Gene smg-1 (Nematode worm)
smg-1
Sequence
Protein domains of smg-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HEAT | smg-1.AA | HEAT | 1496-1526 | 25 | 0.000715 | 17.27 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1496-1526 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) ILPQLFARLSHPSEHIRKTLVDLISKICTAA ||| |. |..|....|.. . ....| . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| Kinase | smg-1.AA | PIKK | 1755-2053 | 33 | 4.5e-99 | 335.43 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1755-2053 Range on HMM: 1-290/290 Sequence Identity: 33% (102 aa) SISRVARQVTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFH | .| ||....|..|||. . |.||| .|.||.|||..|.||||...|.| .|| . ... .... .|.|||...|.||| ||..... . RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDP---ECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKE IYRKWQMKEKALKQAT-------KKNGETVPEIERPSNMYHNMIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWW ||..|. |..... .. . .. . . . . . ....|| . .|||. . .|| |. ...| .. |...|| IYKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS--------------YYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWW SVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFD-KGKNLRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVL .....| ||.|||.||| .|||||||..|...| | .||||.. || ... |. ||.||||||||| |.|| .| || .|.||. .|.. | ERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETL TMLLDAF . ....| MTVCEVF |
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| Kinase | smg-1.AA | PI3_PI4_kinase | 1784-2063 | 28 | 2e-96 | 331.43 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1784-2063 Range on HMM: 1-300/300 Sequence Identity: 28% (93 aa) QVAFLFKGREDLH--LDERVMQFL-----------------------RLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRK ..|.||| .||. |.|.||.. ||.| ... .. .|.. .|...| .||.||..|.| ||. .|.. .| |. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRN---MQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRT WQMKEKALKQATKKNGETVPEIERPSNMYHNMIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDA-TTWWSVTKRYSRSL . .|.|. . .... ...........| ... .||||. ..|||.. . ...|. || ..||.. ... ||. YMVKCKHKHFNKEHKMWMKMWPDWWHLM--------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSC AVMSMVGSVLGLGDRHLDNLLV--DLKWGHVVHIDYNICFD--KGKNLRIPETVPFRLTR------NMRHAL------GPSEMYGTFRESCVHVLSTLRS |.|..|. .||.||||.||..| | ..||..|||...||. |.| . ||.||||.|. .| ||. .||..||.||..|.|.. ||. AGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRR GHQVLTMLL-------DAFVFDPLVDWTS . ....|| ...| |.|..|.| HMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | smg-1.AA | SMG1 | 1763-2005 | 49 | 1.3e-94 | 313.95 | In-house | 1-242 (242) | Show / Hide |
Range on Protein: 1763-2005 Range on HMM: 1-242/242 Sequence Identity: 49% (123 aa) VTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMK .|||||||.|||| |.||||| .|||| ||||||||.|||| . | | || . | ||.| ||| |||||.||.||||.| .|..|| . ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFA---TINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQR EKALKQATKKNGETVPE----IERPSNMYHNMIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWWSVTKRYSRSLA | ||. . | . ||| .| | | . |. | || .. | | | || .|. .||| || ||. | || | EAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPAL--KTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTA VMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPE |||||| ..||||||||| |.|. | ||||||.|||.||| |..|| VMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | smg-1.AA | PI3Kc | 1786-2114 | 24 | 4.3e-86 | 293.24 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1786-2114 Range on HMM: 1-336/336 Sequence Identity: 24% (84 aa) AFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALKQATKKNGETVPEIERPSN |..||...||. |.|.||..||.| ..| |...|... ... ..... | ... ......| . .. ..|.||........|....... ||||. . | AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ-K-N MYHNMIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGH || .||....|.|............|.. ...... . .... ... ||.. ... ||.|...||. .||.||||.||...| | || MY-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN----EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGH VVHIDYNICFDKGKNLRIP-----ETVPFRLTRNMRHALG----PSEMYGTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPL-VDWTSH-EHTATSGVSL ..|||.. .|..|. . . |.||||||..| .. | ||...| ||. |.... .|. . ... |. ..| ||. .|... . . . .. CFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRF ALQLAVYGSNWKTKAKE----RLTDAM-ELLNLRMSEVQTLWLAN |. . .. .... | .. | .. || .. .|. . RLDH-LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | smg-1.AA | FRAP | 1784-2063 | 28 | 1.3e-48 | 167.78 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 1784-2063
Range on HMM: 1-251/251
Sequence Identity: 28% (81 aa)
QVAFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALKQATKKNGETVPEIERP
|| ||.||. |||||| | | .|. .. |..||| ..||| ||. . . | . | . . .
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLS---IQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE-------------
SNMYHNMIRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKW
..| . .| .. | |.|. | . . . ||.. | | ||||.|||.| .|||||||. |.. .
--------------YNIMDRMCNDYDHLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYT
GHVVHIDYNICFDKG-KNLRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPLVDWTS
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GKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
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| Kinase | smg-1.AA | ATR | 1942-2053 | 43 | 2.1e-41 | 138.59 | In-house | 156-267 (267) | Show / Hide |
Range on Protein: 1942-2053 Range on HMM: 156-267/267 Sequence Identity: 43% (49 aa) DATTWWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRS |.. |.| . | || ||..||| ..|||||| ||.|.| | .||.|||. | .|. . .||.||||||.|| ..|| . || || |. .. .| DPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD GHQVLTMLLDAF . . ..|.| HRDDIMSVWDCF |
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| Kinase | smg-1.AA | ATM | 1953-2062 | 42 | 4.7e-31 | 96.16 | In-house | 140-249 (304) | Show / Hide |
Range on Protein: 1953-2062 Range on HMM: 140-249/304 Sequence Identity: 42% (47 aa) YSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVLTMLLDA | || | |.|| .||||||| |.|. . .|||| . |..|| | |||||||||| . .| . | || | . .| | . . YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEV FVFDPLVDWT ..||| ||| LLYDPLFDWT |
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| Kinase | smg-1.AA | DNAPK | 1952-2063 | 32 | 7.3e-24 | 83.61 | In-house | 189-301 (301) | Show / Hide |
Range on Protein: 1952-2063 Range on HMM: 189-301/301 Sequence Identity: 32% (37 aa) RYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFD-KGKNLRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVLTMLL .. |. || . .|| |||||.| .| | .. ||. | . | .|| |||||| . | | .. . .| . .|. .|| HFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFC DAFVFDPLVDWTS | |. ||..|| DVFINDPSFDWKN |
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| Kinase | smg-1.AA | ATR | 1754-1872 | 30 | 3.8e-12 | 37.24 | In-house | 1-115 (267) | Show / Hide |
Range on Protein: 1754-1872 Range on HMM: 1-115/267 Sequence Identity: 30% (36 aa) VSISRVARQVTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMF |. | || . .|||. . ||||| . | ..|| | | |.| | | .. . .. |. |||||| ....| ||. . AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCN---RKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLR HIYRKWQMKEKALKQATKK | | ||| . .. PILDKL-WKEKKQYMQFYQ |
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| Kinase | smg-1.AA | DNAPK | 1754-1847 | 30 | 9.8e-09 | 27.72 | In-house | 2-92 (301) | Show / Hide |
Range on Protein: 1754-1847 Range on HMM: 2-92/301 Sequence Identity: 30% (29 aa) VSISRVARQVTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVE | | ||.. |||.. | | . |..|| ||| .| |. | | . . . | | .||. | ||| ||. VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFE---YDPQCQQRELQLRTYNIIPMTNRLGLIEWVD |
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| Kinase | smg-1.AA | ATM | 1788-1851 | 34 | 2.2e-07 | 19.21 | In-house | 3-63 (304) | Show / Hide |
Range on Protein: 1788-1851 Range on HMM: 3-63/304 Sequence Identity: 34% (22 aa) LFKGREDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATP | |||.|| | . | .|| .|| . . | |.|| ||| . | | | LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICT---YKVVPLSQRSGVLEWCTGTIP |
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| FATC | smg-1.AA | FATC | 2295-2327 | 48 | 8.2e-13 | 44.07 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2295-2327 Range on HMM: 1-33/33 Sequence Identity: 48% (16 aa) RKLSPREEADILIAEATSTPNLSQMYEGWTAWV .||. . .| ||.|||.. ||.||| || .|. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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