Gene Y105C5A.24 (Nematode worm)

Y105C5A.24

Species: Nematode worm
Alias: Y105C5.y, Y105C5A.24, CE23205, aSWK422, Y105C5A.X
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:21.15, WormBase Physical Map location: IV: 15849959-15852704

Classification

Group: TKL
Family: MLK
Subfamily: TAK1

Sequence

Name Sequence Type Origin Length Description Download
Y105C5A.24.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 220 Kinase domain by global Sugen HMM Fasta, JSON
Y105C5A.24.AA Protein Genbank 445 None Fasta, JSON

Protein domain

Protein domains of Y105C5A.24.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y105C5A.24.AA TAK1 43-261 39 7.79999999999e-152 510.72 In-house 1-284 (284) Show / Hide 
Range on Protein: 43-261
Range on HMM: 1-284/284
Sequence Identity: 39% (112 aa)

ELNSHFLGKGTFGVVEKTKYRKTRDDTYR---------------------------------IYGMYESHRNGQGLVMEYMDCGCVADLIYD-RKNIEYK
..|.||.||||.|||.|.|.|.......|                                 .||||..||..|.|||||||||........ ....||.
IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFLHGAKPKWEYT

MDHVASWMYQLSSAVNFFHSKD---QIHRDLKLQNMLLSHHHRTLKICDFGTFTSIHQSMTSNRGSPITMAPEI----------------------FRCE
..|..|||.|....|...||..   |||||.|.|||||...||||||||||||...||.||.|||....||||.                      ||||
HAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTFCDMHQMMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCE

PYNMKADIFSIGIIMWQMIARDHPYTMNMP---ITPFLYNVATRNLRPHEIE---CNPILSNFYKRCWSDNPASRPTSADCVEY
.||||.||.|.|||||..|.|.|||...|.   ...........|..|.|..   |......|.|.||.|||..||....||.|
KYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase Y105C5A.24.AA MLK 43-262 25 2.9e-96 326.11 In-house 1-291 (291) Show / Hide 
Range on Protein: 43-262
Range on HMM: 1-291/291
Sequence Identity: 25% (74 aa)

ELNSHFLGKGTFGVVEKTKYRKTR-----DDTYR-------------------------------------IYGMYESHRNGQG--LVMEYMDCGCVADL
 ......|.|.||.|.|...|...      . .|                                     |. .. .......  .||||...|. ...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IYD-RKNIE-----------YKMDHVASWMYQLSSAVNFFHSKDQ---IHRDLKLQNMLLSH-----HHRTLKICDFGTFTSIHQS---MTSNRGSPITM
... |....           |..||...|..| .......||...   |||||| .|.|...     ||.|||||||||....||.   |.||.|....|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEIF---RCEPYNMKADIFSIGIIMWQMIARDHPYT-MNMPITPFLYNVATRNLRPHEIECNPILSNFYKRCWSDNPASRPTSADCVEYF
|||..   |||.|..|.|..|.|...|.|..| .||  ...|.. . ....... .|....|........|.||...|..||... .|...
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Y105C5A.24.AA TKL 71-262 20 2.2e-48 167.03 In-house 89-364 (364) Show / Hide 
Range on Protein: 71-262
Range on HMM: 89-364/364
Sequence Identity: 20% (58 aa)

RIYGMYESHRNGQ------------GLVMEYMDCGC-VADLIYDRKNIEYKMDHVASWMYQLSSAVNFFHSKD--------QIHRDLKLQNMLLSHHHR-
...|   . ..|.            ..||||...|.   .|.         ...  .|... ....|. ||..         |||||| .| |.  . . 
QFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTN

------------TLKICDFGTFTSIHQS---------------------MTSNRG-SPITMAPEIFRCE----------------PYNMKADIFSIGIIM
            ..||||||. ....||                     .|.... .|  ||||..| .                .|. |.|..| ||..
VSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL

WQMIARDHPYT--MNMPITPF------LYNVATRNLRPHE-------------IECNPILSNFYKRCWSDNPASRPTSADCVEYF
| ...| .||   ..||. ..      .. |. ..|||                 | | ...  ..||. .| .||.  ......
WEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Y105C5A.24.AA Pkinase 71-262 23 2.3e-32 115.53 Pfam 64-293 (293) Show / Hide 
Range on Protein: 71-262
Range on HMM: 64-293/293
Sequence Identity: 23% (55 aa)

RIYGMYESHRNGQGLVMEYMDCG----CVADLIYDRKNIEY--KMDHVASWMYQLSSAVNFFHSKDQIHRDLKLQNMLLSHHHRT---LKICDFGT--F-
|.|...|....   .||||...|      .|.|  ...  .   .... ..|||. ..... ||.  ||||||..| |....  .   .||||||   . 
RLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQF

-TSIHQSMTSNRGSPITMAPEIFR-CEPYNMKADIFSIGIIMWQMIARDHPYTMN------MPITPFLYNVATRNLRPHEIECN----------------
 .   . ||.  |.|  ||||. | ...|  |.|..|.|.|...|. .  |.          ..  .  .  ... .. . .|.                
DY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFH

---PILSNFYKRCWSDNPASRPTSADCVEY--F
   . .  | |.|.  .|..||| .....   |
NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Y105C5A.24.AA CAMK 71-198 18 2.5e-31 97.62 In-house 102-324 (425) Show / Hide 
Range on Protein: 71-198
Range on HMM: 102-324/425
Sequence Identity: 18% (42 aa)

RIYGMYESHR---------NGQG----------LVM---EYMDCG----CVADLIYDRKN-------------IEYKMDHVASWMYQLSSAVNFFHSKDQ
..| .||...         . .           .||   ||.. |     . | | ....               .. . .. .. |. |||.. ||.. 
KLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLQNMLLSHHH----------------RTLKICDFGTFTSIHQ--------------------------SMTSNRGSPITMA-PEIFRC------
.|||||. | ||....                 ..||.|||  . . .                           |.   |.|  || ||...       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EPYNMKADIFSIGIIM
        ..|. |.|. |.|.|.
QNATDEEKPYYGPKCDMWSCGVIL
Kinase Y105C5A.24.AA S_TKc 43-262 24 8e-29 102.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 43-262
Range on HMM: 1-231/231
Sequence Identity: 24% (63 aa)

ELNSHFLGKGTFGVVEKTKYRKTRDDTY------------------------RIYGMYESHRNGQGLVMEYMDC--GCVADLIYDRKNIE----YKMDHV
      .|||.||.| | . .|  .  .                        ..|.....  .   .||||.|   | . |.| .|.       .   |.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA

ASWMYQLSSAVNFFHSKDQIHRDLKLQNMLLSHHHRTLKICDFGTFTSIHQSMTSNRGSPITMAPEIFRCEPYNM-KADIFSIGIIMWQMIARDHPYTMN
...|||. .|... ||.  |||||| .| ||..   ..||||||  . .    |.  |.|  ||||..   .|.  |.|. |.|.|.. |...  |.   
RFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

MPITPFLYNVATRNLRPHEIECNPILSNFYKRCWSDNPASRPTSADCVE---------YF
      ....             | . .| ..|.  .|. |||  .. .         .|
--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y105C5A.24.AA Ciliate-E2 85-208 22 4.1e-27 90.09 In-house 111-296 (365) Show / Hide 
Range on Protein: 85-208
Range on HMM: 111-296/365
Sequence Identity: 22% (43 aa)

LVMEYMDCGCVADLIYDRKNIE---------YKMDHVASWMYQLSS---------------AVNFFHSKD-QIHRDLKLQNMLLSHHHRTLKICDFGTFT
||||| . |   |.|...|  .         ... ...  |.|. .               |... |||   ||||.|..| |.      .||.|||. .
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSK

SIHQSMTSNR----------------------------------GSPITMAPEIFRCEP---------YNMKADIFSIGIIMWQMIARDHPY
 .....  ..                                  |.|  |||||.. ..         |. |.||.|.|.|. .|.   .|.
KYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase Y105C5A.24.AA Ciliate-E2-Unclassified 85-211 23 3.3e-26 87.92 In-house 98-273 (352) Show / Hide 
Range on Protein: 85-211
Range on HMM: 98-273/352
Sequence Identity: 23% (41 aa)

LVMEYMDCGCVADLIYDRKN---------------IEYKMDHVA-----SWMYQLSSAVNFFHSKD-QIHRDLKLQNMLLSHHHR--TLKICDFGTFTSI
.||||.. |   . | .||.                .    ...      ...|. .. .. |.|   ||||.|..| |..  ..   .||.||| .  .
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

HQS------------------MTSNRGSPITM----APEIFRCEPYN----MKADIFSIGIIMWQMIARDHPYTMN
 |.                  |... |.|..|    |||... . |.     |.||.| |.|. .|.   .|.  |
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN
Kinase Y105C5A.24.AA STE 71-257 20 4.5e-25 85.56 In-house 94-350 (359) Show / Hide 
Range on Protein: 71-257
Range on HMM: 94-350/359
Sequence Identity: 20% (55 aa)

RIYGMYESH------RNGQGLVMEYMDCGCVADLIYDRKNIEYKM------------DHVASWMYQLSSA-VNFFHSKDQIHRDLKLQNMLLSHHHRTLK
. ||.|.        ..   ..||||| |.. |.|  .. .   .            . .|   .|.  .  .. ||.  ||||.| .| ||       |
KYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VK

ICDFGTFTSIHQSMT-------------------SNRGSPITMAPEIFRC------EPYNMKADIFSIGIIMWQMIARDHPY-TMNMPITPFLYN-----
.||||. ... .||.                   .  |.|  ||||. ..       .|. |.|| |.|. .. |.   .|. .|. .   |. .     
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-----------VATRNLRPH----------------EIECNPILSNFYKRCWSDNPASRPTSAD
                | .|                  .. | . .| ..|   .|  |||. .
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase Y105C5A.24.AA ULK 116-202 27 1.6e-23 80.36 In-house 132-246 (324) Show / Hide 
Range on Protein: 116-202
Range on HMM: 132-246/324
Sequence Identity: 27% (32 aa)

MYQLSSAVNFFHSKDQIHRDLKLQNMLLSHH-----------HRTLKICDFGTFTSIH------QSMTSNR------GSPITMAPEIFR----CEPYN-M
..|. ..  . |..  ||||.|.|| |....           . .|||.|||   ..       | ...        |.|..|||.|.     ..||.  
FKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDY

KADIFSIGIIMWQMI
|.||.|.|.|. .|.
KCDIWSLGCIFYEML
Kinase Y105C5A.24.AA Dicty5 122-208 40 1.9e-23 77.54 In-house 116-203 (260) Show / Hide 
Range on Protein: 122-208
Range on HMM: 116-203/260
Sequence Identity: 40% (36 aa)

AVNFFHSKDQIHRDLKLQNMLLSHHHRTLKICDFGT--FTSIHQSMTSNRGSPITMAPEIFRCEPYNMKADIFSIGIIMWQMIARDHPY
.  . ||.  ||||||  | |.     . || ||||  |      || . | .  ||.|.|   ||  |.|..| ||. | |..|. ||
SMRHLHSMNIIHRDLKSMNFLITENW-KIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPY
Kinase Y105C5A.24.AA ULK 116-202 27 2.6e-23 78.29 In-house 136-250 (329) Show / Hide 
Range on Protein: 116-202
Range on HMM: 136-250/329
Sequence Identity: 27% (32 aa)

MYQLSSAVNFFHSKDQIHRDLKLQNMLLSHH-----------HRTLKICDFGTFTSIHQS------MTSNR------GSPITMAPEIFR----CEPYN-M
..|. ..  . |..  ||||.|.|| |.. .           . .|||.|||   ..  .      |..        |.|..|||.|.     ..||.  
FKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDY

KADIFSIGIIMWQMI
|.||.|.|.|. .|.
KCDIWSLGCIFYEML
Kinase Y105C5A.24.AA TyrKc 43-262 22 3.1e-12 -24.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-262
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

ELNSHFLGKGTFGVVEKTKYR------KTRDDTYRIYGMYE----------SHRN--------GQG-----------LVMEYMDCGCVADLIYDRKNIEY
    . || | ||.| | ...      . ..|.  .  ...          .| |         |.           .|||||. |.  | . ....   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-L

KMDHVASWMYQLSSAVNFFHSKDQIHRDLKLQNMLLSHHHRTLKICDFG---TFTSI------HQSMTS----NRG--SPIT-MAPEIFRCEPYNMKADI
.|..  |...| ..  .. |||  |||||   | |... | | ||.|||     ..       ..  ..    ..    ||  |||| ..   .. | |.
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

FSIGIIMWQMIAR-DHPYTMN----MPITPFLYNVATRNLRPHEIE--------CNPILSNFYKRCWSDNPASRPTSADCVEYF
.| |. || .  . . ||       |. .  . .| ... .|   .        | . . .  |.||  .|..||| ....|.|
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Y105C5A.24.AA Pkinase_Tyr 85-156 32 2.4e-07 25.49 Pfam 84-156 (270) Show / Hide 
Range on Protein: 85-156
Range on HMM: 84-156/270
Sequence Identity: 32% (24 aa)

LVMEYMDCGCVADLIYDR--KNIEYKMDHVASWMYQLSSAVNFFHSKDQIHRDLKLQNMLLSHHHRTLKICDFG
.||||| .|.  |   ..   .   .| .  .. .| ... .. .||  |||||   | |... . . ||||||
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFG
Kinase Y105C5A.24.AA Dicty5 238-266 34 0.000309 10.48 In-house 232-260 (260) Show / Hide 
Range on Protein: 238-266
Range on HMM: 232-260/260
Sequence Identity: 34% (10 aa)

SNFYKRCWSDNPASRPTSADCVEYFRCLR
||  | || . |  ||.    ..||. . 
SNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase Y105C5A.24.AA TKL 49-63 53 0.001413 8.76 In-house 1-15 (364) Show / Hide 
Range on Protein: 49-63
Range on HMM: 1-15/364
Sequence Identity: 53% (8 aa)

LGKGTFGVVEKTKYR
.|.|.||.| | |.|
IGSGGFGEVYKGKWR
Kinase Y105C5A.24.AA Pkinase_Tyr 242-262 38 0.019303 8.89 Pfam 250-270 (270) Show / Hide 
Range on Protein: 242-262
Range on HMM: 250-270/270
Sequence Identity: 38% (8 aa)

KRCWSDNPASRPTSADCVEYF
|.||  .|. ||| ....| .
KQCWHYDPEDRPTFSEIHEQL
Kinase Y105C5A.24.AA CAMK 48-57 60 0.130454 0.15 In-house 1-10 (425) Show / Hide 
Range on Protein: 48-57
Range on HMM: 1-10/425
Sequence Identity: 60% (6 aa)

FLGKGTFGVV
 ||.|.||.|
TLGRGSFGKV
Kinase Y105C5A.24.AA Pkinase 43-67 28 0.699065 4.2 Pfam 1-25 (293) Show / Hide 
Range on Protein: 43-67
Range on HMM: 1-25/293
Sequence Identity: 28% (7 aa)

ELNSHFLGKGTFGVVEKTKYRKTRD
      .|.|.||.| | . ..|..
YHIGRKIGSGSFGCVYKCHHKGTGK