Gene Y39G8B.5 (Nematode worm)

Y39G8B.5

Species: Nematode worm
Alias: Y39G8B.5, Y39G8B.f, CE28702, aSWK268, Y39G8B.fupdated012199
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: II:18.68, WormBase Physical Map location: II: 13991720-13987498

Classification

Group: Other
Family: Worm3

Sequence

Name Sequence Type Origin Length Description Download
Y39G8B.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON
Y39G8B.5.AA Protein Genbank 1006 None Fasta, JSON

Protein domain

Protein domains of Y39G8B.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y39G8B.5.AA Worm3 21-319 84 2.3e-278 850.95 In-house 1-308 (308) Show / Hide 
Range on Protein: 21-319
Range on HMM: 1-308/308
Sequence Identity: 84% (260 aa)

LYNDEFMAKGAYSQVYRGRTESGRLVAVKTARKTASNKADVDAMCTEIDILKKLKGVANIVQYFGSKNTKIPPGSVTIETISFAMECASRSLDAEMRRPE
|||||||||||||||||||||||||||||||.|||||||||||||.||||||||||||||||||||..||.||||||||||||||||||||||||||||.
LYNDEFMAKGAYSQVYRGRTESGRLVAVKTACKTASNKADVDAMCIEIDILKKLKGVANIVQYFGSNHTKMPPGSVTIETISFAMECASRSLDAEMRRPK

NHKGLPSNVLIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGSPTRGRRSTHLFKLCDMGCSKAISENSSQELNSIAGTKTFLYP--------DHIPP
||.|||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||.|...|.|||.||.|        ||.|.
NHRGLPSNVLIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKAISENSSHEMRTIVGTKNFLHPFLAHEMVDDHMPQ

NGHNWKTKSAYTPEQCDLWSLGCTLYFCATGEFPFESTRADANLYHMAAVDLTRNPNAVAVNLVQVEN-PVTKEKVFNFEPVTELPAEFTRYPKWLVCTM
|.|||||||||||||||||.|||||||||||.||||..|.|.||||||.||||.||.|.|.||||.|. ||..|..|||.|||||||.||||||||| ||
NRHNWKTKSAYTPEQCDLWALGCTLYFCATGKFPFEHERNDKNLYHMAVVDLTQNPDAIAMNLVQKERDPVRREDIFNFQPVTELPAKFTRYPKWLVSTM

TCLLRNFF
||||| ||
TCLLRSFF
Kinase Y39G8B.5.AA IKK 21-247 25 9e-21 68.3 In-house 1-225 (297) Show / Hide 
Range on Protein: 21-247
Range on HMM: 1-225/297
Sequence Identity: 25% (60 aa)

LYNDEFMAKGAYSQVYRGRTE-SGRLVAVKTARKTASNKADVDAMCTEIDILKKLKGV------ANIVQYFGSKNT-KIPPGSVTIETISFAME-CASRS
 . ..   .|| ..||..|   .|| ||||..... . ... . .| |. ..|.|         .||.  ..   . .. .  . .     .|| | . .
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCR-WVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPV----IVMEYCTGGD

LDAEMRRPENHKGLPS-NVLIDLVVDCSMALSALR-EHNIAHRDIKHMNILLFPGSPTRGRRSTHLFKLCDMGCSKAISENSSQELNSIAGTKTFLYPDH
|      |.|. ||.       .  ||. ..  |. .  | |||||  || ..     .|       |. | |  .    .  ..  |  ||  .| || 
LYKYLNSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQ-----KGEDGKTIYKITDFGYAREWDDD--EMFMSFYGTEEYLHPDM

IPPNGHNWKTKSAYTPEQCDLWSLGCTLYFCATGEFPF
 ..   . . . .|.  . |.||.| |.| ||||| ||
YERAVLRKPHQKPYC-ATVDYWSFGVTFYHCATGELPF
Kinase Y39G8B.5.AA S_TKc 21-351 17 1.1e-19 72.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-351
Range on HMM: 1-231/231
Sequence Identity: 17% (62 aa)

LYNDEFMAKGAYSQVYRGRTES-GRLVAVKTARKTASNKADVDAMCTEIDILKKLKGVANIVQYFGSKNTKIPPGSVTIETISFAMECASR---SLDAEM
    .   |||...||..|  . ||.||.|  .         . .. ||.||||  .  |||.....  .         . . . ||...    .|   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYI

RRPENHKG---LPSNVLIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGSPTRGRRSTHLFKLCDMGCSKAISENSSQELNSIAGTKTFLYPDHIPPN
..   |..   .|  .   ..     ||  . .|.| |||.|  ||||               |.|| | .. .        ... ||  .. |  .   
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---

GHNWKTKSAYTPEQCDLWSLGCTLYFCATGEFPFESTRADANLYHMAAVDLTRNPNAVAVNLVQVENPVTKEKVFNFEPVTELPAEFTRYPKWLVCTMTC
         |... || ||.||.|| ...|. ||.    .. ....                                                      
--------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------------------------------

LLRNFFHEPSIEYYAKVAGVMR-N-SKRRTFASVDQ-------MSIV
         | |    . . .. . .|| |   . |       .  .
---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y39G8B.5.AA Ciliate-E2 140-247 24 5.3e-17 54.89 In-house 172-296 (365) Show / Hide 
Range on Protein: 140-247
Range on HMM: 172-296/365
Sequence Identity: 24% (35 aa)

ALSALREHN-IAHRDIKHMNILLFPGSPTRGRRSTHLFKLCDMGCSKAISENSSQEL------------------------------NSIAGTKTFLYP-
||  | . | | |||||  |||.               |..|.| || ..... ...                              |.|.||  .. | 
ALEYLHSKNNIIHRDIKPENILF--------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE

--DHIPPNGHNWKTKSAYTPEQCDLWSLGCTLYFCATGEFPF
     . ..    .|. .  ..||.||||..||.. .|..||
ILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase Y39G8B.5.AA Pkinase 21-262 20 2.1e-15 55.52 Pfam 1-230 (293) Show / Hide 
Range on Protein: 21-262
Range on HMM: 1-230/293
Sequence Identity: 20% (53 aa)

LYNDEFMAKGAYSQVYRGRTESGRL-VAVKTARKTASNKADVDAMCT---EIDILKKLKGVANIVQYFGSKNTKIPPGSVTIETISFAMECASR-----S
.   .   .|....||...  . .  ||||. .|  ..| ..|   .   || |.|.| .  |||.....  .           | . ||..       .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMD

LD----AEMRRPENHKGL--PSNVLIDLVVDCSMALSALREHNIAHRDIKHMNILLF-PGSPTRGRRSTHLFKLCDMGCSKAISENSSQELNSIAGTKTF
|     .     ..|...  . ..... .     .|  . ...| |||.|  |||.   | .         .|.|| |..| ... ... .....||  .
LFDYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------CVKICDFGLAKQFDY-NNS-MTTFCGTPWY

LYPDHIPPNGHNWKTKSAYTPEQCDLWSLGCTLYFCATGEFPFEST----RADANLYHMAAV
. |  |         .. | .  .| ||.||.||  ..|..|| .     . .  .. .. .
MAPEVIR--------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI
Kinase Y39G8B.5.AA Ciliate-E2-Unclassified 140-250 24 2.5e-12 39.08 In-house 155-273 (352) Show / Hide 
Range on Protein: 140-250
Range on HMM: 155-273/352
Sequence Identity: 24% (32 aa)

AL-SALREHNIAHRDIKHMNILLFPGSPTRGRRSTHLFKLCDMGCSKAISEN--------------SSQELNSIAGTKTFL----YPDHIPPNGHNWKTK
.| .  ...|| |||||  |||.  .            |..| | || . .|              ..|......||  ..     |  .  .... .. 
GLEYLHHKNNIIHRDIKPENILFDNNGK------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA

SAYTPEQCDLWSLGCTLYFCATGEFPFEST
     ..|| ||||. ||.. .|..||...
-----YKCDIWSLGVILYEMLFGYYPFYDN
Kinase Y39G8B.5.AA STE 140-247 31 6.4e-12 38.49 In-house 163-268 (359) Show / Hide 
Range on Protein: 140-247
Range on HMM: 163-268/359
Sequence Identity: 31% (39 aa)

A-LSALREHNIAHRDIKHMNILLFPGSPTRGRRSTHLFKLCDMGCSKAISE---------------NSSQELNSIAGTKTFLYPDHIPPNGHNWKTKSAY
. |. | .|.| |||||  ||||               |||| |... ...               ...|. |...||  .  |  | .||.. . .. |
GLLYYLHSHHIIHRDIKPANILL--------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R-DKGY

TPEQCDLWSLGCTLYFCATGEFPF
. ..|| ||||||.   |||. |.
D-TKCDIWSLGCTIIEMATGKPPW
Kinase Y39G8B.5.AA MSN 24-161 29 7.9e-12 35.09 In-house 4-137 (265) Show / Hide 
Range on Protein: 24-161
Range on HMM: 4-137/265
Sequence Identity: 29% (41 aa)

DEFMAKGAYSQVYRGR-TESGRLVAVKTARKTASNKADVDAMCTEIDILKKLKGVANIVQYFGSKNTKIPPGSVTIETISFAME-CASRSLDAEMRRPEN
.| . .|.| |||.|| .  |.|.|.|    .     . . . .||..|||     ||. |.|    | |||    . . . || |.. |. ... .   
VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVRE---DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG--HDHQLWMVMEFCGAGSV-TDLVKMTK

HKGLPSNVLIDLVVDCSMALSALREHNIAHRDIKHMNILL
 . |  . .  .  .    |. | .| . |||||  |.||
GQSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLL
Kinase Y39G8B.5.AA STE 22-86 20 2.2e-11 36.6 In-house 1-98 (359) Show / Hide 
Range on Protein: 22-86
Range on HMM: 1-98/359
Sequence Identity: 20% (20 aa)

YND-EFMAKGAYSQVYRGRTE----------------SGRLVAVKTARKTASNK---------------ADVDAMCTEIDILKKLKG-VANIVQYFGS
. . |.  |||. .||...                  .|...|.|  ..  .|.                ...    ||.|.||..    |||.|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC
Kinase Y39G8B.5.AA MEKK15 144-264 30 1.5e-09 30.79 In-house 117-225 (264) Show / Hide 
Range on Protein: 144-264
Range on HMM: 117-225/264
Sequence Identity: 30% (39 aa)

LREHNIAHRDIKHMNILLFPGSPTRGRRSTHLFKLCDMGCSK----A-ISENSSQELNSIAGTKTFLYPDHIPPNGHNWKTKSAYTPEQCDLWSLGCTLY
| | .. |||||  |..| |         | . || | || |    . |.   |. | |. ||  .. |. |   |.  |          |.||.||| .
LHENCVVHRDIKGNNVMLMP---------TGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRK---------SDIWSIGCTVF

FCATGEFPFESTRADANLYHMAAV-DL
  ||.  |. .    | .. . |  |.
EMATRKPPWADMDRMAAMFYIGAHRDP
Kinase Y39G8B.5.AA ULK 21-90 25 7.1e-09 27.21 In-house 1-90 (329) Show / Hide 
Range on Protein: 21-90
Range on HMM: 1-90/329
Sequence Identity: 25% (23 aa)

LYNDEFMAKGAYSQVYRGR---TE--SGRLVAVKTARKTA-SNKADVD-------AMCTEIDILKKLK----GVA---NIVQYFGSKNTK
 . ..   ||.. .||.||   |.  .. .||.|   |   ..| . .         . ||.|.||||    .     |||...  ..|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETS
Kinase Y39G8B.5.AA CAMK 223-259 26 1.1e-07 20.1 In-house 310-358 (425) Show / Hide 
Range on Protein: 223-259
Range on HMM: 310-358/425
Sequence Identity: 26% (13 aa)

YTPEQCDLWSLGCTLYFCATGEFPFESTR------------ADANLYHM
| ...|| ||.|. ||.. .|..||..               | .|...
YYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEK
Kinase Y39G8B.5.AA TyrKc 21-300 16 1.4e-07 -100.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-300
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

LYNDEFMAKGAYSQVYRGRTESGRLVAVKTARKTASNKADVDAMCTEIDILKKL-KGVANIVQYFGSKNTKIPPGSVTI--------ETISFAME-CASR
.  ..    ||. .||.|.    . ||||. .. |     . ... |. |..|| .   |||. .         | .|         | .   || ..  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY---------GVCTQQGRNFMYIEPLMIVMEYMPHG

SLDAEMRRPENHKGLPSNVLIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGSPTRGRRSTHLFKLCDMGCSKAISEN----SSQELNSIA---GTK-
.|.   |.....  |.   |..  .. .   . | ..|. |||.   |.|.  .            | .| | |..| .      |..  . .   |.| 
DLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

----------TFLYPDHIPPNGHNWKTKSAYTPEQCDLWSLGCTLY-FCATGEFPFEST----RADANLYHMAAVDLTRNPNAV-----AVNLVQVENPV
          ..               .. .| .. | || | ...  .  |. | .        .. ...       . . .          |     .
MLPIRWMAPECI--------------NYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEM

TK--EKVFNFEPV-----TELPAEF
 .  ..  ...|      .|.  .|
YQIMKQCWHEDPEDRPTFSEIHECF
Kinase Y39G8B.5.AA MEKK15 22-85 36 1.7e-07 23.23 In-house 2-68 (264) Show / Hide 
Range on Protein: 22-85
Range on HMM: 2-68/264
Sequence Identity: 36% (25 aa)

YNDEFMAKGAYSQVYRGRTESGRLVAVKTARKTASNKADVDA----MCTEIDILKKLKGVANIVQYFG
   . . ||||  || | |. | |.|||      ..|   .     .  |.|.|| || . ||| | |
KKGNILGKGAYGTVYCGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHK-NIVAYLG
Kinase Y39G8B.5.AA ULK 21-90 27 3.7e-07 21.51 In-house 1-87 (324) Show / Hide 
Range on Protein: 21-90
Range on HMM: 1-87/324
Sequence Identity: 27% (24 aa)

LYNDEFMAKGAYS-QVYRGR---TE-SGRLVAVKTARKTASNKADVD--------AMCTEIDILKKLK---GVAN--IVQYFGSKNTK
 . ..   ||..  .||.||   |. .. .||.|   |   ||   .          . || |.||||   .. |  ||...  ..|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHP-NHHIVKLYDWFETS
Kinase Y39G8B.5.AA ULK 228-249 50 5.1e-07 20.64 In-house 237-258 (329) Show / Hide 
Range on Protein: 228-249
Range on HMM: 237-258/329
Sequence Identity: 50% (11 aa)

CDLWSLGCTLYFCATGEFPFES
||.||||| .| . .|. ||..
CDIWSLGCIFYEMLYGKPPFYA
Kinase Y39G8B.5.AA ULK 228-249 54 8.7e-07 20.18 In-house 233-254 (324) Show / Hide 
Range on Protein: 228-249
Range on HMM: 233-254/324
Sequence Identity: 54% (12 aa)

CDLWSLGCTLYFCATGEFPFES
||.||||| .| . .|. ||.|
CDIWSLGCIFYEMLYGKYPFFS
Kinase Y39G8B.5.AA CAMK 26-82 16 3e-06 15.54 In-house 1-102 (425) Show / Hide 
Range on Protein: 26-82
Range on HMM: 1-102/425
Sequence Identity: 16% (17 aa)

FMAKGAYSQVYRGRTE-SG------------RLVAVKTARKT-ASNKA-------------------------DVDAMCTEIDILKKLKG------VANI
   .|....|....   ..            . ||.|   |. ...|                          | . .  ||.|.|||.|        ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQ
..
IK
Kinase Y39G8B.5.AA ULK 140-201 28 4.2e-05 13.85 In-house 142-214 (329) Show / Hide 
Range on Protein: 140-201
Range on HMM: 142-214/329
Sequence Identity: 28% (21 aa)

ALSALREHNIAHRDIKHMNILLFPGSPTRGRRSTH-----LFKLCDMGCSKAISEN--SSQELNSIA------GT
.. .|..||| |||||  |||.  | | .  .         .|..| | .| ....  . | . .        ||
GFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK-KVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGT
Kinase Y39G8B.5.AA ULK 140-201 29 0.000464 10.37 In-house 138-210 (324) Show / Hide 
Range on Protein: 140-201
Range on HMM: 138-210/324
Sequence Identity: 29% (22 aa)

ALSALREHNIAHRDIKHMNILLFPGSPTRGRRSTH-----LFKLCDMGCSKAISENS--SQELNSIA------GT
.. .|..||| |||||  |||.  | | .  .         .|..| | .| . .|.   | . ..       ||
GFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK-KVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGT
Kinase Y39G8B.5.AA CAMK 146-161 68 0.014102 3.32 In-house 197-212 (425) Show / Hide 
Range on Protein: 146-161
Range on HMM: 197-212/425
Sequence Identity: 68% (11 aa)

EHNIAHRDIKHMNILL
.|||.|||.|  ||||
SHNIVHRDLKPENILL
Sre Y39G8B.5.AA Sre 714-835 30 8.1e-47 166.66 Pfam 184-313 (384) Show / Hide 
Range on Protein: 714-835
Range on HMM: 184-313/384
Sequence Identity: 30% (39 aa)

QTFTMIFS-IVFFFNYLSYVFGISIIAISNIGAVMLMLYSRHYNQKITKIHEDYAH-QS--NYTLAARFQAKENMKCFEMIWKIVIFALCIGIVGFATAL
|.|..... ..|.||.|...| . ...|..|........ ||||||..|..|.... ..  ||||..|||.|||..|..|....|.. |.. .......|
QFFAISMAIYFFIFNWLPFFFIVLPWMICCIISYIMYFFCRHYNQKWYKEMENPRRKHRMHNYTLSQRFQVKENIRCLKMGKRVVFVVLFMIVCCCSGIL

SLYFHI----LPELDTMLNLVMQAMINLPP
.|.|..    .||............|.|.|
FLFFDLSDDVFPEHQPFCCHCFENFIFLYP
ShK Y39G8B.5.AA ShK 836-866 58 1.1e-08 30.0 Pfam 10-40 (40) Show / Hide 
Range on Protein: 836-866
Range on HMM: 10-40/40
Sequence Identity: 58% (18 aa)

CSGWAKNGFCTNCFYTCEQREQYCAKTCEYC
|. |||||||.|.||..... |||.||| .|
CANWAKNGFCNNPFYYQDWMKQYCPKTCGFC
ShK Y39G8B.5.AA ShK 869-875 57 19.757287 0.8 Pfam 34-40 (40) Show / Hide 
Range on Protein: 869-875
Range on HMM: 34-40/40
Sequence Identity: 57% (4 aa)

QKTCENC
.|||  |
PKTCGFC