.|| .       |.  ..|.||.|...
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCIL

IEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLA-------MPFM
.| ..|  |.    .... .|...             | ..  |...||.|| ..||   |.|.       .|..
YEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase sek-1.AA MEK5 50-311 39 4.5e-64 219.17 In-house 1-254 (254) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-254/254
Sequence Identity: 39% (106 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKIGKHIPE
.   . ||.|  | | |  |  || |.||| |   |  . |||.. ||.   . |  | .. |||| | |  . || | ||      ||        |||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCD-SPYIIGFYGAFFVENRISICTEFMDGGSLDMYR-------CIPE

PFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAVG
  .|.|. ... |||.. . | ..||||||||.| | .||.|.||||.|  | ||...|   |   || |||| |.    | . .||||||| ..|.|.|
HILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGD---QYGIHSDVWSLGIFFMEMATG

THPYANWK------TPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFM
  || . .       | . |. .| | ||.||..  ||     |. .|. |   .|||  .|.  ||.
RFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDK-FSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase sek-1.AA MEK1 50-252 41 2e-63 215.55 In-house 1-195 (297) Show / Hide 
Range on Protein: 50-252
Range on HMM: 1-195/297
Sequence Identity: 41% (84 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMD-TSLDKFYRHAYKIGKHIP
. ...|||.|  |.| |..||..|.||| | |.  |    ..|.. ||    .    | .| |||| . .|.. |||| ||  |||   ..|    . ||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA----GRIP

EPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAV
| ..||... |. || ..... ...|||||||||| | .| .|.||||.|| |  |||     | . || |||. |   . | |..|.||.|. ..|.|.
EKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQG---THYTVQSDIWSMGLSLVEMAI

GTHP
|  |
GRYP
Kinase sek-1.AA STE20 50-311 30 1.3e-52 181.12 In-house 1-288 (288) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-288/288
Sequence Identity: 30% (90 aa)

LVVLEELGKGGYGIVEKMQHRQSGII----MAVKRIKSSIND---QSQKQMLNELDACRRSDCCPQMVRFYGAMFRE----GDVWICMEVMDT-SLDKFY
   ||..|.|.|| | |  |...| .     |.|... .  |   ....  ..| .  .... .|  |..||. ...     . ||.|| ..  ||   .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

RHAYKIGK-----HIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTN----SMA-K-TVQAGCKPYMPPERIDGET
.| .|.||      . |. |  .   | .||..  .. . ||||.|  ||||. .|.||..||| .. ||.    .|. |     |   .| || | ...
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCME

--KSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVV--KEPPPKLPM--ESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFM
  .. || ..|.||||||.|| | |  ||..   |.  . ..   ..|||.|     . .| . . ||..||.||...||   .||  || 
GPDKGYDYKCDIWSLGITAIEMAEGEPPYFD-MHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase sek-1.AA Pkinase 50-311 23 6.4e-50 176.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-293/293
Sequence Identity: 23% (73 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLN----ELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDT-----SLD----KF
..... .|.|..| | | .|. .|.| |||.|| . .. |.|.. .    |.   .|  ..|  ||.|... ........|| ..      .|       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

YRHAYKIGKHI--PEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQV----KICDFGISGH--LTNSMAKTVQAGCKPYMPPERIDGETKS
     . .. .  .|  . .... ...||... .. . ||||.||.|||....|..    ||||||.. .  . |.   |. .|  .||.|| |   . .
-----WRHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQ

AYDVRADVWSLGITIIEIAVGTHPYANW---KTPFEQLKQVVKEPPPKLPMESGFS---------------------VDCQYFVKRCLEKDYNERPKYPE
 |. ..|.||.|....| . |  |. .    ..  .|.. ...  .|.|. ..  .                      .|. |.|.||.|| ..||  ..
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLAMPFM
.|  |..
ILQHPWF
Kinase sek-1.AA SLK 52-311 30 4.9e-44 146.38 In-house 3-259 (259) Show / Hide 
Range on Protein: 52-311
Range on HMM: 3-259/259
Sequence Identity: 30% (81 aa)

VLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMD-TSLDKFYRHAYKIGKHIPEP
.. ||| | .| |.| ||.. ... | | |.   ... .  |  |.|     .  |..|. |.| . ....|. .|  |   .|        ... . |.
IIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMV-EIDILSECK-HPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIM---VELEHPLTED

FIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPY-MPPERIDGET--KSAYDVRADVWSLGITIIEIA
 |  ..  ..|.||.. .. ..||||.|  |||.   |.|.. |||.|  ... | |       || | || .  ||     || .||.||||||.||.|
QIQYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMA

VGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFM
 .  |. .   |   | .. |  ||.|   | .|.. . |.|.||.|| . |.   .|.  ...
QMEPPHHEMN-PMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase sek-1.AA TyrKc 50-311 21 3.3e-13 -9.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-311
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRS-DCCPQMVRFYGAMFRE-------GDVWICMEVMDT-SLDKFY-RH
.. ...|| | .|.| | . .   |  ||| .|..     .. ...|.   ..     |  ||.||.   .       . ..| || |.  .|...  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

AYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNS-------MAKTVQA--GCKP-----YMPPERIDGE
  |    .. .   .... . .| ..  .. |.||||    |.|... ..|||.||| |  ...          ....   |.|       |.|| |   
RPK----LCMKDLLSFCWQIACGMEYL-HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

TKSAYDVRADVWSLGITIIEIA-VGTHPYAN-WK--TPFEQLKQVVKEPPPKLPMESG-------FSVDCQYFVKRCLEKDYNERPKYPELLAMPFM
 .. .    |||| |... ||   |  || .  .   . ... . ||.     .....        . .     |.| . | ..||   |.    ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase sek-1.AA MEK1 260-311 44 1.4e-10 31.87 In-house 247-297 (297) Show / Hide 
Range on Protein: 260-311
Range on HMM: 247-297/297
Sequence Identity: 44% (23 aa)

FEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFM
|| |  .|.||||||| .  || . | ||. || |  .||    .|.. .|.
FEMLDYIVNEPPPKLPHRV-FSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase sek-1.AA Pkinase_Tyr 181-269 26 3e-06 21.59 Pfam 141-231 (270) Show / Hide 
Range on Protein: 181-269
Range on HMM: 141-231/270
Sequence Identity: 26% (25 aa)

NILLNRHGQVKICDFGISGHLTNSMAKT-VQAG----CKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAV-GTHP-YANWKTPFEQLKQVVKE
|.|... ..||||||| .  .  .     ...|      . |.|| |       . .  |||| |... ||   |  | |... ...| .... ..
NCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYED
Kinase sek-1.AA Pkinase_Tyr 50-97 22 0.033029 8.1 Pfam 1-54 (270) Show / Hide 
Range on Protein: 50-97
Range on HMM: 1-54/270
Sequence Identity: 22% (12 aa)

LVVLEELGKGGYGIVEKMQHR----QSGIIMAVKRIKSSINDQS--QKQMLNEL
.. ...||.| .| | |   .    . .|  ||| .| .  ..   .. ...|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREA