Gene src-1 (Nematode worm)

src-1

Species: Nematode worm
Alias: CE31390, Y92H12A.1, src-1, aSWK404
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: I: 1566934-1580204,

Classification

Group: TK
Family: Src
Subfamily: Src-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
src-1.AA Protein Genbank 558 None Fasta, JSON
src-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of src-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 src-1.AA SH3 74-131 37 2e-23 85.04 SMART 1-58 (58) Show / Hide 
Range on Protein: 74-131
Range on HMM: 1-58/58
Sequence Identity: 37% (22 aa)

ETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQ
.. .|||.|... ...|||.||| ...|. .. .||..|..||||.|..| |.|....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 src-1.AA SH3_1 77-124 42 1.2e-20 72.48 Pfam 1-49 (49) Show / Hide 
Range on Protein: 77-124
Range on HMM: 1-49/49
Sequence Identity: 42% (21 aa)

VALYPYDSRADGDLSFQKGDAMYLLDHSNC-DWWYVRHQRTGQTGYVPR
||||.|. . ...|||.||| ..... |.  ||| .| ..|||.|..| 
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 src-1.AA SH3_2 82-130 21 3e-06 24.86 Pfam 8-68 (68) Show / Hide 
Range on Protein: 82-130
Range on HMM: 8-68/68
Sequence Identity: 21% (13 aa)

YDS-RADGD-----LSFQKGDAMYLL---DHSNCDWWYV-RHQRTGQT--GYVPRNFVAKQ
|.. .  ..     |.|.|||  ...   |... .||.. .   .|..  |..|...|...
YVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 src-1.AA SH2 138-196 37 6e-14 42.77 Pfam 1-53 (81) Show / Hide 
Range on Protein: 138-196
Range on HMM: 1-53/81
Sequence Identity: 37% (22 aa)

WYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGAKISNFGHF
|| |||.|. |||| ...  | ||||.||.|    ...|. || ..      .... |.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP------GDRVKHY
SH2 src-1.AA SH2 136-219 18 1.2e-05 25.9 SMART 1-87 (87) Show / Hide 
Range on Protein: 136-219
Range on HMM: 1-87/87
Sequence Identity: 18% (18 aa)

EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGAKISNFGHFSVSHLS--EFDFFG----------VIIFYCILWNS
..|| |.|.|  ||.| .. . | |.||.|..| . ....|..|.          . . |. . ..    . . .           . .|     .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK---------GKVKHYRIRRNDDGKYYIDETWRRKFPSLELVNHYQHNPLG
Kinase src-1.AA Src-Unclassified 273-536 69 6.1e-234 783.47 In-house 1-284 (284) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-284/284
Sequence Identity: 69% (197 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPG---TMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDG
.||.||||.|.|||||||||||.|.||.|||.||   ||||||||||||||||.||||||.|.|.|||.|||||..|||.||||||||||||||.||..|
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

-STLGIQAL------------VDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKIS-GVPVVKVADFGLAR-KLMEEDIYEARTGAKFPIKWTAPEAAT
 ..|.||..            ||.|||.|.||||||..|.|||||||||||.|...| |||||||.|||||| |||..|.|..||||.||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

CGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMP--RGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFF
.|||..|||||||||||.|||||||.||||||||||.|.||.|||||.|  ..||..|||....|||.|.|.||||||||||.|
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase src-1.AA Src 273-536 60 1e-184 619.94 In-house 1-255 (255) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-255/255
Sequence Identity: 60% (162 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLR--TDGS
..|.||||.|.|||||.|.|.| ..||.||.|||||||||||        .||||||...|..||.|||||..|||.||.|||| .||||.||.  ..|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFL--------QEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

TLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLME--EDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYG
.| .. |.|||||.|.||.|||.....||||||||||||...    |.||||||||| |..  .|.|.||.|||||||||||||...|.||.||||||.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN----VCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFG

ILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFF
|||.||.|.|.||||||.|.||..||| |||||.|..||...||...|.||.|.|..||||..|..|.
ILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase src-1.AA SFK-Src 273-540 55 5.2e-163 487.39 In-house 1-259 (259) Show / Hide 
Range on Protein: 273-540
Range on HMM: 1-259/259
Sequence Identity: 55% (150 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRT-DGST
  |..||| | ||.|| |.| .  |||.||.|||.|| | ||        .|||.||.  ||||..||||||  || ||||| | .|||| ||.   |  
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFL--------QEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRS

LGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDI-YEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGIL
| .. |||||||.| || |||.   ||||||||||||||      |.||.|||..| | ..|. |.|..|||||||||||||..   | .||||||.|||
LRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNN----VCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGIL

LYEIMTKGQVPYPGMHNREVVEQVEL--GYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYF
..|| | | .||||| | ||. ||.   ||||| | .||.. | .... || ..|| ||||..|    .|.|
MMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYY-KIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase src-1.AA Pkinase_Tyr 273-536 46 4.90000000001e-138 468.11 Pfam 1-270 (270) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-270/270
Sequence Identity: 46% (130 aa)

LHLKRKLGDGNFGEVWYGKWR-----GIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQC-DHPNLVKLYAVCT-REEP--FYIITEYMINGSLLQ
... .||| |.||||. |.|.     . ..||.|..|.|.|...     ..  | |||.||||  .|||.|.||.||| ..||   ||..||| .|.|| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN----CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YLRTD---GSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIY-EARTGAKFPIKWTAPEAATCGNFT
|||.    .  | .. |..|..|||.|| |||.....||||||||.||..      |||..|||||| ....| |  .|.|.|.||||.|||.   | ||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

VKSDVWSYGILLYEIMTKGQVP-YPGMHNREVVEQV-ELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFF
.||||||.|.|..||.| |. | |||| | ||.|.. | |||||.|..||. ||.  ...||.. |..||||  .....
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDL-MKQCWHYDPEDRPTFSEIHEQL
Kinase src-1.AA SrcA 273-536 58 1.1e-133 424.96 In-house 1-250 (250) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-250/250
Sequence Identity: 58% (156 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLR-TDGST
..|.|.||.| ||||| | | |   |||||.|||||||||||.        ||||||.  |  ||.||||   ||| ||.||||  |||| .|.  .|  
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLE--------EAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMCKGSLLDFLKDEEGKY

LGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILL
| .  |||||||.|.|| |.|    .|||| | |.|||...    . |.||||||| |.|.. |.|| ||||||||||||||  | ||.||||||.||||
LKLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGENL----ICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILL

YEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFF
 |..||| |||||| ||||.|||| ||.|| |..||| .. |.. .|| | |. ||||. |  | 
TELVTKGRVPYPGMNNREVLEQVERGYHMPCPQDCPESLH-ELMCQCWRKDPEERPTFEYLQSFL
Kinase src-1.AA TyrKc 273-536 40 1.9e-131 443.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-280/280
Sequence Identity: 40% (120 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQC--DHPNLVKLYAVCTRE-------EPFYIITEYMINGSLLQ
..|..||| |.||||. |.|.  ..||.|..|...          .  |.|||.||..   .|||.|.||.||| .       || .|..||| .|.|..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRTDGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEE-------DIYEART--GAK--FPIKWTAPEA
|||  . .|  . |.... |||.|| ||......||||||||.|||..     .||..||||.|.. ..       | | ...  |.|  .||.|.|||.
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

ATCGNFTVKSDVWSYGILLYEIMTKGQVPYPG-----MHNREVVEQVELGYRMPMPRG--------CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFF
   | || ||||||.|....||.| || ||||     | |.||.|.|. ||||| |          ||. .|. . ..||.  |. |||| .....|
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase src-1.AA Frk 273-540 57 1.8e-128 433.11 In-house 1-260 (260) Show / Hide 
Range on Protein: 273-540
Range on HMM: 1-260/260
Sequence Identity: 57% (156 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLR---TDG
..| |.|| | ||||| |.|   . ||.||.||||| |. ||        |||||||.  || |..||||||.||| ||||| | .|||..||.     |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFL--------REAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG

STLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDI--YEARTGAKFPIKWTAPEAATCGNFTVKSDVWSY
. . .| |||||||.| || |||..  .||||||||||||..     ..|.||||||| || ...  ||.|.||.|||||||||||    ||.||||||.
RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHN----ICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSF

GILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYF
||||.||.| |..||||| |.||...|. ||||| | .||.|.| |..|.|| . |..||||.||   ..|||
GILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLY-EIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase src-1.AA TK 273-536 26 2.9e-125 422.16 In-house 1-486 (486) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

LHLKRKLGDGNFG---EVWYGKWRGI--------------------------VEVAIKTMKPG-TMSPEAFLH---------VKILNFCREAQIMKQCD-
..| .||| |.||   ||. |.|||.                          ..||.|..|.| .||.|.|.          .   .|..||..||. . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGE---DFLEEAEEMKMMCH

----HPNLVKLYAVCTRE------------EPFYIITEYMINGS----LLQYLR----------------------------------------------
    |||.|.||.|||..            ||..|..||| .|.    |..|||                                              
SLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEE

---------TDGSTLGIQALVD-------------------MAAQIANGMMYLEER------KLVHRDLAARNVLVGDKISG-------VPVVKVADFG-
         .....|. . |..                   |..|||.|| ||...      ..|||||||||.|||..          .||.|.|||| 
QDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

-------LARKLMEEDIYEART------------------------GAKFPIKWTAPEAAT---------CGNFTVKSDVWSYGILLYEIMTKGQVPYPG
       |||.. ..| | ...                        |.|.||.|.|||. .          | || ||||||.|.|..||.| ||.||.|
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

-MHN---------REVVEQVELG--------------YRMPMPRGCPE-------------QIYEEVLLKCWDKTPDRRPTFDTLYHFF
 |.|         .||.|... |              .||| | .||.             ..|......||.. |..||||..|....
GMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase src-1.AA SrcB 273-537 55 1.3e-118 400.32 In-house 1-251 (251) Show / Hide 
Range on Protein: 273-537
Range on HMM: 1-251/251
Sequence Identity: 55% (147 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTD-GST
|.| .||| | ||||| | ... . ||.||||.|||||||||         || .||.  |  ||.|||| |.| | ||||||| .|.|| .|.|| || 
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLA--------EANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSK

LGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILL
| .  |.||.|||| || |.|..  .|||| | |.|| . .    . |.||||||| ..|.. | || |||||||||||||   | ||.||||||.||||
LSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETL----CCKIADFGLAR-IIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILL

YEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFD
.||.| |..||||| | ||....| ||||| |  ||| .|. .. .|| . |. ||||| |    |
MEIVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYN-IMMMCWKERPEERPTFDYLQSVLD
Kinase src-1.AA Src-Echino1 273-536 52 3.5e-114 385.62 In-house 1-252 (252) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-252/252
Sequence Identity: 52% (139 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGST-
|....|.|.|..|||| | | |  .||.||.|..|||| .||         || .||.| | ..|..||||  .|| ||.|| | ||.|..||. . .  
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLA--------EANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKH

LGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILL
. .  |.|| |.|| || ||... .|||||||||||||.      |.|.||||||| .|..|.| .. |||.||||||||||  | ||.||||||.|||.
VKMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGN----VCKIADFGLAR-MMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILM

YEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFF
 |..| |..|||||.||||..||..||||| .  ||. .|. ...||| | | .||||. |..||
TEMVTFGRYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase src-1.AA SFK-Abl 275-536 50 1.8e-110 361.8 In-house 3-251 (251) Show / Hide 
Range on Protein: 275-536
Range on HMM: 3-251/251
Sequence Identity: 50% (134 aa)

LKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGI
|   ||.|..|||. | | .   ||||| | . |  |.       .| .|| |||.  |||||.|  ||||| | ||..|.| .| || ||. . |   |
LGHRLGEGQYGEVYKGIW-NNHRVAIKTIKDESM--ET------KDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQI

QALVDM--AAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLY
     |  | |||.||  |||.  .|||||||| ||||  .    .||||||.|| . . |.||||.| |.||||||||.     ||.||||||.|| | 
DHVSMMHCAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQ----IKVADFGMAR-FVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLW

EIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFF
|| | | |||||.| |.|..| . ||||. | .||  || .... |||  || || |  | |  
EIATYGDVPYPGIHHRDVINQLMMGYRMQRPQDCPMEIY-NIMTQCWDVNPDERPSFHDLQHQL
Kinase src-1.AA SRM 273-537 48 3.5e-108 362.99 In-house 1-253 (253) Show / Hide 
Range on Protein: 273-537
Range on HMM: 1-253/253
Sequence Identity: 48% (128 aa)

LHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRT-DGST
  | ||||.| ||||| | |.| |.||||  |   .        .   .  | | ||.  |  ...|.|||.  .| ||||| |  |.|.||||. |.  
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNL-------MHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKA

LGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILL
| |  |.|.| |.| || ||||.. .|||||||||||||      . ||.|||||| |. .|||    . . |.||||||||  . .  ||||||.||||
LPIPHLLDFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNN----LCKVGDFGLAR-LIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILL

YEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFD
.|. |.||.||||| | |   |.. ||||| |  || ...   .|.|| . |. ||.| .|     
HEMFTYGQCPYPGMTNHETFQQIDRGYRMPCPAECPPEVH-KLMLECWCRDPEQRPCFKDLREKLT
Kinase src-1.AA S_TKc 273-540 25 3.4e-53 183.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 273-540
Range on HMM: 1-231/231
Sequence Identity: 25% (72 aa)

LHLKRKLGDGNFGEVWYGKWRG-IVEVAIKTMKPGTMSPEAFLHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMIN--GSLLQYLRTDG
 .. ||.| | ||.|. .....   .|||| .|               ...|| ||.|. .|||.|||| |.   . .|...||. .  |.|..|..  |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

S-----TLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTV-KSD
.      .       ...||.... |. ... .||||   |.|. .      ..|..||||||.|         |       . |||      ..  |.|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCD

VWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYH-----FFDDYF
.|| |..||| .. |. |.|  .  .. ...            ...  .  . ||..| |..|||   . .       . .|
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase src-1.AA Pkinase 273-536 24 1.7e-40 144.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 273-536
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

LHLKRKLGDGNFGEVWYGKWRGIVE-VAIKTMKPGTMSPEAF-LHVKILNFCREAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMING----SLLQYLR
.|..||.| |.||.|. ....|  . ||.|..|  . ...    |...    .|.|||| ..||| |.|| .....   |...||. .|    .|  |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-TDGSTL--GIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAAT-CGNFTVKS
  .. ..    . . ... ||. |. |. ... .||||   |.|. ..    . ||..|||||...  .  ..  |.    . . |||    .   . |.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSYGILLYEIMTKGQVPYPGM----HNREVVEQVELGYRMPMPRGCPEQIY----------------------EEVLLKCWDKTPDRRPTFDTLYHF-
|.||.|..||| .. |. |.||     . ..  . ...  . | .. .|. .                        ... .|..| | .|||.. . .  
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-F
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WF