Gene W02B3.2 (Nematode worm)

W02B3.2

Species: Nematode worm
Alias: CE02074, aSWK005, W02B3.2, YR22_CAEEL
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: III:-26.58, WormBase Physical Map location: III: 676109-680041

Classification

Group: AGC
Family: GRK
Subfamily: BARK

Sequence

Name Sequence Type Origin Length Description Download
W02B3.2.AA Protein Genbank 727 None Fasta, JSON
W02B3.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of W02B3.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS W02B3.2.AA RGS 54-175 26 1.1e-34 122.41 SMART 1-121 (121) Show / Hide 
Range on Protein: 54-175
Range on HMM: 1-121/121
Sequence Identity: 26% (33 aa)

KFDKIF-NQKLGFLLLKDYAENVSESPCPQIKFYEAIKEYEKMETPDERLTKAREIYDHHIMVEMLA-HAHNYSKESLQHVQYHLLKQNVPPDLFHRYVL
 |.... |.. | .. ... ..  ..... ..|..|..|..|||. .||  ||||||| .|... .  |..|..... ...| .| .  ..||.| ..  
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMED-EERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN--PHPDCFDEAQR

EICDQLRGDIFQRFLESDKFTRFC
.... ...| ..|||.||...|..
HVYQLMEKDSYPRFLRSDYYKRYL
RGS W02B3.2.AA RGS 54-174 27 1.4e-33 112.76 Pfam 1-124 (124) Show / Hide 
Range on Protein: 54-174
Range on HMM: 1-124/124
Sequence Identity: 27% (34 aa)

KFDKIFNQKL-GFLLLKDYAENVSESPCPQIKFYEAIKEYEKM--ETPDERLTK-AREIYDHHIMVEMLAHAHNYSKESLQHVQYHLLKQNVPPDLFHRY
 |....| .  |..| ... |.   .. . |.|..|.....||  ........| |||||. .|. .   . || .... .|.| .| .... ||.| ..
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

VLEICDQLRGDIFQRFLESDKFTRF
  .|.. ...| ..|||.||.. ||
QRHIYTLMEKDSYPRFLKSDYYQRF
Kinase W02B3.2.AA BARK 191-455 88 1.5e-227 762.23 In-house 1-264 (264) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-264/264
Sequence Identity: 88% (235 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHGVF
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..||||||||||||||||||||||||||
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVF

TEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDYSKKKPHASVGTHGYMAPEVLAKGVAYDSSADWFSLGCMLYKLLKGHS
.||||.|||.|.|||||||||||||||||||||||||||||||.||||||||.||||||||||||||||||||.||.|||||||||||||||||||.|||
SEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLRGHS

PFRQHKSKDKNEIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEVKEHPFF
||||||.|||.|||.||||...||| ...||..||||||||.|||..||||.|.|..||||||||
PFRQHKTKDKHEIDRMTLTMNVELP-DSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase W02B3.2.AA GRK 191-455 56 1.8e-212 676.49 In-house 1-272 (272) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-272/272
Sequence Identity: 56% (154 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHGV-
|...|..|.||||||..|....||||||.|||||||||...|||.||||...|..|... ||||||||.||....|.||.....|||||||||....|. 
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSR-DCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNN

---FTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDYSKKK--PHASVGTHGYMAPEVLAKGVAYDSSADWFSLGCMLYK
   |.|..|.|||.|...||||||.|..|||||||.|||||..||||.|||||||......  .|..|||||||||||| ...|||.|.||.|||||.|.
EPGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYE

LLKGHSPFRQHKSKDKN-EIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRGK--GPTEVKEHPFF
...||||||||| |.|. |.|..........| . .|....|..|.||..|. .||||||.  |..||||||||
MIEGHSPFRQHKEKVKREEVDRRVKEDPVKYP-DKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase W02B3.2.AA AGC 191-455 26 6.7e-146 380.05 In-house 1-395 (395) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-395/395
Sequence Identity: 26% (108 aa)

FSVHRIIGRGGFGEVYGCRKA------DTGKMYAMKCLDKKR-IKMKQ--GETLALNE------------RIMLSLVS--------TGQDCPFIVC-MTY
| ....||.|.||.|| .||       ||||.||||.|.||. |..|.   .  ...|            | .|....        .  ..||||  . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKS--HHPFIVKILHY

AFQSPDK--LCFILDLMN---------GG-DLHYHLS---QHGVFTEQEMIFYASE-------VILGLEHMHN-RFVVYRD-LKPANILLDENGHVRVSD
.||..|.  |.|....|.         || .|..||    . |.|.|..  |||.|       ..|.||..|. . ...|| ||| ||||||.||.. .|
SFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTD

LGLACDYSK----------------------------------------------------KKPHASVG--THGYMAPEVLAKGVAYDSSADWFS--LGC
 ||..   .                                                    .. .  .|  |. |||||.|     |. ..|| |  |||
FGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGC

MLYKLLKGHSPFRQH-------KSKDKNEIDKMTL------TQDIELPN---------EGLSKDCRDLLEGLLKRDVPDRLGCRGK-----GPTEVKEHP
..| .| |..||. .       . ....|. .  .      ......|.         . .|....||...||..|  .||||.|.     |  |.|.||
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

FF
.|
WF
Kinase W02B3.2.AA GRK 191-455 45 2.1e-101 343.21 In-house 1-265 (265) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-265/265
Sequence Identity: 45% (124 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHG--
|   |. | ||||||  |    |||||| | |.||||| ..||..||||   |  |.     .|.| . ||. . | || .. .|||||| .|.   |  
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVH----SRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGEN

-VFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDYSKKKP-HASVGTHGYMAPEVLAKGVAYDSSADWFSLGCMLYKLL
  | |.  |||| |...|||| | . .||||.|| |||||. ||.|.||||||      ..    ||| |||||||.   . |. | ||..||| .|   
PGFDEERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNER-YTFSPDWWGLGCLIYEMI

KGHSPFRQHKSK-DKNEIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEVKEHPFF
 |.||||| | |  . |.|. .. .. . . |  |.. .|. . ||. |   |||||..|  ||..||||
EGRSPFRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase W02B3.2.AA Pkinase 191-455 28 6.2e-95 326.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-293/293
Sequence Identity: 28% (88 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL--NERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGG----DLHYHL
. ..|.||.|.||.|| |.. .|||..|.|...|...|... .|...    .||..| .    .|.|| . ..|...|..........||    ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

S--QHGVF--TEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHV----RVSDLGLAC---DYSKKKPHASVGTHGYMAPEVLAKGVAYDSSA
|  .||.|  .|.| .||. ... |||..|.. ...|||||.|||.|.|||.    ...| |||.     ..  ..  .|| .||||||. .|  |....
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DWFSLGCMLYKLLKGHSPFRQH----KSKDKNEIDKMTLTQDIELPNE--------------------GLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEV
|..|.||.|| .| |. ||..|    .  |.... ....  ... . .                     .|..|.|.....|..|  .|..     ....
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQI

KEHPFF
..||.|
LQHPWF
Kinase W02B3.2.AA RSK 194-455 35 1.2e-88 300.84 In-house 1-278 (278) Show / Hide 
Range on Protein: 194-455
Range on HMM: 1-278/278
Sequence Identity: 35% (100 aa)

HRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQG-ETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHGV
..  |.||.|.|. |||    |||. |||| |.|. |. .|     .. ||  |...   | .||||   |||| ..||  |.....||.| .||.... 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERC---QQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKH

---FTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDE---NGHVRVSDLGLACD--YS-KKKPHASVGTHGYMAPEVLA---KGVAYDSSADWFS
   |.| |  ||..|..| .||.| . ...||||| |||.|.   .||....| |...    . ... .  ..|. |||||.|.   .....| ..||.|
FGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWS

LGCMLYKLLKGHSPFRQHKSK-DKNEIDKMTLTQD--IELP-NEGLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEVKEHPFF
||. .| .| |..||..   . ...|| |  .. .   ..| .. ||....||. ..|.||  .||||  ..  |.|.||.|
LGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase W02B3.2.AA Akt 191-455 37 1.3e-85 273.63 In-house 1-264 (264) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-264/264
Sequence Identity: 37% (102 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMY-AMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHGV
| . ...|.| || |. ..| ||.|.| ||| | |..| .|     .. || .|  .     .|||| . |.||..|||.|..| .|||.| |||.. ..
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN----HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRR

FTEQEMIFYASEVILGLEHMHNRFVVYRD-LKPANILLDENGHVRVSDLGLAC-D-YSK-KKPHASVGTHGYMAPEVLAKGVAYDSSADWFS-LGCMLYK
|.|..  ||..|.||..|| |.. ..||| ||| |||.|..||... | ||.  .  .   |     ||  |.|||.| . . .. ..|| . ||| .| 
FSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG-NGHTKAVDWWGSLGCVMYE

LLKGHSPFRQHKSKDKNEIDKMTLTQDIELPN-EGLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEVKEHPFF
.. |  ||  .. .|. .  |  ..|... |. . .|..|.||..|||..|   |||   ..  |.|.||.|
MMCGRPPF--YN-QDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase W02B3.2.AA S_TKc 191-455 29 2.9e-85 290.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-231/231
Sequence Identity: 29% (82 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNG--GDLHYHLSQHG
. ..|.||.|.||.|| ||. .||. .|.|...            ...|. .|.      ..|.|| . ..||. |.|........|  |||. .. ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

V------FTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDYSKKKPHASVGTHGYMAPEVLAKGVAYDS-SADWFSLGCM
       |.| .  ||. .....||..|.. ...|||||.||||||  |. ..| |||. .     .  .||  |||||||     |.  ..|| |.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

LYKLLKGHSPFRQHKSKDKNEIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRGKGP--TEVKEHPFF
|| .| |  ||.          . ... . |       |....|.....|..|  .|...        ..| ||.|
LYEMLCGYPPFP----------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase W02B3.2.AA SGK 191-455 36 1.9e-82 254.32 In-house 1-283 (283) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-283/283
Sequence Identity: 36% (106 aa)

FSVHRIIGRGGFGEVYGCRKADT------------------GKMYAMKCLDKKRIK-------MKQGETLALNER-IMLSLVSTGQDCPFIVCMTYAFQS
|    .|| |.||.||  .. |.                  .|.|||| | |. |         |  . . . ||   |....     ||||   |||| 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMK----HPFIVNLHYAFQT

PDKLCFILDLMNGGDLHYHLSQHGVFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDYSKKKPHAS--VGTHGYMAPEV
..|| | .| .|||.. |||   . | | .  |||.|... ||. |   ..|||||| |||||  ||..  | ||.    |..   .   ||  |.||||
KWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEV

LAKGVAYDSSADWFSLGCMLYKLLKGHSPFRQHKSKDKNEIDKMTLTQDIELPNEGLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEVKEHPFF
|.|   .| . ||..||| || .. |  ||    |..|..     . |.. .|  . | |..||..|||..|. .||| . ..  |.|.||||
LRK-QPHDRTVDWWCLGCVLYEMMYGLPPFY---SRNKQQMYDNIINQPLQIP-PQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase W02B3.2.AA AktR 191-455 34 9.2e-80 271.29 In-house 1-268 (268) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-268/268
Sequence Identity: 34% (96 aa)

FSVHRIIGRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKQGETLALNERIMLS-LVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHG
| |....|.|.||.|| ..|  |..|.|||| ..|| |. .. .  ...||  .  ..    . |||| . |.||. .|| ||.. . ||.| .||.. .
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCC----NHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKK

VFTEQEMIFYASEVILGLEHMHNR-FVVYRDLKPANILLDENGHVRVSDLGLAC---DYSK-KKPHASVGTHGYMAPEVLAKGVAYDSSADWFSLGCMLY
 |.|..  ||.....|.||. |..  ..|||||| ||||||.|||. .| ||.    . ..  | .  .||. |||||.. | . .. |.|| ..|. .|
KFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIY

KLLKGHSPFRQHKSKDKNEIDKMTLTQD-IELPN-EGLSKDCRDLLE-GLLKRDVPDRLGCRGKGPTEVKEHPFF
 .. |. || ...   .|.. .. .... .. |  . .|. |.||.. .||...   |||   .|..|.|.||.|
EMVTGCPPFYHKN---QNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase W02B3.2.AA RSK 191-455 35 9.5e-71 241.36 In-house 1-271 (271) Show / Hide 
Range on Protein: 191-455
Range on HMM: 1-271/271
Sequence Identity: 35% (100 aa)

FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQ
. .|. ||.| |..|| |.|    ||.. |||| ..|. .. | .    . .|||.|. .    . ||||   |.||.  |.  |.|.| ||||  .|. 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYG----HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLK

HGVFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDEN----GHVRVSDLGLACDYSKKKPHASVG-------THGYMAPEVLAKGVAYDSSADW
 ..|.|.|  ||..|. | .|. |   .|.|||||.|||.|.     ||... |.|.|     |.  .  |       |  ||||||| .   .| ..||
QKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFA-----KQLRDENGMLMTFCYTANYMAPEVLKR-QGHDQACDW

FSLGCMLYKLLKGHSPFRQHKSKD-KNEIDKMTLTQ-DIELPN-EGLSKDCRDLLEGLLKRDVPDRLGCRGKGPTEVKEHPFF
.|.|  .|  | |. ||     .. .| | .  | . ..  .| . .|. . ||| ..|.||   |||.   |  ..|.||.|
WSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase W02B3.2.AA RSK-Unclassified 191-348 39 1.5e-52 163.15 In-house 1-157 (283) Show / Hide 
Range on Protein: 191-348
Range on HMM: 1-157/283
Sequence Identity: 39% (63 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLS--QHG
| .|| ||.| ||.||  || || ..|||| | |...  ..    .. |.  ...     . |||| . ..||. |.|  ...   |||.  ||      
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATT----NHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEK

VFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDY-SKKKP
 |.| .  ||||||.. ||..| | ..|||||| ||.|.  |||. .| .|  .    |||
CFCEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKP
Kinase W02B3.2.AA RSK-Unclassified 352-455 33 6.9e-28 84.26 In-house 183-283 (283) Show / Hide 
Range on Protein: 352-455
Range on HMM: 183-283/283
Sequence Identity: 33% (36 aa)

VGTHGYMAPEVLAKGVAYDSSADWFSLGCMLYKLLKGHSPFRQHKSKDKNEIDKMTLTQDIELP-NEGLSKDCRDLLEGLLKRDVPDRLGCRGKG-PTEV
.||  |.|||.. ..       ||. || ..| .| |  |.   .   |||. .  ..... .| .. .|..||||.  ||.|    |||| ..|   ..
CGTEEYLAPEMI-RRCGHTKAVDWWTLGIVMYEMLFGCPPY---YGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGC-KMGDADDI

KEHPFF
| ||||
KRHPFF
Kinase W02B3.2.AA S_TK_X 456-535 23 1.9e-16 61.92 SMART 1-79 (79) Show / Hide 
Range on Protein: 456-535
Range on HMM: 1-79/79
Sequence Identity: 23% (21 aa)

KDVDWQTVYL--RRMTPPLIPPRGEVNAADAFDIGNFDDDEVKGVKLQDGDSDLYKNFNIVISER-WQNEIAETI-----FEVVNQDA
...||...|   ....|| .|.  ||.| ...|..|||... ...         ..... ..|.. |||| .||      |.  . ..
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase W02B3.2.AA TyrKc 191-439 18 6.7e-11 -46.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 191-439
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE-RIMLSLVSTGQDCPFIVCMTYAFQSP-------DKLCFILDLMNGGDLHY
 .  ...|.| ||||| ..      . | |.| .        .   ..| ||| .|   | . | ||..  .  ..       . |. .. .| .|||. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKL---GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HLSQHGV-FTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLACDYSKK------KPHASV----GTHG-----YMAPEVLAKG
.|  |.  .. .... ..  .  | |. | . .. |||   |.|..||..|..|| ||. |   .      |   ..    |...      ||||.. .|
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

VAYDSSADWFSLGCMLYKLL-KGHSPFRQ---HKSKDKNEIDKMTLTQDIELPNEG--------LSKDCRDLLEGLLKR---------DVPDRL
. . .  | .| | ... ..  | .|      .  ..  |. .   . .   . .          ...  .. .   ..         .. ...
K-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase W02B3.2.AA Pkinase_Tyr 267-340 26 3.1e-05 18.37 Pfam 81-158 (270) Show / Hide 
Range on Protein: 267-340
Range on HMM: 81-158/270
Sequence Identity: 26% (21 aa)

KLCFILDLMNGGDLHYHLSQH----GVFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVRVSDLGLA
... .. .| .|||. .| .|    . .| .... .. ..  |.|. ...  . |||   |.|..||..|...| |||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase W02B3.2.AA Pkinase_Tyr 191-206 43 0.899233 3.24 Pfam 1-16 (270) Show / Hide 
Range on Protein: 191-206
Range on HMM: 1-16/270
Sequence Identity: 43% (7 aa)

FSVHRIIGRGGFGEVY
 .  . .|.| |||||
ITFGKKLGEGAFGEVY
PH W02B3.2.AA PH 559-680 12 0.00097 19.67 SMART 1-82 (82) Show / Hide 
Range on Protein: 559-680
Range on HMM: 1-82/82
Sequence Identity: 12% (15 aa)

VIVHGYIKKLGGPFTSAWQTKYGKLYPSRLELYPESLTAKPELVFMDQIEDVCAEMQTIKGETAIIVKLRDGFKEPKICLTNSVSENVLKYKTEKKNCRS
|| .|...|..      |. ..  |....| .| ..  .. . .... .  |           .. ..  |.               ..  ..|      
VIKEGWLYKKS---K-RWKKRWFVLFNDCLYYYKDK--KPKGSIPLSDC-TVRE-P-------CFEIHH-DR---------------TYYFQCE------

VYLDEISLKEWHTSLRTAHKVS
   .| ...|| .... | . .
---SEEEMQEWMQAIQKAIHNN