Gene VZC374L.1 (Nematode worm)

VZC374L.1

Species: Nematode worm
Alias: CE16527, aSWK316, VZC374L.1
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: X:1.59, WormBase Physical Map location: X: 10000223-10002064,

Classification

Group: STE
Family: STE7
Subfamily: MEK4

Sequence

Name Sequence Type Origin Length Description Download
VZC374L.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
VZC374L.1.AA Protein Genbank 359 None Fasta, JSON

Protein domain

Protein domains of VZC374L.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase VZC374L.1.AA MEK4 64-326 62 4.90000000001e-210 692.0 In-house 1-275 (275) Show / Hide 
Range on Protein: 64-326
Range on HMM: 1-275/275
Sequence Identity: 62% (171 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYNNI-------CDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRVYSV
|..|...|.|..|||.||.|.|||...|||.||.||.       ..|.|||.|||..|||||.|.||||.||||.||||||||||||||.|..||.||.|
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

KKSRLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERIEN---MDKYDIRSDVWSLGI
.|||..|||.||||||.||||.|||.....|||||||||||....|.||||||||||.||.|.|.|..|||..|.|||||..   ||.||||||||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TLYEIATGVYPYRGWS--NQMEHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY
|.||.|||..|||.|.  .....|..||.||.|||....|..||..|.||||||||.|....||||.|||.|.||
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase VZC374L.1.AA STE7 64-326 44 1e-155 523.6 In-house 1-288 (288) Show / Hide 
Range on Protein: 64-326
Range on HMM: 1-288/288
Sequence Identity: 44% (130 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYNNI--CDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGD--CWICMELMD-ISIDFLYKRVYSV--
|.|....|.| ||.|.||.| .|| ..|||.||..|   ..|...|.|.|...|... |.||.|.||...|||  .|||||.|| ...| .||||. |  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--KKSRLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSY-AITVEAGCVQYLAPERIE-NMDKYDIRSDVWSLG
  ||.|..|.|.|.|.|.....|.||..|.. |||||||||||.|  |.|||||||||| || |. | |. .||..| |||||. |...||.||||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

ITL-YEIATGVYPYRGWSN-----------------QMEHIEIVVNG-DSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKT-FSFY
||. .|.||| |||..|..                  .|.....||. ..|.|       ........|.|.||.|. ..|||| .|.  ..|.
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP------KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase VZC374L.1.AA MEK3 64-326 45 6.7e-105 354.8 In-house 1-264 (264) Show / Hide 
Range on Protein: 64-326
Range on HMM: 1-264/264
Sequence Identity: 45% (123 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN-NICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRVYSVKKSRLN
.  ..  | | || | ||.|  ||  .|||.||   |. .| |.| . |  | |   |  |.|.|| | ||| |||||.|| . | .|..||  .. .  
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

ENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERIE---NMDKYDIRSDVWSLGITLYEIA
|.|.| | . || || |.. .|. |||||||||.|||..| ||.||||| | || | | |..||| .| |||||.   |   ||..|||||||||. |.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TGVYPYRGWSNQMEHIEIVVNGDSPILLQNM-HNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY
.| |||  |    .    || . .| | .         |    ||| ||.||   ||.|  |   .| 
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQD----FINQCLKKNYMERPSYPELMEHPFM
Kinase VZC374L.1.AA STE 64-326 26 1e-89 304.37 In-house 1-359 (359) Show / Hide 
Range on Protein: 64-326
Range on HMM: 1-359/359
Sequence Identity: 26% (97 aa)

LRHLSQVGAGYYGTVHKMQHN------ESGRL---------IAVKKIRYNNI-----------------CDQTRLLKEHDTHMKSEN-VPNIVKFFGACF
.......| | .|||.|  ..      ..|..         .|.|.....|                   .. ..||| ....|. .  |||||..|..|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SEG-------DCWICMELMD-ISIDFLYKRVYSVKK---------SRLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICG
 ||       ..|||||.||  |.| ..|..|...|         .|..|..|..|.. |. .| |.. ....||||.||.|||.     |||||||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

DLVGSYA----------------IT-VEAGCVQYLAPERIEN-----MDKYDIRSDVWSLGITLYEIATGVYPYRG-WSNQ--------------MEHIE
 |. |.|                 .   .|.  . |||.|..     ...||...|.||||.|. | ||| .|.      .              .|.. 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

IVVNGDSPILLQNMH--------------NLHYTDPLCRFINTCLRKNKDDRPKYVNLKT--FSFY
 .|||..| | .. .                ....... ||| ||.|. ..||..  |     .| 
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase VZC374L.1.AA MEK7 64-326 43 5.7e-89 301.88 In-house 1-269 (269) Show / Hide 
Range on Protein: 64-326
Range on HMM: 1-269/269
Sequence Identity: 43% (118 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN-NICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRVYSVKKSRLN
| |..  | |  |.| || | .||  .|||  | . |  .  | |   |   .. . | ||. ||.   . | |||||.|   .| | ||..  |     
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

ENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERIEN----MDKYDIRSDVWSLGITLYEI
| |||...| |. ||.||| |   .||||||||||.   | .||||||| | .| | | |  |||  | |||||       .|||||.|||||||||.| 
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

ATGVYPYRGWSNQMEHIEIVVNG--DSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY
||| ||| |     | . .. |   ..| | . |    .    | |.. ||.|.  .||||  |   .|.
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMK-YNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase VZC374L.1.AA STE7-Unclassified 64-320 33 2.7e-74 253.16 In-house 1-294 (301) Show / Hide 
Range on Protein: 64-320
Range on HMM: 1-294/301
Sequence Identity: 33% (98 aa)

LRHLSQVGAGYYGTVHKMQHNE------SGRLIAVKKIR-YNN-ICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGD---CWICMELMDI-SID---F
|. |. .|.| .||| |  |        .|  .| |.|.  .| . ... .|.|  |  | .  |.||...|| ..|.      ||||.||  |.|    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

LYKRVYS---VKKSRLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSY--AITVEAGCVQYLAPERIENM----
.||..|    .......| ..| |.  .  .|.||..|.. ||||.||.|||.|. | ||.||||.|| |. ..  | |  .||..| .||||.      
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

DKYDIRSDVWSLGITLYEIATGVYPYR------GWSNQ--------MEHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNL
  | ..||.||||.|. | ||| |||       . ...         |  ...||  .|.|  .  .. .   .  ||. |. |.  .|| ...|
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQL
Kinase VZC374L.1.AA S_TKc 64-326 24 6e-63 216.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 64-326
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYNNICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDI---SIDFLYKRVYSVKK-S
 . | ..| | .|.|.| .|...||. |.|.|.        ....| . ..|  . |||||..... . .. ...||..|    .   . |.  . .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

RLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERIENMDKYDI-RSDVWSLGITLYEI
...|  . ...  |..||.|. .. . ||||.||.|||..    .|.||||..  |      |   |   |.||| .    .|.  ..|.||.|..||| 
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ATGVYPYRGWSNQMEHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKT-------FSFY
..|  |..   .... .....                ..... ||. ||.|. ..||    . .         . 
LCGYPPFP---QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase VZC374L.1.AA MEK1 64-264 37 4.2e-51 172.69 In-house 1-195 (297) Show / Hide 
Range on Protein: 64-264
Range on HMM: 1-195/297
Sequence Identity: 37% (77 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN-NICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMD-ISIDFLYKRVYSVKKSRL
. ... .|.|  | | |..| ..| ..| | |.       .  ...|    .   | | || |.|| .|.|.  |||| ||  |.| . |..      |.
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GRI

NENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERIENMDKYDIRSDVWSLGITLYEIATG
 |.|.|...| ..  | ||. | . .||||||||||.|. |..||||||. | |. | |     |   |..|||..    | ..||.||.|. | |.| |
PEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGT-HYTVQSDIWSMGLSLVEMAIG

VYP
 ||
RYP
Kinase VZC374L.1.AA MEK5 64-326 37 4.6e-51 175.96 In-house 1-254 (254) Show / Hide 
Range on Protein: 64-326
Range on HMM: 1-254/254
Sequence Identity: 37% (102 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYNNICD-QTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRVYSVKKSRLN
.|.   .| |  |||.|  |  ||...||| |  .   . | ... | .   | .  | |. |.|| | |    || | ||     .|...         
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCD-SPYIIGFYGAFFVENRISICTEFMDGGSLDMYRCI--------P

ENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERIENMDKYDIRSDVWSLGITLYEIATGV
| |.| .|| ||  | ||   |  .||||||||.|.|  |..||||||.   || | . |   |   |.|||||   |.| | |||||||| . |.||| 
EHILGRMTVAIVKGLNYL-WNLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERIS-GDQYGIHSDVWSLGIFFMEMATGR

YPYRGWS-NQ-----MEHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY
.||     .|     .. .  .|. ..| |  .    .. .|   ||| |..|   ||||  .|    | 
FPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVD----KFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase VZC374L.1.AA STE20 64-266 31 2.9e-39 136.75 In-house 1-228 (288) Show / Hide 
Range on Protein: 64-266
Range on HMM: 1-228/288
Sequence Identity: 31% (73 aa)

LRHLSQVGAGYYGTVHKMQHNESGRL----IAVKKIRYNNI----CDQTRLLKEHDTHMKSENVPNIVKFFGACFSE----GDCWICMELMDI-SIDFLY
   | ..| | ||.|.|  |...|..    .|.||. ...     ...  ..|| .   ..   |||||..|. . .     . ||.||...  |.  ..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

KRVYSVKKS----RLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVG----SYA---ITVEAGCVQYLAPERIENM
|.... .|.    ..||  |  |.  .. .|||| .. ..||||.|  |||..  |.|||.||| |..|      . .    |.  |   ..||| |. |
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTF-VGTPYWMAPEVIQCM

----DKYDIRSDVWSLGITLYEIATGVYPYR
     .|| ..|.||||||. | |.|  ||.
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYF
Kinase VZC374L.1.AA Pkinase 64-315 24 1e-37 134.45 Pfam 1-282 (293) Show / Hide 
Range on Protein: 64-315
Range on HMM: 1-282/293
Sequence Identity: 24% (69 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYNNICDQTR--LLK--EHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDIS---IDFLYKRVYSV
.. ....|.| .|.| | .|  .|.. |||.|.. .. .. .  ...  |   . .  | ||||...... ........||...     .|    ..   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTW

KKSRL--NENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDV----KLCDFGICGD--LVGSYAITVEAGCVQYLAPERIENMDKYDIRSDV
.. ..   |. . ..   |. .|.|. .  . ||||.||.||||.  |..    |.||||..    .  .   |. .|   |.||| |    .|. ..|.
RHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGITLYEIATGVYPYRGW-----SNQMEHIEIVVNGDSPILLQNMHNLHYT---------------DPLCRFINTCLRKNKDDRP
||.|..||| ..|  |..|       .||. |. .  .. .   .. ..  |                .... ||. ||.|.  .||
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase VZC374L.1.AA TKL 70-315 16 1.7e-36 127.61 In-house 1-355 (364) Show / Hide 
Range on Protein: 70-315
Range on HMM: 1-355/364
Sequence Identity: 16% (62 aa)

VGAGYYGTVHKMQHNE--------SGRLIAVKKIRYNN--------------------------ICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGD-
.| | .|.|.| ...         .|. .||||.. .|                          ..     ..|   .|.. . ||||.| |.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------CWICMELMDISI-DFLYKRVYSVKKSRLNENIIGHITVCIVDALDYLKR-------KLNRIHRDVKPSNILINAAGD-----------
            ..| ||...      ..             . . ..   |  ...||         | . |||| |..|||..  .            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---VKLCDFGICGDLVGSY--------------------AITVEAGCVQYLAPERIENMD---------------KYDIRSDVWSLGITLYEIATGVYPY
   .|.||||.. .. .|                     .   . |  ...||| .....               .|. ..||.| || |.||.|.  ||
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

R-GWSNQME-------HIEIVVNGDSPILLQN--------MHNLHYTDPLCRFINTCLRKNKDDRP
.  ....|.        ...|..   . .. .        ... .  ..... .  |   . ..||
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP
Kinase VZC374L.1.AA TyrKc 64-325 23 1.3e-13 -2.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 64-325
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYNNICDQTRLLKEHDTHMKSE--NVPNIVKFFGACFSE-------GDCWICMELMDISIDFLYKRVY
.. . . | | .|.|.| . .   .  |||... .    .  ...|    |..   . ||||...|.| ..       .  .| ||.|.   | .    .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREA-RIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRK

SVKKSRLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGS--------YAIT----VEA--GCVQYLAPERIENMD
. .|  |.     .. . | .  .|| .| | ||||    |.|... . || .||| . |.           |  .     .     .  .||| | |  
HRPK--LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

KYDIRSDVWSLGITLYEIAT-GVYPYRG---WSNQMEHIEIVVNGDSPILLQNMHN------LHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSF
|. . ||||| |....|| | |  || |       |. .|.. . ..   .  ..|       . .| . . . .| . . .|||   ..    |
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase VZC374L.1.AA Pkinase_Tyr 195-271 34 7.5e-10 33.98 Pfam 141-222 (270) Show / Hide 
Range on Protein: 195-271
Range on HMM: 141-222/270
Sequence Identity: 34% (29 aa)

NILINAAGDVKLCDFGICGDL--VGSYAITVEA---GCVQYLAPERIENMDKYDIRSDVWSLGITLYEIAT-GVYP-YRGWSNQ
|.|..  . || |||| . |.   . | ...       .  .||| | ..  . . ||||| |....|| | |  | | |.||.
NCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE
Kinase VZC374L.1.AA MEK1 273-326 25 0.002195 6.84 In-house 248-297 (297) Show / Hide 
Range on Protein: 273-326
Range on HMM: 248-297/297
Sequence Identity: 25% (14 aa)

EHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY
| .. .||.  | | . .    ... .  |.. ||.|| |.|    .|..  | 
EMLDYIVNEPPPKLPHRV----FSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase VZC374L.1.AA STE20 294-326 24 0.008366 6.43 In-house 256-288 (288) Show / Hide 
Range on Protein: 294-326
Range on HMM: 256-288/288
Sequence Identity: 24% (8 aa)

HYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY
.... .. |...|| |. ..||    | . .| 
KWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase VZC374L.1.AA Pkinase_Tyr 64-142 23 0.020382 8.81 Pfam 1-89 (270) Show / Hide 
Range on Protein: 64-142
Range on HMM: 1-89/270
Sequence Identity: 23% (21 aa)

LRHLSQVGAGYYGTVHKMQHN----ESGRLIAVKKIRYNNICDQ--TRLLKEHDTHMKSE-NVPNIVKFFGACF-SEGD--CWICMELM
.. . . |.| .|.|.|   .    . .   |||... .   .|   . . .    ||.  . ||||.. |.|   ..    .| ||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM